FI106260B - Menetelmä verisuonia laajentavien tiatsolidinonin ja oksatsolidinonin johdannaisten valmistamiseksi - Google Patents

Menetelmä verisuonia laajentavien tiatsolidinonin ja oksatsolidinonin johdannaisten valmistamiseksi Download PDF

Info

Publication number
FI106260B
FI106260B FI921340A FI921340A FI106260B FI 106260 B FI106260 B FI 106260B FI 921340 A FI921340 A FI 921340A FI 921340 A FI921340 A FI 921340A FI 106260 B FI106260 B FI 106260B
Authority
FI
Finland
Prior art keywords
group
carbon atoms
formula
groups
compound
Prior art date
Application number
FI921340A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI921340A (fi
FI921340A0 (fi
Inventor
Takao Yoshioka
Sadao Ishihara
Hiroyuki Koike
Fujio Saito
Sigeki Miyake
Hiroshi Mizuno
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI921340A0 publication Critical patent/FI921340A0/fi
Publication of FI921340A publication Critical patent/FI921340A/fi
Application granted granted Critical
Publication of FI106260B publication Critical patent/FI106260B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C07D263/24—Oxygen atoms attached in position 2 with hydrocarbon radicals, substituted by oxygen atoms, attached to other ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/14—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Indole Compounds (AREA)
FI921340A 1991-03-27 1992-03-26 Menetelmä verisuonia laajentavien tiatsolidinonin ja oksatsolidinonin johdannaisten valmistamiseksi FI106260B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6308891 1991-03-27
JP6308891 1991-03-27
JP10275191 1991-05-08
JP10275191 1991-05-08
JP33030491 1991-12-13
JP33030491 1991-12-13

Publications (3)

Publication Number Publication Date
FI921340A0 FI921340A0 (fi) 1992-03-26
FI921340A FI921340A (fi) 1992-09-28
FI106260B true FI106260B (fi) 2000-12-29

Family

ID=27298042

Family Applications (1)

Application Number Title Priority Date Filing Date
FI921340A FI106260B (fi) 1991-03-27 1992-03-26 Menetelmä verisuonia laajentavien tiatsolidinonin ja oksatsolidinonin johdannaisten valmistamiseksi

Country Status (23)

Country Link
US (2) US5298516A (da)
EP (1) EP0506434B1 (da)
JP (1) JPH0780859B2 (da)
KR (1) KR0152097B1 (da)
CN (2) CN1031824C (da)
AT (1) ATE118770T1 (da)
AU (1) AU647599B2 (da)
CA (1) CA2064108C (da)
CZ (1) CZ282529B6 (da)
DE (1) DE69201451T2 (da)
DK (1) DK0506434T3 (da)
ES (1) ES2072095T3 (da)
FI (1) FI106260B (da)
HK (1) HK123595A (da)
HU (2) HU217969B (da)
IE (1) IE67383B1 (da)
IL (1) IL101395A (da)
IS (1) IS1746B (da)
NO (1) NO304311B1 (da)
NZ (1) NZ242154A (da)
PH (1) PH30493A (da)
RU (1) RU2055073C1 (da)
TW (1) TW226015B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
AU6376894A (en) * 1993-03-15 1994-10-11 Byk Nederland Bv Use of substituted alkyl nitrates for the treatment of pathologically increased intra-ocular pressure
DE4429461A1 (de) * 1994-08-19 1996-02-22 Merck Patent Gmbh Adhäsionsrezeptor-Antagonisten
DE69522118T2 (de) * 1994-12-15 2002-04-25 Sankyo Co., Ltd. Thiazolidonon- oder oxazolidinonderivate zur behandlung von angina pectoris und zusammensetzungen die diese als wirkstoffe enthält
DE69612967T2 (de) * 1995-03-02 2002-04-04 Sankyo Co., Ltd. Optisch aktive thiazolidinonderivate
US5925658A (en) * 1995-03-02 1999-07-20 Sankyo Company, Limited Optically active thiazolidinone derivative
AU6016496A (en) * 1995-06-14 1997-01-15 Sankyo Company Limited Antianginal drug comprising nitroxy derivative as active ingredient
BE1010768A3 (nl) * 1996-11-26 1999-01-05 Dsm Nv Een werkwijze voor de bereiding van alpha-aminozuuramiden, alpha-aminozuren en derivaten ervan.
IL120531A (en) * 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
WO2002069967A1 (fr) * 2001-03-01 2002-09-12 Sankyo Company, Limited Compositions a absorption percutanee
WO2013016727A1 (en) * 2011-07-28 2013-01-31 Promentis Pharmaceuticals, Inc. Cysteine prodrugs
US10239847B1 (en) 2016-03-03 2019-03-26 Cellactin Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200640A (en) * 1976-04-02 1980-04-29 Chugai Seiyaku Kabushiki Kaisha Nitric ester of N-(2-hydroxyethyl)nicotinamide and pharmaceutical use
GB8717068D0 (en) * 1987-07-20 1987-08-26 Fujisawa Pharmaceutical Co Nitric ester derivative
WO1990012791A1 (en) * 1989-04-21 1990-11-01 E.I. Du Pont De Nemours And Company Fungicidal oxazolidinones

Also Published As

Publication number Publication date
CN1096265C (zh) 2002-12-18
NO304311B1 (no) 1998-11-30
DK0506434T3 (da) 1995-07-24
AU647599B2 (en) 1994-03-24
HU211969A9 (en) 1996-01-29
FI921340A (fi) 1992-09-28
HK123595A (en) 1995-08-04
HU217969B (hu) 2000-05-28
CN1113435A (zh) 1995-12-20
KR920018036A (ko) 1992-10-21
CA2064108A1 (en) 1992-09-28
IE920966A1 (en) 1992-10-07
JPH0780859B2 (ja) 1995-08-30
NZ242154A (en) 1993-09-27
NO921159D0 (no) 1992-03-25
TW226015B (da) 1994-07-01
DE69201451T2 (de) 1995-10-12
IL101395A0 (en) 1992-11-15
ATE118770T1 (de) 1995-03-15
CN1066067A (zh) 1992-11-11
CN1031824C (zh) 1996-05-22
EP0506434B1 (en) 1995-02-22
PH30493A (en) 1997-05-28
AU1312292A (en) 1992-10-01
DE69201451D1 (de) 1995-03-30
CZ91692A3 (en) 1993-01-13
JPH05213910A (ja) 1993-08-24
ES2072095T3 (es) 1995-07-01
NO921159L (no) 1992-09-28
CA2064108C (en) 2000-09-26
KR0152097B1 (ko) 1998-10-15
HUT68242A (en) 1995-06-28
IL101395A (en) 1996-10-16
RU2055073C1 (ru) 1996-02-27
FI921340A0 (fi) 1992-03-26
US5356918A (en) 1994-10-18
IE67383B1 (en) 1996-03-20
CZ282529B6 (cs) 1997-08-13
IS1746B (is) 2000-07-11
US5298516A (en) 1994-03-29
IS3828A (is) 1992-09-28
EP0506434A1 (en) 1992-09-30
HU9201033D0 (en) 1992-06-29

Similar Documents

Publication Publication Date Title
FI106260B (fi) Menetelmä verisuonia laajentavien tiatsolidinonin ja oksatsolidinonin johdannaisten valmistamiseksi
AU2023285742A1 (en) Compounds and methods for the targeted degradation of androgen receptor
JP2020528918A (ja) アンドロゲン受容体の標的化分解のための化合物および方法
CA2901696C (en) Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer
EP3828173A1 (en) Substituted pyrazoles as human plasma kallikrein inhibitors
JP2002528495A (ja) ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
KR100589544B1 (ko) Ｐｄｆ 억제제로서의 ｎ-포르밀 히드록실아민 화합물
TW200538447A (en) Compounds having human immunodeficiency virus protease inhibitor activity and the uses thereof
DE69612967T2 (de) Optisch aktive thiazolidinonderivate
US5958949A (en) N-linked ureas and carbamates of piperidyl thioesters
WO2005004861A1 (en) A use of novel 2-oxo-heterocyclic compounds and the pharmaceutical compositions comprising the same
CZ282427B6 (cs) Deriváty aminokyselin, způsob výroby a farmaceutické prostředky s jejich obsahem
KR100230633B1 (ko) 니트록시알킬아미드 유도체(Nitroxyalkylamide derivate)
US5925658A (en) Optically active thiazolidinone derivative
CA2359031C (en) Thiazolidinone or oxazolidinone derivatives for treatment of ulcerative disease
EP0903346A1 (en) Sydnone imine derivatives
WO2019126842A1 (en) Therapeutic compounds and uses thereof
CZ2001798A3 (en) Use of thia- or oxazolidinone derivatives for preparing a medicament for therapy or prevention of ulcer diseases

Legal Events

Date Code Title Description
MA Patent expired