FI104489B - Sian somatotropiineja, joissa on kaksoismutaatio alfakierteen 1 alueella - Google Patents

Sian somatotropiineja, joissa on kaksoismutaatio alfakierteen 1 alueella Download PDF

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Publication number
FI104489B
FI104489B FI915654A FI915654A FI104489B FI 104489 B FI104489 B FI 104489B FI 915654 A FI915654 A FI 915654A FI 915654 A FI915654 A FI 915654A FI 104489 B FI104489 B FI 104489B
Authority
FI
Finland
Prior art keywords
mutation
somatotropin
rpst
dna
helix
Prior art date
Application number
FI915654A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI915654A0 (fi
FI915654A (fi
Inventor
Deborah Tardy Chaleff
Meir Fischer
Michael Richard Lebens
Original Assignee
American Cyanamid Co
Bio Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co, Bio Technology General Corp filed Critical American Cyanamid Co
Publication of FI915654A0 publication Critical patent/FI915654A0/fi
Publication of FI915654A publication Critical patent/FI915654A/fi
Application granted granted Critical
Publication of FI104489B publication Critical patent/FI104489B/fi

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/27Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Mold Materials And Core Materials (AREA)
  • Battery Electrode And Active Subsutance (AREA)
  • Secondary Cells (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Electrotherapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FI915654A 1990-11-30 1991-11-29 Sian somatotropiineja, joissa on kaksoismutaatio alfakierteen 1 alueella FI104489B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US62165690A 1990-11-30 1990-11-30
US62165690 1990-11-30

Publications (3)

Publication Number Publication Date
FI915654A0 FI915654A0 (fi) 1991-11-29
FI915654A FI915654A (fi) 1992-05-31
FI104489B true FI104489B (fi) 2000-02-15

Family

ID=24491070

Family Applications (1)

Application Number Title Priority Date Filing Date
FI915654A FI104489B (fi) 1990-11-30 1991-11-29 Sian somatotropiineja, joissa on kaksoismutaatio alfakierteen 1 alueella

Country Status (20)

Country Link
US (1) US5548068A (no)
EP (1) EP0496973B1 (no)
JP (1) JPH05105634A (no)
KR (1) KR100193005B1 (no)
AT (1) ATE163045T1 (no)
CA (1) CA2056467C (no)
DE (1) DE69128877T2 (no)
DK (1) DK0496973T3 (no)
ES (1) ES2112847T3 (no)
FI (1) FI104489B (no)
GR (1) GR3026761T3 (no)
HU (1) HU215947B (no)
IE (1) IE914153A1 (no)
IL (1) IL100169A0 (no)
NO (1) NO301235B1 (no)
NZ (2) NZ240718A (no)
PT (1) PT99648B (no)
SG (1) SG49702A1 (no)
TW (1) TW198040B (no)
ZA (1) ZA919453B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006079A (en) * 1997-06-13 1999-12-21 Motorola, Inc. Radio having a fast adapting direct conversion receiver
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
GB2384001B (en) * 2001-12-14 2004-02-04 Asterion Ltd Chimeric growth hormone-growth hormone receptor proteins
EP1539960B1 (en) * 2002-09-09 2010-04-28 Hanall Pharmaceutical Co., Ltd. Protease-resistant modified interferon alpha polypeptides
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US8067375B2 (en) 2006-10-20 2011-11-29 Biogen Idec Ma Inc. Treatment of demyelinating disorders with soluble lymphotoxin-β-receptor
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
US8637452B2 (en) * 2011-02-23 2014-01-28 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68929273T2 (de) * 1988-08-24 2001-07-05 American Cyanamid Co Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung
CA2345497A1 (en) * 1988-10-28 1990-04-28 Genentech, Inc. Growth hormone variants and method for forming growth hormone variants

Also Published As

Publication number Publication date
KR100193005B1 (ko) 1999-06-15
HUT62327A (en) 1993-04-28
CA2056467A1 (en) 1992-05-31
PT99648A (pt) 1992-10-30
NO914724L (no) 1992-06-01
AU662493B2 (en) 1995-09-07
KR920009413A (ko) 1992-06-25
PT99648B (pt) 1999-05-31
FI915654A0 (fi) 1991-11-29
NO301235B1 (no) 1997-09-29
IL100169A0 (en) 1992-08-18
HU215947B (hu) 1999-03-29
EP0496973B1 (en) 1998-02-04
DE69128877D1 (de) 1998-03-12
EP0496973A3 (en) 1993-02-24
CA2056467C (en) 1998-07-07
SG49702A1 (en) 1998-06-15
HU913723D0 (en) 1992-02-28
IE914153A1 (en) 1992-06-03
FI915654A (fi) 1992-05-31
ATE163045T1 (de) 1998-02-15
DE69128877T2 (de) 1998-06-18
JPH05105634A (ja) 1993-04-27
ZA919453B (en) 1992-08-26
EP0496973A2 (en) 1992-08-05
AU8830091A (en) 1992-06-04
TW198040B (no) 1993-01-11
ES2112847T3 (es) 1998-04-16
NO914724D0 (no) 1991-11-29
NZ260103A (en) 1996-10-28
US5548068A (en) 1996-08-20
GR3026761T3 (en) 1998-07-31
NZ240718A (en) 1996-10-28
DK0496973T3 (da) 1998-05-04

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