FI106961B - Menetelmä terapeuttisesti käyttökelpoisten bis-indolyyli-1H-pyrroli-2,5-dionijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten bis-indolyyli-1H-pyrroli-2,5-dionijohdannaisten valmistamiseksi Download PDF

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Publication number
FI106961B
FI106961B FI942158A FI942158A FI106961B FI 106961 B FI106961 B FI 106961B FI 942158 A FI942158 A FI 942158A FI 942158 A FI942158 A FI 942158A FI 106961 B FI106961 B FI 106961B
Authority
FI
Finland
Prior art keywords
formula
tetrahydropyrido
indolyl
pyrrole
methyl
Prior art date
Application number
FI942158A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI942158A0 (fi
FI942158A7 (fi
Inventor
Christopher Huw Hill
Geoffrey Lawton
William Harris
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939309602A external-priority patent/GB9309602D0/en
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI942158A0 publication Critical patent/FI942158A0/fi
Publication of FI942158A7 publication Critical patent/FI942158A7/fi
Application granted granted Critical
Publication of FI106961B publication Critical patent/FI106961B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)
FI942158A 1993-05-10 1994-05-10 Menetelmä terapeuttisesti käyttökelpoisten bis-indolyyli-1H-pyrroli-2,5-dionijohdannaisten valmistamiseksi FI106961B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9309602 1993-05-10
GB939309602A GB9309602D0 (en) 1993-05-10 1993-05-10 Substituted pyrroles
GB9403249A GB9403249D0 (en) 1993-05-10 1994-02-21 Substituted pyrroles
GB9403249 1994-02-21

Publications (3)

Publication Number Publication Date
FI942158A0 FI942158A0 (fi) 1994-05-10
FI942158A7 FI942158A7 (fi) 1994-11-11
FI106961B true FI106961B (fi) 2001-05-15

Family

ID=26302877

Family Applications (1)

Application Number Title Priority Date Filing Date
FI942158A FI106961B (fi) 1993-05-10 1994-05-10 Menetelmä terapeuttisesti käyttökelpoisten bis-indolyyli-1H-pyrroli-2,5-dionijohdannaisten valmistamiseksi

Country Status (25)

Country Link
EP (1) EP0624586B1 (lt)
JP (1) JP2668818B2 (lt)
CN (1) CN1048014C (lt)
AT (1) ATE184007T1 (lt)
AU (1) AU678435B2 (lt)
BG (1) BG98761A (lt)
BR (1) BR9401935A (lt)
CA (1) CA2121567A1 (lt)
CZ (1) CZ112894A3 (lt)
DE (1) DE69420310T2 (lt)
DK (1) DK0624586T3 (lt)
ES (1) ES2137281T3 (lt)
FI (1) FI106961B (lt)
GR (1) GR3031901T3 (lt)
HR (1) HRP940287B1 (lt)
HU (1) HU215954B (lt)
IL (1) IL109547A (lt)
IS (1) IS1690B (lt)
LT (1) LT3288B (lt)
LV (1) LV11173B (lt)
NO (1) NO301230B1 (lt)
NZ (1) NZ260475A (lt)
RU (1) RU2141960C1 (lt)
SI (1) SI0624586T1 (lt)
SK (1) SK53594A3 (lt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
PL182124B1 (pl) * 1993-12-07 2001-11-30 Lilly Co Eli Nowe zwiazki oraz srodek farmaceutyczny przeznaczony do leczenia powiklan cukrzycowych lub do leczenia nowotworów PL PL PL PL PL PL PL PL
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
DK0817627T3 (da) * 1993-12-23 2005-06-06 Lilly Co Eli Inhibitorer af proteinkinase C
ES2123873T3 (es) * 1994-08-04 1999-01-16 Hoffmann La Roche Pirrolocarbazol.
KR20000064764A (ko) * 1996-03-20 2000-11-06 피터지.스트링거 인돌릴말레이미드의제조방법
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
IL153851A0 (en) 2000-07-27 2003-07-31 Hoffmann La Roche 3-indolyl-4-phenyl-1h-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
IL161156A0 (en) 2001-10-30 2004-08-31 Novartis Ag Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
JP2007501774A (ja) 2003-08-08 2007-02-01 ノバルティス アクチエンゲゼルシャフト スタウロスポリンを含む組み合わせ

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
SK75289A3 (en) * 1988-02-10 1998-05-06 Hoffmann La Roche Substituted pyrroles, their use for producing a drug, and the drug on their base
DE3833008A1 (de) * 1988-09-29 1990-04-05 Goedecke Ag Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles

Also Published As

Publication number Publication date
NZ260475A (en) 1996-02-27
LTIP1927A (en) 1994-11-25
BR9401935A (pt) 1995-03-07
FI942158A0 (fi) 1994-05-10
ES2137281T3 (es) 1999-12-16
NO941682D0 (no) 1994-05-06
EP0624586A1 (en) 1994-11-17
EP0624586B1 (en) 1999-09-01
RU2141960C1 (ru) 1999-11-27
JPH06329672A (ja) 1994-11-29
FI942158A7 (fi) 1994-11-11
NO941682L (no) 1994-11-11
HU215954B (hu) 1999-03-29
ATE184007T1 (de) 1999-09-15
IS4162A (is) 1994-11-11
SI0624586T1 (en) 1999-12-31
HRP940287A2 (en) 1996-12-31
HU9401298D0 (en) 1994-08-29
LV11173B (en) 1996-06-20
BG98761A (en) 1995-03-31
DE69420310D1 (de) 1999-10-07
IL109547A (en) 1998-07-15
DK0624586T3 (da) 2000-03-27
HRP940287B1 (en) 2000-02-29
NO301230B1 (no) 1997-09-29
JP2668818B2 (ja) 1997-10-27
CA2121567A1 (en) 1994-11-11
CN1103402A (zh) 1995-06-07
IS1690B (is) 1998-04-20
LT3288B (en) 1995-06-26
DE69420310T2 (de) 2000-04-13
GR3031901T3 (en) 2000-02-29
CZ112894A3 (en) 1994-12-15
AU6055594A (en) 1994-11-17
IL109547A0 (en) 1994-08-26
LV11173A (lv) 1996-04-20
HUT71492A (en) 1995-11-28
AU678435B2 (en) 1997-05-29
CN1048014C (zh) 2000-01-05
SK53594A3 (en) 1995-02-08

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