FI113044B - 2-hydratsinopyridiinijohdannaisia - Google Patents

2-hydratsinopyridiinijohdannaisia Download PDF

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Publication number
FI113044B
FI113044B FI952141A FI952141A FI113044B FI 113044 B FI113044 B FI 113044B FI 952141 A FI952141 A FI 952141A FI 952141 A FI952141 A FI 952141A FI 113044 B FI113044 B FI 113044B
Authority
FI
Finland
Prior art keywords
compound
formula
acid addition
addition salts
hours
Prior art date
Application number
FI952141A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI952141A (fi
FI952141A0 (fi
Inventor
Michael Jeffrey Abrams
Gary James Bridger
David Aaron Schwartz
Sreenivasan Padmanabhan
Michael Evert Ultee
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Publication of FI952141A publication Critical patent/FI952141A/fi
Publication of FI952141A0 publication Critical patent/FI952141A0/fi
Application granted granted Critical
Publication of FI113044B publication Critical patent/FI113044B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Peptides Or Proteins (AREA)
FI952141A 1992-11-05 1995-05-04 2-hydratsinopyridiinijohdannaisia FI113044B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9223168 1992-11-05
GB929223168A GB9223168D0 (en) 1992-11-05 1992-11-05 Improvements in molecule labelling
GB9302259 1993-02-05
PCT/GB1993/002259 WO1994010149A1 (en) 1992-11-05 1993-11-03 Molecule labelling using 2-hydraninopyridine derivatives

Publications (3)

Publication Number Publication Date
FI952141A FI952141A (fi) 1995-05-04
FI952141A0 FI952141A0 (fi) 1995-05-04
FI113044B true FI113044B (fi) 2004-02-27

Family

ID=10724568

Family Applications (1)

Application Number Title Priority Date Filing Date
FI952141A FI113044B (fi) 1992-11-05 1995-05-04 2-hydratsinopyridiinijohdannaisia

Country Status (19)

Country Link
US (1) US5679778A (ko)
EP (1) EP0667859B1 (ko)
JP (1) JP3542597B2 (ko)
KR (1) KR100295545B1 (ko)
AT (1) ATE195730T1 (ko)
AU (1) AU676863B2 (ko)
CA (1) CA2148595C (ko)
DE (1) DE69329293T2 (ko)
DK (1) DK0667859T3 (ko)
ES (1) ES2150950T3 (ko)
FI (1) FI113044B (ko)
GB (1) GB9223168D0 (ko)
GR (1) GR3034883T3 (ko)
HK (1) HK1013420A1 (ko)
HU (1) HU226459B1 (ko)
NO (1) NO305364B1 (ko)
NZ (1) NZ257376A (ko)
PT (1) PT667859E (ko)
WO (1) WO1994010149A1 (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942210A (en) * 1994-11-15 1999-08-24 Cytogen Corporation Methods for lyoprotecting a macromolecule using tricine
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
ES2398118T3 (es) 1997-04-30 2013-03-13 The Board Of Trustees Of The Leland Stanford Junior University Procedimiento de formación de imágenes de muerte celular in vivo
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
US6844333B1 (en) * 1999-03-26 2005-01-18 The Trustees Of The University Of Pennsylvania Method of treating atherosclerosis
AU2001247697B2 (en) * 2000-03-22 2006-06-22 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6843980B2 (en) 2001-04-03 2005-01-18 Theseus Imaging, Corp. Methods for using annexin for detecting cell death in vivo and treating associated conditions
EP1381839A4 (en) 2001-04-03 2005-10-12 Univ Leland Stanford Junior METHOD FOR THE IMAGE OF CELL DEOD IN VIVO
GB0130845D0 (en) * 2001-12-22 2002-02-06 James Peter Analysis
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
JP5107716B2 (ja) * 2004-11-05 2012-12-26 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 分子治療用生分解性リンカー
CN103403011A (zh) * 2011-01-31 2013-11-20 Eth苏黎世公司 三官能交联试剂
JP6415979B2 (ja) 2011-06-03 2018-10-31 スリーエム イノベイティブ プロパティズ カンパニー ヒドラジノ１ｈ−イミダゾキノリン−４−アミン及びこれから調製された複合体
MX347240B (es) 2011-06-03 2017-04-20 3M Innovative Properties Co Ligadores heterobifuncionales con segmentos polietilenglicol y conjugados modificadores de la respuesta inmunitaria elaborados a partir de los mismos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
IL93432A (en) * 1989-02-24 1994-02-27 Johnson Mathey Inc Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions
US5112953A (en) * 1989-12-29 1992-05-12 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use

Also Published As

Publication number Publication date
KR100295545B1 (ko) 2001-09-17
ES2150950T3 (es) 2000-12-16
JPH08502744A (ja) 1996-03-26
KR950704256A (ko) 1995-11-17
FI952141A (fi) 1995-05-04
ATE195730T1 (de) 2000-09-15
NZ257376A (en) 1996-02-27
CA2148595A1 (en) 1994-05-11
DK0667859T3 (da) 2000-10-16
HUT72332A (en) 1996-04-29
AU676863B2 (en) 1997-03-27
JP3542597B2 (ja) 2004-07-14
DE69329293T2 (de) 2000-12-28
HU226459B1 (en) 2008-12-29
CA2148595C (en) 2002-05-21
FI952141A0 (fi) 1995-05-04
AU5375594A (en) 1994-05-24
PT667859E (pt) 2001-02-28
WO1994010149A1 (en) 1994-05-11
GR3034883T3 (en) 2001-02-28
GB9223168D0 (en) 1992-12-16
NO951751D0 (no) 1995-05-04
HK1013420A1 (en) 1999-08-27
DE69329293D1 (de) 2000-09-28
EP0667859A1 (en) 1995-08-23
NO305364B1 (no) 1999-05-18
EP0667859B1 (en) 2000-08-23
US5679778A (en) 1997-10-21
NO951751L (no) 1995-06-12

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Owner name: ANORMED INC.

MA Patent expired