ES8707223A1 - Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofen. - Google Patents

Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofen.

Info

Publication number
ES8707223A1
ES8707223A1 ES541336A ES541336A ES8707223A1 ES 8707223 A1 ES8707223 A1 ES 8707223A1 ES 541336 A ES541336 A ES 541336A ES 541336 A ES541336 A ES 541336A ES 8707223 A1 ES8707223 A1 ES 8707223A1
Authority
ES
Spain
Prior art keywords
image
group
alkoxy
hydroxy
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES541336A
Other languages
English (en)
Spanish (es)
Other versions
ES541336A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo NV filed Critical Akzo NV
Publication of ES8707223A1 publication Critical patent/ES8707223A1/es
Publication of ES541336A0 publication Critical patent/ES541336A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
ES541336A 1984-03-16 1985-03-15 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofen. Expired ES8707223A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB848406906A GB8406906D0 (en) 1984-03-16 1984-03-16 Benzo-thiazole and benzothiophene derivatives

Publications (2)

Publication Number Publication Date
ES8707223A1 true ES8707223A1 (es) 1987-07-16
ES541336A0 ES541336A0 (es) 1987-07-16

Family

ID=10558202

Family Applications (4)

Application Number Title Priority Date Filing Date
ES541336A Expired ES8707223A1 (es) 1984-03-16 1985-03-15 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofen.
ES551281A Expired ES8704926A1 (es) 1984-03-16 1986-01-27 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
ES551280A Expired ES8704925A1 (es) 1984-03-16 1986-01-27 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
ES551282A Expired ES8704924A1 (es) 1984-03-16 1986-01-27 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES551281A Expired ES8704926A1 (es) 1984-03-16 1986-01-27 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
ES551280A Expired ES8704925A1 (es) 1984-03-16 1986-01-27 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno
ES551282A Expired ES8704924A1 (es) 1984-03-16 1986-01-27 Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno

Country Status (14)

Country Link
US (2) US4665206A (cg-RX-API-DMAC10.html)
EP (1) EP0158380B1 (cg-RX-API-DMAC10.html)
JP (1) JPS60209577A (cg-RX-API-DMAC10.html)
KR (1) KR870000920B1 (cg-RX-API-DMAC10.html)
AU (1) AU568428B2 (cg-RX-API-DMAC10.html)
CA (1) CA1254216A (cg-RX-API-DMAC10.html)
DE (1) DE3567459D1 (cg-RX-API-DMAC10.html)
DK (1) DK119285A (cg-RX-API-DMAC10.html)
ES (4) ES8707223A1 (cg-RX-API-DMAC10.html)
FI (1) FI80883C (cg-RX-API-DMAC10.html)
GB (1) GB8406906D0 (cg-RX-API-DMAC10.html)
HU (1) HU198030B (cg-RX-API-DMAC10.html)
IE (1) IE57977B1 (cg-RX-API-DMAC10.html)
ZA (1) ZA851807B (cg-RX-API-DMAC10.html)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE58555B1 (en) * 1984-12-10 1993-10-06 Warner Almbert Company Novel benzothiophenes and benzofurans having antiallergy activity
EP0253650A3 (en) * 1986-07-18 1989-09-13 Eli Lilly And Company Improvements relating to benzothiophene derivatives
US4873259A (en) * 1987-06-10 1989-10-10 Abbott Laboratories Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds
US4822809A (en) * 1987-11-13 1989-04-18 Abbott Laboratories Benzazole lipoxygenase inhibiting compounds
US4882354A (en) * 1987-12-16 1989-11-21 Norwich Eaton Pharmaceuticals, Inc. N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents
DE68901424D1 (de) * 1988-07-05 1992-06-11 Akzo Nv Verbindungen mit bronchodilatatorischer aktivitaet.
US5276052A (en) * 1990-10-26 1994-01-04 Akzo N.V. Use of a benzo[b]thiopene-2-carboximidamide derivative
IE913683A1 (en) * 1990-10-26 1992-05-22 Akzo Nv USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE
DE4128871A1 (de) * 1991-08-30 1993-03-04 Boehringer Mannheim Gmbh Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel
US5340833A (en) * 1992-05-01 1994-08-23 Eisai Co., Ltd. Urokinase inhibitors
US5436246A (en) * 1992-09-17 1995-07-25 Merrell Dow Pharmaceuticals Inc. Serotonin receptor agents
US5789436A (en) * 1994-04-11 1998-08-04 Chugai Seiyak Kabushiki Kaisha 4,6 Di-t-butyl-5-hydroxy-2,3-dihydrobenzothiophene
US5703116A (en) * 1995-04-18 1997-12-30 Geron Corporation Telomerase Inhibitors
US5656638A (en) * 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5760062A (en) * 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5863936A (en) * 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5770613A (en) * 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) * 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
NZ336143A (en) * 1996-12-13 2002-05-31 Shionogi & Co Benzothiophenecarboxamide derivatives and pgd 2 antagonists comprising them
US6362216B1 (en) 1998-10-27 2002-03-26 Array Biopharma Inc. Compounds which inhibit tryptase activity
SK287231B6 (sk) 1999-08-21 2010-04-07 Nycomed Gmbh Liečivo zahŕňajúce PDE inhibítor a agonistu beta2 adrenoreceptora
MXPA03010679A (es) 2001-05-23 2004-03-02 Tanabe Seiyaku Co Una composicion para acelerar la cicatrizacion de fractura osea.
CN1537018A (zh) 2001-05-23 2004-10-13 田边制药株式会社 一种用于软骨疾病再生治疗的组合物
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
WO2004087211A2 (en) 2003-04-01 2004-10-14 Applied Research Systems Ars Holding N.V. Inhibitors of phosphodiesterases in infertility
US7935724B2 (en) 2003-10-09 2011-05-03 Merck Hdac Research, Llc Thiophene and benzothiophene hydroxamic acid derivatives
WO2006101454A1 (en) * 2005-03-21 2006-09-28 S*Bio Pte Ltd Benzothiophene derivatives: preparation and pharmaceutical applications
MY148644A (en) * 2005-07-18 2013-05-15 Orion Corp New pharmaceutical compounds
WO2007096362A1 (en) * 2006-02-21 2007-08-30 Trigen Limited Heterocyclic compounds and their use in the treatment of cardiovascular disease
ES2627221T3 (es) 2006-12-28 2017-07-27 Rigel Pharmaceuticals, Inc. Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2321341B1 (en) 2008-07-16 2017-02-22 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103764672A (zh) 2011-03-01 2014-04-30 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
US9545446B2 (en) 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
CN114404588A (zh) 2013-08-09 2022-04-29 阿德利克斯公司 用于抑制磷酸盐转运的化合物和方法
WO2020237096A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Combination for lowering serum phosphate in a patient
CN111296447B (zh) * 2020-03-24 2021-09-17 东营施普瑞石油工程技术有限公司 一种油田用杀菌剂及其制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB438211A (en) * 1934-06-01 1935-11-13 Ig Farbenindustrie Ag The manufacture of heterocyclic compounds
US2775593A (en) * 1948-10-01 1956-12-25 Schenley Ind Inc Thiosemicarbazones of aldehydes and ketones of the heterocyclic series
GB1229580A (cg-RX-API-DMAC10.html) * 1967-12-15 1971-04-28
BE759237A (fr) * 1969-11-21 1971-05-01 Montedison Spa Procede de preparation d'amides a partir de composes heterocycliques azotes
BE786520A (fr) * 1971-07-23 1973-01-22 Bayer Ag Nouveaux benzothiazoles substitues, leur preparation et leur application comme fongicides et bactericides
DE2258036A1 (de) * 1972-11-27 1974-05-30 Goedecke Ag Verfahren zur herstellung von benzo eckige klammer auf b eckige klammer zu thiophen-derivaten
FR2305982A1 (fr) * 1975-04-03 1976-10-29 Innothera Lab Sa Nouvelles benzothienyl amino (propyl et butyl) cetones, leur procede de preparation et leur application en therapeutique
DE2834945A1 (de) * 1977-08-15 1979-03-01 Lilly Co Eli Thiadiazolylbenzamide, verfahren zu ihrer herstellung und sie enthaltende insektizide mittel
US4140785A (en) * 1978-05-08 1979-02-20 E. I. Du Pont De Nemours And Company N-(benzothienopyrazol)amide antirhinoviral agents
JPS5936670A (ja) * 1982-08-25 1984-02-28 Takeda Chem Ind Ltd ベンゾチアゾ−ル誘導体，その製造法およびそれを含有する摂食抑制剤

Also Published As

Publication number Publication date
DK119285A (da) 1985-09-17
KR850006391A (ko) 1985-10-05
HU198030B (en) 1989-07-28
IE850592L (en) 1985-09-16
FI851038A0 (fi) 1985-03-15
ES8704926A1 (es) 1987-04-16
ES8704924A1 (es) 1987-04-16
ZA851807B (en) 1985-10-30
US4929636A (en) 1990-05-29
FI80883B (fi) 1990-04-30
ES8704925A1 (es) 1987-04-16
EP0158380B1 (en) 1989-01-11
GB8406906D0 (en) 1984-04-18
HUT37410A (en) 1985-12-28
ES541336A0 (es) 1987-07-16
ES551282A0 (es) 1987-04-16
EP0158380A1 (en) 1985-10-16
FI851038L (fi) 1985-09-17
ES551281A0 (es) 1987-04-16
DK119285D0 (da) 1985-03-15
JPS60209577A (ja) 1985-10-22
US4665206A (en) 1987-05-12
ES551280A0 (es) 1987-04-16
AU3985285A (en) 1985-09-19
AU568428B2 (en) 1987-12-24
DE3567459D1 (en) 1989-02-16
KR870000920B1 (ko) 1987-05-07
FI80883C (fi) 1990-08-10
JPH0588232B2 (cg-RX-API-DMAC10.html) 1993-12-21
IE57977B1 (en) 1993-06-02
CA1254216A (en) 1989-05-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020401