WO2012022496A3 - Method for killing tumor stem cells - Google Patents
Method for killing tumor stem cells Download PDFInfo
- Publication number
- WO2012022496A3 WO2012022496A3 PCT/EP2011/004202 EP2011004202W WO2012022496A3 WO 2012022496 A3 WO2012022496 A3 WO 2012022496A3 EP 2011004202 W EP2011004202 W EP 2011004202W WO 2012022496 A3 WO2012022496 A3 WO 2012022496A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- tumor stem
- killing tumor
- killing
- tumor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10332—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
The present invention is related to a YB-1 dependent virus for use in a method for killing tumor stem cells of a tumor.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10008691.7 | 2010-08-19 | ||
| EP10008691 | 2010-08-19 | ||
| EP10014419 | 2010-11-09 | ||
| EP10014419.5 | 2010-11-09 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2012022496A2 WO2012022496A2 (en) | 2012-02-23 |
| WO2012022496A3 true WO2012022496A3 (en) | 2012-06-07 |
Family
ID=44532745
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP2011/004202 WO2012022496A2 (en) | 2010-08-19 | 2011-08-19 | Method for killing tumor stem cells |
Country Status (1)
| Country | Link |
|---|---|
| WO (1) | WO2012022496A2 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2971008B1 (en) | 2013-03-14 | 2018-07-25 | Salk Institute for Biological Studies | Oncolytic adenovirus compositions |
| KR102471633B1 (en) | 2016-02-23 | 2022-11-25 | 솔크 인스티튜트 포 바이올로지칼 스터디즈 | Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics |
| EP3390428B1 (en) | 2016-02-23 | 2019-09-25 | Salk Institute for Biological Studies | High throughput assay for measuring adenovirus replication kinetics |
| AU2017375633C1 (en) | 2016-12-12 | 2023-04-27 | Salk Institute For Biological Studies | Tumor-targeting synthetic adenoviruses and uses thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1695978A1 (en) | 1990-06-11 | 2006-08-30 | Gilead Sciences, Inc. | Nucleic acid ligands |
| DE69426841T2 (en) | 1993-02-16 | 2001-09-06 | Onyx Pharma Inc | Cytopatic viruses for the therapy and prophylaxis of neoplasia |
| US5838165A (en) | 1996-08-21 | 1998-11-17 | Chatter; Mukesh | High performance self modifying on-the-fly alterable logic FPGA, architecture and method |
| EP0934331B1 (en) | 1996-08-30 | 2002-11-27 | Jens Peter Fürste | Mirror-symmetrical selection and evolution of nucleic acids |
| DE19742706B4 (en) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | lipocalin muteins |
| DE10150984A1 (en) | 2001-10-16 | 2003-04-17 | Holm Per Sonne | Expressing foreign nucleic acids with the adenoviral E2 late promoter, useful in the treatment of tumors, comprises selective activation by Y-box-binding protein-1 in tumor cell nuclei |
| KR101083450B1 (en) | 2002-05-27 | 2011-11-16 | 페르 손네 홀름 | Novel use of adenoviruses and nucleic acids coding therefor |
| PL219321B1 (en) | 2002-10-15 | 2015-04-30 | Per Sonne Holm | Adenovirus expressing genes in reverse order and use thereof |
-
2011
- 2011-08-19 WO PCT/EP2011/004202 patent/WO2012022496A2/en active Application Filing
Non-Patent Citations (3)
| Title |
|---|
| JIANG H ET AL: "Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: Role of autophagic cell death", JOURNAL OF THE NATIONAL CANCER INSTITUTE 200709 GB LNKD- DOI:10.1093/JNCI/DJM102, vol. 99, no. 18, September 2007 (2007-09-01), pages 1410 - 1414, XP002670759, ISSN: 0027-8874 * |
| RIBACKA CAMILLA ET AL: "Virotherapy as an approach against cancer stem cells", CURRENT GENE THERAPY, BENTHAM SCIENCE PUBLISHERS LTD, NL, vol. 8, no. 2, 1 April 2008 (2008-04-01), pages 88 - 96, XP009135177, ISSN: 1566-5232 * |
| ROGNONI E ET AL: "Adenovirus-based virotherapy enabled by cellular YB-1 expression in vitro and in vivo", CANCER GENE THERAPY, vol. 16, no. 10, October 2009 (2009-10-01), pages 753 - 763, XP002670760, ISSN: 0929-1903 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012022496A2 (en) | 2012-02-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL277184A (en) | Method of cryopreserving cells | |
| EP2614064B8 (en) | Inhibitors of human immunodeficiency virus replication | |
| ZA201209596B (en) | Napht-2-ylacetic acid derivatives to treat aids | |
| DK2624785T3 (en) | Heart valve prosthesis | |
| EP2611906A4 (en) | Systemic, allogenic stem cell therapies for treatment of diseases in animals | |
| ZA201207543B (en) | Redox-flow battery and method of operating thereof | |
| WO2012129341A3 (en) | Disease detection in plants | |
| WO2013078217A3 (en) | Anti-microbial peptides and methods of use thereof | |
| EP2561072A4 (en) | Nanozymes, methods of making nanozymes, and methods of using nanozymes | |
| EP2555834A4 (en) | Flippers, boots, systems including same, and methods of using same | |
| WO2011119738A9 (en) | Methods of treatment using stem cell mobilizers | |
| IL225972A0 (en) | Salts of kukoamine b, preparation method and use thereof | |
| EP2731429A4 (en) | Compounds, methods of making, and methods of use | |
| ZA201209738B (en) | Levoisovalerylspiramycin i,ii,iii and preparations,preparation methods and uses thereof | |
| WO2011153429A9 (en) | Methods of treatment | |
| WO2012096960A3 (en) | Stem cell factor inhibitor | |
| WO2012022496A3 (en) | Method for killing tumor stem cells | |
| WO2014033158A3 (en) | Pcsk9 peptide vaccine | |
| HK1203551A1 (en) | Induced pluripotent stem cells prepared from human kidney-derived cells | |
| WO2011130697A3 (en) | Tissue targeting | |
| EP2627341A4 (en) | Coriolus versicolor extracts, methods of preparation and uses thereof | |
| EP2770561A4 (en) | Electrical-device-use negative-electrode active substance | |
| EP2756092A4 (en) | Methods of making cells, tissues, and antibodies | |
| WO2012166659A3 (en) | Anti-emr1 antibodies | |
| AU2012901130A0 (en) | A composition and method for enhancing the permeability of a tissue of a subject to an active agent |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DPE2 | Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101) | ||
| 121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 11749347 Country of ref document: EP Kind code of ref document: A2 |
|
| NENP | Non-entry into the national phase |
Ref country code: DE |
|
| 122 | Ep: pct application non-entry in european phase |
Ref document number: 11749347 Country of ref document: EP Kind code of ref document: A2 |