FI102617B1 - Nukleinsyrasekvens som kodar en aminosyravariant av human plasminogen, expressionsvektor och värdcell som omfattar densamma, samt förfarande för framställning av en aminosyravariant av plasminogen och förfarande för framställning av ett binärt komplex mellan ett fibrinolytiskt... - Google Patents

Nukleinsyrasekvens som kodar en aminosyravariant av human plasminogen, expressionsvektor och värdcell som omfattar densamma, samt förfarande för framställning av en aminosyravariant av plasminogen och förfarande för framställning av ett binärt komplex mellan ett fibrinolytiskt...

Info

Publication number
FI102617B1
FI102617B1 FI905919A FI905919A FI102617B1 FI 102617 B1 FI102617 B1 FI 102617B1 FI 905919 A FI905919 A FI 905919A FI 905919 A FI905919 A FI 905919A FI 102617 B1 FI102617 B1 FI 102617B1
Authority
FI
Finland
Prior art keywords
producing
plasminogen
amino acid
acid variant
sequence encoding
Prior art date
Application number
FI905919A
Other languages
English (en)
Finnish (fi)
Other versions
FI905919A0 (fi
FI102617B (sv
FI905919A (fi
Inventor
Francis J Castellino
Deborah L Higgins
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of FI905919A0 publication Critical patent/FI905919A0/fi
Publication of FI905919A publication Critical patent/FI905919A/fi
Application granted granted Critical
Publication of FI102617B1 publication Critical patent/FI102617B1/sv
Publication of FI102617B publication Critical patent/FI102617B/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI905919A 1989-12-01 1990-11-30 Nukleinsyrasekvens som kodar en aminosyravariant av human plasminogen, expressionsvektor och värdcell som omfattar densamma, samt förfarande för framställning av en aminosyravariant av plasminogen och förfarand e för framställning av ett binärt komplex FI102617B (sv)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44458489 1989-12-01
US07/444,584 US5087572A (en) 1989-12-01 1989-12-01 Dna encoding human plasminogen modified at the cleavage site

Publications (4)

Publication Number Publication Date
FI905919A0 FI905919A0 (fi) 1990-11-30
FI905919A FI905919A (fi) 1991-06-02
FI102617B1 true FI102617B1 (sv) 1999-01-15
FI102617B FI102617B (sv) 1999-01-15

Family

ID=23765514

Family Applications (1)

Application Number Title Priority Date Filing Date
FI905919A FI102617B (sv) 1989-12-01 1990-11-30 Nukleinsyrasekvens som kodar en aminosyravariant av human plasminogen, expressionsvektor och värdcell som omfattar densamma, samt förfarande för framställning av en aminosyravariant av plasminogen och förfarand e för framställning av ett binärt komplex

Country Status (14)

Country Link
US (1) US5087572A (sv)
EP (1) EP0502872B1 (sv)
JP (1) JP3043403B2 (sv)
AT (1) ATE105862T1 (sv)
AU (1) AU641449B2 (sv)
CA (1) CA2072649C (sv)
DE (1) DE69009068T2 (sv)
DK (1) DK0502872T3 (sv)
FI (1) FI102617B (sv)
IE (1) IE62832B1 (sv)
NO (1) NO307305B1 (sv)
PL (1) PL288034A1 (sv)
PT (1) PT96041A (sv)
WO (1) WO1991008297A1 (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5190756A (en) * 1989-12-01 1993-03-02 Genentech, Inc. Methods and materials for expression of human plasminogen variant
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids
AU9088891A (en) * 1990-11-29 1992-06-25 John E. Carbaugh Diagnostic and therapeutic compositions and methods for lipoprotein(a)
DK0643772T3 (da) 1992-06-03 1998-02-02 Genentech Inc Glycosyleringsvarianter af vævsplasminogenaktivator med forbedrede terapeutiske egenskaber
WO1994001128A1 (en) * 1992-07-01 1994-01-20 Beth Israel Hospital Boston Enhancement of thrombolytic therapy with deglycosylated plasminogen
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
US6048850A (en) * 1992-09-22 2000-04-11 Young; Donald A. Method of inhibiting prostaglandin synthesis in a human host
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US5919652A (en) * 1994-11-09 1999-07-06 The Regents Of The University Of California Nucleic acid molecules comprising the prostate specific antigen (PSA) promoter and uses thereof
JP5819293B2 (ja) 2009-07-10 2015-11-24 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
WO2012093132A1 (en) 2011-01-05 2012-07-12 Thrombogenics Nv Plasminogen and plasmin variants
AU2012296884B2 (en) 2011-08-12 2015-02-05 Thrombogenics N.V. Plasminogen and plasmin variants
JP2022540865A (ja) * 2019-07-12 2022-09-20 モナッシュ ユニバーシティ 組換えタンパク質を作製するための方法
EP4281471A1 (en) * 2021-01-20 2023-11-29 Monash University Fusion proteins

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3943245A (en) * 1974-02-14 1976-03-09 Armour Pharmaceutical Company Purification of plasminogen
DE3065190D1 (en) * 1979-11-05 1983-11-10 Beecham Group Plc Enzyme derivatives, and their preparation
AU5390286A (en) * 1985-01-25 1986-08-13 Sagami Chemical Research Center Stabilized human prourokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
US5219569A (en) * 1985-04-22 1993-06-15 Genentech, Inc. Protease resistant urokinase
HU206520B (en) * 1985-04-22 1992-11-30 Genentech Inc Process for producing new human tissue plasminogen activator /tpa/ mutants and pharmaceutical compositions containing them
DK43387A (da) * 1986-01-29 1987-07-30 Beecham Group Plc Fibrinolytisk enzym
PT84589B (en) * 1986-04-02 1989-05-09 Beecham Group Plc Process for preparing a fibrinolytic enzyme
WO1988005081A2 (en) * 1986-12-30 1988-07-14 Cetus Corporation Novel plasminogen activator
NO882226L (no) * 1987-05-22 1988-11-23 Zymogenetics Inc Fibrinolytiske proteiner.
IE67036B1 (en) * 1987-06-04 1996-05-15 Zymogenetics Inc Tissue plasminogen activator analogs having modified growth factor domains
IE64782B1 (en) * 1987-06-04 1995-09-06 Eisai Co Ltd Mutant t-PA with kringle replacement
WO1988010119A1 (en) * 1987-06-22 1988-12-29 Genetics Institute, Inc. Novel thrombolytic proteins

Also Published As

Publication number Publication date
FI905919A0 (fi) 1990-11-30
PL288034A1 (en) 1991-08-12
CA2072649A1 (en) 1991-06-02
DK0502872T3 (da) 1994-09-12
DE69009068T2 (de) 1994-10-27
EP0502872A1 (en) 1992-09-16
DE69009068D1 (de) 1994-06-23
AU641449B2 (en) 1993-09-23
WO1991008297A1 (en) 1991-06-13
NO905211L (no) 1991-06-03
IE904332A1 (en) 1991-06-05
AU6721290A (en) 1991-06-26
CA2072649C (en) 2003-10-21
FI102617B (sv) 1999-01-15
EP0502872B1 (en) 1994-05-18
NO307305B1 (no) 2000-03-13
US5087572A (en) 1992-02-11
FI905919A (fi) 1991-06-02
PT96041A (pt) 1991-09-30
ATE105862T1 (de) 1994-06-15
JP3043403B2 (ja) 2000-05-22
NO905211D0 (no) 1990-11-30
JPH05502373A (ja) 1993-04-28
IE62832B1 (en) 1995-03-08

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Legal Events

Date Code Title Description
FG Patent granted

Owner name: GENENTECH, INC.

FG Patent granted

Owner name: GENENTECH, INC.