HUP0402070A2 - Szigma G-t kódoló gén deletált részeivel rendelkező, nem sporuláló Bacillus subtilis - Google Patents

Szigma G-t kódoló gén deletált részeivel rendelkező, nem sporuláló Bacillus subtilis

Info

Publication number
HUP0402070A2
HUP0402070A2 HU0402070A HUP0402070A HUP0402070A2 HU P0402070 A2 HUP0402070 A2 HU P0402070A2 HU 0402070 A HU0402070 A HU 0402070A HU P0402070 A HUP0402070 A HU P0402070A HU P0402070 A2 HUP0402070 A2 HU P0402070A2
Authority
HU
Hungary
Prior art keywords
bacillus subtilis
deleted
parts
gene encoding
sporulating
Prior art date
Application number
HU0402070A
Other languages
English (en)
Inventor
Pertti Koski
Susanna Kääriänen
Original Assignee
Ipsat Therapies Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsat Therapies Oy filed Critical Ipsat Therapies Oy
Publication of HUP0402070A2 publication Critical patent/HUP0402070A2/hu
Publication of HUP0402070A3 publication Critical patent/HUP0402070A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102—Mutagenizing nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/86—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in cyclic amides, e.g. penicillinase (3.5.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus
    • C12R2001/125—Bacillus subtilis ; Hay bacillus; Grass bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

A találmány egy nem sporuláló Bacillus subtilis törzsre és előállításieljárására vonatkozik, mely törzs sigG génjéből legalább 150 nukleotiddeletált. Továbbá a találmány tárgya a bemutatott nem sporuláló B.subtilis törzs termelő szervezetként történő alkalmazása. A találmánymagában foglal egy eljárást is egy biológiai úton előállított termékelőállítására, mely során a terméket a találmány szerinti nemsporuláló Bacíllus subtilis törzs alkalmazásával állítják elő. Ó
HU0402070A 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted HUP0402070A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20012143A FI112666B (fi) 2001-11-06 2001-11-06 Itiöimätön Bacillus subtilis, sen valmistus ja käyttö
PCT/FI2002/000861 WO2003040352A1 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted

Publications (2)

Publication Number Publication Date
HUP0402070A2 true HUP0402070A2 (hu) 2005-01-28
HUP0402070A3 HUP0402070A3 (en) 2010-01-28

Family

ID=8562192

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0402070A HUP0402070A3 (en) 2001-11-06 2002-11-05 Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted

Country Status (11)

Country Link
US (1) US7319030B2 (hu)
EP (1) EP1451292B1 (hu)
JP (1) JP5486142B2 (hu)
AU (1) AU2002340536C1 (hu)
CA (1) CA2465828C (hu)
ES (1) ES2452292T3 (hu)
FI (1) FI112666B (hu)
HU (1) HUP0402070A3 (hu)
NZ (1) NZ532865A (hu)
PL (1) PL205348B1 (hu)
WO (1) WO2003040352A1 (hu)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101185656B1 (ko) * 2003-06-18 2012-09-24 디에스엠 아이피 어셋츠 비.브이. 포자를 형성할 수 없는 미생물을 사용한 판토텐산염의 제조방법
DE10344200A1 (de) * 2003-09-22 2005-05-04 Basf Ag Verfahren zur Herstellung eines D-Pantothensäure und/oder deren Salze enthaltendes Tierfuttersupplement
FI119190B (fi) * 2006-06-21 2008-08-29 Ipsat Therapies Oy Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
US9290754B2 (en) 2014-04-17 2016-03-22 Synthetic Biologics Inc. Beta-lactamases with improved properties for therapy
JP6803328B2 (ja) 2014-08-28 2021-01-06 シンセティック バイオロジクス，インコーポレイテッド 大腸菌ベースでのベータラクタマーゼ生産
JP6672277B2 (ja) 2014-10-08 2020-04-01 シンセティック・バイオロジクス・インコーポレイテッド ベータラクタマーゼ製剤およびその使用
WO2016105498A1 (en) 2014-12-23 2016-06-30 Synthetic Biologics, Inc. Methods and compositions for inhibiting or preventing adverse effects of oral antibiotics
AU2016222936B2 (en) 2015-02-23 2022-01-06 Theriva Biologics, Inc. Carbapenemases for use with antibiotics for the protection of the intestinal microbiome
AU2016229976B2 (en) 2015-03-06 2021-11-11 Theriva Biologics, Inc. Safe and effective beta-lactamase dosing for microbiome protection
CN105200076A (zh) * 2015-09-23 2015-12-30 江南大学 一株重组表达γ-内酰胺酶的枯草芽孢杆菌、固定化及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2003078A1 (en) * 1988-11-18 1990-05-18 Alan Sloma Protease deletion
CN1190434A (zh) * 1995-07-07 1998-08-12 诺沃挪第克公司 用不能形成芽孢的芽孢杆菌生产蛋白质的方法
WO2002097064A1 (fr) 2001-05-29 2002-12-05 Kao Corporation Micro-organismes hotes

Also Published As

Publication number Publication date
WO2003040352A9 (en) 2003-08-14
JP5486142B2 (ja) 2014-05-07
CA2465828A1 (en) 2003-05-15
US7319030B2 (en) 2008-01-15
NZ532865A (en) 2005-09-30
US20050158843A1 (en) 2005-07-21
PL205348B1 (pl) 2010-04-30
FI20012143A (fi) 2003-05-07
EP1451292A1 (en) 2004-09-01
AU2002340536C1 (en) 2008-05-08
ES2452292T3 (es) 2014-03-31
CA2465828C (en) 2014-05-13
HUP0402070A3 (en) 2010-01-28
JP2005508184A (ja) 2005-03-31
EP1451292B1 (en) 2014-01-29
FI20012143A0 (fi) 2001-11-06
PL370064A1 (en) 2005-05-16
FI112666B (fi) 2003-12-31
AU2002340536B2 (en) 2007-05-24
WO2003040352A1 (en) 2003-05-15

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Legal Events

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FA9A Lapse of provisional patent protection due to relinquishment or protection considered relinquished