WO2015149085A8 - Water-soluble trans-membrane proteins and methods for the preparation and use thereof - Google Patents

Water-soluble trans-membrane proteins and methods for the preparation and use thereof Download PDF

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Publication number
WO2015149085A8
WO2015149085A8 PCT/US2015/032722 US2015032722W WO2015149085A8 WO 2015149085 A8 WO2015149085 A8 WO 2015149085A8 US 2015032722 W US2015032722 W US 2015032722W WO 2015149085 A8 WO2015149085 A8 WO 2015149085A8
Authority
WO
WIPO (PCT)
Prior art keywords
methods
preparation
water
membrane proteins
soluble trans
Prior art date
Application number
PCT/US2015/032722
Other languages
French (fr)
Other versions
WO2015149085A2 (en
WO2015149085A3 (en
Inventor
Shuguang Zhang
Fei TAO
Original Assignee
Massachusetts Institute Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/669,753 external-priority patent/US20150370960A1/en
Priority to EP15729292.1A priority Critical patent/EP3122767B1/en
Priority to AU2015237137A priority patent/AU2015237137A1/en
Priority to JP2017502957A priority patent/JP7061461B2/en
Priority to CN201580023906.8A priority patent/CN106459174B/en
Priority to CA2978076A priority patent/CA2978076A1/en
Application filed by Massachusetts Institute Of Technology filed Critical Massachusetts Institute Of Technology
Priority to EP20184442.0A priority patent/EP3805260A1/en
Priority to SG11201607980UA priority patent/SG11201607980UA/en
Publication of WO2015149085A2 publication Critical patent/WO2015149085A2/en
Publication of WO2015149085A3 publication Critical patent/WO2015149085A3/en
Publication of WO2015149085A8 publication Critical patent/WO2015149085A8/en
Priority to AU2019232778A priority patent/AU2019232778B2/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/50—Molecular design, e.g. of drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computing Systems (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The present invention is directed to water-soluble membrane proteins, methods for the preparation thereof and methods of use thereof.
PCT/US2015/032722 2014-03-27 2015-05-27 Warer-soluble trans-membrane proteins and methods for the preparation and use thereof WO2015149085A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SG11201607980UA SG11201607980UA (en) 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof
AU2015237137A AU2015237137A1 (en) 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof
JP2017502957A JP7061461B2 (en) 2015-02-18 2015-05-27 Water-soluble transmembrane protein and its preparation and usage
CN201580023906.8A CN106459174B (en) 2015-02-18 2015-05-27 Water-soluble transmembrane proteins and methods of making and using same
CA2978076A CA2978076A1 (en) 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof
EP15729292.1A EP3122767B1 (en) 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof
EP20184442.0A EP3805260A1 (en) 2014-03-27 2015-05-27 Water-soluble trans-membrane proteins and methods for the preparation and use thereof
AU2019232778A AU2019232778B2 (en) 2014-03-27 2019-09-16 Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US201461971388P 2014-03-27 2014-03-27
US61/971,388 2014-03-27
US201461993783P 2014-05-15 2014-05-15
US61/993,783 2014-05-15
US201562117550P 2015-02-18 2015-02-18
US62/117,550 2015-02-18
US14/669,753 2015-03-26
US14/669,753 US20150370960A1 (en) 2014-03-27 2015-03-26 Water-soluble membrane proteins and methods for the preparation and use thereof
PCT/US2015/022780 WO2015148820A1 (en) 2014-03-27 2015-03-26 Water-soluble membrane proteins and methods for the preparation and use thereof
USPCT/US2015/022780 2015-03-26

Publications (3)

Publication Number Publication Date
WO2015149085A2 WO2015149085A2 (en) 2015-10-01
WO2015149085A3 WO2015149085A3 (en) 2016-02-18
WO2015149085A8 true WO2015149085A8 (en) 2016-04-14

Family

ID=54196580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2015/032722 WO2015149085A2 (en) 2014-03-27 2015-05-27 Warer-soluble trans-membrane proteins and methods for the preparation and use thereof

Country Status (1)

Country Link
WO (1) WO2015149085A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101963914B1 (en) * 2011-02-23 2019-03-29 매사추세츠 인스티튜트 오브 테크놀로지 Water soluble membrane proteins and methods for the preparation and use thereof
CN110838341B (en) * 2019-11-05 2021-05-18 广州基迪奥生物科技有限公司 Biological information analysis method of ATAC-seq sequencing data

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004205643A1 (en) * 2003-01-21 2004-08-05 The Trustees Of The University Of Pennsylvania Computational design of a water-soluble analog of a protein, such as phospholamban and potassium channel KcsA
WO2006026355A2 (en) * 2004-08-25 2006-03-09 Janssen Pharmaceutica N.V. Relaxin-chimeric polypeptides and their preparation and use
DK2032155T3 (en) * 2006-06-09 2015-03-02 Novartis Ag Stabilized insulin-like growth factor polypeptides
KR101963914B1 (en) * 2011-02-23 2019-03-29 매사추세츠 인스티튜트 오브 테크놀로지 Water soluble membrane proteins and methods for the preparation and use thereof
US20130273585A1 (en) * 2012-04-11 2013-10-17 Gangagen, Inc. Soluble cytoplasmic expression of heterologous proteins in escherichia coli
JP2017520862A (en) * 2014-03-27 2017-07-27 マサチューセッツ インスティテュート オブ テクノロジー Water-soluble membrane proteins and methods for their preparation and use

Also Published As

Publication number Publication date
WO2015149085A2 (en) 2015-10-01
WO2015149085A3 (en) 2016-02-18

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