NO305364B1 - 2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekyler - Google Patents
2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekylerInfo
- Publication number
- NO305364B1 NO305364B1 NO951751A NO951751A NO305364B1 NO 305364 B1 NO305364 B1 NO 305364B1 NO 951751 A NO951751 A NO 951751A NO 951751 A NO951751 A NO 951751A NO 305364 B1 NO305364 B1 NO 305364B1
- Authority
- NO
- Norway
- Prior art keywords
- pct
- compound
- hydraminopyridine
- derivatives
- conjugates containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Cosmetics (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929223168A GB9223168D0 (en) | 1992-11-05 | 1992-11-05 | Improvements in molecule labelling |
| PCT/GB1993/002259 WO1994010149A1 (en) | 1992-11-05 | 1993-11-03 | Molecule labelling using 2-hydraninopyridine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO951751D0 NO951751D0 (no) | 1995-05-04 |
| NO951751L NO951751L (no) | 1995-06-12 |
| NO305364B1 true NO305364B1 (no) | 1999-05-18 |
Family
ID=10724568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO951751A NO305364B1 (no) | 1992-11-05 | 1995-05-04 | 2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekyler |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5679778A (no) |
| EP (1) | EP0667859B1 (no) |
| JP (1) | JP3542597B2 (no) |
| KR (1) | KR100295545B1 (no) |
| AT (1) | ATE195730T1 (no) |
| AU (1) | AU676863B2 (no) |
| CA (1) | CA2148595C (no) |
| DE (1) | DE69329293T2 (no) |
| DK (1) | DK0667859T3 (no) |
| ES (1) | ES2150950T3 (no) |
| FI (1) | FI113044B (no) |
| GB (1) | GB9223168D0 (no) |
| GR (1) | GR3034883T3 (no) |
| HK (1) | HK1013420A1 (no) |
| HU (1) | HU226459B1 (no) |
| NO (1) | NO305364B1 (no) |
| NZ (1) | NZ257376A (no) |
| PT (1) | PT667859E (no) |
| WO (1) | WO1994010149A1 (no) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5942210A (en) * | 1994-11-15 | 1999-08-24 | Cytogen Corporation | Methods for lyoprotecting a macromolecule using tricine |
| US5919934A (en) * | 1997-02-19 | 1999-07-06 | The George Washington University | Compounds, compositions, and methods for cancer imaging and therapy |
| HUP0001261A3 (en) | 1997-04-30 | 2001-11-28 | Univ Washington Seattle | Method of imaging cell death in vivo |
| US6403054B1 (en) * | 1997-05-28 | 2002-06-11 | Bristol-Myers Squibb Pharma Company | Ternary ligand complexes useful as radiopharmaceuticals |
| US6844333B1 (en) * | 1999-03-26 | 2005-01-18 | The Trustees Of The University Of Pennsylvania | Method of treating atherosclerosis |
| CA2723664A1 (en) * | 2000-03-22 | 2001-09-27 | Solulink, Incorporated | Hydrazine-based and carbonyl-based bifunctional crosslinking reagents |
| US6686461B1 (en) | 2000-03-22 | 2004-02-03 | Solulink Bioscience, Inc. | Triphosphate oligonucleotide modification reagents and uses thereof |
| US7102024B1 (en) | 2000-08-01 | 2006-09-05 | Schwartz David A | Functional biopolymer modification reagents and uses thereof |
| WO2002080754A2 (en) | 2001-04-03 | 2002-10-17 | Theseus Imaging Corporation | Methods for using annexin for detecting cell death in vivo and treating associated conditions |
| WO2002082044A2 (en) | 2001-04-03 | 2002-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Method of imaging cell death in vivo |
| GB0130845D0 (en) * | 2001-12-22 | 2002-02-06 | James Peter | Analysis |
| US7158353B2 (en) * | 2003-11-06 | 2007-01-02 | Seagate Technology Llc | Magnetoresistive sensor having specular sidewall layers |
| JP5107716B2 (ja) * | 2004-11-05 | 2012-12-26 | ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア | 分子治療用生分解性リンカー |
| EP2942351B1 (en) * | 2011-01-31 | 2016-10-12 | ETH Zurich | Trifunctional crosslinking reagents |
| CN103582496B (zh) | 2011-06-03 | 2016-05-11 | 3M创新有限公司 | 具有聚乙二醇链段的异双官能连接基以及由其制成的免疫应答调节剂缀合物 |
| BR112013031039B1 (pt) | 2011-06-03 | 2020-04-28 | 3M Innovative Properties Co | compostos de hidrazino 1h-imidazoquinolina-4-aminas, conjugados feitos destes compostos, composição e composição farmacêutica compreendendo ditos compostos e conjugados, usos dos mesmos e método de fabricação do conjugado |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| IL93432A (en) * | 1989-02-24 | 1994-02-27 | Johnson Mathey Inc | Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions |
| US5112953A (en) * | 1989-12-29 | 1992-05-12 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
-
1992
- 1992-11-05 GB GB929223168A patent/GB9223168D0/en active Pending
-
1993
- 1993-11-03 WO PCT/GB1993/002259 patent/WO1994010149A1/en active IP Right Grant
- 1993-11-03 DK DK93924157T patent/DK0667859T3/da active
- 1993-11-03 AU AU53755/94A patent/AU676863B2/en not_active Expired
- 1993-11-03 CA CA002148595A patent/CA2148595C/en not_active Expired - Lifetime
- 1993-11-03 KR KR1019950701810A patent/KR100295545B1/ko not_active IP Right Cessation
- 1993-11-03 US US08/432,204 patent/US5679778A/en not_active Expired - Lifetime
- 1993-11-03 ES ES93924157T patent/ES2150950T3/es not_active Expired - Lifetime
- 1993-11-03 JP JP51085194A patent/JP3542597B2/ja not_active Expired - Lifetime
- 1993-11-03 NZ NZ257376A patent/NZ257376A/en not_active IP Right Cessation
- 1993-11-03 PT PT93924157T patent/PT667859E/pt unknown
- 1993-11-03 DE DE69329293T patent/DE69329293T2/de not_active Expired - Lifetime
- 1993-11-03 AT AT93924157T patent/ATE195730T1/de active
- 1993-11-03 HU HU9501275A patent/HU226459B1/hu unknown
- 1993-11-03 EP EP93924157A patent/EP0667859B1/en not_active Expired - Lifetime
-
1995
- 1995-05-04 NO NO951751A patent/NO305364B1/no not_active IP Right Cessation
- 1995-05-04 FI FI952141A patent/FI113044B/fi not_active IP Right Cessation
-
1998
- 1998-12-22 HK HK98114895A patent/HK1013420A1/xx not_active IP Right Cessation
-
2000
- 2000-11-22 GR GR20000402572T patent/GR3034883T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0667859T3 (da) | 2000-10-16 |
| AU676863B2 (en) | 1997-03-27 |
| HK1013420A1 (en) | 1999-08-27 |
| ATE195730T1 (de) | 2000-09-15 |
| NO951751D0 (no) | 1995-05-04 |
| ES2150950T3 (es) | 2000-12-16 |
| CA2148595A1 (en) | 1994-05-11 |
| EP0667859A1 (en) | 1995-08-23 |
| GR3034883T3 (en) | 2001-02-28 |
| FI952141A (fi) | 1995-05-04 |
| AU5375594A (en) | 1994-05-24 |
| JP3542597B2 (ja) | 2004-07-14 |
| WO1994010149A1 (en) | 1994-05-11 |
| PT667859E (pt) | 2001-02-28 |
| US5679778A (en) | 1997-10-21 |
| DE69329293T2 (de) | 2000-12-28 |
| KR100295545B1 (ko) | 2001-09-17 |
| DE69329293D1 (de) | 2000-09-28 |
| CA2148595C (en) | 2002-05-21 |
| GB9223168D0 (en) | 1992-12-16 |
| HUT72332A (en) | 1996-04-29 |
| NO951751L (no) | 1995-06-12 |
| EP0667859B1 (en) | 2000-08-23 |
| JPH08502744A (ja) | 1996-03-26 |
| NZ257376A (en) | 1996-02-27 |
| FI952141A0 (fi) | 1995-05-04 |
| FI113044B (fi) | 2004-02-27 |
| KR950704256A (ko) | 1995-11-17 |
| HU226459B1 (en) | 2008-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |