FI108230B - Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä - Google Patents

Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä Download PDF

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Publication number
FI108230B
FI108230B FI945363A FI945363A FI108230B FI 108230 B FI108230 B FI 108230B FI 945363 A FI945363 A FI 945363A FI 945363 A FI945363 A FI 945363A FI 108230 B FI108230 B FI 108230B
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FI
Finland
Prior art keywords
oxo
pyridazo
amino
diazepine
compound
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FI945363A
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English (en)
Finnish (fi)
Swedish (sv)
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FI945363A (fi
FI945363A0 (fi
Inventor
Gary Alan Flynn
Patrick Wai-Kwok Shum
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Merrell Dow Pharma
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Publication of FI945363A0 publication Critical patent/FI945363A0/fi
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Publication of FI108230B publication Critical patent/FI108230B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
FI945363A 1992-05-15 1994-11-14 Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä FI108230B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88496392A 1992-05-15 1992-05-15
US88496392 1992-05-15
US4000393A 1993-04-09 1993-04-09
US4000393 1993-04-09
PCT/US1993/003721 WO1993023403A1 (en) 1992-05-15 1993-04-21 NOVEL MERCAPTOACETYLAMIDO PYRIDAZO[1,2]PYRIDAZINE, PYRAZOLO[1,2]PYRIDAZINE, PYRIDAZO[1,2-a][1,2]DIAZEPINE AND PYRAZOLO[1,2-a][1,2]DIAZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE
US9303721 1993-04-21

Publications (3)

Publication Number Publication Date
FI945363A FI945363A (fi) 1994-11-14
FI945363A0 FI945363A0 (fi) 1994-11-14
FI108230B true FI108230B (fi) 2001-12-14

Family

ID=26716641

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945363A FI108230B (fi) 1992-05-15 1994-11-14 Menetelmä uusien merkaptoasetyyliamido- pyridatso[1,2-a][1,2]diatsepiinijohdannaisten valmistamiseksi, jotka ovat käyttökelpoisia enkefalinaasin ja ACE:n estäjinä

Country Status (19)

Country Link
US (1) US5366973A (da)
EP (1) EP0640086B1 (da)
JP (1) JP3360079B2 (da)
KR (1) KR100281450B1 (da)
AT (1) ATE182892T1 (da)
AU (1) AU669364B2 (da)
CA (1) CA2133963C (da)
DE (1) DE69325904T2 (da)
DK (1) DK0640086T3 (da)
ES (1) ES2138622T3 (da)
FI (1) FI108230B (da)
GR (1) GR3031287T3 (da)
HU (1) HU223663B1 (da)
IL (1) IL105680A (da)
MX (1) MX9302824A (da)
NO (1) NO302573B1 (da)
NZ (1) NZ251930A (da)
TW (1) TW270115B (da)
WO (1) WO1993023403A1 (da)

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Also Published As

Publication number Publication date
WO1993023403A1 (en) 1993-11-25
MX9302824A (es) 1994-05-31
NO302573B1 (no) 1998-03-23
FI945363A (fi) 1994-11-14
JP3360079B2 (ja) 2002-12-24
ES2138622T3 (es) 2000-01-16
JPH07506832A (ja) 1995-07-27
DE69325904T2 (de) 1999-12-09
NO944335D0 (no) 1994-11-14
GR3031287T3 (en) 1999-12-31
DK0640086T3 (da) 1999-12-06
NO944335L (no) 1995-01-13
IL105680A0 (en) 1993-09-22
ATE182892T1 (de) 1999-08-15
CA2133963C (en) 1998-07-07
KR100281450B1 (ko) 2001-02-01
EP0640086B1 (en) 1999-08-04
TW270115B (da) 1996-02-11
EP0640086A1 (en) 1995-03-01
CA2133963A1 (en) 1993-11-25
HUT71099A (en) 1995-11-28
HU223663B1 (hu) 2004-11-29
US5366973A (en) 1994-11-22
DE69325904D1 (de) 1999-09-09
IL105680A (en) 1998-01-04
NZ251930A (en) 1996-02-27
AU669364B2 (en) 1996-06-06
AU4033293A (en) 1993-12-13
KR950701634A (ko) 1995-04-28
FI945363A0 (fi) 1994-11-14

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