MX347038B - Proteínas de membrana solubles en agua y métodos para la preparación y uso de las mismas. - Google Patents

Proteínas de membrana solubles en agua y métodos para la preparación y uso de las mismas.

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Publication number
MX347038B
MX347038B MX2013009715A MX2013009715A MX347038B MX 347038 B MX347038 B MX 347038B MX 2013009715 A MX2013009715 A MX 2013009715A MX 2013009715 A MX2013009715 A MX 2013009715A MX 347038 B MX347038 B MX 347038B
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Mexico
Prior art keywords
methods
preparation
membrane proteins
water soluble
soluble membrane
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Application number
MX2013009715A
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English (en)
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MX2013009715A (es
Inventor
Shuguang Zhang
Alexander Rich
Karolina Corin
Lotta T Tegler
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Massachusetts Inst Technology
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Publication date
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Publication of MX2013009715A publication Critical patent/MX2013009715A/es
Publication of MX347038B publication Critical patent/MX347038B/es

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
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    • A61P25/00Drugs for disorders of the nervous system
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    • A61P25/16Anti-Parkinson drugs
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    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
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    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • AHUMAN NECESSITIES
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Abstract

La presente invención se refiere a una variante soluble en agua de un receptor acoplado de proteína G (GPCR), caracterizada porque en dicha variante los residuos hidrofóbicos del dominio ahelicoidal 7-transmembránico, que son leucina (L), isoleucina (I), valina (V) y fenilalanina (F) en la superficie hidrofílica en las posiciones a-helicoidales b, c y f, pero no en las posiciones a-helicoidales a, d, e y g de la GPCR, son reemplazados por glutamina (Q), treonina (T) treonina (T) , tirosina (Y), respectivamente; de manera opcional además comprende sustituciones conservativas en otras partes de la variante.
MX2013009715A 2011-02-23 2012-02-23 Proteínas de membrana solubles en agua y métodos para la preparación y uso de las mismas. MX347038B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161445740P 2011-02-23 2011-02-23
PCT/US2012/026353 WO2012116203A1 (en) 2011-02-23 2012-02-23 Water soluble membrane proteins and methods for the preparation and use thereof

Publications (2)

Publication Number Publication Date
MX2013009715A MX2013009715A (es) 2014-02-28
MX347038B true MX347038B (es) 2017-04-10

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Family Applications (1)

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MX2013009715A MX347038B (es) 2011-02-23 2012-02-23 Proteínas de membrana solubles en agua y métodos para la preparación y uso de las mismas.

Country Status (14)

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US (4) US8637452B2 (es)
EP (1) EP2709647B1 (es)
JP (1) JP6263773B2 (es)
KR (1) KR101963914B1 (es)
CN (2) CN103458915A (es)
AU (3) AU2012220558A1 (es)
BR (1) BR112013020969A2 (es)
CA (1) CA2827187C (es)
CL (1) CL2013002419A1 (es)
EA (1) EA201391041A1 (es)
IL (2) IL227886A0 (es)
MX (1) MX347038B (es)
SG (2) SG192646A1 (es)
WO (1) WO2012116203A1 (es)

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Also Published As

Publication number Publication date
EA201391041A1 (ru) 2014-04-30
MX2013009715A (es) 2014-02-28
AU2016201914A1 (en) 2016-04-21
CA2827187C (en) 2019-01-08
JP6263773B2 (ja) 2018-01-24
US8637452B2 (en) 2014-01-28
CN108752461A (zh) 2018-11-06
JP2014508763A (ja) 2014-04-10
US20180312562A1 (en) 2018-11-01
US9309302B2 (en) 2016-04-12
SG192646A1 (en) 2013-09-30
AU2012220558A1 (en) 2013-08-22
BR112013020969A2 (pt) 2018-07-10
CA2827187A1 (en) 2012-08-30
EP2709647A1 (en) 2014-03-26
US20160264640A1 (en) 2016-09-15
AU2017261525A1 (en) 2017-12-07
IL261151A (en) 2018-10-31
IL227886A0 (en) 2013-09-30
EP2709647B1 (en) 2019-08-07
US20140243277A1 (en) 2014-08-28
EP2709647A4 (en) 2015-01-21
US10035837B2 (en) 2018-07-31
WO2012116203A1 (en) 2012-08-30
CN103458915A (zh) 2013-12-18
KR101963914B1 (ko) 2019-03-29
KR20140027117A (ko) 2014-03-06
CL2013002419A1 (es) 2014-06-06
US20120252719A1 (en) 2012-10-04
SG10201701547VA (en) 2017-03-30

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