IL113076A - Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid - Google Patents

Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid

Info

Publication number
IL113076A
IL113076A IL11307695A IL11307695A IL113076A IL 113076 A IL113076 A IL 113076A IL 11307695 A IL11307695 A IL 11307695A IL 11307695 A IL11307695 A IL 11307695A IL 113076 A IL113076 A IL 113076A
Authority
IL
Israel
Prior art keywords
aminoalkanoylthio
hypotriglyceridemic
hypocholesterolemic
alpha
pharmaceutical
Prior art date
Application number
IL11307695A
Other languages
English (en)
Other versions
IL113076A0 (en
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of IL113076A0 publication Critical patent/IL113076A0/xx
Publication of IL113076A publication Critical patent/IL113076A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
IL11307695A 1994-03-24 1995-03-22 Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid IL113076A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21735094A 1994-03-24 1994-03-24

Publications (2)

Publication Number Publication Date
IL113076A0 IL113076A0 (en) 1995-06-29
IL113076A true IL113076A (en) 2000-09-28

Family

ID=22810704

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11307695A IL113076A (en) 1994-03-24 1995-03-22 Pharmaceutical hypocholesterolemic and hypotriglyceridemic compositions containing tricyclic dipeptide derivatives of alpha-(aminoalkanoylthio) benzenepropionic acid

Country Status (19)

Country Link
US (2) US5624921A (xx)
EP (1) EP0751783B1 (xx)
JP (1) JPH09510476A (xx)
CN (1) CN1144487A (xx)
AT (1) ATE189392T1 (xx)
AU (1) AU698320B2 (xx)
CA (1) CA2184696C (xx)
DE (1) DE69514912T2 (xx)
DK (1) DK0751783T3 (xx)
ES (1) ES2141923T3 (xx)
FI (1) FI963783A0 (xx)
GR (1) GR3033117T3 (xx)
HU (1) HUT75160A (xx)
IL (1) IL113076A (xx)
NO (1) NO963987L (xx)
NZ (1) NZ282568A (xx)
PT (1) PT751783E (xx)
WO (1) WO1995025532A1 (xx)
ZA (1) ZA952284B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10229180A1 (de) * 2002-06-28 2004-01-29 Aventis Pharma Deutschland Gmbh Verwendung von Vasopeptidase-Inhibitoren bei der Behandlung von metabolischen Erkrankungen, Nephropathie und mit AGE assoziierten Erkrankungen
EP2098512A1 (en) * 2003-10-08 2009-09-09 Eli Lilly & Company Compounds and methods for treating dyslipidemia

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3334095A (en) * 1965-02-16 1967-08-01 Sandoz Ag Novel pyrrolo-oxazines and pyrrolo-oxazoles
US3334091A (en) * 1965-03-25 1967-08-01 Sandoz Ag Sedatives
GB1525845A (en) * 1976-07-30 1978-09-20 Ucb Sa 1,2,4,5-tetrahydro-3h-2-benzazepin-3-ones
IE50839B1 (en) * 1980-02-26 1986-07-23 Wyeth John & Brother Ltd Novel processes for preparing proline derivatives and analogous compounds
EP0042100A1 (de) * 1980-06-13 1981-12-23 F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft Pyrazolopyridazin-Derivate, Zwischenprodukte und Verfahren zu deren Herstellung, sowie diese enthaltende Arzneimittel
US4320057A (en) * 1980-06-23 1982-03-16 American Home Products Corporation Aryl--pyrrolo--thiazepin--diones and aryl--piperidino--thiazepin--diones
US4415496A (en) * 1981-03-23 1983-11-15 Merck & Co., Inc. Bicyclic lactams
GB2128984B (en) * 1982-05-12 1985-05-22 Hoffmann La Roche Diaza-bicyclic compounds
NZ204130A (en) * 1982-05-12 1986-03-14 Hoffmann La Roche Bicyclic heterocyclic compounds and pharmaceutical compositions
US4552889A (en) * 1983-06-09 1985-11-12 Eli Lilly And Company 3-Mercaptomethyl-2-oxo-1-pyrrolidine acetic acids and use for hypertension
US4692438A (en) * 1984-08-24 1987-09-08 Hoffmann-La Roche Inc. Pyridazo-diazepines, diazocines, and -triazepines having anti-hypertensive activity
US4584294A (en) * 1984-11-07 1986-04-22 Merck & Co., Inc. Fused tricyclic lactams as angiotensin converting enzyme inhibitors and as antihypertensive agents
ATE60605T1 (de) * 1985-04-30 1991-02-15 Lilly Co Eli 7-substituierte bicyclische pyrazolidinone.
ZA874107B (xx) * 1986-06-13 1987-12-09
ZA874106B (en) * 1986-06-13 1987-12-08 Merrell Dow Pharmaceuticals Inc. Novel antihypertensive agent
US4973585A (en) * 1986-06-13 1990-11-27 Merrell Dow Pharmaceuticals Tricyclic lactams active as antihypertensive agents
GB8629875D0 (en) * 1986-12-15 1987-01-28 Hoffmann La Roche Pyridazodiazepine derivatives
US4824832A (en) * 1987-12-30 1989-04-25 Merrell Dow Pharmaceuticals Inc. Sulfhydryl containing tricyclic lactams and their pharmacological methods of use
US5061694A (en) * 1989-10-23 1991-10-29 E. R. Squibb & Sons, Inc. Method for stabilizing or causing regression of atherosclerosis in coronary arteries employing an ace inhibitor
GB8926512D0 (en) * 1989-11-23 1990-01-10 Pfizer Ltd Therapeutic agents
WO1991009840A1 (en) * 1989-12-22 1991-07-11 Schering Corporation Mercaptocycloacyl aminoacid endopeptidase inhibitors
FR2659332B1 (fr) * 1990-03-08 1994-04-29 Adit Et Cie Nouvelles pyrrolo [1,2-a] thieno [3,2-f] diazepines [1,4], leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
CA2057786C (en) * 1990-12-21 2002-06-18 Gary A. Flynn Amino and nitro containing tricyclic compounds useful as inhibitors or ace
FR2679564A1 (fr) * 1991-07-23 1993-01-29 Inst Nat Sante Rech Med Nouveaux acylmercaptoalcanoldipeptides, leur preparation et les compositions qui les contiennent.
CA2119019A1 (en) * 1991-09-16 1993-04-01 Harry R. Davis Pharmaceutical compositions comprising natriuretic peptides or neutral endopeptidase inhibitors for treating or preventing myointimal proliferation
DK0625987T3 (da) * 1992-02-14 1999-01-11 Merrell Pharma Inc Aminoacetylmercaptoacetylamid-derivater, der kan anvendes som inhibitorer af enkephalinase og ACE
ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
RU2124503C1 (ru) * 1992-05-18 1999-01-10 И.Р.Сквибб энд Санз, Инк. Гетероциклические азотсодержащие производные карбоновой кислоты, способ их получения и фармацевтическая композиция
US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase

Also Published As

Publication number Publication date
NZ282568A (en) 1997-07-27
WO1995025532A1 (en) 1995-09-28
EP0751783B1 (en) 2000-02-02
HUT75160A (en) 1997-04-28
FI963783A (fi) 1996-09-23
US5624921A (en) 1997-04-29
IL113076A0 (en) 1995-06-29
NO963987D0 (no) 1996-09-23
AU1972495A (en) 1995-10-09
CA2184696A1 (en) 1995-09-28
ES2141923T3 (es) 2000-04-01
ATE189392T1 (de) 2000-02-15
DK0751783T3 (da) 2000-06-26
JPH09510476A (ja) 1997-10-21
EP0751783A1 (en) 1997-01-08
ZA952284B (en) 1996-01-09
NO963987L (no) 1996-11-22
CA2184696C (en) 2001-01-02
AU698320B2 (en) 1998-10-29
PT751783E (pt) 2000-05-31
DE69514912D1 (de) 2000-03-09
CN1144487A (zh) 1997-03-05
DE69514912T2 (de) 2000-10-05
FI963783A0 (fi) 1996-09-23
GR3033117T3 (en) 2000-08-31
US5602122A (en) 1997-02-11

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Legal Events

Date Code Title Description
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees
HC Change of name of proprietor(s)

Owner name: AVENTIS INC.

Free format text: FORMER NAME:MERRELL PHARMACEUTICALS INC.