FI104489B - Sian somatotropiineja, joissa on kaksoismutaatio alfakierteen 1 alueella - Google Patents
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- 239000007983 Tris buffer Substances 0.000 description 1
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- KOSRFJWDECSPRO-UHFFFAOYSA-N alpha-L-glutamyl-L-glutamic acid Natural products OC(=O)CCC(N)C(=O)NC(CCC(O)=O)C(O)=O KOSRFJWDECSPRO-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
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- 238000012258 culturing Methods 0.000 description 1
- XVOYSCVBGLVSOL-UHFFFAOYSA-N cysteic acid Chemical group OC(=O)C(N)CS(O)(=O)=O XVOYSCVBGLVSOL-UHFFFAOYSA-N 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
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- 108010089804 glycyl-threonine Proteins 0.000 description 1
- 230000002440 hepatic effect Effects 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
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- 230000000977 initiatory effect Effects 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
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- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
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- 238000004806 packaging method and process Methods 0.000 description 1
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- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
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- 239000002798 polar solvent Substances 0.000 description 1
- 238000011176 pooling Methods 0.000 description 1
- 108010004914 prolylarginine Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 108020004418 ribosomal RNA Proteins 0.000 description 1
- 210000003705 ribosome Anatomy 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 102220014802 rs45527543 Human genes 0.000 description 1
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960004532 somatropin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
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- 238000011830 transgenic mouse model Methods 0.000 description 1
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- 235000011178 triphosphate Nutrition 0.000 description 1
- 125000002264 triphosphate group Chemical class [H]OP(=O)(O[H])OP(=O)(O[H])OP(=O)(O[H])O* 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Endocrinology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Secondary Cells (AREA)
- Mold Materials And Core Materials (AREA)
- Battery Electrode And Active Subsutance (AREA)
- Medicines Containing Plant Substances (AREA)
- Compositions Of Oxide Ceramics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62165690A | 1990-11-30 | 1990-11-30 | |
| US62165690 | 1990-11-30 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI915654A0 FI915654A0 (fi) | 1991-11-29 |
| FI915654A FI915654A (fi) | 1992-05-31 |
| FI104489B true FI104489B (fi) | 2000-02-15 |
Family
ID=24491070
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI915654A FI104489B (fi) | 1990-11-30 | 1991-11-29 | Sian somatotropiineja, joissa on kaksoismutaatio alfakierteen 1 alueella |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5548068A (ko) |
| EP (1) | EP0496973B1 (ko) |
| JP (1) | JPH05105634A (ko) |
| KR (1) | KR100193005B1 (ko) |
| AT (1) | ATE163045T1 (ko) |
| CA (1) | CA2056467C (ko) |
| DE (1) | DE69128877T2 (ko) |
| DK (1) | DK0496973T3 (ko) |
| ES (1) | ES2112847T3 (ko) |
| FI (1) | FI104489B (ko) |
| GR (1) | GR3026761T3 (ko) |
| HU (1) | HU215947B (ko) |
| IE (1) | IE914153A1 (ko) |
| IL (1) | IL100169A0 (ko) |
| NO (1) | NO301235B1 (ko) |
| NZ (2) | NZ260103A (ko) |
| PT (1) | PT99648B (ko) |
| SG (1) | SG49702A1 (ko) |
| TW (1) | TW198040B (ko) |
| ZA (1) | ZA919453B (ko) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6006079A (en) * | 1997-06-13 | 1999-12-21 | Motorola, Inc. | Radio having a fast adapting direct conversion receiver |
| TR200504220T2 (tr) * | 1998-12-17 | 2007-04-24 | Biogen Idec Ma Inc. | Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem. |
| GB2389115B (en) * | 2001-12-14 | 2005-03-16 | Asterion Ltd | Polypeptide having a plurality of modified growth hormone receptor binding domains of growth hormone |
| CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
| US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
| US8338376B2 (en) | 2006-10-20 | 2012-12-25 | Biogen Idec Ma Inc. | Compositions comprising variant LT-B-R-IG fusion proteins |
| MX2009004134A (es) | 2006-10-20 | 2009-08-12 | Biogen Idec Inc | Tratamiento de trastornos de desmielinizacion con el receptor de linfotoxina beta soluble. |
| MX347038B (es) | 2011-02-23 | 2017-04-10 | Massachusetts Inst Technology | Proteínas de membrana solubles en agua y métodos para la preparación y uso de las mismas. |
| US10373702B2 (en) | 2014-03-27 | 2019-08-06 | Massachusetts Institute Of Technology | Water-soluble trans-membrane proteins and methods for the preparation and use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0355460B1 (en) * | 1988-08-24 | 2000-12-27 | American Cyanamid Company | Stabilization of somatotropins by modification of cysteine residues utilizing site directed mutagenesis or chemical derivatization |
| DE68929151T2 (de) * | 1988-10-28 | 2000-07-20 | Genentech, Inc. | Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten |
-
1991
- 1991-11-25 NZ NZ260103A patent/NZ260103A/en unknown
- 1991-11-25 NZ NZ240718A patent/NZ240718A/en unknown
- 1991-11-27 IL IL100169A patent/IL100169A0/xx unknown
- 1991-11-28 DK DK91120396.6T patent/DK0496973T3/da active
- 1991-11-28 ES ES91120396T patent/ES2112847T3/es not_active Expired - Lifetime
- 1991-11-28 AT AT91120396T patent/ATE163045T1/de not_active IP Right Cessation
- 1991-11-28 EP EP91120396A patent/EP0496973B1/en not_active Expired - Lifetime
- 1991-11-28 DE DE69128877T patent/DE69128877T2/de not_active Expired - Fee Related
- 1991-11-28 SG SG1996004237A patent/SG49702A1/en unknown
- 1991-11-28 CA CA002056467A patent/CA2056467C/en not_active Expired - Fee Related
- 1991-11-29 FI FI915654A patent/FI104489B/fi active
- 1991-11-29 HU HU913723A patent/HU215947B/hu not_active IP Right Cessation
- 1991-11-29 JP JP3339516A patent/JPH05105634A/ja active Pending
- 1991-11-29 ZA ZA919453A patent/ZA919453B/xx unknown
- 1991-11-29 PT PT99648A patent/PT99648B/pt not_active IP Right Cessation
- 1991-11-29 IE IE415391A patent/IE914153A1/en not_active Application Discontinuation
- 1991-11-29 NO NO914724A patent/NO301235B1/no not_active IP Right Cessation
- 1991-11-30 KR KR1019910021901A patent/KR100193005B1/ko not_active IP Right Cessation
-
1992
- 1992-02-20 TW TW081101242A patent/TW198040B/zh active
-
1994
- 1994-12-23 US US08/363,982 patent/US5548068A/en not_active Expired - Fee Related
-
1998
- 1998-04-30 GR GR980400960T patent/GR3026761T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69128877D1 (de) | 1998-03-12 |
| AU662493B2 (en) | 1995-09-07 |
| ZA919453B (en) | 1992-08-26 |
| AU8830091A (en) | 1992-06-04 |
| DK0496973T3 (da) | 1998-05-04 |
| JPH05105634A (ja) | 1993-04-27 |
| HU913723D0 (en) | 1992-02-28 |
| FI915654A (fi) | 1992-05-31 |
| PT99648A (pt) | 1992-10-30 |
| NZ240718A (en) | 1996-10-28 |
| CA2056467A1 (en) | 1992-05-31 |
| DE69128877T2 (de) | 1998-06-18 |
| KR100193005B1 (ko) | 1999-06-15 |
| HUT62327A (en) | 1993-04-28 |
| SG49702A1 (en) | 1998-06-15 |
| FI915654A0 (fi) | 1991-11-29 |
| ES2112847T3 (es) | 1998-04-16 |
| EP0496973A2 (en) | 1992-08-05 |
| CA2056467C (en) | 1998-07-07 |
| EP0496973A3 (en) | 1993-02-24 |
| IL100169A0 (en) | 1992-08-18 |
| NO914724L (no) | 1992-06-01 |
| EP0496973B1 (en) | 1998-02-04 |
| TW198040B (ko) | 1993-01-11 |
| NO301235B1 (no) | 1997-09-29 |
| NZ260103A (en) | 1996-10-28 |
| GR3026761T3 (en) | 1998-07-31 |
| ATE163045T1 (de) | 1998-02-15 |
| HU215947B (hu) | 1999-03-29 |
| KR920009413A (ko) | 1992-06-25 |
| PT99648B (pt) | 1999-05-31 |
| IE914153A1 (en) | 1992-06-03 |
| US5548068A (en) | 1996-08-20 |
| NO914724D0 (no) | 1991-11-29 |
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