FI106197B - Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi - Google Patents

Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi Download PDF

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Publication number
FI106197B
FI106197B FI916060A FI916060A FI106197B FI 106197 B FI106197 B FI 106197B FI 916060 A FI916060 A FI 916060A FI 916060 A FI916060 A FI 916060A FI 106197 B FI106197 B FI 106197B
Authority
FI
Finland
Prior art keywords
amino
methyl
oxo
indol
mmol
Prior art date
Application number
FI916060A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI916060A0 (fi
Inventor
Julian Aranda
David Christopher Horwell
Martyn Clive Pritchard
Reginald Stewart Richardson
Edward Roberts
Original Assignee
Warner Lambert Co
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Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of FI916060A0 publication Critical patent/FI916060A0/fi
Application granted granted Critical
Publication of FI106197B publication Critical patent/FI106197B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Rigid Containers With Two Or More Constituent Elements (AREA)
FI916060A 1989-06-29 1991-12-20 Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi FI106197B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US37432789A 1989-06-29 1989-06-29
US37432789 1989-06-29
US42248689A 1989-10-16 1989-10-16
US42248689 1989-10-16
US53081190A 1990-06-05 1990-06-05
US53081190 1990-06-05
US9003553 1990-06-28
PCT/US1990/003553 WO1991000274A1 (fr) 1989-06-29 1990-06-28 DERIVES DE Trp-Phe ET PHENETHYLAMINE A SUBSTITUTION ALPHA DE CYCLOALKYLE ET DE POLYCYCLOALKYLE A SUBSTITUTION N

Publications (2)

Publication Number Publication Date
FI916060A0 FI916060A0 (fi) 1991-12-20
FI106197B true FI106197B (fi) 2000-12-15

Family

ID=27409174

Family Applications (1)

Application Number Title Priority Date Filing Date
FI916060A FI106197B (fi) 1989-06-29 1991-12-20 Menetelmä farmaseuttisesti käyttökelpoisten dipeptoidityyppisten alfa-metyylitryptofaanijohdannaisten valmistamiseksi

Country Status (17)

Country Link
EP (2) EP0479910A1 (fr)
JP (1) JP2972331B2 (fr)
KR (2) KR0167315B1 (fr)
CN (1) CN1049165A (fr)
AT (1) ATE275546T1 (fr)
AU (1) AU644088B2 (fr)
CA (2) CA2060652C (fr)
DE (1) DE69034162T2 (fr)
DK (1) DK0405537T3 (fr)
ES (1) ES2229202T3 (fr)
FI (1) FI106197B (fr)
IE (1) IE902347A1 (fr)
IL (1) IL94903A0 (fr)
NO (1) NO301831B1 (fr)
NZ (1) NZ234264A (fr)
PT (1) PT94543B (fr)
WO (1) WO1991000274A1 (fr)

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US5244915A (en) * 1990-08-31 1993-09-14 Warner-Lambert Company Amico acid derivatives cyclized at the c-terminal
US5340825A (en) * 1990-08-31 1994-08-23 Warner-Lambert Company Pro drugs for CCK antagonists
WO1992004038A1 (fr) * 1990-08-31 1992-03-19 Warner-Lambert Company Pro-medicaments pour antagonistes de cholecystokinine
JPH06502627A (ja) * 1990-08-31 1994-03-24 ワーナー―ランバート・コンパニー 新規コレシストキニンアンタゴニスト、その製造および治療用使用
US5593967A (en) * 1990-08-31 1997-01-14 Warner-Lambert Company Cholecystokinin antagonists, their preparation and therapeutic use
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
AU1907292A (en) * 1991-04-24 1992-12-21 Warner-Lambert Company Alpha-substituted polypeptides having therapeutic activity
HUT68769A (en) * 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
WO1993000897A1 (fr) * 1991-07-12 1993-01-21 Warner-Lambert Company Antagonistes de cholecystokinine utiles dans le traitement de crises de panique
US5153191A (en) * 1991-08-20 1992-10-06 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5217957A (en) * 1991-08-20 1993-06-08 Warner-Lambert Company Cholecystokinin antagonists useful for treating depression
US5389631A (en) * 1991-10-29 1995-02-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4137490A1 (de) * 1991-11-14 1993-05-19 Goedecke Ag Synthese von tricyclo(3.3.1.13,7)dec-2.yl(r-(r*,r*))-3- (1h-indol-3-yl-methyl)-3-methyl-4,9-dioxo- 7,11-diphenyl-10-oxa-2,5,8-triaza-undecanat
US6492531B1 (en) 1992-02-18 2002-12-10 Warner-Lambert Company Method of treating cognitive disorders
GB9316722D0 (en) * 1993-08-12 1993-09-29 Black James Foundation Bicyclo (2.2.2)octane derivatives
DE69310152D1 (en) * 1992-02-20 1997-05-28 Black James Foundation Bicyclo[2.2.2.]oktan derivate als cholestocystokinin harnstoffe
US5514683A (en) * 1992-02-20 1996-05-07 James Black Foundation Limited Bicyclo 2,2,2!octane derivatives
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
DE69313649D1 (en) * 1992-06-19 1997-10-09 Black James Foundation Bicyclooctan und bicycloheptan derivate
US5380872A (en) * 1992-07-14 1995-01-10 Glaxo Inc. Modulators of cholecystokinin
US5922681A (en) * 1992-09-14 1999-07-13 Warner-Lambert Company Endothelin antagonists
AU674553B2 (en) * 1992-10-14 1997-01-02 Merck & Co., Inc. Fibrinogen receptor antagonists
EP0664792B1 (fr) * 1992-10-14 2000-01-05 Merck & Co. Inc. Antagonistes des recepteurs du fibrinogene
US5358956A (en) * 1992-10-14 1994-10-25 Merck & Co., Inc. Fibrinogen receptor antagonists
US5340798A (en) * 1992-10-14 1994-08-23 Merck & Co., Inc. Fibrinogen receptor antagonists
CA2150550A1 (fr) * 1992-12-01 1994-06-09 Melissa S. Egbertson Antagonistes du recepteur du fibrinogene
FR2700540B1 (fr) * 1993-01-15 1995-02-17 Irj alpha-méthyl-(R)-tryptophyl-arylcycloalkylalkylamides ligands aux récepteurs des gastrines, leur préparation et leur utilisation en thérapeutique.
US5441952A (en) * 1993-04-05 1995-08-15 Merck & Co., Inc. Fibrinogen receptor antagonists
US5334596A (en) * 1993-05-11 1994-08-02 Merck & Co., Inc. Fibrinogen receptor antagonists
US5397791A (en) * 1993-08-09 1995-03-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5821241A (en) * 1994-02-22 1998-10-13 Merck & Co., Inc. Fibrinogen receptor antagonists
AU2534295A (en) * 1994-05-27 1995-12-21 James Black Foundation Limited Gastrin and cck antagonists
US5719144A (en) * 1995-02-22 1998-02-17 Merck & Co., Inc. Fibrinogen receptor antagonists
US5852045A (en) * 1995-10-19 1998-12-22 Merck & Co., Inc. Fibrinogen receptor antagonists
US5789421A (en) * 1995-10-26 1998-08-04 Merck & Co., Inc. Fibrinogen receptor antagonist
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
US5889023A (en) * 1996-05-10 1999-03-30 Merck & Co., Inc. Fibrinogen receptor antagonist
US5981584A (en) * 1997-02-06 1999-11-09 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US7375093B2 (en) 2002-07-05 2008-05-20 Intrexon Corporation Ketone ligands for modulating the expression of exogenous genes via an ecdysone receptor complex
US20100222316A1 (en) 2004-04-29 2010-09-02 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8415354B2 (en) 2004-04-29 2013-04-09 Abbott Laboratories Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US7880001B2 (en) 2004-04-29 2011-02-01 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US20090192198A1 (en) 2005-01-05 2009-07-30 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
US8198331B2 (en) 2005-01-05 2012-06-12 Abbott Laboratories Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme
KR101496206B1 (ko) 2005-01-05 2015-02-27 애브비 인코포레이티드 11-베타-하이드록시스테로이드 데하이드로게나제 타입 1 효소의 억제제로서의 아다만틸 유도체
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JP5736098B2 (ja) 2007-08-21 2015-06-17 アッヴィ・インコーポレイテッド 中枢神経系障害を治療するための医薬組成物
EP3609876B1 (fr) * 2017-04-10 2022-03-30 The Regents of The University of Michigan Inhibiteurs covalents à petites molécules de dcn1 et procédés thérapeutiques les utilisant

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Also Published As

Publication number Publication date
NO915122D0 (no) 1991-12-27
NO915122L (no) 1992-02-27
DE69034162T2 (de) 2005-09-22
EP0405537A1 (fr) 1991-01-02
DK0405537T3 (da) 2005-01-10
IE902347L (en) 1990-12-29
WO1991000274A1 (fr) 1991-01-10
PT94543B (pt) 1997-04-30
IL94903A0 (en) 1991-04-15
AU644088B2 (en) 1993-12-02
ES2229202T3 (es) 2005-04-16
CA2060652C (fr) 2001-08-21
CA2344707C (fr) 2002-07-30
IE902347A1 (en) 1991-01-16
CA2344707A1 (fr) 1991-01-10
KR0167315B1 (ko) 1999-01-15
DE69034162D1 (de) 2004-10-14
KR0180539B1 (en) 1999-05-01
NO301831B1 (no) 1997-12-15
AU5962890A (en) 1991-01-17
JPH04506079A (ja) 1992-10-22
EP0405537B1 (fr) 2004-09-08
KR920702678A (ko) 1992-10-06
PT94543A (pt) 1991-03-20
NZ234264A (en) 1993-05-26
FI916060A0 (fi) 1991-12-20
CA2060652A1 (fr) 1990-12-30
JP2972331B2 (ja) 1999-11-08
EP0479910A1 (fr) 1992-04-15
CN1049165A (zh) 1991-02-13
ATE275546T1 (de) 2004-09-15

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