ES8707204A1 - Procedimiento para preparar diazepinoindoles - Google Patents

Procedimiento para preparar diazepinoindoles

Info

Publication number
ES8707204A1
ES8707204A1 ES555042A ES555042A ES8707204A1 ES 8707204 A1 ES8707204 A1 ES 8707204A1 ES 555042 A ES555042 A ES 555042A ES 555042 A ES555042 A ES 555042A ES 8707204 A1 ES8707204 A1 ES 8707204A1
Authority
ES
Spain
Prior art keywords
diazepinoindoles
useful
schizophrenia
anxiety
pharmaceutical compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES555042A
Other languages
English (en)
Other versions
ES555042A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8707204A1 publication Critical patent/ES8707204A1/es
Publication of ES555042A0 publication Critical patent/ES555042A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DIAZEPINOINDOLES.COMPRENDE: A) REDUCIR UN COMPUESTO DE FORMULA (II) CON DIBORANO, PARA OBTENER UN COMPUESTO DE FORMULA (III); B) DIMETILAR A (III) CON ESTER ETILICO, PARA OBTENER UN COMPUESTO DE FORMULA (IV); Y C) ALQUILAR A (IV) CON DERIVADOS N-ACILO, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SALES DE ADICION DE LOS MISMOS. SIENDO: R1 Y R2, H, ALQUILO DE C 1 A 3,5, HAL Y OTROS; RK3, H, ALQUILO DE C 1 A 3 Y OTROS; RL3, CICLOALQUILO DE C 3 A 6, ALQUILO DE C 1 A 3 Y OTROS; R4, R5 Y R6, H O ALQUILO DE C 1 A 4. SE UTILIZA PARA TRATAR LA ESQUIZOFRENIA.
ES555042A 1984-02-22 1986-05-16 Procedimiento para preparar diazepinoindoles Expired ES8707204A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH86384 1984-02-22

Publications (2)

Publication Number Publication Date
ES8707204A1 true ES8707204A1 (es) 1987-07-16
ES555042A0 ES555042A0 (es) 1987-07-16

Family

ID=4196936

Family Applications (2)

Application Number Title Priority Date Filing Date
ES540559A Expired ES8706681A1 (es) 1984-02-22 1985-02-20 Procedimiento para preparar diazepinoindoles.
ES555042A Expired ES8707204A1 (es) 1984-02-22 1986-05-16 Procedimiento para preparar diazepinoindoles

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES540559A Expired ES8706681A1 (es) 1984-02-22 1985-02-20 Procedimiento para preparar diazepinoindoles.

Country Status (23)

Country Link
US (1) US4673674A (es)
JP (1) JPS60202887A (es)
AT (1) AT388379B (es)
BE (1) BE901725A (es)
CA (1) CA1271193A (es)
DE (1) DE3505017A1 (es)
DK (1) DK78385A (es)
ES (2) ES8706681A1 (es)
FI (1) FI79316C (es)
FR (1) FR2609715B1 (es)
GB (1) GB2154584B (es)
GR (1) GR850443B (es)
HU (1) HU193083B (es)
IL (1) IL74388A (es)
IT (1) IT1199949B (es)
LU (1) LU85778A1 (es)
MY (1) MY100083A (es)
NL (1) NL8500370A (es)
PH (1) PH22247A (es)
PL (2) PL146274B1 (es)
PT (1) PT79990B (es)
SE (1) SE8500822L (es)
ZA (1) ZA851373B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3635071A1 (de) * 1986-10-15 1988-04-28 Autoflug Gmbh Rueckenlehnenverriegelung fuer einen mit sicherheitsgurten ausgeruesteten fahrzeugsitz
EP1328525A2 (en) * 2000-03-14 2003-07-23 PHARMACIA & UPJOHN COMPANY 2,3,4,5-tetrahydro-1h-[1,4]diazepino[1,7-a]indole compounds
HUE031380T2 (en) * 2005-06-27 2017-07-28 Glaxosmithkline Biologicals Sa A method for producing vaccines
HU230880B1 (hu) * 2015-04-15 2018-11-29 Richter Gedeon Nyrt Indol származékok

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives
US4210590A (en) * 1978-01-06 1980-07-01 Mcneil Laboratories, Incorporated Reduction of indole compounds to indoline compounds
CH649553A5 (de) * 1982-05-06 1985-05-31 Sandoz Ag Azepinoindole und verfahren zu deren herstellung.

Also Published As

Publication number Publication date
NL8500370A (nl) 1985-09-16
PH22247A (en) 1988-07-01
IT8547704A0 (it) 1985-02-20
IT8547704A1 (it) 1986-08-20
JPS60202887A (ja) 1985-10-14
ES540559A0 (es) 1987-06-16
SE8500822L (sv) 1985-08-23
SE8500822D0 (sv) 1985-02-20
ES8706681A1 (es) 1987-06-16
DK78385A (da) 1985-08-23
GB2154584B (en) 1987-09-30
ZA851373B (en) 1986-09-24
FI79316C (fi) 1989-12-11
IT1199949B (it) 1989-01-05
IL74388A (en) 1988-12-30
IL74388A0 (en) 1985-05-31
PT79990A (en) 1985-03-01
FI850702A0 (fi) 1985-02-20
DE3505017A1 (de) 1985-08-22
FI850702L (fi) 1985-08-23
DK78385D0 (da) 1985-02-20
FR2609715A1 (fr) 1988-07-22
CA1271193A (en) 1990-07-03
ES555042A0 (es) 1987-07-16
PL144329B1 (en) 1988-05-31
BE901725A (fr) 1985-08-13
GB2154584A (en) 1985-09-11
PT79990B (en) 1987-01-13
PL252065A1 (en) 1985-12-03
HUT38642A (en) 1986-06-30
GB8504179D0 (en) 1985-03-20
PL146274B1 (en) 1989-01-31
GR850443B (es) 1985-06-19
ATA52285A (de) 1988-11-15
AT388379B (de) 1989-06-12
MY100083A (en) 1989-08-18
FI79316B (fi) 1989-08-31
FR2609715B1 (fr) 1989-05-26
US4673674A (en) 1987-06-16
LU85778A1 (fr) 1985-12-11
HU193083B (en) 1987-08-28

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