DE69130736D1 - Methode für die präparation von pyridoxyliertem hämoglobin - Google Patents

Methode für die präparation von pyridoxyliertem hämoglobin

Info

Publication number
DE69130736D1
DE69130736D1 DE69130736T DE69130736T DE69130736D1 DE 69130736 D1 DE69130736 D1 DE 69130736D1 DE 69130736 T DE69130736 T DE 69130736T DE 69130736 T DE69130736 T DE 69130736T DE 69130736 D1 DE69130736 D1 DE 69130736D1
Authority
DE
Germany
Prior art keywords
pct
hemoglobin
sec
date
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69130736T
Other languages
English (en)
Other versions
DE69130736T2 (de
Inventor
Robert Marschall
Rainer Eketorp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Octapharma AG
Original Assignee
Pharmacia and Upjohn AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn AB filed Critical Pharmacia and Upjohn AB
Application granted granted Critical
Publication of DE69130736D1 publication Critical patent/DE69130736D1/de
Publication of DE69130736T2 publication Critical patent/DE69130736T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
DE69130736T 1990-04-18 1991-03-21 Methode für die präparation von pyridoxyliertem hämoglobin Expired - Lifetime DE69130736T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9001378A SE9001378D0 (sv) 1990-04-18 1990-04-18 A method for the preparation of pyridoxylated hemoglobin
PCT/SE1991/000221 WO1991016352A1 (en) 1990-04-18 1991-03-21 A method for the preparation of pyridoxylated hemoglobin

Publications (2)

Publication Number Publication Date
DE69130736D1 true DE69130736D1 (de) 1999-02-18
DE69130736T2 DE69130736T2 (de) 1999-07-22

Family

ID=20379201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130736T Expired - Lifetime DE69130736T2 (de) 1990-04-18 1991-03-21 Methode für die präparation von pyridoxyliertem hämoglobin

Country Status (14)

Country Link
US (1) US5380824A (de)
EP (1) EP0528841B1 (de)
JP (1) JPH05506656A (de)
AT (1) ATE175425T1 (de)
AU (1) AU7741791A (de)
CA (1) CA2079006A1 (de)
DE (1) DE69130736T2 (de)
DK (1) DK0528841T3 (de)
ES (1) ES2127726T3 (de)
FI (1) FI104722B (de)
GR (1) GR3029872T3 (de)
NO (1) NO302949B1 (de)
SE (1) SE9001378D0 (de)
WO (1) WO1991016352A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891735A (en) * 1995-09-15 1999-04-06 Duke University Medical Center Method for measuring nitric oxide in nitrosyl (FeII)-hemoglobin and S-nitrosohemoglobin
US6911427B1 (en) 1995-09-15 2005-06-28 Duke University No-modified hemoglobins and uses therefore
US6627738B2 (en) * 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
US6498141B2 (en) * 1996-03-28 2002-12-24 Northfield Laboratories, Inc. Method and apparatus for preparing an acellular red blood cell substitute
US6894150B1 (en) * 1999-10-01 2005-05-17 Ross Walden Tye Non-pyrogenic, endotoxin-free, stroma-free tetrameric hemoglobin
DE10031740A1 (de) * 2000-06-29 2002-02-14 Sanguibio Tech Ag Künstliche Sauerstoffträger aus vernetztem modifizierten Human- oder Schweinehämoglobin mit verbesserten Eigenschaften, Verfahren zu ihrer technisch einfachen Herstellung aus gereinigtem Material in hohen Ausbeuten, sowie deren Verwendung
DE10031744A1 (de) 2000-06-29 2002-01-17 Sanguibio Tech Ag Mit Blutplasma verträgliche, vernetzte und mit Polyalkylenoxiden konjugierte Säugetierhämoglobine als künstliche medizinische Sauerstoffträger, ihre Herstellung und ihre Verwendung
CN100431602C (zh) * 2003-01-29 2008-11-12 北原实验室有限公司 具有低量四聚体的聚合血红蛋白溶液及制备方法
US20090004159A1 (en) * 2006-01-24 2009-01-01 The Board Of Trustees Of The University Of Illinoi Polymerized Hemoglobin Media and Its Use in Isolation and Transplantation of Islet Cells
WO2008021577A2 (en) * 2006-01-24 2008-02-21 The Board Of Trustees Of The University Of Illinois Polymerized hemoglobin media and its use in isolation and transplantation of islet cells
US7494974B2 (en) * 2006-10-24 2009-02-24 Ikor, Inc. Carboxymethylated cross-linked tetrameric hemoglobin
US7504377B2 (en) * 2006-10-23 2009-03-17 Ikor, Inc. Nitric oxide-blocked cross-linked tetrameric hemoglobin
CN105073801B (zh) * 2013-02-15 2017-03-08 和光纯药工业株式会社 着色组合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2449885C3 (de) * 1974-10-21 1980-04-30 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung von chemisch modifizierten haltbaren Hämoglobinpräparaten sowie das nach diesem Verfahren hergestellte modifizierte Hämoglobinpräparat
US4136093A (en) * 1976-04-23 1979-01-23 Biotest-Serum-Institut Gmbh Hemoglobin preparation with increased oxygen release
JPS5716815A (en) * 1980-07-02 1982-01-28 Ajinomoto Co Inc Oxygen transporting agent for artificial blood
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
US4831012A (en) * 1984-03-23 1989-05-16 Baxter International Inc. Purified hemoglobin solutions and method for making same
EP0179075B2 (de) * 1984-03-23 1997-10-15 BAXTER INTERNATIONAL INC. (a Delaware corporation) Hämoglobin mit reduziertem virusrisiko und dessen herstellung

Also Published As

Publication number Publication date
NO302949B1 (no) 1998-05-11
EP0528841A1 (de) 1993-03-03
GR3029872T3 (en) 1999-07-30
EP0528841B1 (de) 1999-01-07
DK0528841T3 (da) 1999-08-30
SE9001378D0 (sv) 1990-04-18
NO923724L (no) 1992-09-24
ES2127726T3 (es) 1999-05-01
US5380824A (en) 1995-01-10
DE69130736T2 (de) 1999-07-22
FI104722B (fi) 2000-03-31
AU7741791A (en) 1991-11-11
CA2079006A1 (en) 1991-10-19
NO923724D0 (no) 1992-09-24
FI924710A (fi) 1992-10-16
WO1991016352A1 (en) 1991-10-31
FI924710A0 (fi) 1992-10-16
JPH05506656A (ja) 1993-09-30
ATE175425T1 (de) 1999-01-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: BIOVITRUM AB, STOCKHOLM, SE

8328 Change in the person/name/address of the agent

Free format text: DERZEIT KEIN VERTRETER BESTELLT

8327 Change in the person/name/address of the patent owner

Owner name: OCTAPHARMA AG, LACHEN, CH