FI103888B1 - Analoginen menetelmä valmistaa terapeuttisesti aktiivista akridiinijohdannaista - Google Patents
Analoginen menetelmä valmistaa terapeuttisesti aktiivista akridiinijohdannaistaInfo
- Publication number
- FI103888B1 FI103888B1 FI933149A FI933149A FI103888B1 FI 103888 B1 FI103888 B1 FI 103888B1 FI 933149 A FI933149 A FI 933149A FI 933149 A FI933149 A FI 933149A FI 103888 B1 FI103888 B1 FI 103888B1
- Authority
- FI
- Finland
- Prior art keywords
- group
- 4alkoxy
- 4alkyl
- hydrogen atom
- atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
- C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/26—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups and being further substituted by halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/27—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups
- C07C205/35—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
- C07C205/36—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system
- C07C205/37—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by etherified hydroxy groups having nitro groups and etherified hydroxy groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton to carbon atoms of the same non-condensed six-membered aromatic ring or to carbon atoms of six-membered aromatic rings being part of the same condensed ring system the oxygen atom of at least one of the etherified hydroxy groups being further bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Plural Heterocyclic Compounds (AREA)
- Laminated Bodies (AREA)
- Soft Magnetic Materials (AREA)
- Paper (AREA)
- Dry Shavers And Clippers (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919100628A GB9100628D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
| GB919100637A GB9100637D0 (en) | 1991-01-11 | 1991-01-11 | Chemical compounds |
| GB919115956A GB9115956D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
| GB919115981A GB9115981D0 (en) | 1991-07-24 | 1991-07-24 | Chemical compounds |
| PCT/EP1992/000020 WO1992012132A1 (en) | 1991-01-11 | 1992-01-07 | Acridine derivatives |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI933149A FI933149A (fi) | 1993-07-09 |
| FI933149A0 FI933149A0 (fi) | 1993-07-09 |
| FI103888B FI103888B (fi) | 1999-10-15 |
| FI103888B1 true FI103888B1 (fi) | 1999-10-15 |
Family
ID=27450605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI933149A FI103888B1 (fi) | 1991-01-11 | 1993-07-09 | Analoginen menetelmä valmistaa terapeuttisesti aktiivista akridiinijohdannaista |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5604237A (de) |
| EP (2) | EP0569380B1 (de) |
| JP (1) | JP2783680B2 (de) |
| KR (1) | KR100220538B1 (de) |
| AT (1) | ATE153660T1 (de) |
| AU (1) | AU652996B2 (de) |
| CA (1) | CA2100258C (de) |
| CZ (1) | CZ283038B6 (de) |
| DE (1) | DE69220037T2 (de) |
| DK (1) | DK0569380T3 (de) |
| ES (1) | ES2104887T3 (de) |
| FI (1) | FI103888B1 (de) |
| GE (1) | GEP20002210B (de) |
| GR (1) | GR3024525T3 (de) |
| HU (2) | HUT68856A (de) |
| IE (1) | IE920083A1 (de) |
| IL (1) | IL100631A (de) |
| MX (1) | MX9200109A (de) |
| NO (1) | NO300267B1 (de) |
| NZ (1) | NZ241278A (de) |
| PL (1) | PL168202B1 (de) |
| RU (1) | RU2119482C1 (de) |
| SG (1) | SG45403A1 (de) |
| SK (1) | SK280864B6 (de) |
| WO (1) | WO1992012132A1 (de) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2119482C1 (ru) * | 1991-01-11 | 1998-09-27 | Лаборатуар Глаксо С.А. | Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей |
| GB9209872D0 (en) * | 1992-05-07 | 1992-06-24 | Ici Plc | Alkyl substituted nitrotoluene derivatives |
| TR28930A (tr) * | 1992-05-07 | 1997-07-21 | Zeneca Ltd | Alkil sübstitüentli nitrotoluen türevleri |
| ATE152443T1 (de) * | 1992-07-10 | 1997-05-15 | Glaxo Lab Sa | Anilide-derivate |
| RU2036198C1 (ru) * | 1993-04-01 | 1995-05-27 | Товарищество с ограниченной ответственностью "Полисан" | N-МЕТИЛ-N-( α,D -ГЛЮКОПИРАНОЗИЛ) АММОНИЯ-2-(АКРИДОН-9-ОН-10-ИЛ)АЦЕТАТ(ЦИКЛОФЕРОН), ОБЛАДАЮЩИЙ ИНТЕРФЕРОНОГЕННОЙ, ПРОТИВОВИРУСНОЙ, В ТОМ ЧИСЛЕ АНТИВИЧ, АНТИПАРАЗИТАРНОЙ, АНТИПРОМОТОРНОЙ И РАДИОПРОТЕКТИВНОЙ АКТИВНОСТЬЮ |
| US5387685A (en) * | 1993-07-16 | 1995-02-07 | American Cyanamid Co | MDR reversal agents |
| DE4422517A1 (de) * | 1994-06-28 | 1996-01-04 | Dresden Arzneimittel | Neue (2-(3,4-Dimethoxy-phenyl)-ethyl)-(2-phenoxy-ethyl)-amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE69531691T2 (de) * | 1994-08-04 | 2004-07-08 | C & C Research Labs | Neues amin-derivat, verfahren zur herstellung und dessen verwendung als anti-arrhythmisches mittel |
| PL319511A1 (en) * | 1994-10-05 | 1997-08-18 | Glaxo Wellcome Inc | Parenteral pharmaceutic compositions containing gf120918a |
| FR2726267B1 (fr) * | 1994-10-26 | 1998-01-02 | Smithkline Beecham Lab | Nouveaux agents anti-arythmiques, compositions pharmaceutiques les contenant, et procede pour les preparer |
| US6395770B1 (en) | 1995-10-26 | 2002-05-28 | Baker Norton Pharmaceuticals, Inc. | Method and compositions for administering taxanes orally to human patients |
| US6245805B1 (en) | 1995-10-26 | 2001-06-12 | Baker Norton Pharmaceuticals, Inc. | Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| WO1997028166A1 (de) * | 1996-02-01 | 1997-08-07 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thienochinoline |
| US6713517B1 (en) | 1996-03-08 | 2004-03-30 | Oxigene, Inc. | Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use |
| RU2118532C1 (ru) * | 1996-04-10 | 1998-09-10 | Олег Викторович Травкин | Противоинфекционное, противовоспалительное и противоопухолевое лекарственное средство |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| GB9710612D0 (en) * | 1997-05-23 | 1997-07-16 | Glaxo Group Ltd | Synthesis of acridine derivatives |
| DE69832173T2 (de) * | 1997-05-27 | 2006-08-03 | IVAX RESEARCH, INC., Miami | Zusammensetzungen zur oralen verabreichung von taxanen und deren verwendung |
| GB9718903D0 (en) * | 1997-09-05 | 1997-11-12 | Glaxo Group Ltd | Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents |
| GB9810876D0 (en) | 1998-05-20 | 1998-07-22 | Smithkline Beecham Plc | Compounds |
| GB9812189D0 (en) * | 1998-06-05 | 1998-08-05 | Glaxo Group Ltd | Methods and compositions for increasing penetration of HIV protease inhibitors |
| WO2000000472A1 (en) * | 1998-06-30 | 2000-01-06 | Du Pont Pharmaceuticals Company | 5-ht7 receptor antagonists |
| CO5140073A1 (es) | 1998-10-08 | 2002-03-22 | Smithkline Beecham Plc | Derivados de 2,3,4,5-tetrahidro-1h-3-benzapina |
| DE60045114D1 (de) | 1999-05-17 | 2010-11-25 | Cancer Res Ventures Ltd | Zubereitungen zur Erhöhung der Bioverfügbarkeit von oral verabreichten pharmazeutischen Verbindungen |
| EP2266607A3 (de) | 1999-10-01 | 2011-04-20 | Immunogen, Inc. | Immunokonjugate für Krebsbehandlung |
| US6521635B1 (en) | 2000-01-20 | 2003-02-18 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibition of MXR transport by acridine derivatives |
| CA2400403C (en) * | 2000-02-18 | 2011-07-19 | New York Medical College | 1-nitroacridine/tumor inhibitor compositions |
| CN100393703C (zh) * | 2000-03-14 | 2008-06-11 | 埃科特莱茵药品有限公司 | 1,2,3,4-四氢异喹啉的衍生物 |
| WO2001085693A1 (fr) | 2000-05-11 | 2001-11-15 | Banyu Pharmaceutical Co., Ltd. | Dérivés n-acyltétrahydroisoquinoline |
| MXPA03003401A (es) * | 2000-10-16 | 2004-06-30 | Neopharm Inc | Formulacion liposomica de mitoxantrona. |
| DE60326341D1 (de) * | 2002-05-14 | 2009-04-09 | Xenova Ltd | Verfahren zur herstellung von anthranilsäurederivat-hydrat |
| WO2004039795A2 (en) * | 2002-10-29 | 2004-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Amide compounds for the treatment of hyperlipidemia |
| KR100848747B1 (ko) | 2004-03-01 | 2008-07-25 | 액테리온 파마슈티칼 리미티드 | 치환된 1,2,3,4-테트라하이드로이소퀴놀린 유도체 |
| RU2346692C2 (ru) * | 2007-03-29 | 2009-02-20 | Ефаг АО | Применение 9-оксоакридин-10-уксусной кислоты, ее солей и сложных эфиров в комбинированной терапии рака яичников, способ лечения и наборы |
| SE531698C2 (sv) * | 2007-07-12 | 2009-07-07 | Respiratorius Ab | Nya bronkdilaterande a,b-omättade amider |
| WO2015142670A1 (en) * | 2014-03-15 | 2015-09-24 | Medisyn Technologies, Inc. | Anti-diabetic compounds, pharmaceutical compositions containing them, and method to treat diabetes |
| CN104434808A (zh) | 2014-07-03 | 2015-03-25 | 石药集团中奇制药技术（石家庄）有限公司 | 一种治疗性纳米粒子及其制备方法 |
| BR112020018669A2 (pt) * | 2018-03-21 | 2020-12-29 | Izumi Technology, Llc | Análogos deuterados de elacridar |
| CN115385847B (zh) * | 2021-06-15 | 2023-09-29 | 山东第一医科大学(山东省医学科学院) | 多取代二芳基类化合物及其制备方法和应用 |
| CN117414367A (zh) * | 2022-08-09 | 2024-01-19 | 北京清华长庚医院 | 一种逆转仑伐替尼耐药的药物组合物及其用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250182A (en) * | 1972-02-24 | 1981-02-10 | Burroughs Wellcome Co. | Pharmaceutical composition containing acridone compounds and method of using same |
| US4021551A (en) * | 1972-06-07 | 1977-05-03 | Boehringer Ingelheim Gmbh | 3,6-Bis-(heterocyclic aminoacyl-amino)-acridines and salts thereof |
| US4127573A (en) * | 1972-09-06 | 1978-11-28 | Burroughs Wellcome Co. | Ditetrazole substituted acridone compounds |
| EP0048898B1 (de) * | 1980-09-30 | 1985-04-17 | Bayer Ag | Verfahren zur Herstellung eines Antithrombin-Heparin-Komplexes sowie diesen Komplex enthaltende pharmazeutische Mischungen |
| NZ198115A (en) * | 1981-08-21 | 1985-05-31 | New Zealand Dev Finance | 9-anilinoacridines;pharmaceutical compositions |
| NZ201084A (en) * | 1982-06-25 | 1985-10-11 | New Zealand Dev Finance | 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such |
| IN164921B (de) * | 1986-07-22 | 1989-07-08 | Hoechst India | |
| US5104858A (en) * | 1988-09-29 | 1992-04-14 | Yale University | Sensitizing multidrug resistant cells to antitumor agents |
| CA1340821C (en) * | 1988-10-06 | 1999-11-16 | Nobuyuki Fukazawa | Heterocyclic compounds and anticancer-drug reinforcing agents containing them as effective components |
| DE69003200T2 (de) * | 1989-06-19 | 1994-01-20 | Wellcome Found | Arylsubstituierte Aminderivate verwendbar in der Krebstherapie. |
| RU2119482C1 (ru) * | 1991-01-11 | 1998-09-27 | Лаборатуар Глаксо С.А. | Производные акридина, способ получения, фармацевтическая композиция и способ лечения злокачественных опухолей |
| US5296602A (en) * | 1991-03-18 | 1994-03-22 | Sloan-Kettering Institute For Cancer Research | Multisubstituted 1-hydroxy-9-acridones with anticancer activity |
| US5240936A (en) * | 1992-05-14 | 1993-08-31 | Texas A&M University System | Treating or preventing ocular inflammation or systemic imflammatory disease |
-
1992
- 1992-01-07 RU RU93051543A patent/RU2119482C1/ru active
- 1992-01-07 JP JP4501671A patent/JP2783680B2/ja not_active Expired - Lifetime
- 1992-01-07 WO PCT/EP1992/000020 patent/WO1992012132A1/en active IP Right Grant
- 1992-01-07 SG SG1996006197A patent/SG45403A1/en unknown
- 1992-01-07 CA CA002100258A patent/CA2100258C/en not_active Expired - Lifetime
- 1992-01-07 HU HU9301989A patent/HUT68856A/hu unknown
- 1992-01-07 KR KR1019930702079A patent/KR100220538B1/ko not_active IP Right Cessation
- 1992-01-07 AT AT92901861T patent/ATE153660T1/de not_active IP Right Cessation
- 1992-01-07 PL PL92299989A patent/PL168202B1/pl unknown
- 1992-01-07 SK SK730-93A patent/SK280864B6/sk not_active IP Right Cessation
- 1992-01-07 DE DE69220037T patent/DE69220037T2/de not_active Expired - Lifetime
- 1992-01-07 CZ CS931378A patent/CZ283038B6/cs not_active IP Right Cessation
- 1992-01-07 ES ES92901861T patent/ES2104887T3/es not_active Expired - Lifetime
- 1992-01-07 GE GEAP19922653A patent/GEP20002210B/en unknown
- 1992-01-07 AU AU11543/92A patent/AU652996B2/en not_active Expired
- 1992-01-07 DK DK92901861.2T patent/DK0569380T3/da active
- 1992-01-07 EP EP92901861A patent/EP0569380B1/de not_active Expired - Lifetime
- 1992-01-07 EP EP92100123A patent/EP0494623A1/de active Pending
- 1992-01-10 IE IE008392A patent/IE920083A1/en not_active IP Right Cessation
- 1992-01-10 MX MX9200109A patent/MX9200109A/es unknown
- 1992-01-10 NZ NZ241278A patent/NZ241278A/en not_active IP Right Cessation
- 1992-01-10 IL IL10063192A patent/IL100631A/en not_active IP Right Cessation
-
1993
- 1993-07-09 FI FI933149A patent/FI103888B1/fi active
- 1993-07-09 NO NO932512A patent/NO300267B1/no not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/468,620 patent/US5604237A/en not_active Expired - Lifetime
- 1995-06-29 HU HU95P/P00524P patent/HU211623A9/hu unknown
-
1997
- 1997-08-22 GR GR970402168T patent/GR3024525T3/el unknown
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