ES2079183T3 - Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales. - Google Patents
Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales.Info
- Publication number
- ES2079183T3 ES2079183T3 ES92905384T ES92905384T ES2079183T3 ES 2079183 T3 ES2079183 T3 ES 2079183T3 ES 92905384 T ES92905384 T ES 92905384T ES 92905384 T ES92905384 T ES 92905384T ES 2079183 T3 ES2079183 T3 ES 2079183T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- granules
- drug
- coated
- meth
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/245—Bismuth; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/52—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an inorganic compound, e.g. an inorganic ion that is complexed with the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
UNA FORMA DE DOSIFICACION FARMACEUTICA ORALMENTE ADMINISTRABLE, PARA ADMINISTRAR SELECTIVAMENTE UNA MEDICINA AL INTESTINO, COMPRENDE UNA PLURALIDAD DE GRANULOS ENTERICOS REVESTIDOS, CONTENIDOS EN UNA CAPSULA ENTERICAMENTE REVESTIDA, QUE LIBERA LOS GRANULOS EN EL INTESTINO DELGADO. LOS GRANULOS ESTAN PREFERENTEMENTE REVESTIDOS CON UN REVESTIMIENTO QUE PERMANECE INTACTO HASTA QUE LOS GRANULOS HAN ALCANZADO POR LO MENOS EL ILEON, Y DESPUES PROPORCIONAR UNA LIBERACION SOSTENIDA DE LA MEDICINA EN EL COLON. SE SELECCIONAN PRODUCTOS ADECUADOS DE REVESTIMIENTO DE LA GAMA EUDRAGIT DE POLIMEROS DE ACIDO DE (METH)ACRILATO Y (METH)ACRILICO. LA INVENCION TIENE APLICACION ESPECIFICA EN MEDICINAS TOPICAMENTE ACTIVAS, TALES COMO ESTEROIDES TOPICAMENTE ACTIVOS, SALES DE BISMUTO Y COMPLEJOS Y, ESPECIALMENTE, ACIDO 5
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9103795A GB2253346A (en) | 1991-02-22 | 1991-02-22 | Delayed release oral dosage forms for treatment of intestinal disorders |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2079183T3 true ES2079183T3 (es) | 1996-01-01 |
Family
ID=10690451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92905384T Expired - Lifetime ES2079183T3 (es) | 1991-02-22 | 1992-02-21 | Formas de dosificacion oral de liberacion retardada para el tratamiento de trastornos intestinales. |
Country Status (23)
Country | Link |
---|---|
US (1) | US5401512A (es) |
EP (1) | EP0572486B1 (es) |
JP (1) | JP2958116B2 (es) |
KR (1) | KR100220322B1 (es) |
AT (1) | ATE129893T1 (es) |
AU (1) | AU652032B2 (es) |
CA (1) | CA2104686C (es) |
CZ (1) | CZ281792B6 (es) |
DE (1) | DE69205971T2 (es) |
DK (1) | DK0572486T3 (es) |
ES (1) | ES2079183T3 (es) |
FI (1) | FI105255B (es) |
GB (1) | GB2253346A (es) |
GE (1) | GEP19971086B (es) |
GR (1) | GR3018455T3 (es) |
HU (1) | HU219449B (es) |
IE (1) | IE74225B1 (es) |
IL (1) | IL101036A (es) |
IN (1) | IN179089B (es) |
NO (1) | NO307405B1 (es) |
NZ (1) | NZ241687A (es) |
WO (1) | WO1992014452A1 (es) |
YU (1) | YU17892A (es) |
Families Citing this family (92)
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EP0542299B1 (en) * | 1991-11-15 | 1999-08-04 | Kanegafuchi Kagaku Kogyo Kabushiki Kaisha | Ester linkage containing polymers for use in pharmaceutical preparations |
US5322697A (en) * | 1992-05-28 | 1994-06-21 | Meyer James H | Composition and method for inducing satiety |
US6204243B1 (en) | 1993-09-01 | 2001-03-20 | Novatis Ag | Pharmaceutical preparations for the targeted treatment of crohn's disease and ulcerative colitis |
GB2292079B (en) * | 1994-08-12 | 1998-07-15 | Flexpharm Ltd | Coated prednisolone preparation for the treatment of inflamatory bowel disease |
US6166024A (en) * | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
US20040018236A1 (en) * | 1995-05-08 | 2004-01-29 | Robert Gurny | Nanoparticles for oral administration of pharmaceutical agents of low solubility |
GB2300807B (en) * | 1995-05-15 | 1999-08-18 | Tillotts Pharma Ag | Oral dosage forms of omega-3 polynunsaturated acids for the treatment of inflammatory bowel disease |
AUPN327695A0 (en) * | 1995-05-30 | 1995-06-22 | Chemeq Pty. Limited | Chemotherapeutic compositions |
US6004581A (en) * | 1995-12-21 | 1999-12-21 | Farmaceutisk Laboratorium Ferring A/S | Modified release oral pharmaceutical composition and method for the treatment of bowel diseases |
US5846983A (en) * | 1996-02-09 | 1998-12-08 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
US5889028A (en) * | 1996-02-09 | 1999-03-30 | Mayo Foundation For Medical Education And Research | Colonic delivery of nicotine to treat inflammatory bowel disease |
US5908912A (en) * | 1996-09-06 | 1999-06-01 | Ppg Industries Ohio, Inc. | Electrodepositable coating composition containing bismuth and amino acid materials and electrodeposition method |
GB9620709D0 (en) * | 1996-10-04 | 1996-11-20 | Danbiosyst Uk | Colonic delivery of weak acid drugs |
US6544523B1 (en) | 1996-11-13 | 2003-04-08 | Chiron Corporation | Mutant forms of Fas ligand and uses thereof |
DE19732903A1 (de) | 1997-07-30 | 1999-02-04 | Falk Pharma Gmbh | Pellet-Formulierung zur Behandlung des Intestinaltraktes |
US20070122481A1 (en) * | 1998-11-02 | 2007-05-31 | Elan Corporation Plc | Modified Release Compositions Comprising a Fluorocytidine Derivative for the Treatment of Cancer |
HU230454B1 (hu) * | 1998-11-02 | 2016-07-28 | Alkermes Pharma Ireland Limited | Metilfenidátot tartalmazó módosított felszabadulású sokszemcsés készítmény |
US20060240105A1 (en) * | 1998-11-02 | 2006-10-26 | Elan Corporation, Plc | Multiparticulate modified release composition |
US20090297597A1 (en) * | 1998-11-02 | 2009-12-03 | Gary Liversidge | Modified Release Ticlopidine Compositions |
US20090149479A1 (en) * | 1998-11-02 | 2009-06-11 | Elan Pharma International Limited | Dosing regimen |
DK1146862T3 (da) | 1999-01-29 | 2003-07-21 | Disphar Int Bv | Farmaceutiske sammensætninger |
ITMI991316A1 (it) * | 1999-06-14 | 2000-12-14 | Cip Ninety Two 92 S A | Composizioni farmaceutiche orali a rilascio modificato di mesalazina |
US20040115134A1 (en) * | 1999-06-22 | 2004-06-17 | Elan Pharma International Ltd. | Novel nifedipine compositions |
JP4806507B2 (ja) | 1999-10-29 | 2011-11-02 | ユーロ−セルティーク エス.エイ. | 制御放出ヒドロコドン処方 |
US10179130B2 (en) | 1999-10-29 | 2019-01-15 | Purdue Pharma L.P. | Controlled release hydrocodone formulations |
US6623757B2 (en) | 2000-02-24 | 2003-09-23 | Advancis Pharmaceutical Corp. | Antibiotic composition |
US6565882B2 (en) | 2000-02-24 | 2003-05-20 | Advancis Pharmaceutical Corp | Antibiotic composition with inhibitor |
US6667057B2 (en) | 2000-02-24 | 2003-12-23 | Advancis Pharmaceutical Corp. | Levofloxacin antibiotic product, use and formulation thereof |
US6638532B2 (en) | 2000-02-24 | 2003-10-28 | Advancis Pharmaceutical Corp. | Tetracycline—doxycycline antibiotic composition |
US6667042B2 (en) | 2000-02-24 | 2003-12-23 | Advancis Pharmaceutical Corp. | Fluroquinilone antibiotic product, use and formulation thereof |
US6991807B2 (en) * | 2000-02-24 | 2006-01-31 | Advancis Pharmaceutical, Corp. | Antibiotic composition |
US6669948B2 (en) | 2000-02-24 | 2003-12-30 | Advancis Pharmaceutical Corp. | Antibiotic product, use and formulation thereof |
US6610328B2 (en) | 2000-02-24 | 2003-08-26 | Advancis Pharmaceutical Corp. | Amoxicillin-clarithromycin antibiotic composition |
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US6663891B2 (en) | 2000-02-24 | 2003-12-16 | Advancis Pharmaceutical Corp. | Erythromyacin antibiotic product, use and formulation thereof |
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CN101317825A (zh) | 2000-10-30 | 2008-12-10 | 欧罗赛铁克股份有限公司 | 控释氢可酮制剂 |
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US20020197314A1 (en) * | 2001-02-23 | 2002-12-26 | Rudnic Edward M. | Anti-fungal composition |
FR2830446B1 (fr) * | 2001-10-09 | 2004-02-06 | Univ Pasteur | Composition pharmaceutique destinee a liberer une substance active au niveau du colon |
AR036797A1 (es) | 2001-10-15 | 2004-10-06 | Ferring Bv | Un metodo para preparar una composicion farmaceutica que comprende acido 5-aminosalicilico para utilizar en el tratamiento de colitis ulcerosa y enfermedades de crohn |
US20080220074A1 (en) * | 2002-10-04 | 2008-09-11 | Elan Corporation Plc | Gamma radiation sterilized nanoparticulate docetaxel compositions and methods of making same |
US20040114368A1 (en) * | 2002-12-13 | 2004-06-17 | Shyu Shing Jy | Light device having rotatable or movable view |
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FR2426477A1 (fr) * | 1978-05-26 | 1979-12-21 | Monsanto Co | Composition de retardement d'incendie comprenant notamment du sulfate d'ammonium et un ether carboxyalkylique ou hydroxyalkylique d'un polygalactomannane |
WO1981002671A1 (en) * | 1980-03-20 | 1981-10-01 | Ferring Farma Lab | Pharmaceutical composition and method for the treatment of colitis ulcerosa and crohn's disease by oral administration |
SE8003805L (sv) * | 1980-05-21 | 1981-11-22 | Haessle Ab | En farmaceutisk beredning med forbettrade utlosningsegenskap |
ZA825384B (en) * | 1981-07-31 | 1983-05-25 | Tillott J B Ltd | Orally administrable pharmaceutical compositions |
DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
IL92343A0 (en) * | 1988-12-20 | 1990-07-26 | Gist Brocades Nv | Granulate for multiparticulate controlled release oral compositions,their preparation and oral pharmaceutical compositions containing them |
DE69020758T2 (de) * | 1989-03-10 | 1995-12-07 | Yamanouchi Pharma Co Ltd | Die Wirkstoffabgabe steuerndes Überzugsmaterial für lang wirksame Formulierungen. |
JPH0334929A (ja) * | 1989-06-29 | 1991-02-14 | Teikoku Seiyaku Kk | 潰瘍性大腸炎およびクローン病治療用経口投与用組成物 |
US5260071A (en) * | 1989-12-18 | 1993-11-09 | Lemelson Jerome H | Drug units and methods for using same |
JPH064531B2 (ja) * | 1990-06-04 | 1994-01-19 | アイセロ化学株式会社 | 大腸崩壊性硬質カプセル |
-
1991
- 1991-02-22 GB GB9103795A patent/GB2253346A/en not_active Withdrawn
- 1991-02-22 GE GEAP19912613A patent/GEP19971086B/en unknown
-
1992
- 1992-02-21 AT AT92905384T patent/ATE129893T1/de not_active IP Right Cessation
- 1992-02-21 AU AU12795/92A patent/AU652032B2/en not_active Ceased
- 1992-02-21 KR KR1019930702488A patent/KR100220322B1/ko not_active IP Right Cessation
- 1992-02-21 CZ CS931626A patent/CZ281792B6/cs not_active IP Right Cessation
- 1992-02-21 IN IN149DE1992 patent/IN179089B/en unknown
- 1992-02-21 DE DE69205971T patent/DE69205971T2/de not_active Expired - Lifetime
- 1992-02-21 HU HU9302379A patent/HU219449B/hu not_active IP Right Cessation
- 1992-02-21 EP EP92905384A patent/EP0572486B1/en not_active Expired - Lifetime
- 1992-02-21 US US08/107,744 patent/US5401512A/en not_active Expired - Lifetime
- 1992-02-21 DK DK92905384.1T patent/DK0572486T3/da active
- 1992-02-21 ES ES92905384T patent/ES2079183T3/es not_active Expired - Lifetime
- 1992-02-21 IE IE920548A patent/IE74225B1/en not_active IP Right Cessation
- 1992-02-21 CA CA002104686A patent/CA2104686C/en not_active Expired - Lifetime
- 1992-02-21 IL IL10103692A patent/IL101036A/en not_active IP Right Cessation
- 1992-02-21 YU YU17892A patent/YU17892A/sh unknown
- 1992-02-21 NZ NZ241687A patent/NZ241687A/xx not_active IP Right Cessation
- 1992-02-21 JP JP4505041A patent/JP2958116B2/ja not_active Expired - Fee Related
- 1992-02-21 WO PCT/GB1992/000318 patent/WO1992014452A1/en active IP Right Grant
-
1993
- 1993-08-20 FI FI933680A patent/FI105255B/fi not_active IP Right Cessation
- 1993-08-20 NO NO932979A patent/NO307405B1/no not_active IP Right Cessation
-
1995
- 1995-12-19 GR GR950403588T patent/GR3018455T3/el unknown
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