FI106197B - Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi - Google Patents
Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi Download PDFInfo
- Publication number
- FI106197B FI106197B FI916060A FI916060A FI106197B FI 106197 B FI106197 B FI 106197B FI 916060 A FI916060 A FI 916060A FI 916060 A FI916060 A FI 916060A FI 106197 B FI106197 B FI 106197B
- Authority
- FI
- Finland
- Prior art keywords
- amino
- methyl
- oxo
- indol
- mmol
- Prior art date
Links
- 0 *=C(CC*C([C@@](CC1=CIc2ccccc12)NC(*C1C2CC(C3)CC1CC3C2)=*)O)*CC(O)=O Chemical compound *=C(CC*C([C@@](CC1=CIc2ccccc12)NC(*C1C2CC(C3)CC1CC3C2)=*)O)*CC(O)=O 0.000 description 3
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37432789A | 1989-06-29 | 1989-06-29 | |
US37432789 | 1989-06-29 | ||
US42248689A | 1989-10-16 | 1989-10-16 | |
US42248689 | 1989-10-16 | ||
US53081190A | 1990-06-05 | 1990-06-05 | |
US53081190 | 1990-06-05 | ||
US9003553 | 1990-06-28 | ||
PCT/US1990/003553 WO1991000274A1 (en) | 1989-06-29 | 1990-06-28 | N-substituted cycloalkyl and polycycloalkyl alpha-substituted trp-phe- and phenethylamine derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
FI916060A0 FI916060A0 (fi) | 1991-12-20 |
FI106197B true FI106197B (fi) | 2000-12-15 |
Family
ID=27409174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI916060A FI106197B (fi) | 1989-06-29 | 1991-12-20 | Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0405537B1 (no) |
JP (1) | JP2972331B2 (no) |
KR (2) | KR0167315B1 (no) |
CN (1) | CN1049165A (no) |
AT (1) | ATE275546T1 (no) |
AU (1) | AU644088B2 (no) |
CA (2) | CA2060652C (no) |
DE (1) | DE69034162T2 (no) |
DK (1) | DK0405537T3 (no) |
ES (1) | ES2229202T3 (no) |
FI (1) | FI106197B (no) |
IE (1) | IE902347A1 (no) |
IL (1) | IL94903A0 (no) |
NO (1) | NO301831B1 (no) |
NZ (1) | NZ234264A (no) |
PT (1) | PT94543B (no) |
WO (1) | WO1991000274A1 (no) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5162336A (en) * | 1990-06-21 | 1992-11-10 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists |
US5340825A (en) * | 1990-08-31 | 1994-08-23 | Warner-Lambert Company | Pro drugs for CCK antagonists |
DE69132805T2 (de) * | 1990-08-31 | 2002-10-24 | Warner-Lambert Co., Ann Arbor | Pro-medikamente für cck-antagonisten |
CA2088195A1 (en) * | 1990-08-31 | 1992-03-01 | David C. Horwell | Cholecystokinin antagonists, their preparation and therapeutic use |
US5244915A (en) * | 1990-08-31 | 1993-09-14 | Warner-Lambert Company | Amico acid derivatives cyclized at the c-terminal |
US5593967A (en) * | 1990-08-31 | 1997-01-14 | Warner-Lambert Company | Cholecystokinin antagonists, their preparation and therapeutic use |
US5264420A (en) * | 1990-09-27 | 1993-11-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
EP0668770A1 (en) * | 1991-04-24 | 1995-08-30 | Warner-Lambert Company | $g(a)-SUBSTITUTED POLYPEPTIDES HAVING THERAPEUTIC ACTIVITY |
WO1992019595A1 (en) * | 1991-05-07 | 1992-11-12 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
CA2110986A1 (en) * | 1991-07-12 | 1993-01-21 | Geoffrey Neil Woodruff | Cholecystokinin antagonists useful in the treatment of panic attacks |
US5153191A (en) * | 1991-08-20 | 1992-10-06 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
US5217957A (en) * | 1991-08-20 | 1993-06-08 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
US5272158A (en) * | 1991-10-29 | 1993-12-21 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5389631A (en) * | 1991-10-29 | 1995-02-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
DE4137490A1 (de) * | 1991-11-14 | 1993-05-19 | Goedecke Ag | Synthese von tricyclo(3.3.1.13,7)dec-2.yl(r-(r*,r*))-3- (1h-indol-3-yl-methyl)-3-methyl-4,9-dioxo- 7,11-diphenyl-10-oxa-2,5,8-triaza-undecanat |
US6492531B1 (en) | 1992-02-18 | 2002-12-10 | Warner-Lambert Company | Method of treating cognitive disorders |
AU3509793A (en) * | 1992-02-20 | 1993-09-13 | James Black Foundation Limited | Bicyclo(2.2.2.)octane derivatives as cholestocystokinin inhibitors |
GB9316722D0 (en) * | 1993-08-12 | 1993-09-29 | Black James Foundation | Bicyclo (2.2.2)octane derivatives |
US5514683A (en) * | 1992-02-20 | 1996-05-07 | James Black Foundation Limited | Bicyclo 2,2,2!octane derivatives |
US5227490A (en) * | 1992-02-21 | 1993-07-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5674905A (en) * | 1992-06-19 | 1997-10-07 | James Black Foundation Limited | Bicyclooctane and bicycloheptane derivatives |
US5380872A (en) * | 1992-07-14 | 1995-01-10 | Glaxo Inc. | Modulators of cholecystokinin |
US5922681A (en) * | 1992-09-14 | 1999-07-13 | Warner-Lambert Company | Endothelin antagonists |
AU674553B2 (en) * | 1992-10-14 | 1997-01-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
ATE188379T1 (de) * | 1992-10-14 | 2000-01-15 | Merck & Co Inc | Fibrinogenrezeptor-antagonisten |
US5340798A (en) * | 1992-10-14 | 1994-08-23 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5358956A (en) * | 1992-10-14 | 1994-10-25 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
AU675689B2 (en) * | 1992-12-01 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
FR2700540B1 (fr) * | 1993-01-15 | 1995-02-17 | Irj | alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique. |
US5441952A (en) * | 1993-04-05 | 1995-08-15 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5334596A (en) * | 1993-05-11 | 1994-08-02 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5397791A (en) * | 1993-08-09 | 1995-03-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5821241A (en) * | 1994-02-22 | 1998-10-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
WO1995032949A1 (en) * | 1994-05-27 | 1995-12-07 | James Black Foundation Limited | Gastrin and cck antagonists |
US5719144A (en) * | 1995-02-22 | 1998-02-17 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5852045A (en) * | 1995-10-19 | 1998-12-22 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5789421A (en) * | 1995-10-26 | 1998-08-04 | Merck & Co., Inc. | Fibrinogen receptor antagonist |
US5780480A (en) * | 1996-02-28 | 1998-07-14 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
US5889023A (en) * | 1996-05-10 | 1999-03-30 | Merck & Co., Inc. | Fibrinogen receptor antagonist |
US5981584A (en) * | 1997-02-06 | 1999-11-09 | Merck & Co., Inc. | Fibrinogen receptor antagonist prodrugs |
US7375093B2 (en) | 2002-07-05 | 2008-05-20 | Intrexon Corporation | Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex |
US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
MX2007008238A (es) | 2005-01-05 | 2007-08-17 | Abbott Lab | Derivados de adamantilo como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1. |
NZ555971A (en) | 2005-01-05 | 2011-01-28 | Abbott Lab | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
CA3059256C (en) * | 2017-04-10 | 2024-04-16 | The Regents Of The University Of Michigan | Covalent small molecule dcn1 inhibitors and therapeutic methods using the same |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4482567A (en) * | 1982-10-07 | 1984-11-13 | Research Foundation For Mental Hygiene, Inc. | N-hexanoyl to n-heptadecanoyl 5-hydroxy tryptophan-5-hydroxytryptophanamides and use as analgesics |
US4757151A (en) * | 1985-11-14 | 1988-07-12 | Warner-Lambert Company | 2-substituted-[2-substituted-amino]-N-arylalkyl-3-[indol-3-yl] |
US4814463A (en) * | 1985-12-31 | 1989-03-21 | Biomeasure, Inc. | CCK antagonists |
-
1990
- 1990-06-27 NZ NZ234264A patent/NZ234264A/xx unknown
- 1990-06-28 AU AU59628/90A patent/AU644088B2/en not_active Ceased
- 1990-06-28 IE IE234790A patent/IE902347A1/en unknown
- 1990-06-28 JP JP2510126A patent/JP2972331B2/ja not_active Expired - Fee Related
- 1990-06-28 DK DK90112333T patent/DK0405537T3/da active
- 1990-06-28 ES ES90112333T patent/ES2229202T3/es not_active Expired - Lifetime
- 1990-06-28 KR KR1019910702001A patent/KR0167315B1/ko not_active IP Right Cessation
- 1990-06-28 CA CA002060652A patent/CA2060652C/en not_active Expired - Fee Related
- 1990-06-28 DE DE69034162T patent/DE69034162T2/de not_active Expired - Fee Related
- 1990-06-28 EP EP90112333A patent/EP0405537B1/en not_active Expired - Lifetime
- 1990-06-28 EP EP90911185A patent/EP0479910A1/en active Pending
- 1990-06-28 AT AT90112333T patent/ATE275546T1/de not_active IP Right Cessation
- 1990-06-28 CA CA002344707A patent/CA2344707C/en not_active Expired - Fee Related
- 1990-06-28 WO PCT/US1990/003553 patent/WO1991000274A1/en active IP Right Grant
- 1990-06-28 IL IL94903A patent/IL94903A0/xx unknown
- 1990-06-29 PT PT94543A patent/PT94543B/pt not_active IP Right Cessation
- 1990-06-29 CN CN90106804A patent/CN1049165A/zh active Pending
-
1991
- 1991-12-20 FI FI916060A patent/FI106197B/fi not_active IP Right Cessation
- 1991-12-27 NO NO915122A patent/NO301831B1/no not_active IP Right Cessation
-
1998
- 1998-06-26 KR KR1019980704957A patent/KR0180539B1/ko not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
IE902347L (en) | 1990-12-29 |
ES2229202T3 (es) | 2005-04-16 |
DE69034162D1 (de) | 2004-10-14 |
NO915122L (no) | 1992-02-27 |
NO301831B1 (no) | 1997-12-15 |
PT94543B (pt) | 1997-04-30 |
EP0479910A1 (en) | 1992-04-15 |
NO915122D0 (no) | 1991-12-27 |
CN1049165A (zh) | 1991-02-13 |
ATE275546T1 (de) | 2004-09-15 |
NZ234264A (en) | 1993-05-26 |
JP2972331B2 (ja) | 1999-11-08 |
IE902347A1 (en) | 1991-01-16 |
CA2344707C (en) | 2002-07-30 |
KR0167315B1 (ko) | 1999-01-15 |
WO1991000274A1 (en) | 1991-01-10 |
CA2060652C (en) | 2001-08-21 |
DE69034162T2 (de) | 2005-09-22 |
JPH04506079A (ja) | 1992-10-22 |
AU644088B2 (en) | 1993-12-02 |
FI916060A0 (fi) | 1991-12-20 |
CA2344707A1 (en) | 1991-01-10 |
IL94903A0 (en) | 1991-04-15 |
AU5962890A (en) | 1991-01-17 |
KR920702678A (ko) | 1992-10-06 |
EP0405537B1 (en) | 2004-09-08 |
EP0405537A1 (en) | 1991-01-02 |
CA2060652A1 (en) | 1990-12-30 |
PT94543A (pt) | 1991-03-20 |
DK0405537T3 (da) | 2005-01-10 |
KR0180539B1 (en) | 1999-05-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI106197B (fi) | Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi | |
US5397788A (en) | Amino acid derivatives cyclized at the C-terminal | |
US5631281A (en) | N-substituted cycloalkyl and polycycloalkyl α-substituted Trp-Phe- and phenethylamine derivatives | |
AU649077B2 (en) | Pro-drugs for CCK antagonists | |
US5278316A (en) | N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives | |
WO1992004045A1 (en) | Novel cholecystokinin antagonists, their preparation and therapeutic use | |
US5264419A (en) | N-substituted cycloalkyl and polycycloalkyl α-substituted TRP derivatives | |
US5340825A (en) | Pro drugs for CCK antagonists | |
WO1992004348A1 (en) | N-substituted cycloalkyl and polycycloakyl polyhydro-β-carboline-phenylalanine-and phenethylamine derivatives | |
US5580896A (en) | Treatment of pain and colorectal cancer with dipeptoids of α-substituted Trp-Phe derivatives | |
AU651390C (en) | Novel cholecystokinin antagonists, their preparation and therapeutic use |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MA | Patent expired |