FI104722B - Pyridoksiloidun hemoglobiinin valmistusmenetelmä - Google Patents

Pyridoksiloidun hemoglobiinin valmistusmenetelmä Download PDF

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Publication number
FI104722B
FI104722B FI924710A FI924710A FI104722B FI 104722 B FI104722 B FI 104722B FI 924710 A FI924710 A FI 924710A FI 924710 A FI924710 A FI 924710A FI 104722 B FI104722 B FI 104722B
Authority
FI
Finland
Prior art keywords
hemoglobin
pyridoxal
reducing agent
phosphate
account
Prior art date
Application number
FI924710A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924710A0 (fi
FI924710A (fi
Inventor
Rainer Eketorp
Robert Marschall
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Publication of FI924710A0 publication Critical patent/FI924710A0/fi
Publication of FI924710A publication Critical patent/FI924710A/fi
Application granted granted Critical
Publication of FI104722B publication Critical patent/FI104722B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Compounds Of Unknown Constitution (AREA)
FI924710A 1990-04-18 1992-10-16 Pyridoksiloidun hemoglobiinin valmistusmenetelmä FI104722B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9001378A SE9001378D0 (sv) 1990-04-18 1990-04-18 A method for the preparation of pyridoxylated hemoglobin
SE9001378 1990-04-18
PCT/SE1991/000221 WO1991016352A1 (en) 1990-04-18 1991-03-21 A method for the preparation of pyridoxylated hemoglobin
SE9100221 1991-03-21

Publications (3)

Publication Number Publication Date
FI924710A0 FI924710A0 (fi) 1992-10-16
FI924710A FI924710A (fi) 1992-10-16
FI104722B true FI104722B (fi) 2000-03-31

Family

ID=20379201

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924710A FI104722B (fi) 1990-04-18 1992-10-16 Pyridoksiloidun hemoglobiinin valmistusmenetelmä

Country Status (14)

Country Link
US (1) US5380824A (no)
EP (1) EP0528841B1 (no)
JP (1) JPH05506656A (no)
AT (1) ATE175425T1 (no)
AU (1) AU7741791A (no)
CA (1) CA2079006A1 (no)
DE (1) DE69130736T2 (no)
DK (1) DK0528841T3 (no)
ES (1) ES2127726T3 (no)
FI (1) FI104722B (no)
GR (1) GR3029872T3 (no)
NO (1) NO302949B1 (no)
SE (1) SE9001378D0 (no)
WO (1) WO1991016352A1 (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911427B1 (en) 1995-09-15 2005-06-28 Duke University No-modified hemoglobins and uses therefore
US6627738B2 (en) * 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
US5891735A (en) * 1995-09-15 1999-04-06 Duke University Medical Center Method for measuring nitric oxide in nitrosyl (FeII)-hemoglobin and S-nitrosohemoglobin
WO1997035883A1 (en) * 1996-03-28 1997-10-02 Northfield Laboratories, Inc. Method and apparatus for preparing an acellular red blood cell substitute
US6894150B1 (en) * 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
DE10031744A1 (de) 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
DE10031740A1 (de) * 2000-06-29 2002-02-14 Sanguibio Tech Ag Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung
CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
WO2007087570A2 (en) * 2006-01-24 2007-08-02 Northfield Laboratories, Inc. Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
CN105073801B (zh) * 2013-02-15 2017-03-08 和光纯药工业株式会社 着色组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
JPS5716815A (en) * 1980-07-02 1982-01-28 Ajinomoto Co Inc Oxygen transporting agent for artificial blood
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
WO1985004407A1 (en) * 1984-03-23 1985-10-10 Baxter Travenol Laboratories, Inc. Virus risk-reduced hemoglobin and method for making same

Also Published As

Publication number Publication date
AU7741791A (en) 1991-11-11
WO1991016352A1 (en) 1991-10-31
SE9001378D0 (sv) 1990-04-18
DE69130736T2 (de) 1999-07-22
EP0528841B1 (en) 1999-01-07
DE69130736D1 (de) 1999-02-18
US5380824A (en) 1995-01-10
ATE175425T1 (de) 1999-01-15
DK0528841T3 (da) 1999-08-30
ES2127726T3 (es) 1999-05-01
JPH05506656A (ja) 1993-09-30
CA2079006A1 (en) 1991-10-19
GR3029872T3 (en) 1999-07-30
NO923724D0 (no) 1992-09-24
FI924710A0 (fi) 1992-10-16
NO923724L (no) 1992-09-24
NO302949B1 (no) 1998-05-11
FI924710A (fi) 1992-10-16
EP0528841A1 (en) 1993-03-03

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Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG

HC Name/ company changed in application

Owner name: PHARMACIA & UPJOHN AKTIEBOLAG