FI112666B - Itiöimätön Bacillus subtilis, sen valmistus ja käyttö - Google Patents

Itiöimätön Bacillus subtilis, sen valmistus ja käyttö Download PDF

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Publication number
FI112666B
FI112666B FI20012143A FI20012143A FI112666B FI 112666 B FI112666 B FI 112666B FI 20012143 A FI20012143 A FI 20012143A FI 20012143 A FI20012143 A FI 20012143A FI 112666 B FI112666 B FI 112666B
Authority
FI
Finland
Prior art keywords
gene
deleted
strain
sigg
region
Prior art date
Application number
FI20012143A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI20012143A (fi
FI20012143A0 (fi
Inventor
Pertti Koski
Susanna Kaeaeriaeinen
Original Assignee
Ipsat Therapies Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsat Therapies Oy filed Critical Ipsat Therapies Oy
Publication of FI20012143A0 publication Critical patent/FI20012143A0/fi
Priority to FI20012143A priority Critical patent/FI112666B/fi
Priority to NZ532865A priority patent/NZ532865A/en
Priority to EP02774801.1A priority patent/EP1451292B1/en
Priority to PCT/FI2002/000861 priority patent/WO2003040352A1/en
Priority to ES02774801.1T priority patent/ES2452292T3/es
Priority to PL370064A priority patent/PL205348B1/pl
Priority to CA2465828A priority patent/CA2465828C/en
Priority to AU2002340536A priority patent/AU2002340536C1/en
Priority to JP2003542599A priority patent/JP5486142B2/ja
Priority to HU0402070A priority patent/HUP0402070A3/hu
Priority to US10/494,411 priority patent/US7319030B2/en
Publication of FI20012143A publication Critical patent/FI20012143A/fi
Application granted granted Critical
Publication of FI112666B publication Critical patent/FI112666B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
FI20012143A 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö FI112666B (fi)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
CA2465828A CA2465828C (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
EP02774801.1A EP1451292B1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
PCT/FI2002/000861 WO2003040352A1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
ES02774801.1T ES2452292T3 (es) 2001-11-06 2002-11-05 Bacillus subtilis no esporulante que tiene partes del gen que codifica Sigma G eliminadas
PL370064A PL205348B1 (pl) 2001-11-06 2002-11-05 Nieprzetrwalnikujący szczep Bacillus subtilis, sposób wytwarzania nieprzetrwalnikującego szczepu Bacillus subtilis, zastosowanie nieprzetrwalnikującego szczepu Bacillus subtilis i sposób wytwarzania biologicznie przygotowanego preparatu
NZ532865A NZ532865A (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma G deleted
AU2002340536A AU2002340536C1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma G deleted
JP2003542599A JP5486142B2 (ja) 2001-11-06 2002-11-05 シグマｇをコードする遺伝子の部分が欠失している非胞子形成枯草菌
HU0402070A HUP0402070A3 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
US10/494,411 US7319030B2 (en) 2001-11-06 2002-11-05 Non-sporulating Bacillus subtilis having parts of the gene encoding sigma G deleted

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20012143 2001-11-06
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö

Publications (3)

Publication Number Publication Date
FI20012143A0 FI20012143A0 (fi) 2001-11-06
FI20012143A FI20012143A (fi) 2003-05-07
FI112666B true FI112666B (fi) 2003-12-31

Family

ID=8562192

Family Applications (1)

Application Number Title Priority Date Filing Date
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö

Country Status (11)

Country Link
US (1) US7319030B2 (es)
EP (1) EP1451292B1 (es)
JP (1) JP5486142B2 (es)
AU (1) AU2002340536C1 (es)
CA (1) CA2465828C (es)
ES (1) ES2452292T3 (es)
FI (1) FI112666B (es)
HU (1) HUP0402070A3 (es)
NZ (1) NZ532865A (es)
PL (1) PL205348B1 (es)
WO (1) WO2003040352A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004113510A2 (en) * 2003-06-18 2004-12-29 Dsm Ip Assets B.V. Production of pantothenate using microorganisms incapable of sporulation
DE10344200A1 (de) * 2003-09-22 2005-05-04 Basf Ag Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
FI119190B (fi) 2006-06-21 2008-08-29 Ipsat Therapies Oy Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
WO2015161243A2 (en) 2014-04-17 2015-10-22 Synthetic Biologics, Inc. Beta-lactamases with improved properties for therapy
CN106574273B (zh) 2014-08-28 2021-07-02 合成生物制品有限公司 β-内酰胺酶的基于大肠杆菌的生产
CN107148473B (zh) 2014-10-08 2021-08-06 合成生物制品有限公司 β-内酰胺酶制剂及其用途
EP3236993B1 (en) 2014-12-23 2023-09-13 Theriva Biologics, Inc. Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
JP6810697B2 (ja) 2015-02-23 2021-01-13 シンセティック・バイオロジクス・インコーポレイテッド 腸内マイクロバイオームの保護のために抗生物質と共に使用するカルバペネマーゼ
AU2016229976B2 (en) 2015-03-06 2021-11-11 Theriva Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
CN105200076A (zh) * 2015-09-23 2015-12-30 江南大学 一株重组表达γ-内酰胺酶的枯草芽孢杆菌、固定化及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2003078A1 (en) * 1988-11-18 1990-05-18 Alan Sloma Protease deletion
CN1190434A (zh) 1995-07-07 1998-08-12 诺沃挪第克公司 用不能形成芽孢的芽孢杆菌生产蛋白质的方法
US7585674B2 (en) * 2001-05-29 2009-09-08 Kao Corporation Host microorganisms

Also Published As

Publication number Publication date
WO2003040352A1 (en) 2003-05-15
ES2452292T3 (es) 2014-03-31
WO2003040352A9 (en) 2003-08-14
US20050158843A1 (en) 2005-07-21
AU2002340536C1 (en) 2008-05-08
CA2465828A1 (en) 2003-05-15
EP1451292B1 (en) 2014-01-29
PL370064A1 (en) 2005-05-16
HUP0402070A2 (hu) 2005-01-28
NZ532865A (en) 2005-09-30
AU2002340536B2 (en) 2007-05-24
FI20012143A (fi) 2003-05-07
CA2465828C (en) 2014-05-13
FI20012143A0 (fi) 2001-11-06
PL205348B1 (pl) 2010-04-30
JP5486142B2 (ja) 2014-05-07
JP2005508184A (ja) 2005-03-31
US7319030B2 (en) 2008-01-15
EP1451292A1 (en) 2004-09-01
HUP0402070A3 (en) 2010-01-28

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