FI102836B1 - Menetelmä glykosaminoglykaanilla muunnetun proteiinin valmistamiseksi - Google Patents
Menetelmä glykosaminoglykaanilla muunnetun proteiinin valmistamiseksiInfo
- Publication number
- FI102836B1 FI102836B1 FI905003A FI905003A FI102836B1 FI 102836 B1 FI102836 B1 FI 102836B1 FI 905003 A FI905003 A FI 905003A FI 905003 A FI905003 A FI 905003A FI 102836 B1 FI102836 B1 FI 102836B1
- Authority
- FI
- Finland
- Prior art keywords
- glycosaminoglycan
- protein
- modified protein
- preparation
- reducing
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract 1
- 125000003172 aldehyde group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000001766 physiological effect Effects 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Analytical Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8116390 | 1990-03-30 | ||
| JP2081163A JP2975632B2 (ja) | 1990-03-30 | 1990-03-30 | グリコサミノグリカン修飾プロテイン |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI905003A0 FI905003A0 (fi) | 1990-10-11 |
| FI905003A FI905003A (fi) | 1991-10-01 |
| FI102836B1 true FI102836B1 (fi) | 1999-02-26 |
| FI102836B FI102836B (fi) | 1999-02-26 |
Family
ID=13738789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI905003A FI102836B (fi) | 1990-03-30 | 1990-10-11 | Menetelmä glykosaminoglykaanilla muunnetun proteiinin valmistamiseksi |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5310881A (da) |
| EP (1) | EP0454898B1 (da) |
| JP (1) | JP2975632B2 (da) |
| KR (1) | KR100188382B1 (da) |
| AT (1) | ATE135375T1 (da) |
| AU (1) | AU649416B2 (da) |
| CA (1) | CA2027447A1 (da) |
| DE (1) | DE69025920T2 (da) |
| DK (1) | DK0454898T3 (da) |
| ES (1) | ES2083989T3 (da) |
| FI (1) | FI102836B (da) |
| NO (1) | NO179044C (da) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU649110B2 (en) * | 1991-03-07 | 1994-05-12 | Mect Corporation | Pharmaceutical preparation |
| GB9112212D0 (en) * | 1991-06-06 | 1991-07-24 | Gregoriadis Gregory | Pharmaceutical compositions |
| US5846951A (en) * | 1991-06-06 | 1998-12-08 | The School Of Pharmacy, University Of London | Pharmaceutical compositions |
| GB2266239B (en) * | 1992-03-25 | 1996-03-06 | Jevco Ltd | Wound healing compositions containing chondroitin sulphate oligosaccharides |
| CA2091544A1 (en) * | 1992-03-26 | 1993-09-27 | Shing F. Kwan | Stabilization of functional proteins |
| JP4011106B2 (ja) * | 1994-02-23 | 2007-11-21 | 協和醗酵工業株式会社 | 血小板増殖促進剤 |
| JPH09503001A (ja) * | 1994-05-09 | 1997-03-25 | ベーリンガー マンハイム ゲゼルシャフト ミット ベシュレンクテル ハフツング | ニューロンを保護するためのコンドロイチン硫酸プロテオグリカンの使用 |
| US6228998B1 (en) | 1994-07-22 | 2001-05-08 | Seikagaku Kogyo Kabushiki Kaisha | Amino spacered glycosaminoglycan derivatives and their use in copolymerization with acrylamide |
| US5912000A (en) * | 1994-09-23 | 1999-06-15 | Zonagen, Inc. | Chitosan induced immunopotentiation |
| ATE223235T1 (de) * | 1994-09-23 | 2002-09-15 | Zonagen Inc | Chitosan induzierte verstärkung |
| US5677276A (en) * | 1994-12-23 | 1997-10-14 | La Jolla Cancer Research Foundation | Immobilization of peptides to hyaluronate |
| CA2232527C (en) * | 1995-09-19 | 2008-09-02 | Seikagaku Corporation | Anti-inflammatory agent |
| US6562781B1 (en) | 1995-11-30 | 2003-05-13 | Hamilton Civic Hospitals Research Development Inc. | Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| US7045585B2 (en) * | 1995-11-30 | 2006-05-16 | Hamilton Civic Hospital Research Development Inc. | Methods of coating a device using anti-thrombin heparin |
| US6491965B1 (en) | 1995-11-30 | 2002-12-10 | Hamilton Civic Hospitals Research Development, Inc. | Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates |
| JP2001502052A (ja) * | 1996-09-25 | 2001-02-13 | ユニバーサル ヘルスウォッチ，インコーポレーテッド | 液体移動および干渉に対する抵抗を改良した診断用検査デバイス |
| WO2001005434A2 (en) * | 1999-07-20 | 2001-01-25 | Amgen Inc. | Hyaluronic acid-protein conjugates |
| EP2279755B1 (en) * | 2001-10-10 | 2014-02-26 | ratiopharm GmbH | Remodelling and glycoconjugation of Fibroblast Growth Factor (FGF) |
| EP2305314B1 (en) * | 2001-10-10 | 2015-12-23 | ratiopharm GmbH | Remodelling and glycoconjugation of antibodies |
| DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
| DE10209822A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
| KR101045422B1 (ko) | 2002-09-11 | 2011-06-30 | 프레제니우스 카비 도이치란트 게엠베하 | 하이드록시알킬 전분 유도체의 제조 방법 |
| US8673333B2 (en) * | 2002-09-25 | 2014-03-18 | The Johns Hopkins University | Cross-linked polymer matrices, and methods of making and using same |
| US7862831B2 (en) * | 2002-10-09 | 2011-01-04 | Synthasome, Inc. | Method and material for enhanced tissue-biomaterial integration |
| EP1558216A4 (en) * | 2002-09-25 | 2007-01-03 | Univ Johns Hopkins Med | RETICULATED POLYMER MATRICES AND METHOD OF MANUFACTURING THE SAME |
| WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
| KR101113726B1 (ko) * | 2003-08-12 | 2012-02-27 | 리폭센 테크놀로지즈 리미티드 | 단백질 유도 및 컨쥬게이션용 시알산 유도체 |
| WO2006089119A2 (en) * | 2005-02-18 | 2006-08-24 | Cartilix, Inc. | Biological adhesive |
| CN101160326B (zh) | 2005-02-23 | 2013-04-10 | 利普生技术有限公司 | 用于蛋白质衍生和缀合的活化的唾液酸衍生物 |
| EP1886696A1 (en) * | 2006-08-03 | 2008-02-13 | Endotis Pharma | Conjugates of antithrombin binding oligosaccharide derivatives and therapeutic proteins |
| US8658593B2 (en) | 2011-06-06 | 2014-02-25 | The Cleveland Clinic Foundation | Treatment of extracellular matrix to reduce inflammation |
| US10196625B2 (en) | 2013-09-30 | 2019-02-05 | Seikagaku Corporation | Method for improving blood persistence of protein |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2824092A (en) * | 1955-01-04 | 1958-02-18 | Robert E Thompson | Process of preparation of a gelatincarboxymethyl cellulose complex |
| GB1479268A (en) * | 1973-07-05 | 1977-07-13 | Beecham Group Ltd | Pharmaceutical compositions |
| US4301153A (en) * | 1977-03-21 | 1981-11-17 | Riker Laboratories, Inc. | Heparin preparation |
| CA1171375A (en) * | 1980-09-15 | 1984-07-24 | Ulf P.F. Lindahl | Oligosaccharides having selective anticoagulation activity |
| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
| US4526714A (en) * | 1982-12-13 | 1985-07-02 | Cordis Europa N.V. | Conjugates of anticoagulant and protein |
| NL188622C (nl) * | 1981-12-15 | 1992-08-17 | Cordis Europ | Werkwijze ter verbetering van de bloedcompatibiliteit van een materiaaloppervlak door bekleding daarvan met een heparine of heparine-analoga en een eiwit houdende film, alsmede voorwerp, omvattende een oppervlak met verbeterde bloedcompatibiliteit verkregen onder toepassing van een op het oppervlak aangebrachte heparine of heparine-analoga en een eiwit houdende film. |
| SE8200751L (sv) * | 1982-02-09 | 1983-08-10 | Olle Larm | Forfarande for kovalent koppling for framstellning av konjugat och hervid erhallna produkter |
| US4585754A (en) * | 1984-01-09 | 1986-04-29 | Valcor Scientific, Ltd. | Stabilization of proteins and peptides by chemical binding with chondroitin |
| US4863907A (en) * | 1984-06-29 | 1989-09-05 | Seikagaku Kogyo Co., Ltd. | Crosslinked glycosaminoglycans and their use |
| DE3680524D1 (de) * | 1986-04-22 | 1991-08-29 | Valcor Scient Ltd | Verfahren zur stabilisierung von proteinen. |
| US4745180A (en) * | 1986-06-27 | 1988-05-17 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using heparin fragments |
| DE3636590A1 (de) * | 1986-10-28 | 1988-05-26 | Braun Melsungen Ag | Blutersatzmittel |
| FR2631970B1 (fr) * | 1988-05-24 | 1993-12-24 | Sanofi | N-polyosyl-polypeptides |
| DE3819079A1 (de) * | 1988-06-04 | 1989-12-07 | Hoechst Ag | Hirudin-derivate mit verzoegerter wirkung |
| US5023078A (en) * | 1988-08-10 | 1991-06-11 | Albert P. Halluin | Plasminogen activator-heparin conjugates |
-
1990
- 1990-03-30 JP JP2081163A patent/JP2975632B2/ja not_active Expired - Lifetime
- 1990-10-10 NO NO904378A patent/NO179044C/no unknown
- 1990-10-10 AU AU64506/90A patent/AU649416B2/en not_active Ceased
- 1990-10-11 FI FI905003A patent/FI102836B/fi not_active IP Right Cessation
- 1990-10-12 ES ES90119607T patent/ES2083989T3/es not_active Expired - Lifetime
- 1990-10-12 DE DE69025920T patent/DE69025920T2/de not_active Expired - Fee Related
- 1990-10-12 DK DK90119607.1T patent/DK0454898T3/da active
- 1990-10-12 CA CA002027447A patent/CA2027447A1/en not_active Abandoned
- 1990-10-12 EP EP90119607A patent/EP0454898B1/en not_active Expired - Lifetime
- 1990-10-12 AT AT90119607T patent/ATE135375T1/de active
- 1990-10-12 KR KR1019900016160A patent/KR100188382B1/ko not_active IP Right Cessation
-
1992
- 1992-07-02 US US07/908,910 patent/US5310881A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69025920T2 (de) | 1996-08-14 |
| FI905003A (fi) | 1991-10-01 |
| DE69025920D1 (de) | 1996-04-18 |
| CA2027447A1 (en) | 1991-10-01 |
| US5310881A (en) | 1994-05-10 |
| NO179044C (no) | 1996-07-24 |
| NO179044B (no) | 1996-04-15 |
| NO904378D0 (no) | 1990-10-10 |
| KR100188382B1 (ko) | 1999-06-01 |
| JP2975632B2 (ja) | 1999-11-10 |
| EP0454898B1 (en) | 1996-03-13 |
| EP0454898A1 (en) | 1991-11-06 |
| FI905003A0 (fi) | 1990-10-11 |
| ATE135375T1 (de) | 1996-03-15 |
| KR910016770A (ko) | 1991-11-05 |
| AU649416B2 (en) | 1994-05-26 |
| AU6450690A (en) | 1991-10-31 |
| NO904378L (no) | 1991-10-01 |
| DK0454898T3 (da) | 1996-04-15 |
| ES2083989T3 (es) | 1996-05-01 |
| FI102836B (fi) | 1999-02-26 |
| JPH03284698A (ja) | 1991-12-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM | Patent lapsed |
Owner name: SEIKAGAKU CORPORATION |