FI108724B - Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin karbamoyylioksijohdannaisten ja niiden farmaseuttisesti hyväksyttävien happoadditiosuolojen valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin karbamoyylioksijohdannaisten ja niiden farmaseuttisesti hyväksyttävien happoadditiosuolojen valmistamiseksi Download PDF

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Publication number
FI108724B
FI108724B FI944822A FI944822A FI108724B FI 108724 B FI108724 B FI 108724B FI 944822 A FI944822 A FI 944822A FI 944822 A FI944822 A FI 944822A FI 108724 B FI108724 B FI 108724B
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FI
Finland
Prior art keywords
formula
compound
hydrogen
give
pharmaceutically acceptable
Prior art date
Application number
FI944822A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI944822A (fi
FI944822A0 (fi
Inventor
Larry Davis
Veronica Taberna
Jr Raymond W Kosley
Original Assignee
Aventis Pharma Inc
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Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of FI944822A0 publication Critical patent/FI944822A0/fi
Publication of FI944822A publication Critical patent/FI944822A/fi
Application granted granted Critical
Publication of FI108724B publication Critical patent/FI108724B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI944822A 1993-10-15 1994-10-13 Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin karbamoyylioksijohdannaisten ja niiden farmaseuttisesti hyväksyttävien happoadditiosuolojen valmistamiseksi FI108724B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13744393 1993-10-15
US08/137,443 US6323196B1 (en) 1993-10-15 1993-10-15 Galanthamine derivatives as acetylcholinesterase inhibitors

Publications (3)

Publication Number Publication Date
FI944822A0 FI944822A0 (fi) 1994-10-13
FI944822A FI944822A (fi) 1995-04-16
FI108724B true FI108724B (fi) 2002-03-15

Family

ID=22477457

Family Applications (1)

Application Number Title Priority Date Filing Date
FI944822A FI108724B (fi) 1993-10-15 1994-10-13 Menetelmä terapeuttisesti käyttökelpoisten 4a,5,9,10,11,12-heksahydro-11-metyyli-6H-bentsofuro[3a,3,2-ef][2]bentsatsepiini-3,6-diolin karbamoyylioksijohdannaisten ja niiden farmaseuttisesti hyväksyttävien happoadditiosuolojen valmistamiseksi

Country Status (24)

Country Link
US (1) US6323196B1 (de)
EP (2) EP0648771B1 (de)
JP (1) JP2718637B2 (de)
KR (1) KR100189043B1 (de)
CN (1) CN1039011C (de)
AT (1) ATE201687T1 (de)
AU (1) AU679560B2 (de)
CA (1) CA2118171C (de)
CZ (1) CZ283561B6 (de)
DE (1) DE69427332T2 (de)
DK (1) DK0648771T3 (de)
EG (1) EG20747A (de)
ES (1) ES2158876T3 (de)
FI (1) FI108724B (de)
GR (1) GR3036068T3 (de)
IL (1) IL111273A (de)
NO (1) NO307463B1 (de)
NZ (1) NZ264681A (de)
PL (1) PL177754B1 (de)
PT (1) PT648771E (de)
RO (1) RO114132B1 (de)
RU (1) RU2113438C1 (de)
TW (1) TW375615B (de)
ZA (1) ZA948060B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT403803B (de) 1996-04-19 1998-05-25 Sanochemia Ltd Neue benzazepinderivate, diese enthaltende arzneimittel und verwendung derselben zum herstellen von arzneimitteln
US7939522B1 (en) 1998-11-23 2011-05-10 Bonnie M Davis Dosage formulations for acetylcholinesterase inhibitors
AP1414A (en) 1998-12-24 2005-06-13 Janssen Pharmaceutica Nv Controlled release galantamine composition.
EP1237524A4 (de) * 1999-12-10 2004-06-30 Bonnie M Davis Analoga des galanthamins und lycoramins als modulatoren von nikotinrezeptoren
RU2241001C2 (ru) 2000-03-31 2004-11-27 Санохемиа Фармацойтика Акциенгезелльшафт Производные галантамина, способ их получения, лекарственное средство на их основе и способ его получения
US20030162770A1 (en) * 2002-02-22 2003-08-28 Davis Bonnie M. Use of modulators of nicotinic receptors for treatment of cognitive dysfunction
AU2003287433A1 (en) * 2002-11-01 2004-06-07 Oregon Health And Science University Treatment of hyperkinetic movement disorder with donepezil
US20050048543A1 (en) * 2003-07-11 2005-03-03 Jeroen Aerssens CHRNA2 genetic markers associated with galantamine response
US20050260613A1 (en) * 2003-10-28 2005-11-24 Genaissance Pharmaceuticals LRPAP1 genetic markers associated with galantamine
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
US7250258B2 (en) * 2003-12-15 2007-07-31 Pgxhealth Llc CDK5 genetic markers associated with galantamine response
US20050142193A1 (en) * 2003-12-31 2005-06-30 Lijuan Tang Galantamine formulations
US20050191349A1 (en) * 2003-12-31 2005-09-01 Garth Boehm Galantamine formulations
JPWO2006004201A1 (ja) * 2004-07-01 2008-04-24 エーザイ・アール・アンド・ディー・マネジメント株式会社 神経再生促進剤
DK1895994T3 (da) * 2005-05-13 2010-12-20 Alza Corp Multilagsmedikamentleveringssystem med barriere mod reservoirmaterialeflow
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
US20090253654A1 (en) 2005-09-22 2009-10-08 Galantos Pharma Gmbh Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
EP1777222A1 (de) * 2005-09-22 2007-04-25 Galantos Pharma GmbH Cholinesterase Inhibitoren mit erhöter Blut Hirn Schranke Permeabilität zur Behandlung von kognitiven Störungen
US20070104771A1 (en) * 2005-09-23 2007-05-10 Jay Audett Transdermal galantamine delivery system
KR100786371B1 (ko) * 2006-12-07 2007-12-17 한국화학연구원 갈란타민의 제조방법
JP5504253B2 (ja) 2008-04-14 2014-05-28 ニューロダイン ライフ サイエンス インコーポレイテッド ヒトの脳疾患の治療のためのプロドラッグとしてのガランタミン誘導体
EP2456434A1 (de) * 2009-07-23 2012-05-30 Shire LLC Galantaminaminosäure- und peptid-prodrugs sowie ihre verwendung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL122665B1 (en) 1978-11-21 1982-08-31 Edinen Zentar Chim Process for preparing novel dienones of narvedine type and their derivatives
US4663318A (en) 1986-01-15 1987-05-05 Bonnie Davis Method of treating Alzheimer's disease
US6150354A (en) * 1987-01-15 2000-11-21 Bonnie Davis Compounds for the treatment of Alzheimer's disease
ATE411026T1 (de) * 1987-05-04 2008-10-15 Bonnie Davis Mittel zur behandlung der alzheimer-krankheit
NL8800350A (nl) 1988-02-12 1989-09-01 Stichting Biomedical Research Synthetische galanthamine-derivaten, werkwijze voor het bereiden daarvan, en farmaceutische samenstellingen.
US5336675A (en) * 1991-05-14 1994-08-09 Ernir Snorrason Method of treating mania in humans
NZ242744A (en) * 1991-05-14 1997-02-24 Ernir Snorrason Use of a cholinesterase inhibitor (eg a galanthamine derivative) for treating fatigue
US5153193A (en) 1991-10-01 1992-10-06 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs
US5231093A (en) * 1991-10-01 1993-07-27 Hoechst-Roussel Pharmaceuticals Incorporated Carbamate derivatives of 4-amino-3-isoxazolidinones, 3-amino-1-hydroxypyrrolidin-2-ones and 1-amino-1-cyclopropanecarboxylic acid analogs

Also Published As

Publication number Publication date
IL111273A0 (en) 1994-12-29
PL177754B1 (pl) 2000-01-31
AU679560B2 (en) 1997-07-03
ZA948060B (en) 1995-06-09
EP1020469A2 (de) 2000-07-19
DE69427332D1 (de) 2001-07-05
RO114132B1 (ro) 1999-01-29
PL305455A1 (en) 1995-04-18
FI944822A (fi) 1995-04-16
NZ264681A (en) 1997-12-19
RU94036761A (ru) 1996-09-10
DK0648771T3 (da) 2001-08-27
JPH07188238A (ja) 1995-07-25
FI944822A0 (fi) 1994-10-13
CZ283561B6 (cs) 1998-05-13
EP0648771A1 (de) 1995-04-19
CA2118171C (en) 1999-12-28
CN1108658A (zh) 1995-09-20
JP2718637B2 (ja) 1998-02-25
NO307463B1 (no) 2000-04-10
US6323196B1 (en) 2001-11-27
CN1039011C (zh) 1998-07-08
TW375615B (en) 1999-12-01
RU2113438C1 (ru) 1998-06-20
DE69427332T2 (de) 2001-10-11
CZ254794A3 (en) 1995-05-17
PT648771E (pt) 2001-09-28
CA2118171A1 (en) 1995-04-16
ES2158876T3 (es) 2001-09-16
EG20747A (en) 2000-01-31
KR100189043B1 (ko) 1999-06-01
AU7581294A (en) 1995-05-04
GR3036068T3 (en) 2001-09-28
EP1020469A3 (de) 2000-07-26
EP0648771B1 (de) 2001-05-30
IL111273A (en) 1998-04-05
KR950011444A (ko) 1995-05-15
NO943894L (no) 1995-04-18
ATE201687T1 (de) 2001-06-15
NO943894D0 (no) 1994-10-14

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: HOECHST MARION ROUSSEL, INC.

PC Transfer of assignment of patent

Owner name: AVENTISUB II INC.

Free format text: AVENTISUB II INC.

MA Patent expired