HUT72971A - Process for producing steroids for treating menopausal complaints and pharmaceutical compositions containing them - Google Patents

Process for producing steroids for treating menopausal complaints and pharmaceutical compositions containing them

Info

Publication number
HUT72971A
HUT72971A HU9501940A HU9501940A HUT72971A HU T72971 A HUT72971 A HU T72971A HU 9501940 A HU9501940 A HU 9501940A HU 9501940 A HU9501940 A HU 9501940A HU T72971 A HUT72971 A HU T72971A
Authority
HU
Hungary
Prior art keywords
pharmaceutical compositions
compositions containing
treating menopausal
menopausal complaints
producing steroids
Prior art date
Application number
HU9501940A
Other languages
Hungarian (hu)
Other versions
HU220615B1 (en
HU9501940D0 (en
Inventor
Hubert Jan Jozef Loozen
Lodewijk Pieter Cornelis Schot
Jane Margretha Len Werfpieters
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of HU9501940D0 publication Critical patent/HU9501940D0/en
Publication of HUT72971A publication Critical patent/HUT72971A/en
Publication of HU220615B1 publication Critical patent/HU220615B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0051—Estrane derivatives
    • C07J1/0081—Substituted in position 17 alfa and 17 beta
    • C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
    • C07J1/0096—Alkynyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J11/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/008—Ketals at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/005—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton spiro-condensed
    • C07J33/007—Cyclic thioketals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0044—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an estrane or gonane skeleton, including 18-substituted derivatives and derivatives where position 17-beta is substituted by a carbon atom not directly bonded to another carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9501940A 1993-02-08 1994-02-04 Steroids useful for treating menopausal complaints and pharmaceuticals comprising the same HU220615B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP93200332 1993-02-08
PCT/EP1994/000348 WO1994018224A1 (en) 1993-02-08 1994-02-04 Steroids for treating menopausal complaints

Publications (3)

Publication Number Publication Date
HU9501940D0 HU9501940D0 (en) 1995-09-28
HUT72971A true HUT72971A (en) 1996-06-28
HU220615B1 HU220615B1 (en) 2002-03-28

Family

ID=8213615

Family Applications (2)

Application Number Title Priority Date Filing Date
HU9501940A HU220615B1 (en) 1993-02-08 1994-02-04 Steroids useful for treating menopausal complaints and pharmaceuticals comprising the same
HU0102320A HU0102320D0 (en) 1993-02-08 1994-02-04 Use of steroids for the treatment of menopausal complaints

Family Applications After (1)

Application Number Title Priority Date Filing Date
HU0102320A HU0102320D0 (en) 1993-02-08 1994-02-04 Use of steroids for the treatment of menopausal complaints

Country Status (15)

Country Link
EP (1) EP0682672A1 (en)
JP (1) JPH08506116A (en)
KR (1) KR100364113B1 (en)
CN (1) CN1046735C (en)
AU (1) AU4675897A (en)
BR (1) BR9405825A (en)
CA (1) CA2155532A1 (en)
FI (1) FI114101B (en)
HU (2) HU220615B1 (en)
NO (1) NO308583B1 (en)
NZ (1) NZ261581A (en)
PL (1) PL182901B1 (en)
RU (1) RU2172740C2 (en)
WO (1) WO1994018224A1 (en)
ZA (1) ZA94715B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW403736B (en) * 1997-02-21 2000-09-01 Akzo Nobel Nv Steroid compounds having contraceptive and anti-osteoporosis activity
TR200002593T2 (en) * 1998-03-09 2000-12-21 Akzo Nobel N.V. A new contraception kit
TR200200575T2 (en) * 1999-09-06 2002-06-21 Akzo Nobel N. V. Non-aromatic estrogenic steroids with a hydrocarbon substituent at position 11.
BR0112791A (en) 2000-07-28 2003-06-24 Akzo Nobel Nv 16alpha-substituted steroidal compound, use thereof, treatment methods for selective activation of alpha subtype estrogen receptors, and for hormone replacement therapy or contraception, and, pharmaceutical composition
UA89964C2 (en) 2004-09-08 2010-03-25 Н.В. Органон 15beta-substituted steroids having selective estrogenic activity
US11034716B2 (en) * 2016-03-03 2021-06-15 Crystal Pharma, S.A.U. Process and new intermediates for the preparation of 11-methylene steroids

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325520A (en) * 1965-12-08 1967-06-13 Searle & Co (optionally 17-hydrocarbon-substituted) 11, 13beta-dialkylgon-4-en-3-ones and esters corresponding
US3465010A (en) * 1966-11-22 1969-09-02 Searle & Co 17 - (unsaturated hydrocarbon - substituted) 11,13beta - dialkylgon -4 - ene - 3,17beta-diols and esters thereof
NL175063C (en) * 1972-12-09 1984-09-17 Akzo Nv PROCESS FOR THE PREPARATION OF 11,11-ALKYLIDE STEROIDS, PROCESS FOR PREPARING PHARMACEUTICAL PREPARATIONS AND FORMED PHARMACEUTICAL PREPARATIONS.
FI54128C (en) * 1972-12-09 1978-10-10 Akzo Nv FREQUENCY REFRIGERATION FOR NY 11,11-ALKYLIDENSTEROIDER UR OESTRAN- OCH 19-NORPREGNANSERIEN MED FOERBAETTRAD HORMONELL VERKAN
NL7317358A (en) * 1973-12-19 1975-06-23 Akzo Nv NEW 11 (BETA) ALKYL STEROIDS FROM THE OESTRAAN SERIES.
NL7701384A (en) * 1977-02-10 1978-08-14 Akzo Nv PROCESS FOR PREPARING NEW STEROIDS FROM THE OESTRAINE SERIES.
AU532512B2 (en) * 1979-09-07 1983-10-06 Upjohn and Horton Anti-allergenic compounds for bone mineral resorption
US4826831A (en) * 1983-08-05 1989-05-02 Pre Jay Holdings Limited Method of hormonal treatment for menopausal or post-menopausal disorders involving continuous administration of progestogens and estrogens
AU572589B2 (en) * 1983-12-14 1988-05-12 Upjohn Company, The 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids
NL8502571A (en) * 1985-09-20 1987-04-16 Akzo Nv Steroidal immuno-modulators - comprising 4-oestrene derivs.
DE3702383A1 (en) * 1987-01-23 1988-08-04 Schering Ag 11SS-ALKINYLESTRENE AND -ESTRADIENE, THEIR PRODUCTION AND THEIR PHARMACEUTICAL PREPARATIONS CONTAINING THEM
HUT52382A (en) * 1988-03-14 1990-07-28 Sandoz Ag Process for producing pharmaceutical compositions comprising as active ingredient unsubstituted progestin in 19-position and estrogen in the given case
ATE99939T1 (en) * 1990-06-14 1994-01-15 Henning Berlin Gmbh LIQUID-FILLED CAPSULE PREPARATIONS.
AU8166191A (en) * 1990-08-10 1992-02-13 Ortho Pharmaceutical Corporation Method for treatment of bone wasting diseases

Also Published As

Publication number Publication date
WO1994018224A1 (en) 1994-08-18
EP0682672A1 (en) 1995-11-22
FI953747A0 (en) 1995-08-07
NO953089D0 (en) 1995-08-07
FI953747A (en) 1995-09-12
PL310125A1 (en) 1995-11-27
KR100364113B1 (en) 2003-04-08
CN1046735C (en) 1999-11-24
CA2155532A1 (en) 1994-08-18
AU6039494A (en) 1994-08-29
PL182901B1 (en) 2002-03-29
AU682170B2 (en) 1997-09-25
HU220615B1 (en) 2002-03-28
HU0102320D0 (en) 2001-08-28
NO953089L (en) 1995-10-06
RU2172740C2 (en) 2001-08-27
BR9405825A (en) 1995-12-05
HU9501940D0 (en) 1995-09-28
ZA94715B (en) 1994-10-24
AU4675897A (en) 1998-02-19
NO308583B1 (en) 2000-10-02
CN1117735A (en) 1996-02-28
NZ261581A (en) 1997-06-24
JPH08506116A (en) 1996-07-02
FI114101B (en) 2004-08-13

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Legal Events

Date Code Title Description
MM4A Lapse of definitive patent protection due to non-payment of fees