DK0496973T3 - Porcine somatotropiner med ændringer i alfa-helix 1 regionen og kombinationer med andre mutationer. - Google Patents
Porcine somatotropiner med ændringer i alfa-helix 1 regionen og kombinationer med andre mutationer.Info
- Publication number
- DK0496973T3 DK0496973T3 DK91120396.6T DK91120396T DK0496973T3 DK 0496973 T3 DK0496973 T3 DK 0496973T3 DK 91120396 T DK91120396 T DK 91120396T DK 0496973 T3 DK0496973 T3 DK 0496973T3
- Authority
- DK
- Denmark
- Prior art keywords
- helix
- alpha
- mutations
- somatotropins
- combinations
- Prior art date
Links
- 230000035772 mutation Effects 0.000 title abstract 2
- 230000004075 alteration Effects 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002741 site-directed mutagenesis Methods 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Secondary Cells (AREA)
- Mold Materials And Core Materials (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Medicines Containing Plant Substances (AREA)
- Electrotherapy Devices (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62165690A | 1990-11-30 | 1990-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0496973T3 true DK0496973T3 (da) | 1998-05-04 |
Family
ID=24491070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91120396.6T DK0496973T3 (da) | 1990-11-30 | 1991-11-28 | Porcine somatotropiner med ændringer i alfa-helix 1 regionen og kombinationer med andre mutationer. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5548068A (no) |
| EP (1) | EP0496973B1 (no) |
| JP (1) | JPH05105634A (no) |
| KR (1) | KR100193005B1 (no) |
| AT (1) | ATE163045T1 (no) |
| CA (1) | CA2056467C (no) |
| DE (1) | DE69128877T2 (no) |
| DK (1) | DK0496973T3 (no) |
| ES (1) | ES2112847T3 (no) |
| FI (1) | FI104489B (no) |
| GR (1) | GR3026761T3 (no) |
| HU (1) | HU215947B (no) |
| IE (1) | IE914153A1 (no) |
| IL (1) | IL100169A0 (no) |
| NO (1) | NO301235B1 (no) |
| NZ (2) | NZ240718A (no) |
| PT (1) | PT99648B (no) |
| SG (1) | SG49702A1 (no) |
| TW (1) | TW198040B (no) |
| ZA (1) | ZA919453B (no) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6006079A (en) * | 1997-06-13 | 1999-12-21 | Motorola, Inc. | Radio having a fast adapting direct conversion receiver |
| TR200504220T2 (tr) | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
| GB2384001B (en) * | 2001-12-14 | 2004-02-04 | Asterion Ltd | Chimeric growth hormone-growth hormone receptor proteins |
| CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| EP2311481A3 (en) | 2006-10-20 | 2013-10-16 | Biogen Idec MA Inc. | Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor |
| US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| US8637452B2 (en) * | 2011-02-23 | 2014-01-28 | Massachusetts Institute Of Technology | Water soluble membrane proteins and methods for the preparation and use thereof |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0355460B1 (en) * | 1988-08-24 | 2000-12-27 | American Cyanamid Company | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization |
| EP0397834B1 (en) * | 1988-10-28 | 2000-02-02 | Genentech, Inc. | Method for identifying active domains and amino acid residues in polypeptides and hormone variants |
-
1991
- 1991-11-25 NZ NZ240718A patent/NZ240718A/en unknown
- 1991-11-25 NZ NZ260103A patent/NZ260103A/en unknown
- 1991-11-27 IL IL100169A patent/IL100169A0/xx unknown
- 1991-11-28 EP EP91120396A patent/EP0496973B1/en not_active Expired - Lifetime
- 1991-11-28 DE DE69128877T patent/DE69128877T2/de not_active Expired - Fee Related
- 1991-11-28 ES ES91120396T patent/ES2112847T3/es not_active Expired - Lifetime
- 1991-11-28 AT AT91120396T patent/ATE163045T1/de not_active IP Right Cessation
- 1991-11-28 CA CA002056467A patent/CA2056467C/en not_active Expired - Fee Related
- 1991-11-28 SG SG1996004237A patent/SG49702A1/en unknown
- 1991-11-28 DK DK91120396.6T patent/DK0496973T3/da active
- 1991-11-29 HU HU913723A patent/HU215947B/hu not_active IP Right Cessation
- 1991-11-29 JP JP3339516A patent/JPH05105634A/ja active Pending
- 1991-11-29 ZA ZA919453A patent/ZA919453B/xx unknown
- 1991-11-29 NO NO914724A patent/NO301235B1/no not_active IP Right Cessation
- 1991-11-29 IE IE415391A patent/IE914153A1/en not_active Application Discontinuation
- 1991-11-29 PT PT99648A patent/PT99648B/pt not_active IP Right Cessation
- 1991-11-29 FI FI915654A patent/FI104489B/fi active
- 1991-11-30 KR KR1019910021901A patent/KR100193005B1/ko not_active IP Right Cessation
-
1992
- 1992-02-20 TW TW081101242A patent/TW198040B/zh active
-
1994
- 1994-12-23 US US08/363,982 patent/US5548068A/en not_active Expired - Fee Related
-
1998
- 1998-04-30 GR GR980400960T patent/GR3026761T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO914724L (no) | 1992-06-01 |
| US5548068A (en) | 1996-08-20 |
| HUT62327A (en) | 1993-04-28 |
| SG49702A1 (en) | 1998-06-15 |
| GR3026761T3 (en) | 1998-07-31 |
| AU8830091A (en) | 1992-06-04 |
| PT99648B (pt) | 1999-05-31 |
| NZ260103A (en) | 1996-10-28 |
| DE69128877D1 (de) | 1998-03-12 |
| EP0496973B1 (en) | 1998-02-04 |
| ES2112847T3 (es) | 1998-04-16 |
| ATE163045T1 (de) | 1998-02-15 |
| IE914153A1 (en) | 1992-06-03 |
| FI915654A0 (fi) | 1991-11-29 |
| TW198040B (no) | 1993-01-11 |
| ZA919453B (en) | 1992-08-26 |
| NZ240718A (en) | 1996-10-28 |
| KR920009413A (ko) | 1992-06-25 |
| HU913723D0 (en) | 1992-02-28 |
| KR100193005B1 (ko) | 1999-06-15 |
| DE69128877T2 (de) | 1998-06-18 |
| HU215947B (hu) | 1999-03-29 |
| NO914724D0 (no) | 1991-11-29 |
| AU662493B2 (en) | 1995-09-07 |
| FI104489B (fi) | 2000-02-15 |
| IL100169A0 (en) | 1992-08-18 |
| FI915654A (fi) | 1992-05-31 |
| NO301235B1 (no) | 1997-09-29 |
| PT99648A (pt) | 1992-10-30 |
| EP0496973A3 (en) | 1993-02-24 |
| CA2056467A1 (en) | 1992-05-31 |
| CA2056467C (en) | 1998-07-07 |
| EP0496973A2 (en) | 1992-08-05 |
| JPH05105634A (ja) | 1993-04-27 |
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