ES8801239A1 - Un procedimiento para la preparacion de derivados de naftaleno - Google Patents

Un procedimiento para la preparacion de derivados de naftaleno

Info

Publication number
ES8801239A1
ES8801239A1 ES557052A ES557052A ES8801239A1 ES 8801239 A1 ES8801239 A1 ES 8801239A1 ES 557052 A ES557052 A ES 557052A ES 557052 A ES557052 A ES 557052A ES 8801239 A1 ES8801239 A1 ES 8801239A1
Authority
ES
Spain
Prior art keywords
preparation
pharmaceutical composition
composition containing
containing same
naphthalene derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557052A
Other languages
English (en)
Other versions
ES557052A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Publication of ES557052A0 publication Critical patent/ES557052A0/es
Publication of ES8801239A1 publication Critical patent/ES8801239A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/94—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of polycyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92—Naphthofurans; Hydrogenated naphthofurans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/33—Polycyclic acids
    • C07C63/337—Polycyclic acids with carboxyl groups bound to condensed ring systems
    • C07C63/34—Polycyclic acids with carboxyl groups bound to condensed ring systems containing two condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/70—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with ring systems containing two or more relevant rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Abstract

METODO DE PREPARAR DERIVADOS DE NAFTALENO. CONSISTE EN TRATAR UN COMPUESTO DE FORMULA (II) DONDE R5 Y R6 SON CADA UNO DE ELLOS UN GRUPO ALQUILO INFERIOR, CON UN AGENTE REDUCTOR EN UN DISOLVENTE Y A UNA TEMPERATURA ENTRE 0JC Y LA TEMPERATURA DE REFLUJO, PARA OBTENER DERIVADOS DE NAFTALENO DE FORMULA (I), DONDE R3 Y R4 SON CADA UNO DE ELLOS UN GRUPO ALCOXI INFERIOR Y H; Y EL ANILLO A ES UN ANILLO BENCENICO QUE PUEDE ESTAR SUSTITUIDO O NO SUSTITUIDO. TIENEN PROPIEDADES FARMACOLOGICAS COMO AGENTES HIPOLIPIDEMICOS.
ES557052A 1985-01-10 1986-09-03 Un procedimiento para la preparacion de derivados de naftaleno Expired ES8801239A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP309085 1985-01-10

Publications (2)

Publication Number Publication Date
ES557052A0 ES557052A0 (es) 1987-12-16
ES8801239A1 true ES8801239A1 (es) 1987-12-16

Family

ID=11547645

Family Applications (2)

Application Number Title Priority Date Filing Date
ES550578A Expired ES8705837A1 (es) 1985-01-10 1985-12-30 Un procedimiento para la preparacion de derivados de naftaleno.
ES557052A Expired ES8801239A1 (es) 1985-01-10 1986-09-03 Un procedimiento para la preparacion de derivados de naftaleno

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES550578A Expired ES8705837A1 (es) 1985-01-10 1985-12-30 Un procedimiento para la preparacion de derivados de naftaleno.

Country Status (18)

Country Link
US (2) US4771072A (es)
EP (1) EP0188248B1 (es)
JP (3) JPS61267541A (es)
KR (1) KR890001884B1 (es)
CN (1) CN1006464B (es)
AT (1) ATE54441T1 (es)
AU (1) AU584153B2 (es)
BG (2) BG45385A3 (es)
DD (1) DD270529A5 (es)
DE (1) DE3672501D1 (es)
ES (2) ES8705837A1 (es)
FI (1) FI87557C (es)
HU (1) HU196737B (es)
IL (1) IL91117A0 (es)
MY (1) MY101268A (es)
NO (1) NO170760C (es)
PH (1) PH22105A (es)
PT (1) PT81814B (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4644072A (en) * 1985-04-12 1987-02-17 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
US5011948A (en) * 1985-04-12 1991-04-30 Bristol-Myers Company Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof
JPS6310746A (ja) * 1986-07-01 1988-01-18 Tanabe Seiyaku Co Ltd ナフタレン誘導体
AT388372B (de) * 1987-10-08 1989-06-12 Tanabe Seiyaku Co Neue naphthalinderivate und sie enthaltende pharmazeutika
JPH01135766A (ja) * 1987-11-20 1989-05-29 Tanabe Seiyaku Co Ltd ビフェニル誘導体
PH26342A (en) * 1988-11-29 1992-04-29 Univ Texas Microbial cellulose modified during synthesis
MY105057A (en) * 1989-01-27 1994-07-30 Tanabe Seiyaku Co A process for preparing naphthalene derivatives
US5003087A (en) * 1989-02-03 1991-03-26 Tanabe Seiyaku Co., Ltd. Process for preparing a naphthalene derivative and a synthetic intermediate thereof
EP0501578A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
US5281720A (en) * 1991-02-28 1994-01-25 Merck Frosst Canada, Inc. Pyranylphenyl hydroxyalkylnaphthoic acids as inhibitors of leukotriene biosynthesis
EP0501579A1 (en) * 1991-02-28 1992-09-02 Merck Frosst Canada Inc. Naphthalene lactones as inhibitors of leukotriene biosynthesis
US5227399A (en) * 1991-02-28 1993-07-13 Merck Frosst Canada, Inc. Pyranylphenyl naphthalene lactones as inhibitors of leukotriene biosynthesis
KR100252428B1 (ko) * 1991-10-17 2000-04-15 시오노 요시히코 리그난유사체,이의제조방법및이를함유한항지혈증제
US5308852A (en) * 1992-06-29 1994-05-03 Merck Frosst Canada, Inc. Heteroarylnaphthalenes as inhibitors of leukotriene biosynthesis
US5428060A (en) * 1992-08-27 1995-06-27 Merck Frosst Canada, Inc. Heteroarylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5426109A (en) * 1992-08-27 1995-06-20 Merck Frosst Canada, Inc. Phenylnaphthalene hydroxy acids
US5350744A (en) * 1992-08-27 1994-09-27 Merck Frosst Canada, Inc. Phenylnaphthalene lactones as inhibitors of leukotriene biosynthesis
US5252599A (en) * 1992-08-27 1993-10-12 Merck Frosst Canada, Inc. Heteroarylnaphthalene hydroxy acids as inhibitors of leukotriene biosynthesis
CA2121060C (en) * 1993-04-16 2004-04-06 Sachio Mori Preparation of lignan analogues
ID18046A (id) * 1996-08-20 1998-02-19 Takeda Chemical Industries Ltd Senyawa siklik campuran, pembuatan dan penngunaannya.
AU5578099A (en) * 1998-08-25 2000-03-14 National Taiwan University Inhibition and treatment of hepatitis b virus and flavivirus by helioxanthin andits analogs
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
JP2003500432A (ja) 1999-06-01 2003-01-07 ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター ジフェニルエーテル誘導体を用いて脱毛症を処置する方法
MXPA01012494A (es) 1999-06-01 2002-07-02 Univ Texas Southwestern Med Ct Metodo para tratar perdida capilar con el uso de compuestos sulfonil tiromimeticos.
SE0102168D0 (sv) * 2001-06-19 2001-06-19 Karolinska Innovations Ab New use and new compounds
HUP0401696A2 (hu) * 2001-08-28 2004-11-29 Sankyo Co., Ltd. Angiotenzin-II receptor antagonistát tartalmazó gyógyászati készítmény
GB0307918D0 (en) 2003-04-05 2003-05-14 Astrazeneca Ab Therapeutic use
EP2575821B1 (en) 2010-05-26 2015-08-12 Satiogen Pharmaceuticals, Inc. Bile acid recycling inhibitors and satiogens for treatment of diabetes, obesity, and inflammatory gastrointestinal conditions
EA029581B1 (ru) 2011-10-28 2018-04-30 ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита
CN107375932B (zh) 2011-10-28 2021-12-21 夏尔人类遗传性治疗公司 用于治疗小儿胆汁淤积性肝病的胆汁酸再循环抑制剂
CA2907230A1 (en) 2013-03-15 2014-09-18 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of primary sclerosing cholangitis and inflammatory bowel disease
EP2968262A1 (en) 2013-03-15 2016-01-20 Lumena Pharmaceuticals, Inc. Bile acid recycling inhibitors for treatment of barrett's esophagus and gastroesophageal reflux disease
US20170119806A1 (en) * 2014-03-31 2017-05-04 Ohio State Innovation Foundation Arylnaphthalene lactone derivatives and methods of making and using thereof
US10682367B2 (en) 2016-02-26 2020-06-16 Ohio State Innovation Foundation Antitumor arylnaphthalene ligand glycosides
MX2021009622A (es) 2019-02-12 2021-11-04 Mirum Pharmaceuticals Inc Metodos para tratar la colestasis.

Also Published As

Publication number Publication date
PT81814A (en) 1986-02-01
JPH0272170A (ja) 1990-03-12
NO170760C (no) 1992-12-02
KR860005778A (ko) 1986-08-13
NO855355L (no) 1986-07-11
PT81814B (pt) 1988-07-29
NO170760B (no) 1992-08-24
JPH0272136A (ja) 1990-03-12
HU196737B (en) 1989-01-30
CN86100090A (zh) 1986-08-20
IL91117A0 (en) 1990-03-19
KR890001884B1 (ko) 1989-05-29
ES557052A0 (es) 1987-12-16
US4771072A (en) 1988-09-13
BG45385A3 (es) 1989-05-15
CN1006464B (zh) 1990-01-17
JPS61267541A (ja) 1986-11-27
EP0188248A3 (en) 1986-12-17
DD270529A5 (de) 1989-08-02
US5070103A (en) 1991-12-03
HUT42428A (en) 1987-07-28
AU5175185A (en) 1986-07-17
PH22105A (en) 1988-06-01
FI860089A (fi) 1986-07-11
JPH0549668B2 (es) 1993-07-26
FI87557C (fi) 1993-01-25
BG45383A3 (es) 1989-05-15
ES8705837A1 (es) 1987-05-16
AU584153B2 (en) 1989-05-18
ES550578A0 (es) 1987-05-16
ATE54441T1 (de) 1990-07-15
DE3672501D1 (de) 1990-08-16
MY101268A (en) 1991-08-17
FI860089A0 (fi) 1986-01-09
EP0188248B1 (en) 1990-07-11
FI87557B (fi) 1992-10-15
EP0188248A2 (en) 1986-07-23

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401