FI109875B - Tryckgasförpackningar erhållna genom att använda polyoxyetylenglyceriloleater - Google Patents
Tryckgasförpackningar erhållna genom att använda polyoxyetylenglyceriloleater Download PDFInfo
- Publication number
- FI109875B FI109875B FI944257A FI944257A FI109875B FI 109875 B FI109875 B FI 109875B FI 944257 A FI944257 A FI 944257A FI 944257 A FI944257 A FI 944257A FI 109875 B FI109875 B FI 109875B
- Authority
- FI
- Finland
- Prior art keywords
- polyoxyethylene
- pressure gas
- weight
- aerosol pressure
- mixture
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Wrappers (AREA)
- Fats And Perfumes (AREA)
- Lubricants (AREA)
- Colloid Chemistry (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
Claims (15)
1. Aerosoltryckgasförpackningar för administrering 5 av biologiskt aktiva substanser, kännetecknade av, att man som stabilisator för vattenfria suspensioner och/eller som ventilsmörjmedel använder polyoxietylen-25-glyceryl-trioleatet med formeln I 1 10 ? CH2-0- (CH2-CH2-0)x-C- (CH2) 7 -CH=CH- (CH2) 7-CH CH-O-(CH2-CH2-0)y-?-(CH2)7-CH=CH-(CH2)7-CH3 15 0 CH2 -0- (CH2 -CH2 -0)z-C-(CH2)7 -CH=CH- (CH2) 7 -CH3 20 varvid x + y + z « 20 - 30
2. Aerosoltryckgasförpackningar för administrering • *’ av biologiskt aktiva substanser, kännetecknade : av, att man som stabilisator för vattenfria suspensioner ·.'·· och/eller som ventilsmör jmedel använder polyoxietylen- 25 30-glycerylmonooleatet med formeln II • • · · · 0‘: CH-(CH2)7-CH3 ch :/.: (ch2)7-c-o-ch2-ch-oh ····; 30 0 CH2(OCH2-CH2)n-OH : Varvid n är ca 30. • · · \ 3. Aerosoltryckgasförpackningar för administrering • » · 35 av biologiskt aktiva substanser, kännetecknade av, att man som stabilisator för vattenfria suspensioner 109875 och/eller som ventilsmörjmedel använder polyoxietylen- 20-glycerylmonooleatet med formeln III HC-(CH2)7CH3
5 CH(CH2)7-C-0-CH2-CH-0H H) CH2(OCH2Cfl2)m-OH Varvid m är ca 20.
4. Aerosoltryckgasförpackningar enligt patentkrav 10 1, kännetecknade av, att andelen polyoxiety- len-25-glyceryl-trioleat med formeln I O ( :h2 -o- ( ch2 -ch2 -o ) x-([- ( ch2 ) 7 -ch=ch- ( ch2 ) 7 -ch 15 0 CH-O- (CH2-CH2-0) y-C- (CH2) 7 -CH=CH- (CH2) 7-CH3 0 20 ch2-o- (CH2-CH2-0) z-C- (CH2)7-CH=CH- (CH2) 7-ch3 beräknad pä blandningens totalvikt ligger mellan 0,01 och 5 •/•j vikt-%. ··· 25 5. Aerosoltryckgasförpackningar enligt patentkrav *·· 1, kännetecknade av, att andelen polyoxiety- len-25-glyceryl-trioleat med formeln I .···. 30 CH2-0-(CH2-CH2-0)x-C-(CH2)7-CH=CH-(CH2)7-CH ·:·:· I? 1 ·; ·: CH-O-(CH2-CH2-0)y-C-(CH2)7-CH=CH-(CH2) η-CH3 I « t 35 ....: 0 CH2-0- (CH2-CH2-0) 2-(l- (CH2) 7-CH=CH- (CH2) 7-ch3 ; 19 109875 beräknad pä blandningens totalvikt, ligger mellan 0,2 och J 2,5 vikt-%.
6. Aerosoltryckgasförpackningar enligt patentkrav 1, kännetecknade av, att andelen polyoxiety- len-25-glyceryl-trioleat med formeln I O
10 CH2-o-(CH2-CH2-O)X-C-(CH2)7-CH=CH-(CH2)η-CH Cj> CH-O-(CH2-CH2-0)y-C-(CH2)η-CH=CH-(CH2)7-CH3 15 ? CH2-0- (CH2-CH2-0) z-c!- (CH2) 7~CH=CH- (CH2) 7-CH3 20 beräknad pä blandningens totalvikt, uppgär tili mellan 0,75 och 1,5 vikt-%. • 7. Aerosoltryckgasförpackningar enligt patentkrav 2, kännetecknade av, att andelen polyoxiety- ·.*·· len-30-glyceryl-monooleat med formeln II ·:· 25 Mil CH-(CH2)7-CH3 S:h (CH2)7-C-0-CH2-CH-OH
30. CH2 (OCH2-CH2v)n-OH * * * »ti « 1 1 » · I » « h beräknad pä blandningens totalvikt, ligger mellan 0,01 och 35. vikt-%. Iitti » 1 109875
8. Aerosoltryckgasförpackningar enligt patentkrav 2, kännetecknade av, att andelen polyoxiety- len-30-glyceryl-monooleat med formeln II | 5 CH-(CH2)7-CH3 ! CH ! ,l I (CH2)7-jj:-0-CH2-CH-0H O CH2(OCH2-CH2)n-OH 10 beräknad pä blandningens totalvikt, ligger mellan 0,2 och 2,5 vikt-%.
9. Aerosoltryckgasförpackningar enligt patentkrav 15 2, kännetecknade av, att andelen polyoxiety- len-30-glyceryl-monooleat med formeln II CH-(CH2)7-CH3 20 fH (CH2)7-c-o-ch2-ch-oh R l O CH2(OCH2-CH2)n-OH • « 1 < t · » · • « · 25 beräknad pä blandningens totalvikt, ligger mellan 0,75 och ;· 1,5 vikt-%. * · ·
10. Aerosoltryckgasförpackningar enligt patentkrav 3, kännetecknade av, att andelen polyoxiety- ,·4 : len-20-glyceryl-monooleat med formeln III .•’••ί 30 ♦ * · :Λ: hJ-(ch2)7ch3 CH(CH2) 7-C-0-CH2-CH-OH . !·. O CH2(OCH2CH2)m-OH .!"· 35 I 21 109875 ! beräknad pä blandningens totalvikt, ligger mellan 0,01 och ! 5 vikt-%.
11. Aerosoltryckgasförpackningar enligt patentkrav 3, kännetecknade av, att andelen polyoxiety-5 len-20-glyceryl-monooleat med formeln III HC-(CH2)7CH3 CH(CH2) 7-<j:-0-CH2-CH-0H
10. CH2(OCH2CH2)m-OH beräknad pä blandningens totalvikt, ligger mellan 0,2 och 2.5 vikt-%.
12. Aerosoltryckgasförpackningar enligt patentkrav 3, kännetecknade av, att andelen polyoxiety-len-20-glyceryl-monooleat med formeln III
20 HC-(CH2)7CH3 ch(ch2)7-c-o-ch2-ch-oh o CH2(OCH2CH2)m-OH • · • i » • · • « • · *·· 25 beräknad pä blandningens totalvikt, ligger mellan 0,75 och 1.5 vikt-%. 111«
13. Aerosoltryckgasförpackningar enligt nägot av patentkraven 1 - 12, kännetecknade av, att man , , som drivmedel använder TG 227 och/eller TG 134a. » · » ),/ 30 14. Förfarande för framställning av aerosol- * t -*' tryckgasförpackningar enligt patentkrav 1 - 12, :Y: kännetecknat av, att man blandar drivmedel » · TG 227 och/eller TG 134a under kylning eller under tryck i i » \ med polyoxietylen-25-glyceryltrioleat, och/eller polyoxi- II· 35 etylen-30-glycerylmonooleat och/eller polyoxietylen-20- glycerylmonooleat och eventuellt med tilläggslösningsmedel, 22 109875 och sedan med aktiv substans och eventuellt med hjälpmedel, och homogeniserar den salunda erhällna suspensionen och fyller pä med drivmedel TG 227 och/eller TG 134a och fyller tryckbeständiga behällare. 5 • I • · · · • I • · • < · It1 t • 1 · • « · · I I I * 1 * I 1 * · * 1 » >
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4208505 | 1992-03-17 | ||
| DE4208505 | 1992-03-17 | ||
| DE4215188 | 1992-05-08 | ||
| DE4215188 | 1992-05-08 | ||
| DE4230876A DE4230876A1 (de) | 1992-03-17 | 1992-09-16 | Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten |
| DE4230876 | 1992-09-16 | ||
| PCT/EP1993/000496 WO1993018746A1 (de) | 1992-03-17 | 1993-03-04 | Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten |
| EP9300496 | 1993-03-04 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI944257A FI944257A (sv) | 1994-09-14 |
| FI944257A0 FI944257A0 (sv) | 1994-09-14 |
| FI109875B true FI109875B (sv) | 2002-10-31 |
Family
ID=27203527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944257A FI109875B (sv) | 1992-03-17 | 1994-09-14 | Tryckgasförpackningar erhållna genom att använda polyoxyetylenglyceriloleater |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5415853A (sv) |
| EP (1) | EP0630229B1 (sv) |
| JP (1) | JP3380242B2 (sv) |
| KR (1) | KR100255261B1 (sv) |
| CN (3) | CN1069191C (sv) |
| AT (1) | ATE155680T1 (sv) |
| AU (1) | AU664080B2 (sv) |
| BR (1) | BR9306089A (sv) |
| CA (1) | CA2129855C (sv) |
| CZ (1) | CZ285135B6 (sv) |
| DE (2) | DE4230876A1 (sv) |
| DK (1) | DK0630229T3 (sv) |
| ES (1) | ES2105233T3 (sv) |
| FI (1) | FI109875B (sv) |
| GE (1) | GEP19991518B (sv) |
| GR (1) | GR3024600T3 (sv) |
| HK (2) | HK1029046A1 (sv) |
| HU (1) | HU214914B (sv) |
| IL (1) | IL105062A (sv) |
| MX (1) | MX9301450A (sv) |
| NO (1) | NO307282B1 (sv) |
| RU (1) | RU2106862C1 (sv) |
| SK (1) | SK279953B6 (sv) |
| TW (1) | TW238334B (sv) |
| WO (1) | WO1993018746A1 (sv) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4322703A1 (de) * | 1993-07-08 | 1995-01-12 | Asta Medica Ag | Druckgaspackungen unter Verwendung von Polyoxyethylen-glyceryl-fettsäureestern als Suspensionsstabilisatoren und Ventilschmiermittel |
| DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
| CA2183557A1 (en) * | 1994-03-14 | 1995-09-21 | Mou-Ying Fu Lu | Aerosol drug formulations containing vitamin e |
| US5635159A (en) * | 1994-08-26 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing polyglycolyzed glycerides |
| GB9425160D0 (en) * | 1994-12-10 | 1995-02-08 | Glaxo Group Ltd | Medicaments |
| US5840213A (en) * | 1995-04-28 | 1998-11-24 | Great Lakes Chemical Corporation | Uses of heptafluoropropane |
| GB9526392D0 (en) * | 1995-12-22 | 1996-02-21 | Glaxo Group Ltd | Medicaments |
| US5955098A (en) * | 1996-04-12 | 1999-09-21 | Flemington Pharmaceutical Corp. | Buccal non polar spray or capsule |
| GB9620187D0 (en) † | 1996-09-27 | 1996-11-13 | Minnesota Mining & Mfg | Medicinal aerosol formulations |
| US6039932A (en) * | 1996-09-27 | 2000-03-21 | 3M Innovative Properties Company | Medicinal inhalation aerosol formulations containing budesonide |
| US20010031244A1 (en) * | 1997-06-13 | 2001-10-18 | Chiesi Farmaceutici S.P.A. | Pharmaceutical aerosol composition |
| DE19753108A1 (de) * | 1997-11-29 | 1999-08-05 | Wella Ag | Mittel zur Erhöhung der Formbarkeit und des Glanzes von Haaren |
| DZ2947A1 (fr) * | 1998-11-25 | 2004-03-15 | Chiesi Farma Spa | Inhalateur à compteur de dose sous pression. |
| US6315985B1 (en) * | 1999-06-18 | 2001-11-13 | 3M Innovative Properties Company | C-17/21 OH 20-ketosteroid solution aerosol products with enhanced chemical stability |
| IT1313553B1 (it) | 1999-07-23 | 2002-09-09 | Chiesi Farma Spa | Formulazioni ottimizzate costituite da soluzioni di steroidi dasomministrare per inalazione. |
| IT1317720B1 (it) * | 2000-01-07 | 2003-07-15 | Chiesi Farma Spa | Dispositivo per la somministrazione di aerosol dosati pressurizzati inpropellenti idrofluoroalcani. |
| IT1317846B1 (it) | 2000-02-22 | 2003-07-15 | Chiesi Farma Spa | Formulazioni contenenti un farmaco anticolinergico per il trattamentodella broncopneumopatia cronica ostruttiva. |
| IT1318514B1 (it) * | 2000-05-12 | 2003-08-27 | Chiesi Farma Spa | Formulazioni contenenti un farmaco glucocorticosteroide per iltrattamento di patologie broncopolmonari. |
| EA005179B1 (ru) | 2000-05-22 | 2004-12-30 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Стабильные фармацевтические препараты в виде растворов для дозированных ингаляторов под давлением |
| TR200401980T4 (tr) | 2001-07-02 | 2004-09-21 | Chiesi Farmaceutici S.P.A. | Aerosol olarak uygulama için en uygun hale getirilmiş tobramisin formülasyonu |
| NZ535018A (en) * | 2002-03-01 | 2007-02-23 | Chiesi Farmaceutici S | Pharmaceutical aerosol formulation containing formoterol, and its method of production |
| EP1595531A1 (en) | 2004-05-13 | 2005-11-16 | CHIESI FARMACEUTICI S.p.A. | Stable pharmaceutical solution formulations for pressurized metered dose inhalers |
| GB2437488A (en) * | 2006-04-25 | 2007-10-31 | Optinose As | Pharmaceutical oily formulation for nasal or buccal administration |
| US20070286814A1 (en) * | 2006-06-12 | 2007-12-13 | Medispray Laboratories Pvt. Ltd. | Stable aerosol pharmaceutical formulations |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4010252A (en) * | 1974-12-19 | 1977-03-01 | Colgate-Palmolive Company | Antimicrobial compositions |
| NL7506407A (nl) * | 1975-05-30 | 1976-12-02 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat. |
| US4581225A (en) * | 1984-04-25 | 1986-04-08 | Eli Lilly And Company | Sustained release intranasal formulation and method of use thereof |
| EP0203211A1 (en) * | 1985-05-28 | 1986-12-03 | Chemisch Adviesbureau Drs. J.C.P. Schreuder B.V. | Composition for treatment of skin affections and process for its preparation |
| JP2573275B2 (ja) * | 1986-03-10 | 1997-01-22 | ブルグハルト，クルト | 薬学的製剤及びその製造法 |
| CA1293929C (en) * | 1986-03-10 | 1992-01-07 | Kurt Burghart | Pharmaceutical composition containing nifedipine |
| US5225183A (en) * | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB8828477D0 (en) * | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| IL95952A0 (en) * | 1989-10-19 | 1991-07-18 | Sterling Drug Inc | Aerosol composition for topical medicament |
| US4963720A (en) * | 1989-12-05 | 1990-10-16 | Jong Jiunn Neng | Apparatus for counting lump foodstuffs |
-
1992
- 1992-09-16 DE DE4230876A patent/DE4230876A1/de not_active Withdrawn
- 1992-12-23 CZ CS923858A patent/CZ285135B6/cs not_active IP Right Cessation
- 1992-12-23 SK SK3858-92A patent/SK279953B6/sk not_active IP Right Cessation
-
1993
- 1993-03-04 JP JP51620193A patent/JP3380242B2/ja not_active Expired - Fee Related
- 1993-03-04 AT AT93906483T patent/ATE155680T1/de not_active IP Right Cessation
- 1993-03-04 KR KR1019940703219A patent/KR100255261B1/ko not_active IP Right Cessation
- 1993-03-04 ES ES93906483T patent/ES2105233T3/es not_active Expired - Lifetime
- 1993-03-04 CA CA002129855A patent/CA2129855C/en not_active Expired - Fee Related
- 1993-03-04 HU HU9402671A patent/HU214914B/hu not_active IP Right Cessation
- 1993-03-04 RU RU94041703A patent/RU2106862C1/ru not_active IP Right Cessation
- 1993-03-04 AU AU37459/93A patent/AU664080B2/en not_active Ceased
- 1993-03-04 EP EP93906483A patent/EP0630229B1/de not_active Expired - Lifetime
- 1993-03-04 DK DK93906483.8T patent/DK0630229T3/da active
- 1993-03-04 BR BR9306089A patent/BR9306089A/pt not_active Application Discontinuation
- 1993-03-04 DE DE59306978T patent/DE59306978D1/de not_active Expired - Lifetime
- 1993-03-04 GE GEAP19932335A patent/GEP19991518B/en unknown
- 1993-03-04 WO PCT/EP1993/000496 patent/WO1993018746A1/de active IP Right Grant
- 1993-03-16 CN CN93104061A patent/CN1069191C/zh not_active Expired - Fee Related
- 1993-03-16 IL IL105062A patent/IL105062A/xx not_active IP Right Cessation
- 1993-03-16 MX MX9301450A patent/MX9301450A/es unknown
- 1993-03-17 US US08/033,789 patent/US5415853A/en not_active Expired - Lifetime
- 1993-03-18 TW TW082102062A patent/TW238334B/zh not_active IP Right Cessation
-
1994
- 1994-09-07 NO NO943305A patent/NO307282B1/no not_active IP Right Cessation
- 1994-09-14 FI FI944257A patent/FI109875B/sv not_active IP Right Cessation
-
1997
- 1997-09-02 GR GR970402244T patent/GR3024600T3/el unknown
-
1999
- 1999-11-19 CN CN99124841A patent/CN1085525C/zh not_active Expired - Fee Related
- 1999-11-19 CN CN99124842A patent/CN1085526C/zh not_active Expired - Fee Related
-
2000
- 2000-11-10 HK HK00107168A patent/HK1029046A1/xx not_active IP Right Cessation
- 2000-11-17 HK HK00107334A patent/HK1027969A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Transfer of assignment of patent |
Owner name: MEDA PHARMA GMBH & CO.KG Free format text: MEDA PHARMA GMBH & CO.KG |
|
| MM | Patent lapsed |