FI105255B - Förfarande för framställning av orala doseringsformer med fördröjd frigöring - Google Patents

Förfarande för framställning av orala doseringsformer med fördröjd frigöring Download PDF

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Publication number
FI105255B
FI105255B FI933680A FI933680A FI105255B FI 105255 B FI105255 B FI 105255B FI 933680 A FI933680 A FI 933680A FI 933680 A FI933680 A FI 933680A FI 105255 B FI105255 B FI 105255B
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FI
Finland
Prior art keywords
coating
granules
drug
coated
asa
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Application number
FI933680A
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English (en)
Finnish (fi)
Other versions
FI933680A0 (fi
FI933680A (fi
Inventor
John Rhodes
Brian Kenneth Evans
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John Rhodes
Brian Kenneth Evans
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Filing date
Publication date
Application filed by John Rhodes, Brian Kenneth Evans filed Critical John Rhodes
Publication of FI933680A0 publication Critical patent/FI933680A0/fi
Publication of FI933680A publication Critical patent/FI933680A/fi
Application granted granted Critical
Publication of FI105255B publication Critical patent/FI105255B/sv

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/245—Bismuth; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Claims (12)

1. Förfarande för framställande av en oralt doserbar farma-seutisk doseringsform för selektiv dosering av ett läkemedel tili tarmen, kännetecknat av att ett flertal granuler av läkemedlet, överdras enskilt med ett beläggnings-material, som löser sig i tarmen, de överdragna granulerna innesluts i en kapsel och kapsein överdras med samma eller ett annat beläggningsmaterial, som löser sig i tarmen.
2. Förfarande enligt patentkravet 1, kännetecknat av att granulerna överdras med en beläggning som bibehälls i huvudsak intakt tills de överdragna granulerna när ätminstone ileum och kapsein överdras med en enterisk beläggning som frigör granulerna i tunntarmen.
3. Förfarande enligt patentkravet 2, kännetecknat av att nämnda granulbeläggning bestär av en anjonisk polymer som inte löser sig i magsaft eller i tarmsaft under pH 7, men som löser sig i tjocktarmsaften, varigenom beläggningen pä de frigörningsöverdragna granulerna bibehälls i huvudsak intakt tills granulerna när ätminstone ileum.
4. Förfarande enligt patentkravet 3, kännetecknat ·. av att den anjoniska polymeren är en delvis metylesterifierad metakrylsyrapolymer.
5. Förfarande enligt patentkravet 4, kännetecknat av att förhällandet mellan fria syragrupper och estergrupper är cirka 1:2 i den delvis metylesterifierade metakrylsyra-polymeren.
6. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat av att nämnda beläggning ger en fördröjd frigöring av läkemedlet i tjocktarmen. « 21 105255
7. Förfarande enligt nägot av de föregäende patentkraven, . - kännetecknat av att nämnda läkemedel är 5-amino- salicylsyra eller dess farmaceutiskt acceptabla sait eller ester.
8. Förfarande enligt nägot av patentkraven 1-6, kanne -tecknat av att läkemedlet är en topiskt aktiv steroid eller ett vismutsalt eller -komplex.
9. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat av att kapsein är en härdgelatin-kapsel.
10. Förfarande enligt nägot av de föregäende patentkraven, kännetecknat av att kapselns beläggning är en anjonisk karboxylakrylpolymer.
11. Förfarande enligt patentkravet 10, känneteck nat av att kapselns beläggning är en delvis metylesterifie-rad metakrylsyrapolymer.
12. Förfarande enligt patentkravet 11, känneteck nat av att kapselns beläggning är en delvis metylesterifie- . rad metakrylsyrapolymer, där förhällandet mellan fria syra- grupper och estergrupper är cirka 1:1. « 9 V
FI933680A 1991-02-22 1993-08-20 Förfarande för framställning av orala doseringsformer med fördröjd frigöring FI105255B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9103795 1991-02-22
GB9103795A GB2253346A (en) 1991-02-22 1991-02-22 Delayed release oral dosage forms for treatment of intestinal disorders
PCT/GB1992/000318 WO1992014452A1 (en) 1991-02-22 1992-02-21 Delayed release oral dosage forms for treatment of intestinal disorders
GB9200318 1992-02-21

Publications (3)

Publication Number Publication Date
FI933680A0 FI933680A0 (fi) 1993-08-20
FI933680A FI933680A (fi) 1993-08-20
FI105255B true FI105255B (sv) 2000-07-14

Family

ID=10690451

Family Applications (1)

Application Number Title Priority Date Filing Date
FI933680A FI105255B (sv) 1991-02-22 1993-08-20 Förfarande för framställning av orala doseringsformer med fördröjd frigöring

Country Status (23)

Country Link
US (1) US5401512A (sv)
EP (1) EP0572486B1 (sv)
JP (1) JP2958116B2 (sv)
KR (1) KR100220322B1 (sv)
AT (1) ATE129893T1 (sv)
AU (1) AU652032B2 (sv)
CA (1) CA2104686C (sv)
CZ (1) CZ281792B6 (sv)
DE (1) DE69205971T2 (sv)
DK (1) DK0572486T3 (sv)
ES (1) ES2079183T3 (sv)
FI (1) FI105255B (sv)
GB (1) GB2253346A (sv)
GE (1) GEP19971086B (sv)
GR (1) GR3018455T3 (sv)
HU (1) HU219449B (sv)
IE (1) IE74225B1 (sv)
IL (1) IL101036A (sv)
IN (1) IN179089B (sv)
NO (1) NO307405B1 (sv)
NZ (1) NZ241687A (sv)
WO (1) WO1992014452A1 (sv)
YU (1) YU17892A (sv)

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GB2253346A (en) 1992-09-09
DE69205971D1 (de) 1995-12-14
DK0572486T3 (da) 1995-12-11
KR100220322B1 (ko) 1999-09-15
AU1279592A (en) 1992-09-15
HU219449B (hu) 2001-04-28
ATE129893T1 (de) 1995-11-15
IL101036A0 (en) 1992-11-15
CZ281792B6 (cs) 1997-01-15
NO932979D0 (no) 1993-08-20
GR3018455T3 (en) 1996-03-31
EP0572486B1 (en) 1995-11-08
KR930702963A (ko) 1993-11-29
GEP19971086B (en) 1997-12-02
CA2104686C (en) 2000-05-02
FI933680A0 (fi) 1993-08-20
CA2104686A1 (en) 1992-08-23
IE920548A1 (en) 1992-08-26
GB9103795D0 (en) 1991-04-10
NZ241687A (en) 1993-09-27
JPH06505246A (ja) 1994-06-16
NO932979L (no) 1993-08-20
IN179089B (sv) 1997-08-23
US5401512A (en) 1995-03-28
AU652032B2 (en) 1994-08-11
DE69205971T2 (de) 1996-04-11
IL101036A (en) 1996-05-14
IE74225B1 (en) 1997-07-16
NO307405B1 (no) 2000-04-03
CZ162693A3 (en) 1994-10-19
WO1992014452A1 (en) 1992-09-03
ES2079183T3 (es) 1996-01-01
YU17892A (sh) 1994-12-28
JP2958116B2 (ja) 1999-10-06
HU9302379D0 (en) 1993-11-29
EP0572486A1 (en) 1993-12-08
HUT65914A (en) 1994-07-28
FI933680A (fi) 1993-08-20

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