SG11201507370TA - Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies - Google Patents

Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

Info

Publication number
SG11201507370TA
SG11201507370TA SG11201507370TA SG11201507370TA SG11201507370TA SG 11201507370T A SG11201507370T A SG 11201507370TA SG 11201507370T A SG11201507370T A SG 11201507370TA SG 11201507370T A SG11201507370T A SG 11201507370TA SG 11201507370T A SG11201507370T A SG 11201507370TA
Authority
SG
Singapore
Prior art keywords
layered
long
sustained release
human antibodies
assembling peptide
Prior art date
Application number
SG11201507370TA
Inventor
Sotirios Koutsopoulos
Shuguang Zhang
Original Assignee
Massachusetts Inst Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology filed Critical Massachusetts Inst Technology
Publication of SG11201507370TA publication Critical patent/SG11201507370TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5015—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
SG11201507370TA 2013-03-14 2014-03-14 Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies SG11201507370TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361782791P 2013-03-14 2013-03-14
PCT/US2014/027693 WO2014152751A1 (en) 2013-03-14 2014-03-14 Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

Publications (1)

Publication Number Publication Date
SG11201507370TA true SG11201507370TA (en) 2015-10-29

Family

ID=51581306

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201507370TA SG11201507370TA (en) 2013-03-14 2014-03-14 Multi-layered injectable self-assembling peptide scaffold hydrogels for long-term sustained release of human antibodies

Country Status (7)

Country Link
US (1) US9700521B2 (en)
EP (1) EP2968135A4 (en)
JP (1) JP6134050B2 (en)
CN (1) CN105228592A (en)
HK (2) HK1218858A1 (en)
SG (1) SG11201507370TA (en)
WO (1) WO2014152751A1 (en)

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Publication number Priority date Publication date Assignee Title
WO2010033726A2 (en) 2008-09-17 2010-03-25 The Brigham And Women's Hospital, Inc. Drug delivery composition comprising a self-assembled gelator
JP2013540757A (en) 2010-09-24 2013-11-07 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド Nanostructured gel with the ability to control the release of encapsulated agent
PT3219330T (en) * 2014-11-14 2020-01-17 3 D Matrix Ltd Synthesis of nano aggregate of chitosan modified by self-assembling peptide and application thereof to protein delivery
WO2016138525A1 (en) 2015-02-27 2016-09-01 University Of Washington Polypeptide assemblies and methods for the production thereof
US10526371B2 (en) 2015-07-13 2020-01-07 Universiteit Gent Hydrogel-forming peptides
WO2017015703A1 (en) 2015-07-24 2017-02-02 The University Of Sydney Antiseptic polymer and synthesis thereof
US10449259B2 (en) 2015-10-02 2019-10-22 Cornell University Enzyme-responsive peptide nanofiber compositions and uses thereof
US9962339B2 (en) 2015-10-08 2018-05-08 The Brigham And Women's Hospital, Inc. Stabilized assembled nanostructures for delivery of encapsulated agents
EP3419642B1 (en) 2016-02-16 2023-10-04 Vrije Universiteit Brussel Hydrogel-forming composition comprising a peptide hydrogelator for controlled release
CN115837006A (en) 2016-05-06 2023-03-24 布里格姆及妇女医院股份有限公司 Binary self-assembling gels for controlled delivery of encapsulated agents into cartilage
EP3452014A1 (en) * 2016-05-06 2019-03-13 The Brigham and Women's Hospital, Inc. Self-assembled gel for controlled delivery of thermolabile agents
WO2018144991A1 (en) 2017-02-03 2018-08-09 The Brigham And Women's Hospital, Inc. Self-assembled gels formed with anti-retroviral drugs, prodrugs thereof, and pharmaceutical uses thereof
US10881745B2 (en) 2017-05-08 2021-01-05 Alivio Therapeutics, Inc. Formulation of nanostructured gels for increased agent loading and adhesion
US11661439B2 (en) 2017-12-17 2023-05-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Peptide hydrogels and use thereof
US20190307885A1 (en) * 2018-04-04 2019-10-10 Alivio Therapeutics, Inc. Self-assembled gels for controlled delivery of biologics and methods of making thereof
JP7323608B2 (en) 2018-10-11 2023-08-08 アリヴィオ セラピューティクス， インコーポレイテッド Non-injectable hydrogel formulation for smart release
CN114341157A (en) * 2019-07-22 2022-04-12 新加坡科技研究局 A series of injectable hydrogels self-assembled from short peptides for various biomedical applications
US12037418B2 (en) * 2020-06-30 2024-07-16 Nanyang Technological University Hydrogel-forming peptides, and methods of use thereof
CN111939323B (en) * 2020-08-08 2022-06-10 武汉速普生物科技有限公司 Functional polypeptide hydrogel containing hyaluronic acid connecting peptide and connecting protein terminal peptide and application thereof

Family Cites Families (21)

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US5670483A (en) 1992-12-28 1997-09-23 Massachusetts Insititute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US5955343A (en) 1992-12-28 1999-09-21 Massachusetts Institute Of Technology Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
US7449180B2 (en) 2001-02-06 2008-11-11 John Kisiday Macroscopic scaffold containing amphiphilic peptides encapsulating cells
WO2003006043A1 (en) 2001-07-10 2003-01-23 Massachusetts Institute Of Technology Surfactant peptide nanostructures, and uses thereof
KR20040091100A (en) * 2002-03-04 2004-10-27 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. Sustained release drug formulations containing a carrier peptide
AU2003249606A1 (en) 2002-05-13 2003-12-02 Massachusetts Institute Of Technology Angiogenesis and cardiac tissue engineering with peptide hydrogels and related compositions and methods of use thereof
US7713923B2 (en) 2003-06-25 2010-05-11 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
US7846891B2 (en) 2003-10-17 2010-12-07 Massachusetts Institute Of Technology Self-assembling peptides for regeneration and repair of neural tissue
US8039258B2 (en) * 2004-09-28 2011-10-18 Ethicon, Inc. Tissue-engineering scaffolds containing self-assembled-peptide hydrogels
AU2006241123B2 (en) 2005-04-25 2013-10-03 Massachusetts Institute Of Technology Compositions and methods for promoting hemostasis and other physiological activities
ES2709125T3 (en) 2006-09-26 2019-04-15 Massachusetts Inst Technology Modified self-assembling peptides
US20090069547A1 (en) 2007-05-01 2009-03-12 Massachusetts Institute Of Technology Stabilization of mammalian membrane proteins by short surfactant peptides
US8729032B2 (en) 2009-03-09 2014-05-20 Menicon Co., Ltd. Self-assembling peptide and peptide gel with high strength
US20110200560A1 (en) 2009-05-26 2011-08-18 Massachusetts Institute Of Technology Non-ionic self-assembling peptides and uses thereof
JP5732691B2 (en) * 2010-01-14 2015-06-10 学校法人同志社 Insulin preparations
US8741833B2 (en) 2010-07-16 2014-06-03 Massachusetts Institute Of Technology Self-assembling peptides incorporating modifications and methods of use thereof
WO2012116203A1 (en) 2011-02-23 2012-08-30 Massachusetts Institute Of Technology Water soluble membrane proteins and methods for the preparation and use thereof
CN102526753B (en) * 2011-12-15 2014-01-22 成都师创生物医药科技有限公司 In-situ phase change gel slow release system taking phospholipid as substrate and preparation method thereof
EP2854778A4 (en) 2012-05-31 2016-03-30 Massachusetts Inst Technology Sustained delivery of molecules using peptide surfactants and uses thereof
US20150370960A1 (en) 2014-03-27 2015-12-24 Massachusetts Institute Of Technology Water-soluble membrane proteins and methods for the preparation and use thereof
US10373702B2 (en) 2014-03-27 2019-08-06 Massachusetts Institute Of Technology Water-soluble trans-membrane proteins and methods for the preparation and use thereof

Also Published As

Publication number Publication date
WO2014152751A1 (en) 2014-09-25
EP2968135A4 (en) 2016-10-26
US9700521B2 (en) 2017-07-11
HK1220401A1 (en) 2017-05-05
EP2968135A1 (en) 2016-01-20
JP6134050B2 (en) 2017-05-24
CN105228592A (en) 2016-01-06
HK1218858A1 (en) 2017-03-17
JP2016515136A (en) 2016-05-26
US20140302144A1 (en) 2014-10-09

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