KR970701535A - 비타민 E를 함유하는 에어로졸 약물 제형(Aerosol drug formulations containing vitamin'E) - Google Patents
비타민 E를 함유하는 에어로졸 약물 제형(Aerosol drug formulations containing vitamin'E)Info
- Publication number
- KR970701535A KR970701535A KR1019960705052A KR19960705052A KR970701535A KR 970701535 A KR970701535 A KR 970701535A KR 1019960705052 A KR1019960705052 A KR 1019960705052A KR 19960705052 A KR19960705052 A KR 19960705052A KR 970701535 A KR970701535 A KR 970701535A
- Authority
- KR
- South Korea
- Prior art keywords
- tocopherol
- pharmaceutical composition
- alpha tocopherol
- propellant
- group
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
(a) 약제, (b) 비-클로로플루오로카본 분사제 및 (c) 토코페롤 또는 이의 약제학적으로 허용되는 유도체를 포함하는 에어로졸 운반용 약제학적 조성물 뿐만 아니라, 약제의 바람직하지 않은 응집이 계면활성제 또는 보조용매를 사용하지 않고 방지되는 조성물의 제조방법이 기술되어 있다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (14)
- 약제, 비-클로로플루오로카본 분사제 및 토코페롤을 포함하는 에어로졸 운반용 약제학적 조성물.
- 제1항에 있어서, 분사제가 할로겐화 알칸인 약제학적 조성물.
- 제2항에 있어서, 분사제가 HFC-134a 및 HFC-227ea로 이루어진 그룹중에서 선택된 약제학적 조성물.
- 제2항에 있어서, 토코페롤이 d-알파 토코페롤, dl-알파 토코페롤, d-알파 토코페롤 아세테이트, dl-알파 토코페롤 아세테이트, d-알파 토코페롤산 석시네이트 및 dl-알파 토코페롤산 석시네이트로 이루어진 그룹중에서 선택된 형태로 존재하는 약제학적 조성물.
- 제1항에 있어서, 토코페롤이 0.00001 내지 10중량%의 농도로 존재하는 약제학적 조성물.
- 제1항에 있어서, 토코페롤이 0.001 내지 5중량%의 농도로 존재하는 약제학적 조성물.
- 제3항에 있어서, 약제가 LHRH 동족체, 5-리폭시게나제 억제제, 면역억제제 및 기관지확장제로 이루어진 그룹중에서 선택된 약제학적 조성물.
- 제2항에 있어서, 약제가 류프롤리드 아세테이트, Ac-D-2-Nal-D-4-ClPhe-D-3-Pal-Ser-N-MeTyr-D-Lys(Nic)-Leu-Lys(N-Isp)-Pro-D-Ala-NH2, N-[3-[5-(4-플루오로페닐메틸)-2-티에닐]-1-메틸-2-프로피닐]-N-하이드록시우레아, 사이클로스포린 및 이소프로테레놀로 이루어진 그룹중에서 선택된 약제학적 조성물.
- 제8항에 있어서, 분사제가 HFC-134a인 약제학적 조성물.
- 제9항에 있어서, 토코페롤이 0.001 내지 5중량%의 농도로 존재하는 약제학적 조성물.
- 현탁액에 입자 응집을 방지하기에 충분한 양의 토코페롤을 첨가함을 포함하여, 액상 비-클로로플루오로카본 에어로졸 분사제중의 약제 입자의 안정한 현탁액을 제조하는 방법.
- 제11항에 있어서, 분사제가 HFC-134a 및 HFC-227ea로 이루어진 그룹중에서 선택되는 방법.
- 제11항에 있어서, 토코페롤이 d-알파 토코페롤, dl-알파 토코페롤, d-알파 토코페롤 아세테이트, dl-알파 토코페롤 아세테이트, d-알파 토코페롤산 석시네이트 및 dl-알파 토코페롤산 석시네이트로 이루어진 그룹중에서 선택된 형태인 방법.
- 제12항 또는 제13항에 있어서, 약제가 류프롤리드 아세테이트, Ac-D-2-Nal-D-4-ClPhe-D-3-Pal-Ser-N-MeTyr-D-Lys(Nic)-Leu-Lys(N-Isp)-Pro-D-Ala-NH2, N-[3-[5-(4-플루오로페닐메틸)-2-티에닐]-1-메틸-2-프로피닐]-N-하이드록시우레아, 사이클로스포린 및 이소프로테레놀로 이루어진 그룹중에서 선택된 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21247294A | 1994-03-14 | 1994-03-14 | |
US08/212,472 | 1994-03-14 | ||
ITRM94U000063 | 1994-03-25 | ||
PCT/US1995/002764 WO1995024892A1 (en) | 1994-03-14 | 1995-03-02 | Aerosol drug formulations containing vitamin e |
Publications (1)
Publication Number | Publication Date |
---|---|
KR970701535A true KR970701535A (ko) | 1997-04-12 |
Family
ID=22791169
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019960705052A KR970701535A (ko) | 1994-03-14 | 1995-03-02 | 비타민 E를 함유하는 에어로졸 약물 제형(Aerosol drug formulations containing vitamin'E) |
Country Status (7)
Country | Link |
---|---|
EP (1) | EP0804157A1 (ko) |
JP (1) | JPH09510445A (ko) |
KR (1) | KR970701535A (ko) |
AU (1) | AU709783B2 (ko) |
CA (1) | CA2183557A1 (ko) |
IL (1) | IL112897A0 (ko) |
WO (1) | WO1995024892A1 (ko) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9409778D0 (en) | 1994-05-16 | 1994-07-06 | Dumex Ltd As | Compositions |
EP0914143A1 (en) * | 1996-07-08 | 1999-05-12 | Rhone-Poulenc Rorer Limited | Medicinal cyclosporin-a aerosol solution formulation |
US6458373B1 (en) | 1997-01-07 | 2002-10-01 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US6193954B1 (en) | 1997-03-21 | 2001-02-27 | Abbott Laboratories | Formulations for pulmonary delivery of dopamine agonists |
US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
US7030155B2 (en) | 1998-06-05 | 2006-04-18 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
SI1458360T1 (sl) | 2001-12-19 | 2011-08-31 | Novartis Ag | Pulmonalno dajanje aminoglikozidov |
DE102006051512A1 (de) | 2005-12-06 | 2007-06-14 | Pari GmbH Spezialisten für effektive Inhalation | Pharmazeutische Medikamentenzusammensetzungen mit Cyclosporin |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9024365D0 (en) * | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
EP0504112A3 (en) * | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
ES2158910T3 (es) * | 1991-06-10 | 2001-09-16 | Schering Corp | Formulaciones en aerosol sin clorofluorocarbonos. |
EP0587790B2 (en) * | 1991-06-10 | 2000-03-08 | Schering Corporation | Non-chlorofluorocarbon aerosol formulations |
EP0616525B1 (en) * | 1991-12-12 | 1995-09-27 | Glaxo Group Limited | Pharmaceutical aerosol formulation |
DE69233319T2 (de) * | 1991-12-18 | 2005-02-17 | Minnesota Mining & Manufacturing Company, St. Paul | Aerosolzusammensetzungen für Arzneimittelsuspensionen |
DE4203306A1 (de) * | 1992-02-06 | 1993-08-12 | Ig Spruehtechnik Gmbh | Asthma oder pulmonal-aerosolzubereitungen mit lecithin |
US5301664A (en) * | 1992-03-06 | 1994-04-12 | Sievers Robert E | Methods and apparatus for drug delivery using supercritical solutions |
DE4230876A1 (de) * | 1992-03-17 | 1993-09-23 | Asta Medica Ag | Druckgaspackungen unter verwendung von polyoxyethylen-glyceryl-oleaten |
-
1995
- 1995-03-02 KR KR1019960705052A patent/KR970701535A/ko not_active Application Discontinuation
- 1995-03-02 CA CA002183557A patent/CA2183557A1/en not_active Abandoned
- 1995-03-02 AU AU19804/95A patent/AU709783B2/en not_active Ceased
- 1995-03-02 JP JP7524061A patent/JPH09510445A/ja not_active Withdrawn
- 1995-03-02 EP EP95912746A patent/EP0804157A1/en not_active Withdrawn
- 1995-03-02 WO PCT/US1995/002764 patent/WO1995024892A1/en not_active Application Discontinuation
- 1995-03-06 IL IL11289795A patent/IL112897A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2183557A1 (en) | 1995-09-21 |
JPH09510445A (ja) | 1997-10-21 |
EP0804157A1 (en) | 1997-11-05 |
AU1980495A (en) | 1995-10-03 |
AU709783B2 (en) | 1999-09-09 |
WO1995024892A1 (en) | 1995-09-21 |
IL112897A0 (en) | 1995-06-29 |
MX9604004A (es) | 1997-12-31 |
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Legal Events
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A201 | Request for examination | ||
E902 | Notification of reason for refusal | ||
E601 | Decision to refuse application |