FI104074B1 - Menetelmä terapeuttisesti käyttökelpoisten 2-[2-(3-karboksifenyylikarbamoyyli)pyrrolidin-4-yylitio]karbapeneemijohdannaisten valmistamiseksi - Google Patents
Menetelmä terapeuttisesti käyttökelpoisten 2-[2-(3-karboksifenyylikarbamoyyli)pyrrolidin-4-yylitio]karbapeneemijohdannaisten valmistamiseksiInfo
- Publication number
- FI104074B1 FI104074B1 FI930474A FI930474A FI104074B1 FI 104074 B1 FI104074 B1 FI 104074B1 FI 930474 A FI930474 A FI 930474A FI 930474 A FI930474 A FI 930474A FI 104074 B1 FI104074 B1 FI 104074B1
- Authority
- FI
- Finland
- Prior art keywords
- carboxyphenylcarbamoyl
- ylthio
- pyrrolidin
- preparation
- therapeutically useful
- Prior art date
Links
- RYXKQQDDGSUSKA-DNOWBOINSA-N C(=O)(O)C=1C=C(C=CC1)NC(=O)C1NCC(C1)SC=1C[C@H]2N(C1)C(C2)=O Chemical class C(=O)(O)C=1C=C(C=CC1)NC(=O)C1NCC(C1)SC=1C[C@H]2N(C1)C(C2)=O RYXKQQDDGSUSKA-DNOWBOINSA-N 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/568—Four-membered rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929202298A GB9202298D0 (en) | 1992-02-04 | 1992-02-04 | Antibiotic compounds |
GB9202298 | 1992-02-04 |
Publications (4)
Publication Number | Publication Date |
---|---|
FI930474A0 FI930474A0 (fi) | 1993-02-03 |
FI930474A FI930474A (fi) | 1993-08-05 |
FI104074B FI104074B (fi) | 1999-11-15 |
FI104074B1 true FI104074B1 (fi) | 1999-11-15 |
Family
ID=10709764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI930474A FI104074B1 (fi) | 1992-02-04 | 1993-02-03 | Menetelmä terapeuttisesti käyttökelpoisten 2-[2-(3-karboksifenyylikarbamoyyli)pyrrolidin-4-yylitio]karbapeneemijohdannaisten valmistamiseksi |
Country Status (35)
Country | Link |
---|---|
US (7) | US5478820A (de) |
EP (1) | EP0579826B1 (de) |
JP (1) | JP2730600B2 (de) |
KR (1) | KR100200986B1 (de) |
CN (1) | CN1036006C (de) |
AP (1) | AP398A (de) |
AT (1) | ATE173262T1 (de) |
AU (1) | AU668133B2 (de) |
CA (1) | CA2106370C (de) |
CZ (1) | CZ286878B6 (de) |
DE (2) | DE69322007T2 (de) |
DK (1) | DK0579826T3 (de) |
ES (1) | ES2123654T3 (de) |
FI (1) | FI104074B1 (de) |
GB (2) | GB9202298D0 (de) |
GE (1) | GEP20022694B (de) |
HK (1) | HK1013998A1 (de) |
HR (1) | HRP930103B1 (de) |
HU (3) | HUT66514A (de) |
IL (1) | IL104588A (de) |
LU (1) | LU90970I2 (de) |
MY (1) | MY111685A (de) |
NL (1) | NL300104I2 (de) |
NO (2) | NO304315B1 (de) |
NZ (2) | NZ272038A (de) |
PL (3) | PL174601B1 (de) |
RU (1) | RU2117659C1 (de) |
SG (1) | SG48817A1 (de) |
SI (1) | SI9300056B (de) |
SK (1) | SK280890B6 (de) |
TW (1) | TW408124B (de) |
UA (1) | UA44885C2 (de) |
WO (1) | WO1993015078A1 (de) |
YU (1) | YU48998B (de) |
ZA (1) | ZA93453B (de) |
Families Citing this family (59)
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GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
CA2106330A1 (en) * | 1992-10-07 | 1994-04-08 | Patrice J. Siret | Antibiotic compounds |
US5602118A (en) * | 1993-03-16 | 1997-02-11 | American Cyanamid Company | 2-thiosubstituted carbapenems |
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UA62920C2 (en) * | 1996-05-28 | 2004-01-15 | Merck & Co Inc | Carbapeneme antibiotic, a composition and a method for the preparation |
HRP970281B1 (en) * | 1996-05-28 | 2002-04-30 | Merck & Co Inc | Carbapenem antibiotic, composition and method of preparation |
AR008255A1 (es) * | 1996-07-12 | 1999-12-29 | Merck & Co Inc | Procedimiento para sintetizar antibioticos de carbapenem |
US6946468B1 (en) | 1996-08-17 | 2005-09-20 | Zeneca Limited | 3-mercaptopyrrolidines as farnesyl protein transferase inhibitors |
US5877328A (en) * | 1996-10-10 | 1999-03-02 | Merck & Co., Inc. | Process for synthesizing carbapenem side chain intermediates |
ATE229962T1 (de) * | 1996-10-10 | 2003-01-15 | Merck & Co Inc | Verfahren zur herstellung von zwischenprodukten in herstellung von carbapenem-seitenketten |
AU725298B2 (en) * | 1996-10-28 | 2000-10-12 | Merck & Co., Inc. | Stabilized carbapenem antibiotic compositions and method of making |
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WO1999002492A1 (en) * | 1997-07-10 | 1999-01-21 | Merck & Co., Inc. | Crystalline forms of antibiotic side chain intermediates |
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US5872250A (en) * | 1997-07-30 | 1999-02-16 | Merck & Co., Inc. | Process for synthesizing carbapenem antibiotics |
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ATE321762T1 (de) * | 1998-03-02 | 2006-04-15 | Merck & Co Inc | Verfahren zur synthese von carbapenem-antibiotika |
US6489471B1 (en) | 1998-06-17 | 2002-12-03 | Merck & Co., Inc. | Process for the synthesis of carbapenem intermediates, and compounds produced |
US6548492B1 (en) | 1999-10-29 | 2003-04-15 | Merck & Co., Inc. | Process for formulation of carbapenem antibiotic compositions |
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WO2011048583A1 (en) | 2009-10-23 | 2011-04-28 | Ranbaxy Laboratories Limited | Process for the preparation of carbapenem compounds |
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CN102558182B (zh) * | 2010-12-31 | 2015-02-11 | 石药集团中奇制药技术(石家庄)有限公司 | 一种厄他培南钠晶型及其制备方法 |
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GB9107341D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
GB9107342D0 (en) * | 1991-04-08 | 1991-05-22 | Ici Plc | Antibiotic compounds |
CZ167792A3 (en) * | 1991-06-04 | 1995-12-13 | Sankyo Co | 1-methylcarbapenem derivatives process of their preparation and use |
ZA929008B (en) * | 1991-12-13 | 1993-05-21 | Bristol Myers Squibb Co | Piperazinyl- and piperidinyl-cyclohexanols. |
GB9202298D0 (en) * | 1992-02-04 | 1992-03-18 | Ici Plc | Antibiotic compounds |
GB9304156D0 (en) * | 1992-03-26 | 1993-04-21 | Zeneca Ltd | Antibiotic compounds |
CA2091309A1 (en) * | 1992-03-26 | 1993-09-27 | Frederic H. Jung | Antibiotic compounds |
CA2099818A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
CA2099817A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
CA2099811A1 (en) * | 1992-07-21 | 1994-01-22 | Frederic H. Jung | Antibiotic compounds |
CA2106141A1 (en) * | 1992-09-28 | 1994-03-29 | Michael J. Betts | Antibiotic compounds |
-
1992
- 1992-02-04 GB GB929202298A patent/GB9202298D0/en active Pending
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1993
- 1993-01-12 GB GB939300456A patent/GB9300456D0/en active Pending
- 1993-01-21 AP APAP/P/1993/000480A patent/AP398A/en active
- 1993-01-21 ZA ZA93453A patent/ZA93453B/xx unknown
- 1993-01-27 MY MYPI93000120A patent/MY111685A/en unknown
- 1993-01-29 YU YU5493A patent/YU48998B/sh unknown
- 1993-02-02 CA CA002106370A patent/CA2106370C/en not_active Expired - Lifetime
- 1993-02-02 SK SK1063-93A patent/SK280890B6/sk active Protection Beyond IP Right Term
- 1993-02-02 NZ NZ272038A patent/NZ272038A/en not_active IP Right Cessation
- 1993-02-02 PL PL93317447A patent/PL174601B1/pl unknown
- 1993-02-02 DE DE69322007T patent/DE69322007T2/de not_active Expired - Lifetime
- 1993-02-02 KR KR1019930702942A patent/KR100200986B1/ko not_active IP Right Cessation
- 1993-02-02 WO PCT/GB1993/000217 patent/WO1993015078A1/en active IP Right Grant
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- 1993-02-02 IL IL10458893A patent/IL104588A/en active Protection Beyond IP Right Term
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- 1993-02-02 AU AU34574/93A patent/AU668133B2/en not_active Expired
- 1993-02-02 DK DK93914514T patent/DK0579826T3/da active
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- 1993-02-02 CZ CZ19932067A patent/CZ286878B6/cs not_active IP Right Cessation
- 1993-02-02 NZ NZ246917A patent/NZ246917A/en not_active IP Right Cessation
- 1993-02-02 ES ES93914514T patent/ES2123654T3/es not_active Expired - Lifetime
- 1993-02-02 RU RU93058253/04A patent/RU2117659C1/ru active
- 1993-02-02 PL PL93300768A patent/PL174649B1/pl unknown
- 1993-02-02 PL PL93317448A patent/PL174936B1/pl unknown
- 1993-02-02 AT AT93914514T patent/ATE173262T1/de active
- 1993-02-02 HU HU9302777D patent/HUT66514A/hu unknown
- 1993-02-02 EP EP93914514A patent/EP0579826B1/de not_active Expired - Lifetime
- 1993-02-02 DE DE2002199041 patent/DE10299041I2/de active Active
- 1993-02-02 HU HU9302777A patent/HU213675B/hu unknown
- 1993-02-03 FI FI930474A patent/FI104074B1/fi not_active IP Right Cessation
- 1993-02-03 HR HR9202298.7A patent/HRP930103B1/xx not_active IP Right Cessation
- 1993-02-04 CN CN93101472A patent/CN1036006C/zh not_active Expired - Lifetime
- 1993-02-09 TW TW082100868A patent/TW408124B/zh not_active IP Right Cessation
- 1993-06-18 UA UA93003121A patent/UA44885C2/uk unknown
- 1993-10-01 NO NO933530A patent/NO304315B1/no not_active IP Right Cessation
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1995
- 1995-06-05 US US08/462,037 patent/US5652233A/en not_active Expired - Lifetime
- 1995-06-14 HU HU95P/P00201P patent/HU211840A9/hu active Protection Beyond IP Right Term
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1997
- 1997-04-03 US US08/833,056 patent/US5856321A/en not_active Expired - Lifetime
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1998
- 1998-10-08 US US09/168,293 patent/US6187804B1/en not_active Expired - Lifetime
- 1998-12-24 HK HK98115416A patent/HK1013998A1/xx not_active IP Right Cessation
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2001
- 2001-02-13 US US09/781,556 patent/US6521612B2/en not_active Expired - Fee Related
- 2001-08-31 GE GE4468A patent/GEP20022694B/en unknown
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2002
- 2002-10-09 NO NO2002010C patent/NO2002010I2/no unknown
- 2002-10-09 LU LU90970C patent/LU90970I2/fr unknown
- 2002-10-18 NL NL300104C patent/NL300104I2/nl unknown
- 2002-11-14 US US10/293,561 patent/US7041836B2/en not_active Expired - Fee Related
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2005
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