NO305364B1 - 2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekyler - Google Patents

2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekyler

Info

Publication number
NO305364B1
NO305364B1 NO951751A NO951751A NO305364B1 NO 305364 B1 NO305364 B1 NO 305364B1 NO 951751 A NO951751 A NO 951751A NO 951751 A NO951751 A NO 951751A NO 305364 B1 NO305364 B1 NO 305364B1
Authority
NO
Norway
Prior art keywords
pct
compound
hydraminopyridine
derivatives
conjugates containing
Prior art date
Application number
NO951751A
Other languages
English (en)
Other versions
NO951751D0 (no
NO951751L (no
Inventor
Michael Jeffrey Abrams
Gary James Bridger
David Aaron Schwartz
Sreenivasan Padmanabhan
Michael Evert Ultee
Original Assignee
Anormed Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anormed Inc filed Critical Anormed Inc
Publication of NO951751D0 publication Critical patent/NO951751D0/no
Publication of NO951751L publication Critical patent/NO951751L/no
Publication of NO305364B1 publication Critical patent/NO305364B1/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79Acids; Esters
    • C07D213/80Acids; Esters in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Peptides Or Proteins (AREA)
NO951751A 1992-11-05 1995-05-04 2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekyler NO305364B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929223168A GB9223168D0 (en) 1992-11-05 1992-11-05 Improvements in molecule labelling
PCT/GB1993/002259 WO1994010149A1 (en) 1992-11-05 1993-11-03 Molecule labelling using 2-hydraninopyridine derivatives

Publications (3)

Publication Number Publication Date
NO951751D0 NO951751D0 (no) 1995-05-04
NO951751L NO951751L (no) 1995-06-12
NO305364B1 true NO305364B1 (no) 1999-05-18

Family

ID=10724568

Family Applications (1)

Application Number Title Priority Date Filing Date
NO951751A NO305364B1 (no) 1992-11-05 1995-05-04 2-hydraminopyridin-derivater, konjugater inneholdende disse og merkete makro molekyler

Country Status (19)

Country Link
US (1) US5679778A (no)
EP (1) EP0667859B1 (no)
JP (1) JP3542597B2 (no)
KR (1) KR100295545B1 (no)
AT (1) ATE195730T1 (no)
AU (1) AU676863B2 (no)
CA (1) CA2148595C (no)
DE (1) DE69329293T2 (no)
DK (1) DK0667859T3 (no)
ES (1) ES2150950T3 (no)
FI (1) FI113044B (no)
GB (1) GB9223168D0 (no)
GR (1) GR3034883T3 (no)
HK (1) HK1013420A1 (no)
HU (1) HU226459B1 (no)
NO (1) NO305364B1 (no)
NZ (1) NZ257376A (no)
PT (1) PT667859E (no)
WO (1) WO1994010149A1 (no)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5942210A (en) * 1994-11-15 1999-08-24 Cytogen Corporation Methods for lyoprotecting a macromolecule using tricine
US5919934A (en) * 1997-02-19 1999-07-06 The George Washington University Compounds, compositions, and methods for cancer imaging and therapy
ES2398118T3 (es) 1997-04-30 2013-03-13 The Board Of Trustees Of The Leland Stanford Junior University Procedimiento de formación de imágenes de muerte celular in vivo
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
US6844333B1 (en) * 1999-03-26 2005-01-18 The Trustees Of The University Of Pennsylvania Method of treating atherosclerosis
AU2001247697B2 (en) * 2000-03-22 2006-06-22 Solulink, Incorporated Hydrazine-based and carbonyl-based bifunctional crosslinking reagents
US6686461B1 (en) 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
US6843980B2 (en) 2001-04-03 2005-01-18 Theseus Imaging, Corp. Methods for using annexin for detecting cell death in vivo and treating associated conditions
EP1381839A4 (en) 2001-04-03 2005-10-12 Univ Leland Stanford Junior METHOD FOR THE IMAGE OF CELL DEOD IN VIVO
GB0130845D0 (en) * 2001-12-22 2002-02-06 James Peter Analysis
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
JP5107716B2 (ja) * 2004-11-05 2012-12-26 ザ・チルドレンズ・ホスピタル・オブ・フィラデルフィア 分子治療用生分解性リンカー
CN103403011A (zh) * 2011-01-31 2013-11-20 Eth苏黎世公司 三官能交联试剂
JP6415979B2 (ja) 2011-06-03 2018-10-31 スリーエム イノベイティブ プロパティズ カンパニー ヒドラジノ1h−イミダゾキノリン−4−アミン及びこれから調製された複合体
MX347240B (es) 2011-06-03 2017-04-20 3M Innovative Properties Co Ligadores heterobifuncionales con segmentos polietilenglicol y conjugados modificadores de la respuesta inmunitaria elaborados a partir de los mismos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861869A (en) * 1986-05-29 1989-08-29 Mallinckrodt, Inc. Coupling agents for joining radionuclide metal ions with biologically useful proteins
IL93432A (en) * 1989-02-24 1994-02-27 Johnson Mathey Inc Hydrazines and hydrazides, their conjugates with macromolecules, and such conjugates labeled with metallic ions
US5112953A (en) * 1989-12-29 1992-05-12 Neorx Corporation Radiolabeled proteins for diagnostic or therapeutic use

Also Published As

Publication number Publication date
KR100295545B1 (ko) 2001-09-17
ES2150950T3 (es) 2000-12-16
JPH08502744A (ja) 1996-03-26
KR950704256A (ko) 1995-11-17
FI952141A (fi) 1995-05-04
ATE195730T1 (de) 2000-09-15
NZ257376A (en) 1996-02-27
CA2148595A1 (en) 1994-05-11
DK0667859T3 (da) 2000-10-16
HUT72332A (en) 1996-04-29
AU676863B2 (en) 1997-03-27
JP3542597B2 (ja) 2004-07-14
DE69329293T2 (de) 2000-12-28
FI113044B (fi) 2004-02-27
HU226459B1 (en) 2008-12-29
CA2148595C (en) 2002-05-21
FI952141A0 (fi) 1995-05-04
AU5375594A (en) 1994-05-24
PT667859E (pt) 2001-02-28
WO1994010149A1 (en) 1994-05-11
GR3034883T3 (en) 2001-02-28
GB9223168D0 (en) 1992-12-16
NO951751D0 (no) 1995-05-04
HK1013420A1 (en) 1999-08-27
DE69329293D1 (de) 2000-09-28
EP0667859A1 (en) 1995-08-23
EP0667859B1 (en) 2000-08-23
US5679778A (en) 1997-10-21
NO951751L (no) 1995-06-12

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