FI109202B - Proteiinin puhdistus - Google Patents

Proteiinin puhdistus Download PDF

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Publication number
FI109202B
FI109202B FI944412A FI944412A FI109202B FI 109202 B FI109202 B FI 109202B FI 944412 A FI944412 A FI 944412A FI 944412 A FI944412 A FI 944412A FI 109202 B FI109202 B FI 109202B
Authority
FI
Finland
Prior art keywords
cell cell
protein
chromatography
methacrylate copolymer
ethylene glycol
Prior art date
Application number
FI944412A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI944412A0 (fi
FI944412A (fi
Inventor
Gail Folena-Wasserman
John H O'grady
Thomas M Smith
John Lifter
Original Assignee
Avant Immunotherapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avant Immunotherapeutics Inc filed Critical Avant Immunotherapeutics Inc
Publication of FI944412A0 publication Critical patent/FI944412A0/fi
Publication of FI944412A publication Critical patent/FI944412A/fi
Application granted granted Critical
Publication of FI109202B publication Critical patent/FI109202B/fi

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI944412A 1992-03-24 1994-09-23 Proteiinin puhdistus FI109202B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/857,022 US5252216A (en) 1992-03-24 1992-03-24 Protein purification
US85702292 1992-03-24
PCT/US1993/002732 WO1993018835A1 (en) 1992-03-24 1993-03-24 Protein purification
US9302732 1993-03-24

Publications (3)

Publication Number Publication Date
FI944412A0 FI944412A0 (fi) 1994-09-23
FI944412A FI944412A (fi) 1994-09-23
FI109202B true FI109202B (fi) 2002-06-14

Family

ID=25324998

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944412A FI109202B (fi) 1992-03-24 1994-09-23 Proteiinin puhdistus

Country Status (19)

Country Link
US (1) US5252216A (de)
EP (1) EP0643608B1 (de)
JP (1) JP3335629B2 (de)
KR (1) KR100241172B1 (de)
AT (1) ATE193839T1 (de)
AU (1) AU659936B2 (de)
CA (1) CA2132533C (de)
DE (1) DE69328864T2 (de)
DK (1) DK0643608T3 (de)
ES (1) ES2149206T3 (de)
FI (1) FI109202B (de)
GR (1) GR3034332T3 (de)
MX (1) MX9301655A (de)
NO (1) NO310855B1 (de)
NZ (1) NZ251601A (de)
PT (1) PT643608E (de)
TW (1) TW321651B (de)
WO (1) WO1993018835A1 (de)
ZA (1) ZA932015B (de)

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US6395888B1 (en) * 1996-02-01 2002-05-28 Gilead Sciences, Inc. High affinity nucleic acid ligands of complement system proteins
DE4331358A1 (de) * 1992-10-12 1994-04-14 Braun Melsungen Ag Verfahren zur quantitativen selektiven Entfernung oder präparativen Gewinnung von Tumor-Nekrose-Faktor (TNF) oder/und Lipopolysacchariden (LPS) aus wäßrigen Flüssigkeiten
JPH08512323A (ja) * 1993-07-09 1996-12-24 スミスクライン・ビーチャム・コーポレイション タンパク精製方法
US5679546A (en) * 1993-09-24 1997-10-21 Cytomed, Inc. Chimeric proteins which block complement activation
US5429746A (en) * 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
DE19549420A1 (de) * 1995-04-27 1997-09-18 Braun Melsungen Ag Verfahren zur simultanen extrakorporalen Elimination von Tumor-Nekrose Faktor alpha (TNF alpha) und bakteriellen Lipopolysacchariden (LPS) aus Vollblut oder/und Blutplasma
EP1300679A3 (de) * 1995-06-26 2004-04-14 Perseptive Biosystems, Inc. Molekulare Selektion und Analyse
DE69627333T2 (de) * 1995-06-26 2004-02-12 PerSeptive Biosystems, Inc., Framingham Automatisierte, kontinuierliche mehrdimensionale hochgeschwindigkeitsmolekularselektion und -analyse
GB9515196D0 (en) * 1995-07-25 1995-09-20 Matthey Rustenburg Refines Interseparation of platignum group metals
JP2002511147A (ja) * 1997-06-27 2002-04-09 ライフ テクノロジーズ インク． 生体分子の濃縮および精製のための一工程装置および方法
US5993653C1 (en) * 1997-08-11 2001-11-06 Phenomenex Composition and column used in hplc
US6869796B2 (en) * 1997-08-26 2005-03-22 Avaris Ab Method of introducing organic molecules into target cells
US20070122904A1 (en) * 2000-09-29 2007-05-31 Unisearch Limited Method and apparatus for culturing cells
US6855263B2 (en) * 2002-07-23 2005-02-15 Nuvue Technologies, Inc. Rapid process for purification and concentration of plasmin
DE10255508A1 (de) * 2002-11-27 2004-06-17 Forschungszentrum Jülich GmbH Verfahren zur Kultivierung von Zellen zur Produktion von Substanzen
US6913695B2 (en) * 2003-07-08 2005-07-05 Bayer Healthcare Llc Sanitization of chromatographic media
WO2005012349A2 (en) * 2003-08-01 2005-02-10 Lorantis Limited Chromatographic process for the purification of notch ligands
US7329353B2 (en) * 2004-01-23 2008-02-12 Amgen Inc. LC/MS method of analyzing high molecular weight proteins
US7803931B2 (en) 2004-02-12 2010-09-28 Archemix Corp. Aptamer therapeutics useful in the treatment of complement-related disorders
RU2426795C2 (ru) * 2004-07-20 2011-08-20 Симфоген А/С Способ структурной характеристики рекомбинантного поликлонального белка или поликлональной клеточной линии
US20090042274A1 (en) * 2004-07-27 2009-02-12 Genomidea Inc. Method of Purifying Virus Envelope
US8652334B2 (en) * 2004-08-12 2014-02-18 Lipoxen Technologies Limited Fractionation of charged polysaccharide
EP1738763A1 (de) 2005-06-30 2007-01-03 AVANT Immunotherapeutics, Inc. Verwendung eines Komplement-inhibierenden Proteins zur Behandlung von Rückenmarksverletzungen
WO2007053235A1 (en) * 2005-11-04 2007-05-10 Sachem, Inc. Cation-exchange displacement chromatography process and cationic organic compounds for use as displacer compounds in cation-exchange displacement chromatography process
SI2596807T1 (sl) 2006-03-08 2016-03-31 Archemix Llc Komplement vezavni aptameri in sredstva proti C5, uporabni pri zdravljenju očesnih motenj
US20100222560A1 (en) 2009-03-02 2010-09-02 Zymo Research Corporation Universal column
KR102071834B1 (ko) 2009-10-26 2020-01-30 에프. 호프만-라 로슈 아게 글리코실화된 면역글로불린의 제조 방법
CN103237557A (zh) 2010-09-15 2013-08-07 赛尔戴克斯治疗公司 用可溶性I型补体受体(sCR1)治疗慢性肾病
WO2012048298A2 (en) 2010-10-08 2012-04-12 Caridianbct, Inc. Methods and systems of growing and harvesting cells in a hollow fiber bioreactor system with control conditions
CA2815237C (en) 2010-10-27 2018-10-09 Celldex Therapeutics, Inc. Method of improving transplant function using soluble complement receptor type i (scr1)
CN106715676A (zh) 2014-09-26 2017-05-24 泰尔茂比司特公司 按计划供养
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11624046B2 (en) 2017-03-31 2023-04-11 Terumo Bct, Inc. Cell expansion
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
WO2023240322A1 (en) * 2022-06-17 2023-12-21 CSL Innovation Pty Ltd Purification of soluble complement receptor and variants thereof

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DE2319495C2 (de) * 1973-04-17 1985-01-10 Yeda Research And Development Co., Ltd., Rehovot Verfahren zum selektiven, reversiblen Binden von Biomolekülen an ein Adsorbens in einer chromatographischen Säule
US4000098A (en) * 1974-08-16 1976-12-28 Palo Alto Medical Research Foundation Separation of proteins by hydrophobic adsorption
DE3149360A1 (de) * 1981-12-12 1983-06-16 Biotest-Serum-Institut Gmbh, 6000 Frankfurt "verfahren zur reinigung und/oder phytohaemagglutinin-abtrennung von human-interleukin-2"
US4920196A (en) * 1982-07-30 1990-04-24 Genentech, Inc. Human lymphotoxin
US4908434A (en) * 1984-04-25 1990-03-13 Sloan-Kettering Institute For Cancer Research Process for preparing purified interleukin-2
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US4894439A (en) * 1986-05-22 1990-01-16 Cetus Corporation N-terminal derivatives of tumor necrosis factor purified by microporous PTFE membranes
AU597924B2 (en) * 1985-12-11 1990-06-14 Natinco Nv Solubilization of protein aggregates
US4770781A (en) * 1986-03-03 1988-09-13 Merck & Co., Inc. Purification of human interleukin-1 species
US4771128A (en) * 1986-10-10 1988-09-13 Cetus Corporation Method of purifying toxin conjugates using hydrophobic interaction chromatography
AU609824B2 (en) * 1987-06-15 1991-05-09 Southern Cross Biotech Pty Ltd. Production of proteins in active forms
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
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US5030352A (en) * 1990-01-25 1991-07-09 Purdue Research Foundation Coated media for chromatography

Also Published As

Publication number Publication date
CA2132533A1 (en) 1993-09-30
ZA932015B (en) 1994-09-21
EP0643608B1 (de) 2000-06-14
ES2149206T3 (es) 2000-11-01
NZ251601A (en) 1997-03-24
GR3034332T3 (en) 2000-12-29
PT643608E (pt) 2000-11-30
CA2132533C (en) 2004-01-13
WO1993018835A1 (en) 1993-09-30
DE69328864T2 (de) 2000-12-14
EP0643608A1 (de) 1995-03-22
FI944412A0 (fi) 1994-09-23
JPH07505469A (ja) 1995-06-15
NO943546L (no) 1994-11-23
ATE193839T1 (de) 2000-06-15
EP0643608A4 (de) 1997-11-26
DK0643608T3 (da) 2000-10-02
KR100241172B1 (ko) 2000-02-01
NO943546D0 (no) 1994-09-23
KR950700779A (ko) 1995-02-20
US5252216A (en) 1993-10-12
AU3932493A (en) 1993-10-21
DE69328864D1 (de) 2000-07-20
TW321651B (de) 1997-12-01
NO310855B1 (no) 2001-09-10
FI944412A (fi) 1994-09-23
JP3335629B2 (ja) 2002-10-21
AU659936B2 (en) 1995-06-01
MX9301655A (es) 1994-03-31

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Legal Events

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HC Name/ company changed in application

Owner name: SMITHKLINE BEECHAM CORPORATION

MA Patent expired