ES2137281T3 - Pirroles sustituidos. - Google Patents

Pirroles sustituidos.

Info

Publication number
ES2137281T3
ES2137281T3 ES94106812T ES94106812T ES2137281T3 ES 2137281 T3 ES2137281 T3 ES 2137281T3 ES 94106812 T ES94106812 T ES 94106812T ES 94106812 T ES94106812 T ES 94106812T ES 2137281 T3 ES2137281 T3 ES 2137281T3
Authority
ES
Spain
Prior art keywords
lower alkyl
amino
formula
aryl
prevention
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94106812T
Other languages
English (en)
Inventor
William Harris
Christopher Huw Hill
Geoffrey Lawton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939309602A external-priority patent/GB9309602D0/en
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Application granted granted Critical
Publication of ES2137281T3 publication Critical patent/ES2137281T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Communicable Diseases (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

LA INVENCION PROPORCIONA COMPUESTOS DE LA FORMULA: EN DONDE R1 REPRESENTA ALQUILO INFERIOR, CICLOALQUILO INFERIOR, ARILO O ARALQUILO INFERIOR, R2 REPRESENTA HIDROGENO, ARILO O ALQUILO INFERIOR OPCIONALMENTE SUSTITUIDO POR HIDROXILO, ACILOXILO, AMINO, MONO(ALQUILO INFERIOR)AMINO, DI(ALQUILO INFERIOR)AMINO, CARBOXILO, ALCOXICARBONILO INFERIOR O AMINOCARBONILO Y M Y N REPRESENTAN 1 O 2. ASI COMO SALES FARMACEUTICAMENTE ACEPTABLES DE COMPUESTOS ACIDOS DE FORMULA I CON BASES Y DE COMPUESTOS BASICOS DE FORMULA I CON ACIDOS, LOS CUALES SE USAN EN EL CONTROL O PREVENCION DE INDISPOSICIONES, ESPECIALMENTE EN EL CONTROL O PREVENCION DE DESORDENES INFLAMATORIOS, INMUNOLOGICOS, ONCOLOGICOS, BRONCOPULMONARES, DERMATOLOGICOS Y CARDIOVASCULARES, EN EL TRATAMIENTO DE ASMA, SIDA O COMPLICACIONES DIABETICAS O PARA LA ESTIMULACION DEL CRECIMIENTO DEL CABELLO.
ES94106812T 1993-05-10 1994-05-02 Pirroles sustituidos. Expired - Lifetime ES2137281T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB939309602A GB9309602D0 (en) 1993-05-10 1993-05-10 Substituted pyrroles
GB9403249A GB9403249D0 (en) 1993-05-10 1994-02-21 Substituted pyrroles

Publications (1)

Publication Number Publication Date
ES2137281T3 true ES2137281T3 (es) 1999-12-16

Family

ID=26302877

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94106812T Expired - Lifetime ES2137281T3 (es) 1993-05-10 1994-05-02 Pirroles sustituidos.

Country Status (25)

Country Link
EP (1) EP0624586B1 (es)
JP (1) JP2668818B2 (es)
CN (1) CN1048014C (es)
AT (1) ATE184007T1 (es)
AU (1) AU678435B2 (es)
BG (1) BG98761A (es)
BR (1) BR9401935A (es)
CA (1) CA2121567A1 (es)
CZ (1) CZ112894A3 (es)
DE (1) DE69420310T2 (es)
DK (1) DK0624586T3 (es)
ES (1) ES2137281T3 (es)
FI (1) FI106961B (es)
GR (1) GR3031901T3 (es)
HR (1) HRP940287B1 (es)
HU (1) HU215954B (es)
IL (1) IL109547A (es)
IS (1) IS1690B (es)
LT (1) LT3288B (es)
LV (1) LV11173B (es)
NO (1) NO301230B1 (es)
NZ (1) NZ260475A (es)
RU (1) RU2141960C1 (es)
SI (1) SI0624586T1 (es)
SK (1) SK53594A3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA44690C2 (uk) * 1993-12-07 2002-03-15 Елі Ліллі Енд Компані Макроциклічна сполука іміду біс-індол-малеїнової кислоти, спосіб її одержання та фармацевтична композиція, макроциклічні сполуки іміду біс-індол-малеїнової кислоти та біс-індол-малеїнового ангідриду, спосіб одержання (варіанти)
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
ATE456367T1 (de) * 1993-12-23 2010-02-15 Lilly Co Eli Proteinkinase c inhibitoren
DK0695755T3 (da) * 1994-08-04 1999-06-28 Hoffmann La Roche Pyrrolocarbazoler
EP0888339A4 (en) * 1996-03-20 2001-02-28 Lilly Co Eli SYNTHESIS OF INDOLYLMALEINIMIDES
KR100499190B1 (ko) * 1996-03-29 2006-04-17 교와 핫꼬 고교 가부시끼가이샤 육모제
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
JP3984157B2 (ja) 2000-07-27 2007-10-03 エフ．ホフマン−ラ ロシュ アーゲー グリコーゲンシンターゼキナーゼ−３ベータのインヒビターとしての３−インドリル−４−フェニル−１ｈ−ピロール−２，５−ジオン誘導体
DK1441737T3 (da) * 2001-10-30 2006-11-13 Novartis Ag Staurosporin-derivater som inhibitorer af FLT3-receptor-tyrosinkinase-aktivitet
CA2393720C (en) 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP2305265A1 (en) 2003-08-08 2011-04-06 Novartis AG Combinations comprising staurosporines

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
NZ227850A (en) * 1988-02-10 1991-11-26 Hoffmann La Roche Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
DE3833008A1 (de) * 1988-09-29 1990-04-05 Goedecke Ag Pyrrolocarbozol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
MC2096A1 (fr) * 1989-02-23 1991-02-15 Hoffmann La Roche Pyrroles substitues
CA2046801C (en) * 1990-08-07 2002-02-26 Peter D. Davis Substituted pyrroles

Also Published As

Publication number Publication date
IL109547A (en) 1998-07-15
BR9401935A (pt) 1995-03-07
EP0624586A1 (en) 1994-11-17
SI0624586T1 (en) 1999-12-31
RU2141960C1 (ru) 1999-11-27
LT3288B (en) 1995-06-26
BG98761A (en) 1995-03-31
NO301230B1 (no) 1997-09-29
DE69420310D1 (de) 1999-10-07
JP2668818B2 (ja) 1997-10-27
LTIP1927A (en) 1994-11-25
HU9401298D0 (en) 1994-08-29
HRP940287A2 (en) 1996-12-31
ATE184007T1 (de) 1999-09-15
JPH06329672A (ja) 1994-11-29
DE69420310T2 (de) 2000-04-13
CZ112894A3 (en) 1994-12-15
NZ260475A (en) 1996-02-27
IS4162A (is) 1994-11-11
CN1048014C (zh) 2000-01-05
FI106961B (fi) 2001-05-15
LV11173A (lv) 1996-04-20
IS1690B (is) 1998-04-20
CN1103402A (zh) 1995-06-07
IL109547A0 (en) 1994-08-26
FI942158A0 (fi) 1994-05-10
HUT71492A (en) 1995-11-28
NO941682L (no) 1994-11-11
AU678435B2 (en) 1997-05-29
AU6055594A (en) 1994-11-17
HU215954B (hu) 1999-03-29
HRP940287B1 (en) 2000-02-29
DK0624586T3 (da) 2000-03-27
EP0624586B1 (en) 1999-09-01
SK53594A3 (en) 1995-02-08
CA2121567A1 (en) 1994-11-11
NO941682D0 (no) 1994-05-06
FI942158A (fi) 1994-11-11
LV11173B (en) 1996-06-20
GR3031901T3 (en) 2000-02-29

Similar Documents

Publication Publication Date Title
ES2137281T3 (es) Pirroles sustituidos.
ATE282630T1 (de) Dolastatin-derivate
ES2132076T3 (es) Pirroles sustituidos.
NO975028D0 (no) Piperazinoderivater som neurokininantagonister
RU94015830A (ru) Замещенные пирролы
DE69418744D1 (de) Verwendung von Pregnanderivaten zur Behandlung von Tumoren
AU3895689A (en) Cyclic sulfur-containing amino acid derivatives
NO904135L (no) Fremgangsmaate for fremstilling av nye substituerte alkylpiperidiner og deres anvendelse som inhibitorer av kolesterolsyntese.
AU686104B2 (en) Substituted amidinonaphthyl ester derivatives
YU19194A (sh) Supstituisani piroli
DK0551844T3 (da) Svovlholdige galdesyrederivater
ATE122352T1 (de) 3-(3-ethyl-1,2,4-oxadiazol-5-yl)-1- azabicycloheptan, verfahren zu seiner herstellung und dieses enthaltende pharmazeutische zubereitungen.
HUP0300348A2 (hu) Eljárás (aril-imino-metil)-karbamidsav-észterek előállítására

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 624586

Country of ref document: ES