FI106206B - Menetelmä polypeptidin valmistamiseksi - Google Patents

Menetelmä polypeptidin valmistamiseksi Download PDF

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Publication number
FI106206B
FI106206B FI920889A FI920889A FI106206B FI 106206 B FI106206 B FI 106206B FI 920889 A FI920889 A FI 920889A FI 920889 A FI920889 A FI 920889A FI 106206 B FI106206 B FI 106206B
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FI
Finland
Prior art keywords
ala
gly
pro
cys
leu
Prior art date
Application number
FI920889A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI920889A0 (fi
Inventor
Ei Mochida
Akio Uemura
Atsushi Nii
Hideaki Morishita
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Publication of FI920889A0 publication Critical patent/FI920889A0/fi
Application granted granted Critical
Publication of FI106206B publication Critical patent/FI106206B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI920889A 1990-06-27 1992-02-27 Menetelmä polypeptidin valmistamiseksi FI106206B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP16876690 1990-06-27
JP16876690 1990-06-27
PCT/JP1991/000873 WO1992000325A1 (en) 1990-06-27 1991-06-27 Anticoagulant polypeptides
JP9100873 1991-06-27

Publications (2)

Publication Number Publication Date
FI920889A0 FI920889A0 (fi) 1992-02-27
FI106206B true FI106206B (fi) 2000-12-15

Family

ID=15874056

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920889A FI106206B (fi) 1990-06-27 1992-02-27 Menetelmä polypeptidin valmistamiseksi

Country Status (8)

Country Link
US (2) US5516659A (no)
EP (1) EP0489180A4 (no)
JP (1) JP3189052B2 (no)
AU (1) AU643306B2 (no)
CA (1) CA2065409C (no)
FI (1) FI106206B (no)
NO (1) NO302527B1 (no)
WO (1) WO1992000325A1 (no)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816494A1 (en) * 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha DNA coding for a peptide promoting the activation of protein C by thrombin, and process for producing the same
JP3537440B2 (ja) * 1993-12-17 2004-06-14 持田製薬株式会社 可溶性トロンボモジュリンを長期保存安定化させる方法
US6465620B1 (en) 2000-01-21 2002-10-15 Hyseq, Inc. Methods and materials relating to novel von Willebrand/Thrombospondin-like polypeptides and polynucleotides
US7510845B2 (en) * 2000-05-04 2009-03-31 California Institute Of Technology Assay employing G protein-coupled receptor expressed in dorsal root ganglia
US20030092035A1 (en) * 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
US7691604B1 (en) 2000-05-04 2010-04-06 California Institute Of Technology MRG polypeptides and nucleic acids encoding the same
US20030152941A1 (en) * 2000-06-21 2003-08-14 Boyle Bryan J. Nucleic acids encoding novel von Willebrand/Thrombospondin factor-like polypeptides and uses of same
AU2001283055A1 (en) * 2000-07-28 2002-02-13 Emory University Biological component comprising artificial membrane
ATE304021T1 (de) * 2001-05-25 2005-09-15 Vlaams Interuniv Inst Biotech Lektin-ähnliche domäne von thrombomodulin und therapeutische verwendung davon
JP4187141B2 (ja) * 2002-04-12 2008-11-26 興和株式会社 新規なトロンボモジュリン発現促進剤
US20040121410A1 (en) * 2002-12-20 2004-06-24 Anderson David J. Pain signaling molecules
KR20090051777A (ko) 2006-10-06 2009-05-22 아사히 가세이 파마 가부시키가이샤 파종성 혈관내 혈액 응고 증후군의 치료 및/또는 개선제
TWI461434B (zh) 2007-03-23 2014-11-21 Asahi Kasei Pharma Corp Preparation of high purity soluble thrombin modulators
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
CA2743141A1 (en) * 2008-11-12 2010-05-20 Eli Lilly And Company Compositions and methods of use for soluble thrombomodulin variants
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
SG184530A1 (en) 2010-04-30 2012-11-29 Asahi Kasei Pharma Corp Highly-purified soluble thrombomodulin and method for producing same
KR20130099027A (ko) 2010-08-05 2013-09-05 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 혈전용해 및 응고억제 특성을 갖는 단백질 융합 구조물
PL2781221T3 (pl) 2011-11-15 2020-08-24 Asahi Kasei Pharma Corporation Lek do leczenia i/lub uzyskiwania poprawy w posocznicy
PT2857037T (pt) 2012-05-31 2019-07-19 Univ Kinki Agente para prevenção e/ou tratamento de dor neuropática periférica causada por fármaco anticanceroso
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
US20230165941A1 (en) 2018-10-22 2023-06-01 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis accompanied by coagulopathy
CN114686443B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
JPS6330423A (ja) * 1986-07-22 1988-02-09 Kowa Co トロンビン結合性物質およびその製法
JPS63146898A (ja) * 1986-07-15 1988-06-18 Kowa Co トロンビン結合性物質およびその製法
DE3750664T2 (de) * 1986-07-15 1995-06-22 Kowa Co Throminbindende Substanz und Verfahren zu ihrer Herstellung.
EP0816494A1 (en) * 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha DNA coding for a peptide promoting the activation of protein C by thrombin, and process for producing the same
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
JPH0219399A (ja) * 1988-07-05 1990-01-23 Oklahoma Medical Res Found トロンビン結合ポリピペプチド
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US5273962A (en) * 1990-11-30 1993-12-28 Kowa Co., Ltd. Human urinary thrombomodulin with a modified glycosaminoglycan (GAG) binding site

Also Published As

Publication number Publication date
FI920889A0 (fi) 1992-02-27
NO920762D0 (no) 1992-02-26
US5695964A (en) 1997-12-09
JP3189052B2 (ja) 2001-07-16
WO1992000325A1 (en) 1992-01-09
NO920762L (no) 1992-04-24
CA2065409C (en) 2002-05-14
US5516659A (en) 1996-05-14
NO302527B1 (no) 1998-03-16
EP0489180A1 (en) 1992-06-10
AU643306B2 (en) 1993-11-11
CA2065409A1 (en) 1991-12-28
EP0489180A4 (en) 1993-03-31
AU8080091A (en) 1992-01-23

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