NO914724L - Somatotropiner med forandringer i alfa-spiral-1-omraadet ogkombinasjoner med andre mutasjoner - Google Patents

Somatotropiner med forandringer i alfa-spiral-1-omraadet ogkombinasjoner med andre mutasjoner

Info

Publication number
NO914724L
NO914724L NO91914724A NO914724A NO914724L NO 914724 L NO914724 L NO 914724L NO 91914724 A NO91914724 A NO 91914724A NO 914724 A NO914724 A NO 914724A NO 914724 L NO914724 L NO 914724L
Authority
NO
Norway
Prior art keywords
changes
mutations
helix
alpha
combinations
Prior art date
Application number
NO91914724A
Other languages
English (en)
Other versions
NO914724D0 (no
NO301235B1 (no
Inventor
Meir Fischer
Michael Richard Lebens
Deborah Tardy Chaleff
Original Assignee
Bio Technology General Corp
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bio Technology General Corp, American Cyanamid Co filed Critical Bio Technology General Corp
Publication of NO914724D0 publication Critical patent/NO914724D0/no
Publication of NO914724L publication Critical patent/NO914724L/no
Publication of NO301235B1 publication Critical patent/NO301235B1/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/27—Growth hormone [GH] (Somatotropin)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
NO914724A 1990-11-30 1991-11-29 Svinesomatotropiner med en dobbeltmutasjon i <alfa>-heliks-1-regionen NO301235B1 (no)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62165690A 1990-11-30 1990-11-30

Publications (3)

Publication Number Publication Date
NO914724D0 NO914724D0 (no) 1991-11-29
NO914724L true NO914724L (no) 1992-06-01
NO301235B1 NO301235B1 (no) 1997-09-29

Family

ID=24491070

Family Applications (1)

Application Number Title Priority Date Filing Date
NO914724A NO301235B1 (no) 1990-11-30 1991-11-29 Svinesomatotropiner med en dobbeltmutasjon i <alfa>-heliks-1-regionen

Country Status (20)

Country Link
US (1) US5548068A (no)
EP (1) EP0496973B1 (no)
JP (1) JPH05105634A (no)
KR (1) KR100193005B1 (no)
AT (1) ATE163045T1 (no)
CA (1) CA2056467C (no)
DE (1) DE69128877T2 (no)
DK (1) DK0496973T3 (no)
ES (1) ES2112847T3 (no)
FI (1) FI104489B (no)
GR (1) GR3026761T3 (no)
HU (1) HU215947B (no)
IE (1) IE914153A1 (no)
IL (1) IL100169A0 (no)
NO (1) NO301235B1 (no)
NZ (2) NZ260103A (no)
PT (1) PT99648B (no)
SG (1) SG49702A1 (no)
TW (1) TW198040B (no)
ZA (1) ZA919453B (no)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6006079A (en) * 1997-06-13 1999-12-21 Motorola, Inc. Radio having a fast adapting direct conversion receiver
TR200504220T2 (tr) 1998-12-17 2007-04-24 Biogen Idec Ma Inc. Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
GB2384001B (en) * 2001-12-14 2004-02-04 Asterion Ltd Chimeric growth hormone-growth hormone receptor proteins
AU2003263552A1 (en) * 2002-09-09 2004-03-29 Nautilus Biotech Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
US8338376B2 (en) 2006-10-20 2012-12-25 Biogen Idec Ma Inc. Compositions comprising variant LT-B-R-IG fusion proteins
CA2666934A1 (en) 2006-10-20 2008-04-24 Biogen Idec Ma Inc. Treatment of demyelinating disorders with soluble lymphotoxin-beta-receptor
KR101963914B1 (ko) * 2011-02-23 2019-03-29 매사추세츠 인스티튜트 오브 테크놀로지 수용성 막 단백질 및 이의 제조 방법 및 이의 사용 방법
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0355460B1 (en) * 1988-08-24 2000-12-27 American Cyanamid Company Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization
WO1990004788A1 (en) * 1988-10-28 1990-05-03 Genentech, Inc. Method for identifying active domains and amino acid residues in polypeptides and hormone variants

Also Published As

Publication number Publication date
DE69128877D1 (de) 1998-03-12
HU215947B (hu) 1999-03-29
JPH05105634A (ja) 1993-04-27
NO914724D0 (no) 1991-11-29
PT99648A (pt) 1992-10-30
PT99648B (pt) 1999-05-31
FI915654A0 (fi) 1991-11-29
CA2056467A1 (en) 1992-05-31
EP0496973B1 (en) 1998-02-04
NZ240718A (en) 1996-10-28
EP0496973A3 (en) 1993-02-24
AU662493B2 (en) 1995-09-07
TW198040B (no) 1993-01-11
GR3026761T3 (en) 1998-07-31
KR920009413A (ko) 1992-06-25
HU913723D0 (en) 1992-02-28
FI915654A (fi) 1992-05-31
NZ260103A (en) 1996-10-28
CA2056467C (en) 1998-07-07
SG49702A1 (en) 1998-06-15
NO301235B1 (no) 1997-09-29
KR100193005B1 (ko) 1999-06-15
DK0496973T3 (da) 1998-05-04
IL100169A0 (en) 1992-08-18
FI104489B (fi) 2000-02-15
US5548068A (en) 1996-08-20
IE914153A1 (en) 1992-06-03
EP0496973A2 (en) 1992-08-05
ZA919453B (en) 1992-08-26
ES2112847T3 (es) 1998-04-16
AU8830091A (en) 1992-06-04
HUT62327A (en) 1993-04-28
DE69128877T2 (de) 1998-06-18
ATE163045T1 (de) 1998-02-15

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Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees

Free format text: LAPSED IN MAY 2003