IL113076A - Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid - Google Patents
Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acidInfo
- Publication number
- IL113076A IL113076A IL11307695A IL11307695A IL113076A IL 113076 A IL113076 A IL 113076A IL 11307695 A IL11307695 A IL 11307695A IL 11307695 A IL11307695 A IL 11307695A IL 113076 A IL113076 A IL 113076A
- Authority
- IL
- Israel
- Prior art keywords
- aminoalkanoylthio
- hypotriglyceridemic
- hypocholesterolemic
- alpha
- pharmaceutical
- Prior art date
Links
- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 title 2
- 108010016626 Dipeptides Proteins 0.000 title 1
- 230000000871 hypocholesterolemic effect Effects 0.000 title 1
- 230000000999 hypotriglyceridemic effect Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 208000035150 Hypercholesterolemia Diseases 0.000 abstract 1
- -1 aminoacetylmercapto Chemical class 0.000 abstract 1
- 208000006575 hypertriglyceridemia Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US21735094A | 1994-03-24 | 1994-03-24 |
Publications (2)
Publication Number | Publication Date |
---|---|
IL113076A0 IL113076A0 (en) | 1995-06-29 |
IL113076A true IL113076A (en) | 2000-09-28 |
Family
ID=22810704
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IL11307695A IL113076A (en) | 1994-03-24 | 1995-03-22 | Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid |
Country Status (19)
Country | Link |
---|---|
US (2) | US5624921A (xx) |
EP (1) | EP0751783B1 (xx) |
JP (1) | JPH09510476A (xx) |
CN (1) | CN1144487A (xx) |
AT (1) | ATE189392T1 (xx) |
AU (1) | AU698320B2 (xx) |
CA (1) | CA2184696C (xx) |
DE (1) | DE69514912T2 (xx) |
DK (1) | DK0751783T3 (xx) |
ES (1) | ES2141923T3 (xx) |
FI (1) | FI963783A (xx) |
GR (1) | GR3033117T3 (xx) |
HU (1) | HUT75160A (xx) |
IL (1) | IL113076A (xx) |
NO (1) | NO963987L (xx) |
NZ (1) | NZ282568A (xx) |
PT (1) | PT751783E (xx) |
WO (1) | WO1995025532A1 (xx) |
ZA (1) | ZA952284B (xx) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10229180A1 (de) * | 2002-06-28 | 2004-01-29 | Aventis Pharma Deutschland Gmbh | Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen |
SI1670768T1 (sl) * | 2003-10-08 | 2010-01-29 | Lilly Co Eli | Spojine in metode za zdravljenje dislipidemije |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3334095A (en) * | 1965-02-16 | 1967-08-01 | Sandoz Ag | Novel pyrrolo-oxazines and pyrrolo-oxazoles |
US3334091A (en) * | 1965-03-25 | 1967-08-01 | Sandoz Ag | Sedatives |
GB1525845A (en) * | 1976-07-30 | 1978-09-20 | Ucb Sa | 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones |
IE50839B1 (en) * | 1980-02-26 | 1986-07-23 | Wyeth John & Brother Ltd | Novel processes for preparing proline derivatives and analogous compounds |
EP0042100A1 (de) * | 1980-06-13 | 1981-12-23 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel |
US4320057A (en) * | 1980-06-23 | 1982-03-16 | American Home Products Corporation | Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
GB2128984B (en) * | 1982-05-12 | 1985-05-22 | Hoffmann La Roche | Diaza-bicyclic compounds |
ZA833214B (en) * | 1982-05-12 | 1983-12-28 | Hoffmann La Roche | Bicyclic compounds |
US4552889A (en) * | 1983-06-09 | 1985-11-12 | Eli Lilly And Company | 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension |
US4692438A (en) * | 1984-08-24 | 1987-09-08 | Hoffmann-La Roche Inc. | Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity |
US4584294A (en) * | 1984-11-07 | 1986-04-22 | Merck & Co., Inc. | Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents |
IL78634A0 (en) * | 1985-04-30 | 1986-08-31 | Lilly Co Eli | 7-substituted bicyclic pyrazolidinones |
ZA874106B (en) * | 1986-06-13 | 1987-12-08 | Merrell Dow Pharmaceuticals Inc. | Novel antihypertensive agent |
ZA874107B (xx) * | 1986-06-13 | 1987-12-09 | ||
US4973585A (en) * | 1986-06-13 | 1990-11-27 | Merrell Dow Pharmaceuticals | Tricyclic lactams active as antihypertensive agents |
GB8629875D0 (en) * | 1986-12-15 | 1987-01-28 | Hoffmann La Roche | Pyridazodiazepine derivatives |
US4824832A (en) * | 1987-12-30 | 1989-04-25 | Merrell Dow Pharmaceuticals Inc. | Sulfhydryl containing tricyclic lactams and their pharmacological methods of use |
US5061694A (en) * | 1989-10-23 | 1991-10-29 | E. R. Squibb & Sons, Inc. | Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor |
GB8926512D0 (en) * | 1989-11-23 | 1990-01-10 | Pfizer Ltd | Therapeutic agents |
US5407960A (en) * | 1989-12-22 | 1995-04-18 | Schering Corporation | Mercaptocycloacyl aminoacid endopeptidase inhibitors |
FR2659332B1 (fr) * | 1990-03-08 | 1994-04-29 | Adit Et Cie | Nouvelles pyrrolo [1,2-a] thieno [3,2-f] diazepines [1,4], leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
CA2053340C (en) * | 1990-10-18 | 2002-04-02 | Timothy P. Burkholder | Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace |
AU642321B2 (en) * | 1990-12-21 | 1993-10-14 | Merrell Pharmaceuticals Inc. | Novel amino and nitro containing tricyclic compounds useful as inhibitors of ace |
US5208230A (en) * | 1990-12-21 | 1993-05-04 | Merrell Dow Pharmaceuticals | Amino and nitro containing tricyclic compounds useful as inhibitors of ACE |
FR2679564A1 (fr) * | 1991-07-23 | 1993-01-29 | Inst Nat Sante Rech Med | Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent. |
EP0605589A1 (en) * | 1991-09-16 | 1994-07-13 | Schering Corporation | Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation |
AU668707B2 (en) * | 1992-02-14 | 1996-05-16 | Merrell Pharmaceuticals Inc. | Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE |
KR100281450B1 (ko) * | 1992-05-15 | 2001-02-01 | 슈테펜 엘. 네스비트 | 엔케팔리나제 및 안지오텐신 전환 효소의 억제제로서 유용한 신규 메르캅토아세틸아미도 피리다조[1,2]피리다진, 피라졸로[1,2]피리다진, 피리다조[1,2-a][1,2]디아제핀 및 피라졸로[1,2-a][1,2]디아제핀 유도체 |
RU2124503C1 (ru) * | 1992-05-18 | 1999-01-10 | И.Р.Сквибб энд Санз, Инк. | Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция |
US5238932A (en) * | 1992-05-20 | 1993-08-24 | Merrell Dow Pharmaceuticals Inc. | Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase |
-
1995
- 1995-02-28 WO PCT/US1995/002458 patent/WO1995025532A1/en active IP Right Grant
- 1995-02-28 AU AU19724/95A patent/AU698320B2/en not_active Ceased
- 1995-02-28 ES ES95912634T patent/ES2141923T3/es not_active Expired - Lifetime
- 1995-02-28 DE DE69514912T patent/DE69514912T2/de not_active Expired - Fee Related
- 1995-02-28 NZ NZ282568A patent/NZ282568A/en unknown
- 1995-02-28 DK DK95912634T patent/DK0751783T3/da active
- 1995-02-28 EP EP95912634A patent/EP0751783B1/en not_active Expired - Lifetime
- 1995-02-28 PT PT95912634T patent/PT751783E/pt unknown
- 1995-02-28 JP JP7524646A patent/JPH09510476A/ja not_active Abandoned
- 1995-02-28 HU HU9602604A patent/HUT75160A/hu unknown
- 1995-02-28 CN CN95192233A patent/CN1144487A/zh active Pending
- 1995-02-28 AT AT95912634T patent/ATE189392T1/de not_active IP Right Cessation
- 1995-02-28 CA CA002184696A patent/CA2184696C/en not_active Expired - Fee Related
- 1995-03-20 ZA ZA952284A patent/ZA952284B/xx unknown
- 1995-03-22 IL IL11307695A patent/IL113076A/xx not_active IP Right Cessation
- 1995-08-09 US US08/513,101 patent/US5624921A/en not_active Expired - Fee Related
- 1995-10-26 US US08/548,604 patent/US5602122A/en not_active Expired - Fee Related
-
1996
- 1996-09-23 NO NO963987A patent/NO963987L/no not_active Application Discontinuation
- 1996-09-23 FI FI963783A patent/FI963783A/fi unknown
-
2000
- 2000-03-31 GR GR20000400807T patent/GR3033117T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2141923T3 (es) | 2000-04-01 |
EP0751783B1 (en) | 2000-02-02 |
WO1995025532A1 (en) | 1995-09-28 |
DE69514912T2 (de) | 2000-10-05 |
CA2184696C (en) | 2001-01-02 |
ATE189392T1 (de) | 2000-02-15 |
AU698320B2 (en) | 1998-10-29 |
EP0751783A1 (en) | 1997-01-08 |
CA2184696A1 (en) | 1995-09-28 |
FI963783A0 (fi) | 1996-09-23 |
PT751783E (pt) | 2000-05-31 |
ZA952284B (en) | 1996-01-09 |
AU1972495A (en) | 1995-10-09 |
NO963987L (no) | 1996-11-22 |
NZ282568A (en) | 1997-07-27 |
US5624921A (en) | 1997-04-29 |
JPH09510476A (ja) | 1997-10-21 |
US5602122A (en) | 1997-02-11 |
HUT75160A (en) | 1997-04-28 |
IL113076A0 (en) | 1995-06-29 |
CN1144487A (zh) | 1997-03-05 |
NO963987D0 (no) | 1996-09-23 |
DE69514912D1 (de) | 2000-03-09 |
GR3033117T3 (en) | 2000-08-31 |
FI963783A (fi) | 1996-09-23 |
DK0751783T3 (da) | 2000-06-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX9702175A (es) | Combinacion de un inhibidor de absorcion de colesterol y un inhibidor de sintesis de colesterol. | |
IL126038A0 (en) | Novel benzothiepines and derivatives thereof and pharmaceutical compositions comprising them | |
PL323825A1 (en) | Peptidyloheterocycli compounds useful in treating diorders associated with thrombosin | |
GEP20043149B (en) | Use of Substituted Azetidinones Agents | |
AU3435497A (en) | Autocross-linked hyaluronic acid and related pharmaceutical compositions for the treatment of arthropathies | |
BG101209A (en) | Hypolipidemic compounds | |
AU1729397A (en) | Process to prepare soluble delivery systems using volatile salts | |
AU7449598A (en) | Medicinal composition for prevention or treatment of hepatopathy | |
AU2740797A (en) | Androstene derivatives | |
AU4871797A (en) | Magnesium (-)hydroxycitrate, preparation process, uses and compositions, in particular pharmaceutical compositions, containing it | |
HUP9901153A3 (en) | Azetidinone derivatives for the treatment of atherosclerosis, their production and pharmaceutical compositions containing them | |
HUP9801880A3 (en) | Novel cryptophycins, their use and pharmaceutical compositions containing them | |
MX9403088A (es) | Composiciones farmaceuticas que contienen deriva- dos de indol y metodos de uso. | |
UA35566C2 (uk) | Лікарський засіб для профілактики і лікування порушень ліпоїдного і холестеринового обміну речовин і спосіб профілактики і лікування цих порушень | |
IL113076A (en) | Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid | |
IL113074A (en) | Hypocholesterolemic antiatherosclerotic and hypotriglyceridemic pharmaceutical compositions comprising derivatives of mercaptoacetamido-oxopyrrolo (and pyrido) benzazepinecarboxylic acids | |
AU5963396A (en) | Cis-resorcylide, pharmaceutical composition containing it, use thereof in the treatment of thrombosis and related disorders | |
IL111804A0 (en) | Pharmaceutical compositions comprising dimeticone for the treatment of constipation | |
IL109108A0 (en) | Salts of (s)-alpha- phenyl - 2 - pyridineethanamine, their preparation and pharmaceutical compositions containing them | |
AU5994696A (en) | Modified alpha-d-glcp-(1-2)-alpha-d-glcp-(1-3)-alpha-d-glcp- analogues | |
CA2184692A1 (en) | Hypocholesterolemic, Antiatherosclerotic and Hypotriglyceridemic Mercaptoacetylamide Disulfide Derivatives | |
AU5602898A (en) | Pharmaceutical compositions for mucolysis and treatment of inflammation | |
IL145758A0 (en) | Pharmaceutical compositions for treatment and prevention of arteriosclerosis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
KB | Patent renewed | ||
MM9K | Patent not in force due to non-payment of renewal fees | ||
HC | Change of name of proprietor(s) |
Owner name: AVENTIS INC. Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC. |