ES8707424A1 - Un procedimiento para encapsular un compuesto organico cuya solubilidad es mayor en un primer disolvente que en un se- gundo disolvente - Google Patents
Un procedimiento para encapsular un compuesto organico cuya solubilidad es mayor en un primer disolvente que en un se- gundo disolventeInfo
- Publication number
- ES8707424A1 ES8707424A1 ES550244A ES550244A ES8707424A1 ES 8707424 A1 ES8707424 A1 ES 8707424A1 ES 550244 A ES550244 A ES 550244A ES 550244 A ES550244 A ES 550244A ES 8707424 A1 ES8707424 A1 ES 8707424A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- encapsulating material
- encapsulation
- solvent
- small particle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5089—Processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/06—Making microcapsules or microballoons by phase separation
- B01J13/10—Complex coacervation, i.e. interaction of oppositely charged particles
Abstract
PROCEDIMIENTO PARA EL ENCAPSULADO DE UN COMPUESTO ORGANICO CUYA SOLUBILIDAD ES MAYOR EN UN PRIMER DISOLVENTE QUE EN UN SEGUNDO DISOLVENTE.COMPRENDE LAS OPERACIONES DE DISOLVER EL COMPUESTO EN CUESTION EN UN PRIMER DISOLVENTE; EN PREPARAR UNA SOLUCION DE UN MATERIAL DE ENCAPSULACION Y UN ELECTROLITO EN UN SEGUNDO DISOLVENTE, EL CUAL ES MISCIBLE CON EL PRIMER DISOLVENTE Y EN EL QUE EL COMPUESTO QUE HA DE ENCAPSULARSE ES MAS O MENOS INSOLUBLE; EN MEZCLAR LAS SOLUCIONES PROCEDENTES DE LAS OPERACIONES ANTERIORES, MIENTRAS SE AGITA, PARA PRODUCIR LA PRECIPITACION SIMULTANEA DEL COMPUESTO EN FORMA DE PEQUEÑAS PARTICULAS Y LA FORMACION DE UN COACERVATO DEL MATERIAL DE ENCAPSULACION; Y EN GELIFICAR EL MATERIAL DE ENCAPSULACION.DE APLICACION EN LA PREPARACION DE COMPUESTOS FARMACEUTICOS ACTIVOS, ENCAPSULADOS Y FACILMENTE SOLUBLES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/684,457 US4606940A (en) | 1984-12-21 | 1984-12-21 | Small particle formation and encapsulation |
Publications (2)
Publication Number | Publication Date |
---|---|
ES550244A0 ES550244A0 (es) | 1987-08-01 |
ES8707424A1 true ES8707424A1 (es) | 1987-08-01 |
Family
ID=24748123
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES550244A Expired ES8707424A1 (es) | 1984-12-21 | 1985-12-20 | Un procedimiento para encapsular un compuesto organico cuya solubilidad es mayor en un primer disolvente que en un se- gundo disolvente |
Country Status (18)
Country | Link |
---|---|
US (1) | US4606940A (es) |
EP (1) | EP0207134B1 (es) |
JP (1) | JPH0611395B2 (es) |
KR (1) | KR930001803B1 (es) |
AT (1) | ATE109974T1 (es) |
AU (1) | AU588275B2 (es) |
CA (1) | CA1239838A (es) |
DE (1) | DE3587908T2 (es) |
DK (1) | DK171772B1 (es) |
ES (1) | ES8707424A1 (es) |
FI (1) | FI83391C (es) |
HU (1) | HU204695B (es) |
IL (1) | IL77184A (es) |
MY (1) | MY100084A (es) |
NO (1) | NO173124C (es) |
NZ (1) | NZ214598A (es) |
PH (1) | PH21226A (es) |
WO (1) | WO1986003676A1 (es) |
Families Citing this family (80)
Publication number | Priority date | Publication date | Assignee | Title |
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SE458576B (sv) * | 1985-06-20 | 1989-04-17 | Lejus Medical Ab | Foerfarande foer framstaellning av en guar-gum produkt |
SE459005B (sv) * | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
DE3615043A1 (de) * | 1986-05-03 | 1987-11-05 | Hoechst Ag | Verfahren zur verkapselung von biologisch aktivem material |
FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
US4975270A (en) * | 1987-04-21 | 1990-12-04 | Nabisco Brands, Inc. | Elastomer encased active ingredients |
US6056992A (en) * | 1988-06-02 | 2000-05-02 | Campbell Soup Company | Encapsulated additives |
US5229148A (en) * | 1989-04-19 | 1993-07-20 | Wm. Wrigley Jr. Company | Method of combining active ingredients with polyvinyl acetates |
US5198251A (en) * | 1989-04-19 | 1993-03-30 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
US5154939A (en) * | 1989-04-19 | 1992-10-13 | Wm. Wrigley Jr. Company | Use of salt to improve extrusion encapsulation of chewing gum ingredients |
US5165944A (en) * | 1989-04-19 | 1992-11-24 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
US4978537A (en) * | 1989-04-19 | 1990-12-18 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
US5108762A (en) * | 1989-04-19 | 1992-04-28 | Wm. Wrigley Jr. Company | Gradual release structures for chewing gum |
US5153029A (en) * | 1989-08-11 | 1992-10-06 | Eastman Kodak Company | Solid-form additive systems dispersible in aqueous media, methods for the preparation and application thereof to polymeric particles |
US5300256A (en) * | 1989-08-11 | 1994-04-05 | Eastman Chemical Company | Solid-form additive systems dispersible in aqueous media |
US5089271A (en) * | 1989-09-18 | 1992-02-18 | Smithkline Beecham Corporation | Stabilized antibiotic compositions for animal feeding |
FI904598A0 (fi) * | 1989-10-10 | 1990-09-18 | Wrigley W M Jun Co | Gradvis aemnesfrigoerande strukturer som framstaellts med fiberspinningsteknik. |
US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
SE8903914D0 (sv) | 1989-11-22 | 1989-11-22 | Draco Ab | Oral composition for the treatment of inflammatory bowel diseases |
US5132117A (en) * | 1990-01-11 | 1992-07-21 | Temple University | Aqueous core microcapsules and method for their preparation |
US5128155A (en) * | 1990-12-20 | 1992-07-07 | Wm. Wrigley Jr. Company | Flavor releasing structures for chewing gum |
US5252337A (en) * | 1991-06-25 | 1993-10-12 | Eurand America, Inc. | Controlled release calcium channel blocker microcapsules |
US6090925A (en) * | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US5981719A (en) * | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6531156B1 (en) | 1994-04-15 | 2003-03-11 | Temple University | Aqueous solven encapsulation method, apparatus and microcapsules |
SE9403846D0 (sv) * | 1994-11-09 | 1994-11-09 | Univ Ohio State Res Found | Small particle formation |
US5686113A (en) * | 1995-03-21 | 1997-11-11 | Temple University Of The Commonwealth System Of Higher Education | Microcapsules of predetermined peptide(s) specificity (ies), their preparation and uses |
EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
US20040224327A1 (en) * | 1996-10-30 | 2004-11-11 | Meulenberg Johanna Jacoba Maria | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
CA2290220C (en) | 1998-12-22 | 2013-11-19 | Pfizer Products Inc. | An infectious cdna clone of north american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof |
US7132106B2 (en) * | 1998-12-22 | 2006-11-07 | Pfizer Inc. | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7691389B2 (en) | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
US7618797B2 (en) * | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
DK1035133T3 (da) * | 1999-02-17 | 2005-05-02 | Pfizer Prod Inc | Fusionsproteiner, der omfatter bærere, som kan inducere et dobbelt immunrespons |
EP1157121B1 (en) * | 1999-03-08 | 2013-04-24 | Boehringer Ingelheim Vetmedica GmbH | Prrsv replicon |
AU4482200A (en) * | 1999-04-22 | 2000-11-10 | United States Department Of Agriculture | Porcine reproductive and respiratory syndrome vaccine, based on isolate ja-142 |
SE9901667D0 (sv) | 1999-05-07 | 1999-05-07 | Astra Ab | Method and device for forming particles |
US6544646B2 (en) | 2000-04-27 | 2003-04-08 | Verion Inc. | Zero order release and temperature-controlled microcapsules and process for the preparation thereof |
US8067032B2 (en) * | 2000-12-22 | 2011-11-29 | Baxter International Inc. | Method for preparing submicron particles of antineoplastic agents |
US6607784B2 (en) * | 2000-12-22 | 2003-08-19 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US20040022862A1 (en) * | 2000-12-22 | 2004-02-05 | Kipp James E. | Method for preparing small particles |
US6977085B2 (en) * | 2000-12-22 | 2005-12-20 | Baxter International Inc. | Method for preparing submicron suspensions with polymorph control |
US7193084B2 (en) * | 2000-12-22 | 2007-03-20 | Baxter International Inc. | Polymorphic form of itraconazole |
US6884436B2 (en) * | 2000-12-22 | 2005-04-26 | Baxter International Inc. | Method for preparing submicron particle suspensions |
US20050048126A1 (en) | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
US6951656B2 (en) * | 2000-12-22 | 2005-10-04 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
US9700866B2 (en) | 2000-12-22 | 2017-07-11 | Baxter International Inc. | Surfactant systems for delivery of organic compounds |
US20030072807A1 (en) * | 2000-12-22 | 2003-04-17 | Wong Joseph Chung-Tak | Solid particulate antifungal compositions for pharmaceutical use |
US20040256749A1 (en) * | 2000-12-22 | 2004-12-23 | Mahesh Chaubal | Process for production of essentially solvent-free small particles |
JP4376518B2 (ja) * | 2000-12-22 | 2009-12-02 | バクスター・インターナショナル・インコーポレイテッド | サブミクロン粒子の懸濁物を調製する方法 |
US6878309B2 (en) * | 2001-02-12 | 2005-04-12 | Dober Chemical Corp. | Controlled release cooling additive composition |
AU2002337692B2 (en) | 2001-09-26 | 2007-09-13 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
US20060003012A9 (en) * | 2001-09-26 | 2006-01-05 | Sean Brynjelsen | Preparation of submicron solid particle suspensions by sonication of multiphase systems |
US7112340B2 (en) | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
JP2007520555A (ja) * | 2004-02-05 | 2007-07-26 | バクスター・インターナショナル・インコーポレイテッド | 自己安定化剤の使用により調製された分散剤 |
TW200604526A (en) * | 2004-06-18 | 2006-02-01 | Unviersity Of Minnesota | Identifying virally infected and vaccinated organisms |
US7632636B2 (en) * | 2004-09-21 | 2009-12-15 | Boehringer Ingelheim Vetmedica, Inc. | Porcine reproductive and respiratory syndrome isolates and methods of use |
PT1904631E (pt) | 2005-06-24 | 2012-07-16 | Univ Minnesota | Vírus srrp, clones infecciosos, os seus mutantes e processos de utilização |
US8722736B2 (en) | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
US8426467B2 (en) | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
US20100028503A1 (en) * | 2008-07-30 | 2010-02-04 | Jimbay Peter Loh | Simultaneous Multiple Acervation Process |
US20110117129A1 (en) * | 2008-08-25 | 2011-05-19 | Boehringer Ingelheim Vetmedica, Inc. | Vaccine Against Highly Pathogenic Porcine Reproductive and Respiratory Syndrome (HP PRRS) |
WO2010044889A2 (en) * | 2008-10-16 | 2010-04-22 | Pfizer Inc. | Torque teno virus (ttv) isolates and compositions |
TWI627281B (zh) * | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低pcv-2組合物殺病毒活性之方法及具有改良免疫原性之pcv-2組合物 |
US8846388B2 (en) | 2009-10-16 | 2014-09-30 | Zoetis Llc | Infectious clones of torque teno virus |
UA108902C2 (uk) | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
MX346636B (es) | 2011-02-17 | 2017-03-27 | Boehringer Ingelheim Vetmedica Gmbh | Procedimiento para la produccion a escala comercial de prrsv. |
DK2675475T3 (en) | 2011-02-17 | 2015-09-14 | Boehringer Ingelheim Vetmed | NEW EUROPEAN PRRSV TRIAL |
WO2012168818A1 (en) | 2011-06-08 | 2012-12-13 | Ah Usa 42 Llc | Infectious clones of torque teno virus |
WO2013017570A1 (en) | 2011-07-29 | 2013-02-07 | Boehringer Ingelheim Vetmedica Gmbh | Novel prrs virus inducing type i interferon in susceptible cells |
US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
JP6386999B2 (ja) | 2012-05-17 | 2018-09-05 | ゾエティス・エルエルシー | ブタ生殖および呼吸症候群(prrs)ウイルスに対する離乳前の効果的なワクチン接種 |
CN105073130A (zh) | 2013-03-15 | 2015-11-18 | 勃林格殷格翰动物保健公司 | 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法 |
JP2013231185A (ja) * | 2013-06-12 | 2013-11-14 | Pfizer Products Inc | ヒドロキシプロピルメチルセルロース硬カプセルおよび製造方法 |
CA3018328A1 (en) | 2014-10-31 | 2016-04-30 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
US11013798B2 (en) | 2016-03-21 | 2021-05-25 | South Dakota Board Of Regents | Orf virus-based platform for vaccine delivery |
WO2018112169A2 (en) | 2016-12-14 | 2018-06-21 | Zoetis Services Llc | Effective vaccination against european strains of porcine reproductive and respiratory syndrome (prrs) virus prior to weaning |
US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
CN114315985A (zh) | 2020-09-29 | 2022-04-12 | 硕腾服务有限责任公司 | 减毒猪流行性腹泻病毒 |
CN115216451A (zh) | 2021-04-16 | 2022-10-21 | 硕腾服务有限责任公司 | 伪狂犬病病毒疫苗 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3037849A (en) * | 1958-08-06 | 1962-06-05 | Fmc Corp | Method for crystallizing a sodium carbonate |
US3242051A (en) * | 1958-12-22 | 1966-03-22 | Ncr Co | Coating by phase separation |
US3043782A (en) * | 1958-12-22 | 1962-07-10 | Upjohn Co | Process for preparing a more impermeable coating by liquid-liquid phase separation |
US3533958A (en) * | 1966-07-22 | 1970-10-13 | Ncr Co | Process for making minute capsules |
US3574132A (en) * | 1968-01-12 | 1971-04-06 | Benjamin Mosier | Process of encapsulating basic nitrogen compounds with alkali-precursor gelatin |
US3725014A (en) * | 1971-04-21 | 1973-04-03 | Allied Chem | Sodium carbonate crystallization process with foam prevention |
AT324281B (de) * | 1973-09-11 | 1975-08-25 | Spiegel Paul Dr Et Mr | Verfahren zur herstellung von gelatine-mikrokapseln mit flüssigem bzw. festem inhalt |
SU676316A1 (ru) * | 1978-03-24 | 1979-07-30 | Киевский Ордена Ленина Государственный Университет Им.Т.Г.Шевченко | Способ получени микрокапсул |
IT1148784B (it) * | 1980-04-09 | 1986-12-03 | Eurand Spa | Procedimento per la preparazione di microcapsule in un veicolo liquido |
EP0130162B1 (en) * | 1983-06-22 | 1987-09-09 | The Ohio State University Research Foundation | Small particle formation and encapsulation |
-
1984
- 1984-12-21 US US06/684,457 patent/US4606940A/en not_active Expired - Lifetime
-
1985
- 1985-11-29 IL IL77184A patent/IL77184A/xx not_active IP Right Cessation
- 1985-12-17 JP JP61500308A patent/JPH0611395B2/ja not_active Expired - Lifetime
- 1985-12-17 EP EP86900510A patent/EP0207134B1/en not_active Expired - Lifetime
- 1985-12-17 KR KR1019860700590A patent/KR930001803B1/ko not_active IP Right Cessation
- 1985-12-17 NZ NZ214598A patent/NZ214598A/xx unknown
- 1985-12-17 AU AU53075/86A patent/AU588275B2/en not_active Ceased
- 1985-12-17 HU HU86557A patent/HU204695B/hu not_active IP Right Cessation
- 1985-12-17 AT AT86900510T patent/ATE109974T1/de not_active IP Right Cessation
- 1985-12-17 WO PCT/US1985/002492 patent/WO1986003676A1/en active IP Right Grant
- 1985-12-17 DE DE3587908T patent/DE3587908T2/de not_active Expired - Fee Related
- 1985-12-18 CA CA000497981A patent/CA1239838A/en not_active Expired
- 1985-12-20 PH PH33231A patent/PH21226A/en unknown
- 1985-12-20 ES ES550244A patent/ES8707424A1/es not_active Expired
-
1986
- 1986-07-29 DK DK359186A patent/DK171772B1/da not_active IP Right Cessation
- 1986-08-14 NO NO863286A patent/NO173124C/no unknown
- 1986-08-20 FI FI863372A patent/FI83391C/fi not_active IP Right Cessation
-
1987
- 1987-09-28 MY MYPI87001998A patent/MY100084A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO863286D0 (no) | 1986-08-14 |
FI863372A (fi) | 1986-08-20 |
ATE109974T1 (de) | 1994-09-15 |
ES550244A0 (es) | 1987-08-01 |
DK359186D0 (da) | 1986-07-29 |
NO173124C (no) | 1993-11-03 |
PH21226A (en) | 1987-08-21 |
CA1239838A (en) | 1988-08-02 |
MY100084A (en) | 1989-08-18 |
AU5307586A (en) | 1986-07-22 |
KR930001803B1 (ko) | 1993-03-13 |
NZ214598A (en) | 1989-02-24 |
JPS62501198A (ja) | 1987-05-14 |
DK359186A (da) | 1986-07-29 |
DE3587908D1 (de) | 1994-09-22 |
FI83391B (fi) | 1991-03-28 |
JPH0611395B2 (ja) | 1994-02-16 |
IL77184A (en) | 1989-08-15 |
HU204695B (en) | 1992-02-28 |
EP0207134B1 (en) | 1994-08-17 |
AU588275B2 (en) | 1989-09-14 |
DE3587908T2 (de) | 1995-01-05 |
FI863372A0 (fi) | 1986-08-20 |
NO863286L (no) | 1986-08-14 |
NO173124B (no) | 1993-07-26 |
IL77184A0 (en) | 1986-04-29 |
US4606940A (en) | 1986-08-19 |
EP0207134A1 (en) | 1987-01-07 |
WO1986003676A1 (en) | 1986-07-03 |
DK171772B1 (da) | 1997-05-20 |
KR870700017A (ko) | 1987-02-28 |
HUT40912A (en) | 1987-03-30 |
FI83391C (fi) | 1991-07-10 |
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