FI106720B - Fuusioproteiinien valmistus in vitro - Google Patents

Fuusioproteiinien valmistus in vitro Download PDF

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Publication number
FI106720B
FI106720B FI913405A FI913405A FI106720B FI 106720 B FI106720 B FI 106720B FI 913405 A FI913405 A FI 913405A FI 913405 A FI913405 A FI 913405A FI 106720 B FI106720 B FI 106720B
Authority
FI
Finland
Prior art keywords
amino acid
protein
lys
ser
asp
Prior art date
Application number
FI913405A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI913405A7 (fi
FI913405A0 (fi
Inventor
Jutta Heim
Kenji Takabayashi
Peter Seeboth
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI913405A0 publication Critical patent/FI913405A0/fi
Publication of FI913405A7 publication Critical patent/FI913405A7/fi
Application granted granted Critical
Publication of FI106720B publication Critical patent/FI106720B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/58—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi
    • C12N9/60—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from fungi from yeast
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Diabetes (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
FI913405A 1990-07-18 1991-07-15 Fuusioproteiinien valmistus in vitro FI106720B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909015825A GB9015825D0 (en) 1990-07-18 1990-07-18 In vitro processing of fusion proteins
GB9015825 1990-07-18

Publications (3)

Publication Number Publication Date
FI913405A0 FI913405A0 (fi) 1991-07-15
FI913405A7 FI913405A7 (fi) 1992-01-19
FI106720B true FI106720B (fi) 2001-03-30

Family

ID=10679295

Family Applications (1)

Application Number Title Priority Date Filing Date
FI913405A FI106720B (fi) 1990-07-18 1991-07-15 Fuusioproteiinien valmistus in vitro

Country Status (19)

Country Link
EP (1) EP0467839B1 (enExample)
JP (1) JP3140488B2 (enExample)
AT (1) ATE141645T1 (enExample)
AU (1) AU651830B2 (enExample)
CA (1) CA2047119C (enExample)
DE (1) DE69121489T2 (enExample)
DK (1) DK0467839T3 (enExample)
ES (1) ES2091897T3 (enExample)
FI (1) FI106720B (enExample)
GB (1) GB9015825D0 (enExample)
GR (1) GR3020840T3 (enExample)
HU (1) HU216104B (enExample)
IE (1) IE73209B1 (enExample)
NO (1) NO303132B1 (enExample)
NZ (1) NZ238989A (enExample)
PT (1) PT98332B (enExample)
SG (1) SG49863A1 (enExample)
TW (1) TW209247B (enExample)
ZA (1) ZA915579B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5525491A (en) * 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
CA2213512A1 (en) * 1995-12-22 1997-07-03 Toray Industries, Inc. Method for producing bioactive fusion protein
US6800726B1 (en) 1996-11-01 2004-10-05 Pioneer Hi-Bred International, Inc. Proteins with increased levels of essential amino acids
US6265204B1 (en) 1997-01-17 2001-07-24 Genencor International, Inc. DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi
GB9716790D0 (en) 1997-08-07 1997-10-15 Creative Peptides Sweden Ab Recombinant DNA molecules comprising multimeric copies of a gene sequence and expression thereof
WO2014138371A1 (en) 2013-03-06 2014-09-12 Glaxosmithkline Llc Host cells and methods of use
CN118515782B (zh) * 2024-06-03 2025-03-18 浙江毓昌生物技术有限公司 一种融合蛋白及基于该融合蛋白制备重组人生长激素的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MC1834A1 (fr) * 1986-07-10 1988-06-03 Transgene Sa Bloc fonctionnel d'adn et plasmide codant pour l'hirudine,levure transformee,procede de preparation de l'hirudine,hirudine obtenue et son utilisation
US5010182A (en) * 1987-07-28 1991-04-23 Chiron Corporation DNA constructs containing a Kluyveromyces alpha factor leader sequence for directing secretion of heterologous polypeptides
DK105489D0 (da) * 1989-03-03 1989-03-03 Novo Nordisk As Polypeptid

Also Published As

Publication number Publication date
JPH04229188A (ja) 1992-08-18
DE69121489T2 (de) 1997-02-27
IE912501A1 (en) 1992-01-29
PT98332B (pt) 1999-01-29
GR3020840T3 (en) 1996-11-30
AU651830B2 (en) 1994-08-04
DE69121489D1 (de) 1996-09-26
HU912398D0 (en) 1991-12-30
ZA915579B (en) 1992-03-25
CA2047119C (en) 2002-10-08
TW209247B (enExample) 1993-07-11
NO912803D0 (no) 1991-07-17
FI913405A7 (fi) 1992-01-19
NZ238989A (en) 1992-09-25
AU8046391A (en) 1992-01-23
NO912803L (no) 1992-01-20
EP0467839A1 (en) 1992-01-22
CA2047119A1 (en) 1992-01-19
SG49863A1 (en) 2002-03-19
ATE141645T1 (de) 1996-09-15
EP0467839B1 (en) 1996-08-21
ES2091897T3 (es) 1996-11-16
FI913405A0 (fi) 1991-07-15
HU216104B (hu) 1999-04-28
NO303132B1 (no) 1998-06-02
HUT58369A (en) 1992-02-28
GB9015825D0 (en) 1990-09-05
DK0467839T3 (da) 1996-09-16
JP3140488B2 (ja) 2001-03-05
IE73209B1 (en) 1997-05-07
PT98332A (pt) 1992-05-29

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Owner name: NOVARTIS AG