FI113763B - Nipekotiinihappojohdannaisia hyytymistä estävinä aineina - Google Patents

Nipekotiinihappojohdannaisia hyytymistä estävinä aineina Download PDF

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Publication number
FI113763B
FI113763B FI955498A FI955498A FI113763B FI 113763 B FI113763 B FI 113763B FI 955498 A FI955498 A FI 955498A FI 955498 A FI955498 A FI 955498A FI 113763 B FI113763 B FI 113763B
Authority
FI
Finland
Prior art keywords
compound
lys
boc
nip
ala
Prior art date
Application number
FI955498A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955498A0 (fi
FI955498A (fi
Inventor
William J Hoekstra
Mary Pat Beavers
Patricia Andrade-Gordon
Original Assignee
Ortho Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Pharma Corp filed Critical Ortho Pharma Corp
Publication of FI955498A0 publication Critical patent/FI955498A0/fi
Publication of FI955498A publication Critical patent/FI955498A/fi
Application granted granted Critical
Publication of FI113763B publication Critical patent/FI113763B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI955498A 1994-03-16 1995-11-15 Nipekotiinihappojohdannaisia hyytymistä estävinä aineina FI113763B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US21377294A 1994-03-16 1994-03-16
US21377294 1994-03-16
US36489694A 1994-12-27 1994-12-27
US36489694 1994-12-27
US9503145 1995-03-14
PCT/US1995/003145 WO1995025091A2 (fr) 1994-03-16 1995-03-14 Derives d'acide nipecotique utilises en tant que composes antithrombotiques

Publications (3)

Publication Number Publication Date
FI955498A0 FI955498A0 (fi) 1995-11-15
FI955498A FI955498A (fi) 1996-01-15
FI113763B true FI113763B (fi) 2004-06-15

Family

ID=26908383

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955498A FI113763B (fi) 1994-03-16 1995-11-15 Nipekotiinihappojohdannaisia hyytymistä estävinä aineina

Country Status (20)

Country Link
US (1) US5770575A (fr)
EP (1) EP0746545B1 (fr)
JP (1) JPH09510453A (fr)
KR (1) KR100328287B1 (fr)
CN (1) CN1083834C (fr)
AT (1) ATE180470T1 (fr)
AU (1) AU703397B2 (fr)
CA (1) CA2163027A1 (fr)
DE (1) DE69509875T2 (fr)
DK (1) DK0746545T3 (fr)
ES (1) ES2131313T3 (fr)
FI (1) FI113763B (fr)
GR (1) GR3030566T3 (fr)
HU (1) HUT74871A (fr)
MX (1) MX9504800A (fr)
NO (1) NO304885B1 (fr)
NZ (1) NZ283209A (fr)
RU (1) RU2135470C1 (fr)
TW (1) TW318179B (fr)
WO (1) WO1995025091A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2164109T3 (es) * 1993-09-22 2002-02-16 Fujisawa Pharmaceutical Co Derivados de n-(3-piperidinilcarbonil)-beta-alanina como antagonistas de paf.
WO1996029309A1 (fr) * 1995-03-17 1996-09-26 Fujisawa Pharmaceutical Co., Ltd. ACIDES N-ACYLPIPERIDINYLCARBONYLAMINOCARBOXYLIQUES ET LEUR UTILISATION EN TANT QU'ANTAGONISTES DE LA GLYCOPROTEINE IIB/IIIa ET INHIBITEURS DE LIAISON DU FIBRINOGENE ET DES PLAQUETTES SANGUINES
KR19990087694A (ko) * 1996-03-13 1999-12-27 후지야마 아키라 피브리노겐 수용체 길항제로서의 N-[(R)-１-{３-(４-피페리딜)프로피오닐-３-피페리딜카보닐]-２(S)-아세틸아미노-β-알라닌
TR199802207T2 (xx) * 1996-05-01 2001-06-21 Ortho-Mcneil Pharmacetical, Inc. Tromboz'a kar�� kullan�lmaya mahsus pirrolidin, piperidin ve heksahidroazepin'in karboksamid t�revleri.
EP1184374B1 (fr) * 1996-05-01 2009-01-28 Ortho-McNeil Pharmaceutical, Inc. Derivés carboxamide de pyrrolidine, pipéridine et hexahydroazépine utilisés dans le traitement de troubles thrombotiques
DE19741235A1 (de) * 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
US6066651A (en) * 1997-10-29 2000-05-23 Ortho-Mcneil Pharmaceutical, Inc. Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
WO1999025685A1 (fr) * 1997-11-18 1999-05-27 Merck & Co., Inc. Derives de 4-piperidine carboxamides 4-substitues
US6020347A (en) * 1997-11-18 2000-02-01 Merck & Co., Inc. 4-substituted-4-piperidine carboxamide derivatives
JP2002540108A (ja) * 1999-03-22 2002-11-26 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ［Ｓ−（Ｒ＊，Ｓ＊）］−β−［［［１−［１−オキソ−３−（４−ピペリジニル）プロピル］−３−ピペリジニル］カルボニル］アミノ］−３−ピリジンプロパン酸及び誘導体を製造する方法
AUPQ570100A0 (en) 2000-02-17 2000-03-09 Fujisawa Pharmaceutical Co., Ltd. Beta-alanine derivatives and their use as receptor antagonists
US20070189970A1 (en) 2004-02-25 2007-08-16 Astellas Pharma Inc. Contrast medium for thrombus formation
EP3184149A1 (fr) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Glycoprotéine v soluble pour le traitement de maladies thrombotiques
CN109734655B (zh) * 2019-03-11 2020-06-02 都创(上海)医药科技有限公司 一种fkbp配体的同型二聚体合成工艺

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4857508A (en) * 1987-12-03 1989-08-15 Monsanto Company Novel platelet-aggregation inhibitor peptide derivatives
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
TW201303B (fr) * 1990-07-05 1993-03-01 Hoffmann La Roche
IE912760A1 (en) * 1990-08-06 1992-02-12 Smith Kline French Lab Compounds
JPH07503944A (ja) * 1991-11-22 1995-04-27 イエダ　リサーチ　アンド　デベロツプメント　カンパニー　リミテツド Ａｒｇ−ｇｌｙ−ａｓｐ配列の非ペプチド代替物およびそれらからなる医薬組成物
US5219867A (en) * 1991-12-16 1993-06-15 Research Corporation Technologies, Inc. Platelet aggregation inhibitory agents
CA2150371C (fr) * 1992-12-11 2002-09-17 Dov Borovsky Pesticides et mode d'emploi
US5559209A (en) * 1993-02-18 1996-09-24 The General Hospital Corporation Regulator regions of G proteins

Also Published As

Publication number Publication date
AU2119195A (en) 1995-10-03
NO954609L (no) 1996-01-05
HUT74871A (en) 1997-02-28
NO954609D0 (no) 1995-11-15
DK0746545T3 (da) 1999-11-08
KR100328287B1 (ko) 2002-10-11
ES2131313T3 (es) 1999-07-16
AU703397B2 (en) 1999-03-25
NO304885B1 (no) 1999-03-01
EP0746545A1 (fr) 1996-12-11
FI955498A0 (fi) 1995-11-15
TW318179B (en) 1997-10-21
WO1995025091A2 (fr) 1995-09-21
EP0746545B1 (fr) 1999-05-26
DE69509875T2 (de) 1999-12-09
JPH09510453A (ja) 1997-10-21
CA2163027A1 (fr) 1995-09-21
MX9504800A (es) 1997-05-31
ATE180470T1 (de) 1999-06-15
US5770575A (en) 1998-06-23
CN1083834C (zh) 2002-05-01
FI955498A (fi) 1996-01-15
NZ283209A (en) 1998-04-27
CN1128022A (zh) 1996-07-31
HU9503270D0 (en) 1996-05-28
GR3030566T3 (en) 1999-10-29
DE69509875D1 (de) 1999-07-01
RU2135470C1 (ru) 1999-08-27
WO1995025091A3 (fr) 1995-10-12

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