FI109274B - Menetelmä luuta muodostavaa proteiinia sisältävän farmaseuttisen koostumuksen valmistamiseksi - Google Patents

Menetelmä luuta muodostavaa proteiinia sisältävän farmaseuttisen koostumuksen valmistamiseksi Download PDF

Info

Publication number
FI109274B
FI109274B FI935732A FI935732A FI109274B FI 109274 B FI109274 B FI 109274B FI 935732 A FI935732 A FI 935732A FI 935732 A FI935732 A FI 935732A FI 109274 B FI109274 B FI 109274B
Authority
FI
Finland
Prior art keywords
bone
protein
particles
osteogenic protein
poly
Prior art date
Application number
FI935732A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI935732A0 (fi
FI935732A (fi
Inventor
Richard A Kenley
Eyal Ron
Thomas J Turek
Benjamin S Isaacs
Himakshi Patel
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of FI935732A0 publication Critical patent/FI935732A0/fi
Publication of FI935732A publication Critical patent/FI935732A/fi
Application granted granted Critical
Publication of FI109274B publication Critical patent/FI109274B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1875—Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Transplantation (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
FI935732A 1991-06-21 1993-12-20 Menetelmä luuta muodostavaa proteiinia sisältävän farmaseuttisen koostumuksen valmistamiseksi FI109274B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US71872191A 1991-06-21 1991-06-21
US71872191 1991-06-21
US9205309 1992-06-22
PCT/US1992/005309 WO1993000050A1 (fr) 1991-06-21 1992-06-22 Compositions pharmaceutiques de proteines osteogeniques

Publications (3)

Publication Number Publication Date
FI935732A0 FI935732A0 (fi) 1993-12-20
FI935732A FI935732A (fi) 1993-12-20
FI109274B true FI109274B (fi) 2002-06-28

Family

ID=24887221

Family Applications (1)

Application Number Title Priority Date Filing Date
FI935732A FI109274B (fi) 1991-06-21 1993-12-20 Menetelmä luuta muodostavaa proteiinia sisältävän farmaseuttisen koostumuksen valmistamiseksi

Country Status (15)

Country Link
US (1) US5597897A (fr)
EP (1) EP0591392B1 (fr)
JP (1) JP3351525B2 (fr)
KR (1) KR0145278B1 (fr)
AT (1) ATE142460T1 (fr)
AU (1) AU663328B2 (fr)
CA (1) CA2111199C (fr)
DE (1) DE69213739T2 (fr)
DK (1) DK0591392T3 (fr)
ES (1) ES2094359T3 (fr)
FI (1) FI109274B (fr)
GR (1) GR3021627T3 (fr)
MX (1) MX9203083A (fr)
NO (2) NO307402B1 (fr)
WO (1) WO1993000050A1 (fr)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5705485A (en) * 1987-09-18 1998-01-06 Ethicon, Inc. Gel formulations containing growth factors
US5674844A (en) * 1991-03-11 1997-10-07 Creative Biomolecules, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US7056882B2 (en) 1991-03-11 2006-06-06 Curis, Inc. Treatment to prevent loss of and/or increase bone mass in metabolic bone diseases
US5171579A (en) * 1991-10-11 1992-12-15 Genetics Institute, Inc. Formulations of blood clot-polymer matrix for delivery of osteogenic proteins
US5385887A (en) * 1993-09-10 1995-01-31 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
US6027919A (en) 1993-12-07 2000-02-22 Genetics Institute, Inc. BMP-12 and BMP-13 proteins and DNA encoding them
EP0733109B9 (fr) 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons
WO1995024210A1 (fr) 1994-03-08 1995-09-14 Genetics Institute, Inc. Procedes et compositions utilises dans le traitement de la parodontolyse et la reparation des lesions periodontiques
DE69528128T2 (de) 1994-06-10 2003-03-13 United States Surgical Corp., Norwalk Rekombinante Chimäre Proteine und Verfahren zur deren Verwendung
US5520923A (en) * 1994-09-19 1996-05-28 Genetics Institute, Inc. Formulations for delivery of osteogenic proteins
FR2726571B1 (fr) * 1994-11-03 1997-08-08 Izoret Georges Colle biologique, procede de preparation et dispositif d'application pour colle biologique, et durcisseurs pour colle biologique
US5869079A (en) * 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
US20060280774A1 (en) * 1995-06-02 2006-12-14 Allergan, Inc. Compositions and methods for treating glaucoma
ES2440441T3 (es) 1995-06-05 2014-01-29 Genetics Institute, Llc Uso de proteínas morfogenéticas óseas para cicatrización y reparación de uniones de tejido conjuntivo
US6352972B1 (en) * 1995-06-06 2002-03-05 Marcel E. Nimni Bone morphogenetic proteins and their use in bone growth
US5674292A (en) 1995-06-07 1997-10-07 Stryker Corporation Terminally sterilized osteogenic devices and preparation thereof
JPH09143093A (ja) * 1995-11-17 1997-06-03 Hoechst Japan Ltd 軟骨・骨誘導性修復用材料
AU734312B2 (en) 1996-03-22 2001-06-07 General Hospital Corporation, The Administration of polypeptide growth factors following central nervous system ischemia or trauma
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
US6492508B1 (en) 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
GB9621825D0 (en) * 1996-10-19 1996-12-11 Andaris Ltd Microparticles and their use as therapeutic vehicles
AU6245898A (en) * 1997-01-21 1998-08-07 Genetics Institute Inc. Injectable formulations for treatment of osteoporotic bone
IL130967A0 (en) * 1997-01-30 2001-01-28 Hoechst Marion Roussel Ltd Freeze-dried composition of bone morphogenetic protein human mp52
US20040132653A1 (en) * 1997-01-30 2004-07-08 Biopharm Gmbh Lyophilized composition of bone morphogenetic factor human MP52
US20010016646A1 (en) 1998-03-20 2001-08-23 David C. Rueger Osteogenic devices and methods of use thereof for repair of endochondral bone, osteochondral and chondral defects
US7041641B2 (en) * 1997-03-20 2006-05-09 Stryker Corporation Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects
EP0902036A1 (fr) 1997-09-05 1999-03-17 Roche Diagnostics GmbH Peptide contenant une mimétique d'arginine pour traiter de l'ostéoporose, leur production et des compositions les contenant
FR2764514B1 (fr) * 1997-06-13 1999-09-03 Biopharmex Holding Sa Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique
DE19726412A1 (de) * 1997-06-21 1998-12-24 Merck Patent Gmbh Implantatmaterial mit einer Träger-Wirkstoff-Kombination
US7923250B2 (en) 1997-07-30 2011-04-12 Warsaw Orthopedic, Inc. Methods of expressing LIM mineralization protein in non-osseous cells
JP4302877B2 (ja) 1997-07-30 2009-07-29 エモリー・ユニバーシテイ 新規な骨鉱化蛋白質、ｄｎａ、ベクター及び発現系
US6911553B1 (en) 1997-10-02 2005-06-28 Roche Diagnostics Gmbh Osteoblast-specific mitogens and drugs containing such compounds
EP0906759A1 (fr) 1997-10-02 1999-04-07 Roche Diagnostics GmbH Nouveaux mitogènes spécifiques pour des ostéoblastes: procédé pour leur préparation et médicament contenant ces composés
US6767892B1 (en) * 1997-11-07 2004-07-27 Chrion Corporation Compositions providing for increased IGF-I solubility
AU752816B2 (en) 1997-11-28 2002-10-03 Curis, Inc. An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
AU1831999A (en) * 1997-12-18 1999-07-05 Comfort Biomedical, Inc. Bone augmentation for prosthetic implants and the like
US6214049B1 (en) 1999-01-14 2001-04-10 Comfort Biomedical, Inc. Method and apparatus for augmentating osteointegration of prosthetic implant devices
US20030147860A1 (en) 2002-02-07 2003-08-07 Marchosky J. Alexander Compositions and methods for forming and strengthening bone
US6849255B2 (en) 1998-08-18 2005-02-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods and compositions for enhancing cartilage repair
US6630457B1 (en) * 1998-09-18 2003-10-07 Orthogene Llc Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same
AU5998799A (en) * 1998-09-30 2000-04-17 Takeda Chemical Industries Ltd. Bone repair materials/artificial bone compositions
US6663870B2 (en) 1998-12-07 2003-12-16 Zymogenetics, Inc. Methods for promoting growth of bone using zvegf3
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
US6468543B1 (en) 1999-05-03 2002-10-22 Zymogenetics, Inc. Methods for promoting growth of bone using ZVEGF4
AU782394B2 (en) 1999-06-29 2005-07-21 J. Alexander Marchosky Compositions and methods for forming and strengthening bone
AU2000251259A1 (en) * 2000-02-04 2001-08-14 Zymogenetics Inc. Methods for promoting growth of bone, ligament, and cartilage using zvegf4
US6726918B1 (en) 2000-07-05 2004-04-27 Oculex Pharmaceuticals, Inc. Methods for treating inflammation-mediated conditions of the eye
AU2002214595A1 (en) * 2000-10-24 2002-05-06 Sdgi Holdings, Inc. Osteogenic packing device and method
AU3649502A (en) * 2000-11-29 2002-06-11 Oculex Pharm Inc Methods for reducing or preventing transplant rejection in the eye and intraocular implants for use therefor
US6949251B2 (en) * 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
CA2445523A1 (fr) 2001-04-30 2002-11-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Squelettes composites et procedes d'utilisation associes pour generer des greffes de tissus complexes
TWI267378B (en) 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
AU2003209071B2 (en) * 2002-02-08 2008-08-14 The University Of Erlangen-Nuremberg Formulation comprising bioactive agents and method of using same
WO2003070292A1 (fr) * 2002-02-22 2003-08-28 Biomatera Inc. Implant osseux biodegradable
EP1551955A4 (fr) 2002-07-16 2006-11-29 Yissum Res Dev Co Procedes servant a implanter des cellules souches mesenchymateuses pour la reparation et le developpement de tissus
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
US20050048099A1 (en) 2003-01-09 2005-03-03 Allergan, Inc. Ocular implant made by a double extrusion process
US20050003007A1 (en) * 2003-07-02 2005-01-06 Michele Boix Method of sterilization of polymeric microparticles
US7141544B2 (en) * 2003-10-10 2006-11-28 Baxter International, Inc. Stabilization of pharmaceutical protein formulations with small peptides
US20070224278A1 (en) * 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050250737A1 (en) * 2003-11-12 2005-11-10 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
US20050101582A1 (en) * 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20060141049A1 (en) * 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
JP2007518804A (ja) 2004-01-20 2007-07-12 アラーガン、インコーポレイテッド トリアムシノロンアセトニドおよびヒアルロン酸を好ましく含有する眼局所治療用組成物
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US20050244462A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US8119154B2 (en) * 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US8147865B2 (en) * 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US20050244478A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Anti-excititoxic sustained release intraocular implants and related methods
US20050244472A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US7993634B2 (en) * 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
WO2005107708A1 (fr) 2004-04-30 2005-11-17 Allergan, Inc. Implants d'inhibiteurs de tyrosine kinase intravitreens, biodegradables
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
US20050244469A1 (en) 2004-04-30 2005-11-03 Allergan, Inc. Extended therapeutic effect ocular implant treatments
WO2006007368A2 (fr) 2004-06-16 2006-01-19 Affinergy, Inc. Revetements biofonctionnels
JP2008505978A (ja) * 2004-07-12 2008-02-28 アラーガン、インコーポレイテッド 眼病用組成物および眼病治療法
US8512730B2 (en) * 2004-07-12 2013-08-20 Isto Technologies, Inc. Methods of tissue repair and compositions therefor
AU2005287402B2 (en) 2004-07-12 2011-03-03 Isto Technologies Ii, Llc Tissue matrix system
US20060258578A1 (en) * 2005-05-10 2006-11-16 The University Of Zurich Pharmaceutical composition
US20060286171A1 (en) * 2005-06-17 2006-12-21 Tianhong Zhou Bone morphogenetic protein formulations
WO2007067637A2 (fr) * 2005-12-07 2007-06-14 Isto Technologies, Inc. Procedes de reparation de cartilage
US20070178138A1 (en) * 2006-02-01 2007-08-02 Allergan, Inc. Biodegradable non-opthalmic implants and related methods
MX2008015263A (es) 2006-06-02 2008-12-17 Wyeth Corp Uso de proteinas y pepetidos de la superfamilia del factor beta transformador de crecimiento para purificacion y metodos terapeuticos.
US7754689B2 (en) 2006-06-02 2010-07-13 Wyeth Llc Finger-1 peptide analogs of the TGF-β superfamily
US20070298073A1 (en) * 2006-06-23 2007-12-27 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8802128B2 (en) * 2006-06-23 2014-08-12 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
DE102006060958A1 (de) * 2006-12-20 2008-06-26 Jennissen, Herbert P., Prof. Dr. Verfahren zur Herstellung einer Polymermatrix, daraus bestehende Implantate sowie deren Verwendung
US7911053B2 (en) * 2007-04-19 2011-03-22 Marvell World Trade Ltd. Semiconductor packaging with internal wiring bus
EP2144624A1 (fr) 2007-05-15 2010-01-20 Stryker Corporation Préparations de protéines concentrées de protéines morphogénétiques d'os et procédés d'utilisation correspondant
DE102007051914A1 (de) * 2007-10-29 2009-05-07 Herbert Prof. Dr. Jennissen Verfahren zur Herstellung von mit Wachstumsfaktoren beladenen Partikeln sowie die so erhaltenen Partikel
US8764350B2 (en) 2008-06-05 2014-07-01 Alstom Technology Ltd Conveyor for transporting powder, and a method for conveying powder
CN102724951A (zh) 2009-11-09 2012-10-10 阿勒根公司 用于刺激毛发生长的组合物和方法
EP2569342B1 (fr) 2010-05-11 2022-01-26 Howmedica Osteonics Corp. Composés métalliques multivalents organophosphorés et compositions de réseau interpénétrant d'adhésif polymère et procédés
JP2012082180A (ja) * 2010-10-14 2012-04-26 Nagoya Univ 骨再生用自己組織化ペプチドハイドロゲル
WO2012158527A2 (fr) 2011-05-13 2012-11-22 Howmedica Osteonics Compositions à base de composés métalliques multivalents et organophosphorés et procédés associés
DK2851085T3 (da) * 2012-05-14 2019-09-09 Teijin Ltd Proteinsammensætning steriliseret ved stråling
US10245306B2 (en) 2012-11-16 2019-04-02 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
EP2956096A1 (fr) 2013-02-15 2015-12-23 Allergan, Inc. Implant à administration de médicament prolongée
RS59285B1 (sr) 2014-03-20 2019-10-31 Stayble Therapeutics Ab Kompozicija za upotrebu u lečenju bola povezanog sa intervertebralnim diskom
US10179191B2 (en) 2014-10-09 2019-01-15 Isto Technologies Ii, Llc Flexible tissue matrix and methods for joint repair
US10195305B2 (en) * 2015-03-24 2019-02-05 Orthovita, Inc. Bioactive flowable wash-out resistant bone graft material and method for production thereof
US10265284B2 (en) 2015-09-14 2019-04-23 Stayble Therapeutics Ab Composition for use in the treatment of intervertebral disc-related pain
JP6901721B2 (ja) * 2017-03-30 2021-07-14 国立大学法人東海国立大学機構 骨髄止血剤
KR102066392B1 (ko) 2017-11-14 2020-01-16 한국치아은행 주식회사 골 이식용 복합체 제조방법 및 이에 의해 제조된 골 이식용 복합체
CN109125791B (zh) * 2018-09-29 2019-08-30 广州贝奥吉因生物科技有限公司 一种具有促进骨修复功能的可吸收骨蜡及制备方法
EP3936165A1 (fr) * 2020-07-10 2022-01-12 MedPark Co., Ltd. Procédé de préparation de greffe osseuse et composition de greffe osseuse

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3407076A (en) * 1964-08-28 1968-10-22 Hercules Inc Protein-polymer complexes and process
GB1332505A (en) * 1970-10-16 1973-10-03 Ethicon Inc Sutures and other surgical aids
US3991766A (en) * 1973-05-31 1976-11-16 American Cyanamid Company Controlled release of medicaments using polymers from glycolic acid
US4033938A (en) * 1974-01-21 1977-07-05 American Cyanamid Company Polymers of unsymmetrically substituted 1,4-dioxane-2,5-diones
DE3484584D1 (de) * 1983-10-14 1991-06-20 Sumitomo Pharma Injektionen mit verzoegerter abgabe.
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
US4818542A (en) * 1983-11-14 1989-04-04 The University Of Kentucky Research Foundation Porous microspheres for drug delivery and methods for making same
US4563489A (en) * 1984-02-10 1986-01-07 University Of California Biodegradable organic polymer delivery system for bone morphogenetic protein
US4637931A (en) * 1984-10-09 1987-01-20 The United States Of America As Represented By The Secretary Of The Army Polyactic-polyglycolic acid copolymer combined with decalcified freeze-dried bone for use as a bone repair material
DE3678308D1 (de) * 1985-02-07 1991-05-02 Takeda Chemical Industries Ltd Verfahren zur herstellung von mikrokapseln.
JPS62223112A (ja) * 1986-03-25 1987-10-01 Rooto Seiyaku Kk 歯周病治療剤
IL83003A (en) * 1986-07-01 1995-07-31 Genetics Inst Factors that soak bone formation
US4877864A (en) * 1987-03-26 1989-10-31 Genetics Institute, Inc. Osteoinductive factors
DE3624171A1 (de) * 1986-07-17 1988-01-21 Bosch Gmbh Robert Heiz- und/oder klimaanlage fuer kraftfahrzeuge
NL8702563A (nl) * 1987-10-28 1989-05-16 Cca Biochem B V Polymeer lactide, werkwijze voor het bereiden van een dergelijk polymeer lactide, alsmede een samenstelling, die een dergelijk polymeer lactide bevat.
JP2670680B2 (ja) * 1988-02-24 1997-10-29 株式会社ビーエムジー 生理活性物質含有ポリ乳酸系微小球およびその製造法
US5108753A (en) * 1988-04-08 1992-04-28 Creative Biomolecules Osteogenic devices
US4975526A (en) * 1989-02-23 1990-12-04 Creative Biomolecules, Inc. Bone collagen matrix for zenogenic implants
KR900700617A (ko) * 1988-04-08 1990-08-16 브루스 엠. 에이센 뼈 및 연골 유도 조성물
CA1338663C (fr) * 1988-04-08 1996-10-22 Hermann Oppermann Proteines d'osteogenese biosynthetiques et dispositifs d'osteogenese a base de ces proteines
WO1990009783A1 (fr) * 1989-02-22 1990-09-07 Massachusetts Institute Of Technology Systeme d'acheminement a liberation regulee de facteurs bioactifs
JPH05503286A (ja) * 1989-06-05 1993-06-03 マサチューセッツ インスティテュート オブ テクノロジー 骨における薬物送達のための生体侵食性ポリマー
CA2024196A1 (fr) * 1990-06-13 1991-12-14 Thomas M. S. Chang Microbilles poreuses permeables aux macromolecules comprenant au moins une substance biologique particulaire immobilisee
CA2065156A1 (fr) * 1990-07-03 1992-01-04 Richard L. Dunn Systemes de liberation intragingival pour le traitement d'une maladie periodontique

Also Published As

Publication number Publication date
AU663328B2 (en) 1995-10-05
NO934573L (no) 1993-12-13
JP3351525B2 (ja) 2002-11-25
KR0145278B1 (ko) 1998-07-15
NO934573D0 (no) 1993-12-13
ATE142460T1 (de) 1996-09-15
EP0591392A1 (fr) 1994-04-13
US5597897A (en) 1997-01-28
EP0591392B1 (fr) 1996-09-11
JPH06508777A (ja) 1994-10-06
DE69213739T2 (de) 1997-02-20
AU2254292A (en) 1993-01-25
WO1993000050A1 (fr) 1993-01-07
DK0591392T3 (da) 1996-09-30
GR3021627T3 (en) 1997-02-28
ES2094359T3 (es) 1997-01-16
CA2111199C (fr) 2008-08-05
FI935732A0 (fi) 1993-12-20
NO307402B1 (no) 2000-04-03
MX9203083A (es) 1994-08-31
DE69213739D1 (de) 1996-10-17
CA2111199A1 (fr) 1993-01-07
FI935732A (fi) 1993-12-20

Similar Documents

Publication Publication Date Title
FI109274B (fi) Menetelmä luuta muodostavaa proteiinia sisältävän farmaseuttisen koostumuksen valmistamiseksi
JP3336010B2 (ja) 骨形成性蛋白の送達のための血餅−ポリマー・マトリックスの処方
AU695374B2 (en) Formulations for delivery of osteogenic proteins
US5520923A (en) Formulations for delivery of osteogenic proteins
AU774427B2 (en) Formulations of hyaluronic acid for delivery of osteogenic proteins
US8197838B2 (en) Sustained release systems of ascorbic acid phosphate
JP2547769B2 (ja) 高分子医薬化合物の遅延／持続形放出制御素材
EP0567391A1 (fr) Système biodégradable de délivrance de TGF-bêta pour la régénération osseuse
JPH0834747A (ja) コラーゲンベースの注入可能な薬剤送達製剤およびその使用
Schrier et al. Effect of a freeze-dried CMC/PLGA microsphere matrix of rhBMP-2 on bone healing
EP1454640A2 (fr) Formulations d'acide hyaluronique pour la libération de protéines osteogéniques
CN118121685A (zh) 促进肌腱-骨重建的金属离子水凝胶及其制备方法与应用
AU8023000B2 (fr)