FI105032B - Menetelmä 5-substituoitujen pyrrolo[2,3-d]pyrimidiinien valmistamiseksi - Google Patents

Menetelmä 5-substituoitujen pyrrolo[2,3-d]pyrimidiinien valmistamiseksi Download PDF

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Publication number
FI105032B
FI105032B FI934182A FI934182A FI105032B FI 105032 B FI105032 B FI 105032B FI 934182 A FI934182 A FI 934182A FI 934182 A FI934182 A FI 934182A FI 105032 B FI105032 B FI 105032B
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FI
Finland
Prior art keywords
formula
preparation
mmol
pyrrolo
mixture
Prior art date
Application number
FI934182A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI934182L (fi
FI934182A0 (fi
Inventor
Charles Jackson Barnett
Thomas Michael Wilson
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/066,831 external-priority patent/US5416211A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI934182A0 publication Critical patent/FI934182A0/fi
Publication of FI934182L publication Critical patent/FI934182L/fi
Application granted granted Critical
Publication of FI105032B publication Critical patent/FI105032B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI934182A 1992-09-25 1993-09-24 Menetelmä 5-substituoitujen pyrrolo[2,3-d]pyrimidiinien valmistamiseksi FI105032B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95151592A 1992-09-25 1992-09-25
US95151592 1992-09-25
US08/066,831 US5416211A (en) 1992-09-25 1993-05-24 Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US6683193 1993-05-24

Publications (3)

Publication Number Publication Date
FI934182A0 FI934182A0 (fi) 1993-09-24
FI934182L FI934182L (fi) 1994-03-26
FI105032B true FI105032B (fi) 2000-05-31

Family

ID=26747196

Family Applications (2)

Application Number Title Priority Date Filing Date
FI934182A FI105032B (fi) 1992-09-25 1993-09-24 Menetelmä 5-substituoitujen pyrrolo[2,3-d]pyrimidiinien valmistamiseksi
FI981709A FI981709L (fi) 1992-09-25 1993-09-24 Menetelmä 5-substituoitujen 2-amino-4-okso-pyrrolo/2,3-d/-pyrimidiinien valmistamiseksi

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI981709A FI981709L (fi) 1992-09-25 1993-09-24 Menetelmä 5-substituoitujen 2-amino-4-okso-pyrrolo/2,3-d/-pyrimidiinien valmistamiseksi

Country Status (17)

Country Link
US (4) US5663339A (cs)
EP (1) EP0589720A3 (cs)
JP (1) JPH06211862A (cs)
CN (1) CN1038415C (cs)
AU (1) AU667568B2 (cs)
BR (1) BR9303876A (cs)
CA (1) CA2106630A1 (cs)
CZ (1) CZ283281B6 (cs)
FI (2) FI105032B (cs)
HU (1) HUT70208A (cs)
IL (1) IL107041A (cs)
MX (1) MX9305833A (cs)
MY (1) MY111886A (cs)
NO (1) NO180587C (cs)
NZ (1) NZ248725A (cs)
PL (1) PL173738B1 (cs)
RU (1) RU2127274C1 (cs)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998008382A1 (en) * 1996-08-30 1998-03-05 Eli Lilly And Company Nonclassical pyrrolo[2,3-d]pyrimidine antifolates
US7863444B2 (en) 1997-03-19 2011-01-04 Abbott Laboratories 4-aminopyrrolopyrimidines as kinase inhibitors
HUP0003954A3 (en) * 1997-09-26 2002-12-28 Lilly Co Eli Processes and intermediates useful to prepare pyrrolo [2,3-d] pyrimidine derivatives
US6262262B1 (en) * 1997-09-26 2001-07-17 Eli Lilly And Company Processes and intermediates useful to make antifolates
US6713474B2 (en) 1998-09-18 2004-03-30 Abbott Gmbh & Co. Kg Pyrrolopyrimidines as therapeutic agents
US7071199B1 (en) 1999-09-17 2006-07-04 Abbott Gmbh & Cco. Kg Kinase inhibitors as therapeutic agents
DE60211670T2 (de) * 2001-04-04 2006-10-26 Bionumerik Pharmaceuticals, Inc., San Antonio Verfahren zur kupplung von aminosäuren an das gerüst eines folsäureantagonisten
EP1497019B1 (en) * 2002-04-23 2015-05-20 Bristol-Myers Squibb Company Pyrrolo-triazine aniline compounds useful as kinase inhibitors
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
MY145634A (en) * 2003-12-29 2012-03-15 Bristol Myers Squibb Co Pyrrolotriazine compounds as kinase inhibitors
CN100344615C (zh) * 2004-11-25 2007-10-24 重庆医药工业研究院有限责任公司 制备N－(吡咯并[2,3－d]嘧啶－5－基)酰基谷氨酸衍生物的方法及中间体
JP2008543975A (ja) * 2006-08-14 2008-12-04 シコール インコーポレイティド 高度に純粋なペメトレキセド二酸およびその調製方法
US8232376B2 (en) 2007-06-29 2012-07-31 Ricoh Company, Ltd. Azo compound and method of preparing the azo compound
CN101417998B (zh) 2007-10-24 2012-10-24 重庆医药工业研究院有限责任公司 一种培美曲塞盐的纯化方法
WO2012056285A1 (en) * 2010-10-25 2012-05-03 Fresenius Kabi Oncology Ltd. An improved process for the preparation of pemetrexed
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法
ITRM20120398A1 (it) * 2012-08-08 2014-02-09 Berlin Chemie Ag Procedimento di sintesi pemetrexed e suo sale di lisina.
WO2014185797A1 (en) 2013-05-17 2014-11-20 Instytut Farmaceutyczny Process for the preparation of high purity amorphous pemetrexed disodium and crystalline forms of n-[4-[2-(2-amino-4,7-dihydro-4-oxo-3h-pyrrolo[2,3- d] pyrimidin-5-yl)ethyl] benzoyl]-l-glutamic acid
NZ630292A (en) 2013-11-25 2015-02-27 Shilpa Medicare Ltd Process for crystalline pemetrexed dipotassium salt
CN109721604B (zh) * 2019-01-25 2021-03-23 南京亚东启天药业有限公司 培美曲塞酸的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
NO169490C (no) * 1988-03-24 1992-07-01 Takeda Chemical Industries Ltd Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolopyrimidinderivater
JP2983254B2 (ja) * 1989-06-14 1999-11-29 武田薬品工業株式会社 ピロロ〔２，３―ｄ〕ピリミジン誘導体の製造法およびその中間体
KR0162654B1 (ko) * 1989-12-11 1998-11-16 알렌 제이. 시니스갤리 N-(피롤로[2,3-d]피리미딘-3-일아크릴)-글루타민산 유도체
CA2032695A1 (en) * 1989-12-20 1991-06-21 Hiroshi Akimoto Condensed heterocyclic compounds, their production and use
ATE147386T1 (de) * 1991-08-12 1997-01-15 Takeda Chemical Industries Ltd Kondensierte pyrimidinderivate, ihre herstellung und ihre verwendung als antitumormittel
JP3144903B2 (ja) * 1991-08-21 2001-03-12 エーザイ株式会社 縮合ピリミジン誘導体
US5235053A (en) * 1992-06-22 1993-08-10 Eli Lilly And Company Process for the synthesis of 4-hydroxy-5-halopyrrold[2,3-d]pyrimidine intermediates
US5278307A (en) * 1992-09-25 1994-01-11 Eli Lilly And Company Process for preparing 4-hydroxypyrrolo(2,3-d)pyrimidine based antifolate compounds and intermediates
US5416211A (en) * 1992-09-25 1995-05-16 Eli Lilly And Company Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines
US5426187A (en) * 1993-11-30 1995-06-20 Eli Lilly And Company Process for the preparation of 4-hydroxy-5-substituted ethynylpyrrolo [2,3-d]pyrimidine intermediates

Also Published As

Publication number Publication date
CZ195293A3 (en) 1994-04-13
FI981709A0 (fi) 1998-08-06
EP0589720A2 (en) 1994-03-30
NO933395L (no) 1994-03-28
NO933395D0 (no) 1993-09-23
US5892034A (en) 1999-04-06
MY111886A (en) 2001-02-28
PL173738B1 (pl) 1998-04-30
EP0589720A3 (en) 1994-06-22
BR9303876A (pt) 1994-03-29
HU9302654D0 (en) 1993-12-28
AU4757593A (en) 1994-03-31
FI934182L (fi) 1994-03-26
AU667568B2 (en) 1996-03-28
FI934182A0 (fi) 1993-09-24
NO180587B (no) 1997-02-03
MX9305833A (es) 1994-06-30
US5612482A (en) 1997-03-18
FI981709A7 (fi) 1998-08-06
CZ283281B6 (cs) 1998-02-18
NO180587C (no) 1997-05-14
FI981709L (fi) 1998-08-06
CN1038415C (zh) 1998-05-20
CA2106630A1 (en) 1994-03-26
US5644058A (en) 1997-07-01
JPH06211862A (ja) 1994-08-02
IL107041A (en) 2000-02-17
IL107041A0 (en) 1993-12-28
HUT70208A (en) 1995-09-28
NZ248725A (en) 1995-06-27
US5663339A (en) 1997-09-02
RU2127274C1 (ru) 1999-03-10
CN1087910A (zh) 1994-06-15

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