FI112229B - Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,4-oksadiatsolyyli-fenoksialkyyli-isoksatsolien valmistamiseksi - Google Patents

Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,4-oksadiatsolyyli-fenoksialkyyli-isoksatsolien valmistamiseksi Download PDF

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Publication number
FI112229B
FI112229B FI931707A FI931707A FI112229B FI 112229 B FI112229 B FI 112229B FI 931707 A FI931707 A FI 931707A FI 931707 A FI931707 A FI 931707A FI 112229 B FI112229 B FI 112229B
Authority
FI
Finland
Prior art keywords
formula
alkoxy
compound
alkyl
alkoxyalkyl
Prior art date
Application number
FI931707A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931707A0 (fi
FI931707A (fi
Inventor
Guy Dominic Diana
Theodore John Nitz
Original Assignee
Sanofi Synthelabo
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Publication date
Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo
Publication of FI931707A0 publication Critical patent/FI931707A0/fi
Publication of FI931707A publication Critical patent/FI931707A/fi
Application granted granted Critical
Publication of FI112229B publication Critical patent/FI112229B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI931707A 1992-04-15 1993-04-15 Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,4-oksadiatsolyyli-fenoksialkyyli-isoksatsolien valmistamiseksi FI112229B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86928792 1992-04-15
US07/869,287 US5349068A (en) 1992-04-15 1992-04-15 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (3)

Publication Number Publication Date
FI931707A0 FI931707A0 (fi) 1993-04-15
FI931707A FI931707A (fi) 1993-10-16
FI112229B true FI112229B (fi) 2003-11-14

Family

ID=25353269

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931707A FI112229B (fi) 1992-04-15 1993-04-15 Menetelmä uusien, terapeuttisesti käyttökelpoisten 1,2,4-oksadiatsolyyli-fenoksialkyyli-isoksatsolien valmistamiseksi

Country Status (26)

Country Link
US (3) US5349068A (ru)
EP (1) EP0566199B1 (ru)
JP (1) JP3103845B2 (ru)
KR (1) KR100314158B1 (ru)
AT (1) ATE189958T1 (ru)
AU (1) AU666528B2 (ru)
CA (1) CA2094012C (ru)
CZ (1) CZ285845B6 (ru)
DE (1) DE69327913T2 (ru)
DK (1) DK0566199T3 (ru)
ES (1) ES2143487T3 (ru)
FI (1) FI112229B (ru)
GR (1) GR3033486T3 (ru)
HU (2) HU220606B1 (ru)
IL (1) IL105372A (ru)
MX (1) MX9302169A (ru)
MY (1) MY110191A (ru)
NO (1) NO302700B1 (ru)
NZ (1) NZ247411A (ru)
PH (1) PH30454A (ru)
PT (1) PT566199E (ru)
RU (1) RU2114112C1 (ru)
SG (1) SG50663A1 (ru)
SK (1) SK279786B6 (ru)
TW (1) TW239140B (ru)
UA (1) UA35557C2 (ru)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5552420A (en) * 1994-05-13 1996-09-03 Sterling Winthrop Inc. Therapeutic phenoxyalkylazoles and phenoxyalkylazines
IL118657A0 (en) * 1996-06-14 1996-10-16 Arad Dorit Inhibitors for picornavirus proteases
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) * 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
AUPQ105499A0 (en) 1999-06-18 1999-07-08 Biota Scientific Management Pty Ltd Antiviral agents
AUPR213700A0 (en) * 2000-12-18 2001-01-25 Biota Scientific Management Pty Ltd Antiviral agents
KR20040004705A (ko) * 2001-06-08 2004-01-13 시토비아 인크. 카스파제의 활성제 및 아폽토시스의 유도제로서의 치환된3-아릴-5-아릴-[1,2,4]-옥사디아졸과 유사체 및 이의 용도
US7129359B2 (en) * 2002-07-09 2006-10-31 National Health Research Institutes Imidazolidinone compounds
CA2459376A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
WO2003020270A1 (en) * 2001-08-29 2003-03-13 Viropharma Incorporated Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents
EP1317923B1 (en) 2001-12-07 2010-04-28 Ana Maria Sandino Compositions for increasing the survival of aquatic animals exposed to a RNA virus
CA2475971A1 (en) * 2002-02-14 2003-08-21 Viropharma Incorporated Methods of reducing rhinovirus contagion and related compositions
JP2006516250A (ja) * 2002-12-18 2006-06-29 サイトビア インコーポレイティッド カスパーゼ活性化剤およびアポトーシス誘導物質としての３，５−二置換−［１，２，４］−オキサジアゾールおよびそれらの誘導体ならびにそれらの使用
US7259174B2 (en) * 2004-05-25 2007-08-21 National Health Research Institutes Imidazolidinone compounds
JP2008509143A (ja) * 2004-08-04 2008-03-27 シェーリング コーポレイション 気道疾患の処置のためのプレコナリルを含む薬学的処方物
MX2008010350A (es) * 2006-02-09 2008-10-31 Schering Corp Formulaciones farmaceuticas.
AR059358A1 (es) * 2006-02-09 2008-03-26 Schering Corp Formulaciones farmaceuticas
US20070203104A1 (en) * 2006-02-09 2007-08-30 Chaudhry Saeed M Pharmaceutical Formulations
RU2469032C2 (ru) 2006-12-13 2012-12-10 Ф.Хоффманн-Ля Рош Аг Производные 2-(пиперидин-4-ил)-4-фенокси- или фениламинопиримидина в качестве ненуклеозидных ингибиторов обратной транскриптазы
KR101031584B1 (ko) * 2009-04-21 2011-04-27 파인오토시스템(주) 전면부가 개폐되는 차량용 적외선 조사장치
CN103102348B (zh) * 2011-11-14 2016-06-08 上海交通大学 噁二唑类化合物及其制备方法、药物组合物及其用途
BR112021002515A2 (pt) 2018-08-21 2021-07-27 Kyorin Pharmaceutical Co., Ltd. derivado de anel heteroaromático bicíclico
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA846525B (en) * 1983-08-29 1985-04-24 Sterling Drug Inc (substituted)phenyl-aliphatic-isoxazoles useful as antiviral agents and preparation thereof
US4843087A (en) * 1983-08-29 1989-06-27 Sterling Drug Inc. Di-heterocyclic compounds and their use as antiviral agents
US4861791A (en) * 1983-08-29 1989-08-29 Sterling Drug Inc. Dihydro-oxazolyl substituted-phenyl-aliphatic lower alkyl and their use as antiviral agents
CA1280753C (en) * 1985-07-02 1991-02-26 Philip Michael Carabateas Process for preparing heterocyclic substituted- phenoxyalkyl isoxazoles and-furans
NZ234760A (en) * 1989-08-18 1991-09-25 Sterling Drug Inc Antiviral oxazole compounds and compositions
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US5175178A (en) * 1989-08-21 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
US5643929A (en) 1997-07-01
DE69327913T2 (de) 2000-10-12
ATE189958T1 (de) 2000-03-15
US5349068A (en) 1994-09-20
HU9301084D0 (en) 1993-06-28
HU211320A9 (en) 1995-11-28
FI931707A0 (fi) 1993-04-15
EP0566199A1 (en) 1993-10-20
CA2094012C (en) 2001-08-21
IL105372A (en) 1998-12-27
CZ285845B6 (cs) 1999-11-17
NO302700B1 (no) 1998-04-14
CA2094012A1 (en) 1993-10-16
TW239140B (ru) 1995-01-21
PT566199E (pt) 2000-09-29
SG50663A1 (en) 1998-07-20
HUT65574A (en) 1994-07-28
NO931366D0 (no) 1993-04-14
SK35393A3 (en) 1994-06-08
GR3033486T3 (en) 2000-09-29
AU3688193A (en) 1993-10-21
NZ247411A (en) 1994-06-27
HU220606B1 (hu) 2002-03-28
MX9302169A (es) 1993-10-01
NO931366L (no) 1993-10-18
FI931707A (fi) 1993-10-16
DK0566199T3 (da) 2000-06-19
EP0566199B1 (en) 2000-03-01
KR930021637A (ko) 1993-11-22
MY110191A (en) 1998-02-28
RU2114112C1 (ru) 1998-06-27
CZ59793A3 (en) 1994-02-16
AU666528B2 (en) 1996-02-15
JP3103845B2 (ja) 2000-10-30
DE69327913D1 (de) 2000-04-06
UA35557C2 (ru) 2001-04-16
JPH0649066A (ja) 1994-02-22
KR100314158B1 (ko) 2002-02-19
PH30454A (en) 1997-05-28
IL105372A0 (en) 1993-08-18
ES2143487T3 (es) 2000-05-16
US5464848A (en) 1995-11-07
SK279786B6 (sk) 1999-03-12

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Owner name: SANOFI

PC Transfer of assignment of patent

Owner name: SANOFI

MA Patent expired