FI113763B - Nipekotiinihappojohdannaisia hyytymistä estävinä aineina - Google Patents
Nipekotiinihappojohdannaisia hyytymistä estävinä aineina Download PDFInfo
- Publication number
- FI113763B FI113763B FI955498A FI955498A FI113763B FI 113763 B FI113763 B FI 113763B FI 955498 A FI955498 A FI 955498A FI 955498 A FI955498 A FI 955498A FI 113763 B FI113763 B FI 113763B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- lys
- boc
- nip
- ala
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21377294A | 1994-03-16 | 1994-03-16 | |
US21377294 | 1994-03-16 | ||
US36489694A | 1994-12-27 | 1994-12-27 | |
US36489694 | 1994-12-27 | ||
PCT/US1995/003145 WO1995025091A2 (en) | 1994-03-16 | 1995-03-14 | Nipecotic acid derivatives as antithrombic compounds |
US9503145 | 1995-03-14 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI955498A0 FI955498A0 (fi) | 1995-11-15 |
FI955498A FI955498A (fi) | 1996-01-15 |
FI113763B true FI113763B (fi) | 2004-06-15 |
Family
ID=26908383
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI955498A FI113763B (fi) | 1994-03-16 | 1995-11-15 | Nipekotiinihappojohdannaisia hyytymistä estävinä aineina |
Country Status (20)
Country | Link |
---|---|
US (1) | US5770575A (no) |
EP (1) | EP0746545B1 (no) |
JP (1) | JPH09510453A (no) |
KR (1) | KR100328287B1 (no) |
CN (1) | CN1083834C (no) |
AT (1) | ATE180470T1 (no) |
AU (1) | AU703397B2 (no) |
CA (1) | CA2163027A1 (no) |
DE (1) | DE69509875T2 (no) |
DK (1) | DK0746545T3 (no) |
ES (1) | ES2131313T3 (no) |
FI (1) | FI113763B (no) |
GR (1) | GR3030566T3 (no) |
HU (1) | HUT74871A (no) |
MX (1) | MX9504800A (no) |
NO (1) | NO304885B1 (no) |
NZ (1) | NZ283209A (no) |
RU (1) | RU2135470C1 (no) |
TW (1) | TW318179B (no) |
WO (1) | WO1995025091A2 (no) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT669912E (pt) * | 1993-09-22 | 2002-03-28 | Fujisawa Pharmaceutical Co | Derivados de n-(3-piperidinil-carbonil)-beta-alanina como antagonistas de paf |
IL117495A (en) * | 1995-03-17 | 2002-05-23 | Fujisawa Pharmaceutical Co | History of b-alanine, the process for their preparation and the pharmaceutical preparations containing them |
JP2000506524A (ja) * | 1996-03-13 | 2000-05-30 | 藤沢薬品工業株式会社 | フィブリノーゲン受容体拮抗剤であるN―[(R)―1―{3―(4―ピペリジル)プロピオニル}―3―ピペリジルカルボニル]―2(S)―アセチルアミノ―β―アラニン |
UA70285C2 (en) * | 1996-05-01 | 2004-10-15 | Carboxamide derivatives of piperidine, a compositicarboxamide derivatives of piperidine, a composition based thereon and a method for treatment of thron based thereon and a method for treatment of thrombotic disorders ombotic disorders | |
SI0923555T1 (en) * | 1996-05-01 | 2005-10-31 | Ortho-Mcneil Pharmaceutical, Inc. | Carboxamide derivatives of pyrrolidine, piperidine and hexahydroazepine for the treatment of thrombosis disorders |
DE19741235A1 (de) * | 1997-09-18 | 1999-03-25 | Hoechst Marion Roussel De Gmbh | Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate |
US6066651A (en) * | 1997-10-29 | 2000-05-23 | Ortho-Mcneil Pharmaceutical, Inc. | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |
WO1999025685A1 (en) * | 1997-11-18 | 1999-05-27 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
US6020347A (en) * | 1997-11-18 | 2000-02-01 | Merck & Co., Inc. | 4-substituted-4-piperidine carboxamide derivatives |
CN1351600A (zh) * | 1999-03-22 | 2002-05-29 | 奥索一麦克尼尔药品公司 | 制备[S-(R*,S*)]-β-[[[1-[1-氧代-3-(4-(哌啶基)丙基]-3-哌啶基]羰基]氨基]-3-吡啶丙酸及其衍生物的方法 |
AUPQ570100A0 (en) * | 2000-02-17 | 2000-03-09 | Fujisawa Pharmaceutical Co., Ltd. | Beta-alanine derivatives and their use as receptor antagonists |
WO2005079863A1 (ja) | 2004-02-25 | 2005-09-01 | Astellas Pharma Inc. | 血栓造影剤 |
EP3184149A1 (en) * | 2015-12-23 | 2017-06-28 | Julius-Maximilians-Universität Würzburg | Soluble glycoprotein v for treating thrombotic diseases |
CN109734655B (zh) * | 2019-03-11 | 2020-06-02 | 都创(上海)医药科技有限公司 | 一种fkbp配体的同型二聚体合成工艺 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4857508A (en) * | 1987-12-03 | 1989-08-15 | Monsanto Company | Novel platelet-aggregation inhibitor peptide derivatives |
US5318899A (en) * | 1989-06-16 | 1994-06-07 | Cor Therapeutics, Inc. | Platelet aggregation inhibitors |
TW201303B (no) * | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
IE912760A1 (en) * | 1990-08-06 | 1992-02-12 | Smith Kline French Lab | Compounds |
WO1993009795A1 (en) * | 1991-11-22 | 1993-05-27 | Yeda Research And Development Co. Ltd. | Non-peptidic surrogates of the arg-gly-asp sequence and pharmaceutical compositions comprising them |
US5219867A (en) * | 1991-12-16 | 1993-06-15 | Research Corporation Technologies, Inc. | Platelet aggregation inhibitory agents |
JP3401005B2 (ja) * | 1992-12-11 | 2003-04-28 | ユニバーシティ オブ フロリダ | 有害生物の防除のための材料および方法 |
US5559209A (en) * | 1993-02-18 | 1996-09-24 | The General Hospital Corporation | Regulator regions of G proteins |
-
1995
- 1995-03-06 US US08/395,533 patent/US5770575A/en not_active Expired - Lifetime
- 1995-03-14 DK DK95914023T patent/DK0746545T3/da active
- 1995-03-14 HU HU9503270A patent/HUT74871A/hu unknown
- 1995-03-14 AT AT95914023T patent/ATE180470T1/de not_active IP Right Cessation
- 1995-03-14 CN CN95190367A patent/CN1083834C/zh not_active Expired - Fee Related
- 1995-03-14 EP EP95914023A patent/EP0746545B1/en not_active Expired - Lifetime
- 1995-03-14 WO PCT/US1995/003145 patent/WO1995025091A2/en active IP Right Grant
- 1995-03-14 RU RU95122287A patent/RU2135470C1/ru not_active IP Right Cessation
- 1995-03-14 CA CA002163027A patent/CA2163027A1/en not_active Abandoned
- 1995-03-14 ES ES95914023T patent/ES2131313T3/es not_active Expired - Lifetime
- 1995-03-14 NZ NZ283209A patent/NZ283209A/en unknown
- 1995-03-14 KR KR1019950705100A patent/KR100328287B1/ko not_active IP Right Cessation
- 1995-03-14 MX MX9504800A patent/MX9504800A/es not_active IP Right Cessation
- 1995-03-14 AU AU21191/95A patent/AU703397B2/en not_active Ceased
- 1995-03-14 JP JP7524128A patent/JPH09510453A/ja active Pending
- 1995-03-14 DE DE69509875T patent/DE69509875T2/de not_active Expired - Fee Related
- 1995-11-15 FI FI955498A patent/FI113763B/fi active
- 1995-11-15 NO NO954609A patent/NO304885B1/no unknown
- 1995-12-18 TW TW084113492A patent/TW318179B/zh active
-
1999
- 1999-06-17 GR GR990401649T patent/GR3030566T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
NO954609L (no) | 1996-01-05 |
NZ283209A (en) | 1998-04-27 |
NO304885B1 (no) | 1999-03-01 |
JPH09510453A (ja) | 1997-10-21 |
ATE180470T1 (de) | 1999-06-15 |
DE69509875D1 (de) | 1999-07-01 |
FI955498A (fi) | 1996-01-15 |
RU2135470C1 (ru) | 1999-08-27 |
EP0746545B1 (en) | 1999-05-26 |
EP0746545A1 (en) | 1996-12-11 |
US5770575A (en) | 1998-06-23 |
FI955498A0 (fi) | 1995-11-15 |
DE69509875T2 (de) | 1999-12-09 |
GR3030566T3 (en) | 1999-10-29 |
CA2163027A1 (en) | 1995-09-21 |
ES2131313T3 (es) | 1999-07-16 |
AU703397B2 (en) | 1999-03-25 |
CN1083834C (zh) | 2002-05-01 |
CN1128022A (zh) | 1996-07-31 |
MX9504800A (es) | 1997-05-31 |
HUT74871A (en) | 1997-02-28 |
DK0746545T3 (da) | 1999-11-08 |
NO954609D0 (no) | 1995-11-15 |
WO1995025091A3 (en) | 1995-10-12 |
AU2119195A (en) | 1995-10-03 |
WO1995025091A2 (en) | 1995-09-21 |
HU9503270D0 (en) | 1996-05-28 |
KR100328287B1 (ko) | 2002-10-11 |
TW318179B (en) | 1997-10-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI113763B (fi) | Nipekotiinihappojohdannaisia hyytymistä estävinä aineina | |
Hilpert et al. | Design and synthesis of potent and highly selective thrombin inhibitors | |
US5750520A (en) | Antithrombotic amidinophenylalanine and amidinopyridylalanine derivatives | |
KR100510854B1 (ko) | 혈전성질환의치료를위한피롤리딘,피페리딘및헥사하이드로아제핀의카르복사미드유도체 | |
US5798352A (en) | Antithrombotic amidinotetrahydropyridylalanine derivatives | |
Kohrt et al. | The Discovery of (2R, 4R)‐N‐(4‐chlorophenyl)‐N‐(2‐fluoro‐4‐(2‐oxopyridin‐1 (2H)‐yl) phenyl)‐4‐methoxypyrrolidine‐1, 2‐dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor | |
AU759631B2 (en) | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders | |
EP1492767B1 (en) | Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor xa | |
EP1409479A2 (en) | 1-glycinyl-4-(1-methylpiperidin-4-yl)piperazines and -piperidines as factor xa antagonists | |
MXPA00004201A (en) | Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders |