FI963783A0 - Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä aminoasetyylimerkaptojohdannaisia - Google Patents

Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä aminoasetyylimerkaptojohdannaisia

Info

Publication number
FI963783A0
FI963783A0 FI963783A FI963783A FI963783A0 FI 963783 A0 FI963783 A0 FI 963783A0 FI 963783 A FI963783 A FI 963783A FI 963783 A FI963783 A FI 963783A FI 963783 A0 FI963783 A0 FI 963783A0
Authority
FI
Finland
Prior art keywords
aminoacetylmercapto
derivatives
hypotriglyceridemic
hypocholesterolemic
atherosclerotic
Prior art date
Application number
FI963783A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963783A (fi
Inventor
Gary Alan Flynn
Rd John Fitzhugh French
Richard Cyrus Dage
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI963783A0 publication Critical patent/FI963783A0/fi
Publication of FI963783A publication Critical patent/FI963783A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
FI963783A 1994-03-24 1996-09-23 Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä aminoasetyylimerkaptojohdannaisia FI963783A (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US21735094A 1994-03-24 1994-03-24
PCT/US1995/002458 WO1995025532A1 (en) 1994-03-24 1995-02-28 Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic aminoacetylmercapto derivatives

Publications (2)

Publication Number Publication Date
FI963783A0 true FI963783A0 (fi) 1996-09-23
FI963783A FI963783A (fi) 1996-09-23

Family

ID=22810704

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963783A FI963783A (fi) 1994-03-24 1996-09-23 Hypokolesteroleemisiä, antiateroskleroottisia ja hypotriglyserideemisiä aminoasetyylimerkaptojohdannaisia

Country Status (19)

Country Link
US (2) US5624921A (de)
EP (1) EP0751783B1 (de)
JP (1) JPH09510476A (de)
CN (1) CN1144487A (de)
AT (1) ATE189392T1 (de)
AU (1) AU698320B2 (de)
CA (1) CA2184696C (de)
DE (1) DE69514912T2 (de)
DK (1) DK0751783T3 (de)
ES (1) ES2141923T3 (de)
FI (1) FI963783A (de)
GR (1) GR3033117T3 (de)
HU (1) HUT75160A (de)
IL (1) IL113076A (de)
NO (1) NO963987L (de)
NZ (1) NZ282568A (de)
PT (1) PT751783E (de)
WO (1) WO1995025532A1 (de)
ZA (1) ZA952284B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
SI1670768T1 (sl) * 2003-10-08 2010-01-29 Lilly Co Eli Spojine in metode za zdravljenje dislipidemije

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
ZA833214B (en) * 1982-05-12 1983-12-28 Hoffmann La Roche Bicyclic compounds
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
IL78634A0 (en) * 1985-04-30 1986-08-31 Lilly Co Eli 7-substituted bicyclic pyrazolidinones
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
ZA874107B (de) * 1986-06-13 1987-12-09
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5061694A (en) * 1989-10-23 1991-10-29 E. R. Squibb & Sons, Inc. Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
US5407960A (en) * 1989-12-22 1995-04-18 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
FR2659332B1 (fr) * 1990-03-08 1994-04-29 Adit Et Cie Nouvelles pyrrolo [1,2-a] thieno [3,2-f] diazepines [1,4], leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU642321B2 (en) * 1990-12-21 1993-10-14 Merrell Pharmaceuticals Inc. Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
EP0605589A1 (de) * 1991-09-16 1994-07-13 Schering Corporation Natriuretische peptide oder neutrale endopeptidaseinhibitoren enthaltene pharmazeutische zusammensetzungen (arznei) der behandlung oder vorbeugung myointimaler wucherung
AU668707B2 (en) * 1992-02-14 1996-05-16 Merrell Pharmaceuticals Inc. Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
KR100281450B1 (ko) * 1992-05-15 2001-02-01 슈테펜 엘. 네스비트 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 신규 메르캅토아세틸아미도 피리다조[1,2]피리다진, 피라졸로[1,2]피리다진, 피리다조[1,2-a][1,2]디아제핀 및 피라졸로[1,2-a][1,2]디아제핀 유도체
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Also Published As

Publication number Publication date
ES2141923T3 (es) 2000-04-01
EP0751783B1 (de) 2000-02-02
WO1995025532A1 (en) 1995-09-28
DE69514912T2 (de) 2000-10-05
CA2184696C (en) 2001-01-02
ATE189392T1 (de) 2000-02-15
AU698320B2 (en) 1998-10-29
EP0751783A1 (de) 1997-01-08
CA2184696A1 (en) 1995-09-28
PT751783E (pt) 2000-05-31
ZA952284B (en) 1996-01-09
AU1972495A (en) 1995-10-09
NO963987L (no) 1996-11-22
NZ282568A (en) 1997-07-27
US5624921A (en) 1997-04-29
JPH09510476A (ja) 1997-10-21
US5602122A (en) 1997-02-11
HUT75160A (en) 1997-04-28
IL113076A0 (en) 1995-06-29
CN1144487A (zh) 1997-03-05
NO963987D0 (no) 1996-09-23
DE69514912D1 (de) 2000-03-09
IL113076A (en) 2000-09-28
GR3033117T3 (en) 2000-08-31
FI963783A (fi) 1996-09-23
DK0751783T3 (da) 2000-06-26

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