ATE189392T1 - Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten - Google Patents
Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivatenInfo
- Publication number
- ATE189392T1 ATE189392T1 AT95912634T AT95912634T ATE189392T1 AT E189392 T1 ATE189392 T1 AT E189392T1 AT 95912634 T AT95912634 T AT 95912634T AT 95912634 T AT95912634 T AT 95912634T AT E189392 T1 ATE189392 T1 AT E189392T1
- Authority
- AT
- Austria
- Prior art keywords
- aminoacetylmercapto
- derivatives
- hypotriglyceridemic
- antiatherosclerotic
- hypocholesterolemic
- Prior art date
Links
- -1 AMINOACETYLMERCAPTO Chemical class 0.000 title abstract 2
- 230000000879 anti-atherosclerotic effect Effects 0.000 title 1
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- 230000000999 hypotriglyceridemic effect Effects 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21735094A | 1994-03-24 | 1994-03-24 | |
PCT/US1995/002458 WO1995025532A1 (en) | 1994-03-24 | 1995-02-28 | Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE189392T1 true ATE189392T1 (de) | 2000-02-15 |
Family
ID=22810704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT95912634T ATE189392T1 (de) | 1994-03-24 | 1995-02-28 | Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten |
Country Status (19)
Country | Link |
---|---|
US (2) | US5624921A (de) |
EP (1) | EP0751783B1 (de) |
JP (1) | JPH09510476A (de) |
CN (1) | CN1144487A (de) |
AT (1) | ATE189392T1 (de) |
AU (1) | AU698320B2 (de) |
CA (1) | CA2184696C (de) |
DE (1) | DE69514912T2 (de) |
DK (1) | DK0751783T3 (de) |
ES (1) | ES2141923T3 (de) |
FI (1) | FI963783A0 (de) |
GR (1) | GR3033117T3 (de) |
HU (1) | HUT75160A (de) |
IL (1) | IL113076A (de) |
NO (1) | NO963987L (de) |
NZ (1) | NZ282568A (de) |
PT (1) | PT751783E (de) |
WO (1) | WO1995025532A1 (de) |
ZA (1) | ZA952284B (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10229180A1 (de) * | 2002-06-28 | 2004-01-29 | Aventis Pharma Deutschland Gmbh | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
CN1863778A (zh) * | 2003-10-08 | 2006-11-15 | 伊莱利利公司 | 用于治疗血脂异常的化合物及方法 |
Family Cites Families (31)
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US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
NZ204130A (en) * | 1982-05-12 | 1986-03-14 | Hoffmann La Roche | Bicyclic heterocyclic compounds and pharmaceutical compositions |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
AU5675586A (en) * | 1985-04-30 | 1986-11-13 | Eli Lilly And Company | 1,5-diazabicyclo (3.3.0) octa-2-ene derivatives |
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
ZA874107B (de) * | 1986-06-13 | 1987-12-09 | ||
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
US5061694A (en) * | 1989-10-23 | 1991-10-29 | E. R. Squibb & Sons, Inc. | Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
US5407960A (en) * | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
FR2659332B1 (fr) * | 1990-03-08 | 1994-04-29 | Adit Et Cie | Nouvelles pyrrolo [1,2-a] thieno [3,2-f] diazepines [1,4], leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
ATE158303T1 (de) * | 1990-12-21 | 1997-10-15 | Merrell Pharma Inc | Neue trizyklische amino- und nitro verbindungen mit ace-hemmenden eigenschaften |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
EP0605589A1 (de) * | 1991-09-16 | 1994-07-13 | Schering Corporation | Natriuretische peptide oder neutrale endopeptidaseinhibitoren enthaltene pharmazeutische zusammensetzungen (arznei) der behandlung oder vorbeugung myointimaler wucherung |
KR100276029B1 (ko) * | 1992-02-14 | 2000-12-15 | 슈테펜엘.네스비트 | 아미노아세틸 머캅토아세틸 아미드 유도체 및 이의 제조방법 |
EP0640086B1 (de) * | 1992-05-15 | 1999-08-04 | Merrell Pharmaceuticals Inc. | MERCAPTOACETYLAMIDE VON PYRIDAZO[1,2-a][1,2]-DIAZEPIN -DERIVATEN ALS EUKEPHALINASE UND ACE-INHIBITOREN |
RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
-
1995
- 1995-02-28 CN CN95192233A patent/CN1144487A/zh active Pending
- 1995-02-28 NZ NZ282568A patent/NZ282568A/en unknown
- 1995-02-28 AT AT95912634T patent/ATE189392T1/de not_active IP Right Cessation
- 1995-02-28 EP EP95912634A patent/EP0751783B1/de not_active Expired - Lifetime
- 1995-02-28 AU AU19724/95A patent/AU698320B2/en not_active Ceased
- 1995-02-28 JP JP7524646A patent/JPH09510476A/ja not_active Abandoned
- 1995-02-28 PT PT95912634T patent/PT751783E/pt unknown
- 1995-02-28 WO PCT/US1995/002458 patent/WO1995025532A1/en active IP Right Grant
- 1995-02-28 DE DE69514912T patent/DE69514912T2/de not_active Expired - Fee Related
- 1995-02-28 ES ES95912634T patent/ES2141923T3/es not_active Expired - Lifetime
- 1995-02-28 HU HU9602604A patent/HUT75160A/hu unknown
- 1995-02-28 CA CA002184696A patent/CA2184696C/en not_active Expired - Fee Related
- 1995-02-28 DK DK95912634T patent/DK0751783T3/da active
- 1995-03-20 ZA ZA952284A patent/ZA952284B/xx unknown
- 1995-03-22 IL IL11307695A patent/IL113076A/xx not_active IP Right Cessation
- 1995-08-09 US US08/513,101 patent/US5624921A/en not_active Expired - Fee Related
- 1995-10-26 US US08/548,604 patent/US5602122A/en not_active Expired - Fee Related
-
1996
- 1996-09-23 NO NO963987A patent/NO963987L/no not_active Application Discontinuation
- 1996-09-23 FI FI963783A patent/FI963783A0/fi unknown
-
2000
- 2000-03-31 GR GR20000400807T patent/GR3033117T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
JPH09510476A (ja) | 1997-10-21 |
IL113076A (en) | 2000-09-28 |
CA2184696A1 (en) | 1995-09-28 |
CA2184696C (en) | 2001-01-02 |
PT751783E (pt) | 2000-05-31 |
GR3033117T3 (en) | 2000-08-31 |
US5624921A (en) | 1997-04-29 |
US5602122A (en) | 1997-02-11 |
FI963783A (fi) | 1996-09-23 |
CN1144487A (zh) | 1997-03-05 |
AU1972495A (en) | 1995-10-09 |
NO963987L (no) | 1996-11-22 |
HUT75160A (en) | 1997-04-28 |
NZ282568A (en) | 1997-07-27 |
ES2141923T3 (es) | 2000-04-01 |
EP0751783B1 (de) | 2000-02-02 |
ZA952284B (en) | 1996-01-09 |
IL113076A0 (en) | 1995-06-29 |
NO963987D0 (no) | 1996-09-23 |
DK0751783T3 (da) | 2000-06-26 |
WO1995025532A1 (en) | 1995-09-28 |
FI963783A0 (fi) | 1996-09-23 |
DE69514912T2 (de) | 2000-10-05 |
DE69514912D1 (de) | 2000-03-09 |
EP0751783A1 (de) | 1997-01-08 |
AU698320B2 (en) | 1998-10-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |