FI101538B - Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-mety yli-1-piperatsinyyli)-10H-tieno£2,3-b|£1,5|bentsodiatsepiinijohdannais ten valmistamiseksi - Google Patents

Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-mety yli-1-piperatsinyyli)-10H-tieno£2,3-b|£1,5|bentsodiatsepiinijohdannais ten valmistamiseksi

Info

Publication number
FI101538B
FI101538B FI932445A FI932445A FI101538B FI 101538 B FI101538 B FI 101538B FI 932445 A FI932445 A FI 932445A FI 932445 A FI932445 A FI 932445A FI 101538 B FI101538 B FI 101538B
Authority
FI
Finland
Prior art keywords
methyl
thieno
piperazinyl
preparation
therapeutically useful
Prior art date
Application number
FI932445A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI101538B1 (fi
FI932445A0 (fi
FI932445L (fi
Inventor
John Fairhurst
Terrence Michael Hotten
David Edward Tupper
Original Assignee
Lilly Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929211379A external-priority patent/GB9211379D0/en
Priority claimed from GB939309025A external-priority patent/GB9309025D0/en
Application filed by Lilly Industries Ltd filed Critical Lilly Industries Ltd
Publication of FI932445A0 publication Critical patent/FI932445A0/fi
Publication of FI932445L publication Critical patent/FI932445L/fi
Application granted granted Critical
Publication of FI101538B1 publication Critical patent/FI101538B1/fi
Publication of FI101538B publication Critical patent/FI101538B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Anesthesiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI932445A 1992-05-29 1993-05-28 Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-mety yli-1-piperatsinyyli)-10H-tieno£2,3-b|£1,5|bentsodiatsepiinijohdannais ten valmistamiseksi FI101538B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929211379A GB9211379D0 (en) 1992-05-29 1992-05-29 Pharmaceutical compounds
GB939309025A GB9309025D0 (en) 1993-04-30 1993-04-30 Pharmaceutical compounds

Publications (4)

Publication Number Publication Date
FI932445A0 FI932445A0 (fi) 1993-05-28
FI932445L FI932445L (fi) 1993-11-30
FI101538B1 FI101538B1 (fi) 1998-07-15
FI101538B true FI101538B (fi) 1998-07-15

Family

ID=26300951

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932445A FI101538B (fi) 1992-05-29 1993-05-28 Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-mety yli-1-piperatsinyyli)-10H-tieno£2,3-b|£1,5|bentsodiatsepiinijohdannais ten valmistamiseksi

Country Status (21)

Country Link
EP (1) EP0582368B1 (cg-RX-API-DMAC7.html)
JP (1) JP3219541B2 (cg-RX-API-DMAC7.html)
CN (1) CN1043994C (cg-RX-API-DMAC7.html)
AT (1) ATE198891T1 (cg-RX-API-DMAC7.html)
AU (1) AU668159B2 (cg-RX-API-DMAC7.html)
CA (1) CA2097016A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ282783B6 (cg-RX-API-DMAC7.html)
DE (1) DE69329887T2 (cg-RX-API-DMAC7.html)
DK (1) DK0582368T3 (cg-RX-API-DMAC7.html)
ES (1) ES2153373T3 (cg-RX-API-DMAC7.html)
FI (1) FI101538B (cg-RX-API-DMAC7.html)
GR (1) GR3035587T3 (cg-RX-API-DMAC7.html)
HU (1) HU218278B (cg-RX-API-DMAC7.html)
IL (1) IL105827A (cg-RX-API-DMAC7.html)
MX (1) MX9303124A (cg-RX-API-DMAC7.html)
MY (1) MY109943A (cg-RX-API-DMAC7.html)
NO (1) NO305125B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ247703A (cg-RX-API-DMAC7.html)
PT (1) PT582368E (cg-RX-API-DMAC7.html)
RU (1) RU2125574C1 (cg-RX-API-DMAC7.html)
TW (1) TW268005B (cg-RX-API-DMAC7.html)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5457101A (en) * 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
CR5278A (es) * 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
EG24221A (en) * 1995-03-24 2008-11-10 Lilly Co Eli Process for preparing olanzapine
EG23659A (en) * 1995-03-24 2007-03-26 Lilly Co Eli Process and crystal forms of methyl-thieno-benzodiazepine
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
AU725556B2 (en) * 1996-03-25 2000-10-12 Eli Lilly And Company Method for treating pain
UA44838C2 (uk) * 1996-03-25 2002-03-15 Елі Ліллі Енд Компані Спосіб лікування мігрені
CN1219878A (zh) * 1996-03-25 1999-06-16 伊莱利利公司 治疗疼痛的方法
PL194074B1 (pl) 1996-09-23 2007-04-30 Lilly Co Eli Polimorf Dihydrat D olanzapiny i preparat farmaceutyczny zawierający Dihydrat D olanzapiny
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
ID21762A (id) * 1996-09-24 1999-07-22 Lilly Co Eli Formulasi partikel bersaput
RU2185383C1 (ru) * 2001-05-22 2002-07-20 Институт молекулярной генетики РАН ВЫСОКОМЕЧЕННЫЙ ТРИТИЕМ 2-МЕТИЛ-4-(4-МЕТИЛ-1-ПИПЕРАЗИНИЛ)-10Н-ТИЕНО[2,3-b][1,5]БЕНЗОДИАЗЕПИН
CN108640996A (zh) 2012-08-21 2018-10-12 詹森药业有限公司 帕潘立酮的抗体及其用途
EP3663316A1 (en) 2012-08-21 2020-06-10 Janssen Pharmaceutica NV Antibodies to aripiprazole and use thereof
CA2882563C (en) 2012-08-21 2022-11-29 Eric Hryhorenko Antibodies to risperidone haptens and use thereof
PL3462173T3 (pl) 2012-08-21 2021-08-16 Janssen Pharmaceutica Nv Przeciwciała przeciwko rysperydonowi i ich zastosowanie
JP6131415B2 (ja) 2012-08-21 2017-05-24 ヤンセン ファーマシューティカ エヌ．ベー． イムノアッセイに使用するためのクエチアピンのハプテン
JP2015529199A (ja) 2012-08-21 2015-10-05 オルソ−クリニカル ダイアグノスティクス，インコーポレイティド パリペリドンハプテンに対する抗体及びその使用
PT3663317T (pt) 2012-08-21 2023-01-23 Janssen Pharmaceutica Nv Anticorpos para haptenos de quetiapina e sua utilização
PT3415516T (pt) 2012-08-21 2022-01-28 Janssen Pharmaceutica Nv Haptenos de risperidona e paliperidona
US9494608B2 (en) 2012-08-21 2016-11-15 Janssen Pharmaceutica Nv Antibodies to olanzapine and use thereof
AU2013305907B2 (en) 2012-08-21 2018-01-18 Saladax Biomedical Inc. Antibodies to quetiapine and use thereof
ES2733963T3 (es) 2012-08-21 2019-12-03 Janssen Pharmaceutica Nv Anticuerpos contra haptenos de olanzapina y uso de los mismos
CN104736567B (zh) 2012-08-21 2019-09-03 詹森药业有限公司 阿立哌唑半抗原的抗体及其用途
PL3321254T3 (pl) 2012-08-21 2021-01-11 Janssen Pharmaceutica Nv Hapteny arypiprazolu i ich zastosowanie w testach immunologicznych
PL2888269T3 (pl) 2012-08-21 2019-06-28 Janssen Pharmaceutica Nv Hapteny olanzapiny
ES2739383T3 (es) 2012-08-21 2020-01-30 Janssen Pharmaceutica Nv Haptenos de paliperidona
WO2017106508A1 (en) 2015-12-17 2017-06-22 Janssen Pharmaceutica Nv Antibodies to quetiapine and use thereof
EP3390449A1 (en) 2015-12-17 2018-10-24 Janssen Pharmaceutica N.V. Antibodies to risperidone and use thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH569731A5 (cg-RX-API-DMAC7.html) * 1972-04-04 1975-11-28 Wander Ag Dr A
US3962248A (en) * 1972-04-04 1976-06-08 Sandoz, Inc. Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
SU629879A3 (ru) * 1974-11-26 1978-10-25 Лилли Индастриз Лимитед, (Фирма) Способ получени тиено(1,5) бензодиазепинов или их солей
US4061752A (en) * 1975-08-06 1977-12-06 Sandoz Ltd. 6-Piperazino-11-methylene-dibenzazepines[b,e]
DE2641378A1 (de) * 1975-09-24 1977-04-07 Sandoz Ag Neue organische verbindungen, ihre verwendung und herstellung
CH624682A5 (cg-RX-API-DMAC7.html) * 1976-11-10 1981-08-14 Sandoz Ag
US4761411A (en) * 1983-05-18 1988-08-02 Hoechst-Roussel Pharmaceuticals Inc. Dihydrobenzopyrrolobenzodiazepines useful for treating pyschoses
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
NO305125B1 (no) 1999-04-06
DK0582368T3 (da) 2001-02-05
CZ102493A3 (en) 1993-12-15
DE69329887T2 (de) 2001-05-23
FI101538B1 (fi) 1998-07-15
JP3219541B2 (ja) 2001-10-15
IL105827A0 (en) 1993-09-22
EP0582368A1 (en) 1994-02-09
CN1085903A (zh) 1994-04-27
AU3980793A (en) 1993-12-02
HU9301579D0 (en) 1993-09-28
CN1043994C (zh) 1999-07-07
NO931917L (no) 1993-11-30
MY109943A (en) 1997-10-31
TW268005B (cg-RX-API-DMAC7.html) 1996-01-11
GR3035587T3 (en) 2001-06-29
RU2125574C1 (ru) 1999-01-27
HUT66180A (en) 1994-09-28
NZ247703A (en) 1995-07-26
FI932445A0 (fi) 1993-05-28
HU218278B (en) 2000-07-28
JPH0687862A (ja) 1994-03-29
NO931917D0 (no) 1993-05-26
CA2097016A1 (en) 1993-11-30
CZ282783B6 (cs) 1997-10-15
PT582368E (pt) 2001-05-31
MX9303124A (es) 1993-11-01
ES2153373T3 (es) 2001-03-01
IL105827A (en) 1997-02-18
EP0582368B1 (en) 2001-01-24
FI932445L (fi) 1993-11-30
DE69329887D1 (de) 2001-03-01
ATE198891T1 (de) 2001-02-15
AU668159B2 (en) 1996-04-26

Similar Documents

Publication Publication Date Title
FI101538B (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten 2-metyyli-4-(4-mety yli-1-piperatsinyyli)-10H-tieno£2,3-b|£1,5|bentsodiatsepiinijohdannais ten valmistamiseksi
SE9703205D0 (sv) Ny kristallform av 2-metyl-4-(4-metyl-1-piperazinyl)-10H-tieno (2,3-b) (1,5)bensodiazepin och framställning därav
FR2511678B1 (fr) Derives de carbapeneme, leur procede de preparation et leur application en therapeutique
HU906402D0 (en) Process for producing tricyclic carbapeneme derivatives an pharmaceutical preparatives containing these compounds as active substance
EP0255908A3 (en) 7-ûû3-(aminomethyl)-3-alkyl¨-1-pyrrolidinyl¨-quinoline-carboxylic acid-derivatives and pharmaceutical compositions containing them
AU636351B2 (en) N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments
AU7124391A (en) Condensed thiazole compounds, their production and use
AU630575B2 (en) Benzodiazepine derivatives
HUT55397A (en) Process for producing mevalonic acid derivatives comprising thienopyridine ring and pharmaceutical compositions containing such active ingredient
FI92932B (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1,3a,8-trimetyylipyrrolo/2,3-b/indol-5-yyli-karbonaattiestereiden valmistamiseksi
FI102178B (fi) Menetelmä terapeuttisesti käyttökelpoisten 1,2,3,3a,8,8a-heksahydro-1, 3a,8-trimetyylipyrrolo£2,3-b|indol-5-yylijohdannaisten valmistamiseksi
DK0594099T3 (da) Fremgangsmåde til rensning af rå clavulansyre
ES2051996T3 (es) Producto farmaceutico.
FI103885B1 (fi) Menetelmä terapeuttisesti aktiivisten 1-bentsyyli-4-fenyylipiperatsiinijohdannaisten valmistamiseksi ja välituotteina käyttökelpoisia yhdisteitä
FR2639944B1 (fr) Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FI104078B (fi) Menetelmä terapeuttisesti käyttökelpoisten (3-(1-piperatsinyyli)tieno£2,3-b|- ja -£2,3-c|pyridiinijohdannaisten valmistamiseksi
AU657423B2 (en) Novel piperidine derivatives and process for preparation thereof
FR2710911B1 (fr) Nouveaux intermédiaires de préparation de la vitamine A et des caroténoïdes et leur procédé de préparation.
CA2112980A1 (fr) Procede de preparation de l'isomere dextrogyre d'un derive de l'isoindolinone
KR937000511A (ko) 신규한 화합물
JO1870B1 (en) CO2 derivatives - pyridinyl benzimidazole innovative