FI114101B - Menetelmä vaihdevuosivaivojen hoitoon käyttökelpoisten steroidien valmistamiseksi - Google Patents

Menetelmä vaihdevuosivaivojen hoitoon käyttökelpoisten steroidien valmistamiseksi Download PDF

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Publication number
FI114101B
FI114101B FI953747A FI953747A FI114101B FI 114101 B FI114101 B FI 114101B FI 953747 A FI953747 A FI 953747A FI 953747 A FI953747 A FI 953747A FI 114101 B FI114101 B FI 114101B
Authority
FI
Finland
Prior art keywords
hydroxy
optionally
group
csch
wittig
Prior art date
Application number
FI953747A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI953747A (fi
FI953747A0 (fi
Inventor
Hubert Jan Josef Loozen
Lodewijk Pieter Cornelis Schot
Der Werf-Pieters Jane Marg Van
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of FI953747A0 publication Critical patent/FI953747A0/fi
Publication of FI953747A publication Critical patent/FI953747A/fi
Application granted granted Critical
Publication of FI114101B publication Critical patent/FI114101B/fi

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051Estrane derivatives
    • C07J1/0081Substituted in position 17 alfa and 17 beta
    • C07J1/0088Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096Alkynyl derivatives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J11/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J21/00Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005Ketals
    • C07J21/008Ketals at position 17
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J33/00Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007Cyclic thioketals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI953747A 1993-02-08 1995-08-07 Menetelmä vaihdevuosivaivojen hoitoon käyttökelpoisten steroidien valmistamiseksi FI114101B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP93200332 1993-02-08
EP93200332 1993-02-08
PCT/EP1994/000348 WO1994018224A1 (fr) 1993-02-08 1994-02-04 Steroides pour le traitement d'affections menopausiques
EP9400348 1994-02-04

Publications (3)

Publication Number Publication Date
FI953747A0 FI953747A0 (fi) 1995-08-07
FI953747A FI953747A (fi) 1995-09-12
FI114101B true FI114101B (fi) 2004-08-13

Family

ID=8213615

Family Applications (1)

Application Number Title Priority Date Filing Date
FI953747A FI114101B (fi) 1993-02-08 1995-08-07 Menetelmä vaihdevuosivaivojen hoitoon käyttökelpoisten steroidien valmistamiseksi

Country Status (15)

Country Link
EP (1) EP0682672A1 (fr)
JP (1) JPH08506116A (fr)
KR (1) KR100364113B1 (fr)
CN (1) CN1046735C (fr)
AU (1) AU4675897A (fr)
BR (1) BR9405825A (fr)
CA (1) CA2155532A1 (fr)
FI (1) FI114101B (fr)
HU (2) HU220615B1 (fr)
NO (1) NO308583B1 (fr)
NZ (1) NZ261581A (fr)
PL (1) PL182901B1 (fr)
RU (1) RU2172740C2 (fr)
WO (1) WO1994018224A1 (fr)
ZA (1) ZA94715B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403736B (en) * 1997-02-21 2000-09-01 Akzo Nobel Nv Steroid compounds having contraceptive and anti-osteoporosis activity
ID25621A (id) * 1998-03-09 2000-10-19 Akzo Nobel Nv Perlengkapan kontrasepsi baru
MXPA02001831A (es) 1999-09-06 2002-10-23 Akzo Nobel Nv Esteroides estrogenicos no aromaticos con un sustituyente de hidrocarburo en posicion 11.
AU8201601A (en) 2000-07-28 2002-02-13 Akzo Nobel Nv 16alpha-methyl or ethyl substituted estrogens
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
ES2881336T3 (es) * 2016-03-03 2021-11-29 Crystal Pharma Sau Procedimiento y nuevos productos intermedios para la preparación de 11-metilen-esteroides

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325520A (en) * 1965-12-08 1967-06-13 Searle & Co (optionally 17-hydrocarbon-substituted) 11, 13beta-dialkylgon-4-en-3-ones and esters corresponding
US3465010A (en) * 1966-11-22 1969-09-02 Searle & Co 17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof
NL175063C (nl) * 1972-12-09 1984-09-17 Akzo Nv Werkwijze ter bereiding van 11,11-alkylideensteroiden, werkwijze ter bereiding van farmaceutische preparaten en gevormde farmaceutische preparaten.
FI54128C (fi) * 1972-12-09 1978-10-10 Akzo Nv Foerfarande foer framstaellning av nya 11,11-alkylidensteroider ur oestran- och 19-norpregnanserien med foerbaettrad hormonell verkan
NL7317358A (nl) * 1973-12-19 1975-06-23 Akzo Nv Nieuwe 11(beta)-alkylsteroiden van de oestraanreeks.
NL7701384A (nl) * 1977-02-10 1978-08-14 Akzo Nv Werkwijze voor het bereiden van nieuwe steroiden van de oestraanreeks.
AU532512B2 (en) * 1979-09-07 1983-10-06 Upjohn and Horton Anti-allergenic compounds for bone mineral resorption
US4826831A (en) * 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
AU572589B2 (en) * 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
NL8502571A (nl) * 1985-09-20 1987-04-16 Akzo Nv Steroiden met immunomodulerende eigenschappen.
DE3702383A1 (de) * 1987-01-23 1988-08-04 Schering Ag 11ss-alkinylestrene und -estradiene, deren herstellung und diese enthaltende pharmazeutische praeparate
HUT52382A (en) * 1988-03-14 1990-07-28 Sandoz Ag Process for producing pharmaceutical compositions comprising as active ingredient unsubstituted progestin in 19-position and estrogen in the given case
DK0461290T3 (da) * 1990-06-14 1994-02-21 Henning Berlin Gmbh Væskefyldte stikkapsler
AU8166191A (en) * 1990-08-10 1992-02-13 Ortho Pharmaceutical Corporation Method for treatment of bone wasting diseases

Also Published As

Publication number Publication date
HU0102320D0 (en) 2001-08-28
NO953089L (no) 1995-10-06
RU2172740C2 (ru) 2001-08-27
WO1994018224A1 (fr) 1994-08-18
HUT72971A (en) 1996-06-28
HU220615B1 (hu) 2002-03-28
BR9405825A (pt) 1995-12-05
NZ261581A (en) 1997-06-24
HU9501940D0 (en) 1995-09-28
FI953747A (fi) 1995-09-12
PL310125A1 (en) 1995-11-27
FI953747A0 (fi) 1995-08-07
CN1046735C (zh) 1999-11-24
PL182901B1 (pl) 2002-03-29
NO953089D0 (no) 1995-08-07
NO308583B1 (no) 2000-10-02
ZA94715B (en) 1994-10-24
AU4675897A (en) 1998-02-19
JPH08506116A (ja) 1996-07-02
CN1117735A (zh) 1996-02-28
EP0682672A1 (fr) 1995-11-22
AU682170B2 (en) 1997-09-25
CA2155532A1 (fr) 1994-08-18
AU6039494A (en) 1994-08-29
KR100364113B1 (ko) 2003-04-08

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