ES8704868A1 - Procedimiento para la obtencion de nuevos derivados fenolicos - Google Patents

Procedimiento para la obtencion de nuevos derivados fenolicos

Info

Publication number
ES8704868A1
ES8704868A1 ES554611A ES554611A ES8704868A1 ES 8704868 A1 ES8704868 A1 ES 8704868A1 ES 554611 A ES554611 A ES 554611A ES 554611 A ES554611 A ES 554611A ES 8704868 A1 ES8704868 A1 ES 8704868A1
Authority
ES
Spain
Prior art keywords
group
pharmaceutical compositions
hydrogen
compounds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554611A
Other languages
English (en)
Other versions
ES554611A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruenenthal GmbH
Original Assignee
Gruenenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruenenthal GmbH filed Critical Gruenenthal GmbH
Publication of ES554611A0 publication Critical patent/ES554611A0/es
Publication of ES8704868A1 publication Critical patent/ES8704868A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C07C39/19—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring containing carbon-to-carbon double bonds but no carbon-to-carbon triple bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/18—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/88—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C07F9/5428—Acyclic unsaturated phosphonium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Signal Processing For Digital Recording And Reproducing (AREA)
  • Fixed Capacitors And Capacitor Manufacturing Machines (AREA)
  • Emergency Protection Circuit Devices (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA OBTENER NUEVOS DERIVADOS FENOLICOS. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN PRESENCIA DE UNA SAL DE COBRE, EN UN DISO/LVENTE APROTICO Y ENTRE C80 Y 75JC, PARA OBTENER COMPUESTOS DE FORMULA (I) Y SUS SALES DE TOLERANCIA FARMACEUTICA, SIENDO: A Y B IGUALES O DIFERENTES -CFC-, CIS-CHFCH Y OTROS; R1, H, ALQUILO DE C 1 A 6 Y OTROS; R2, H, METILO O ETILO; R9, ALQUILO DE C 1 A 4; R14, R9; R15, OR14; R16, N O R9; R17, GRUPO PROTECTOR; R18, BR O I Y ME ES UN ATOMO DE LITIO. TIENEN APLICACIONES FARMACEUTICAS COMO ANTIISQUEMICOS.
ES554611A 1985-05-24 1986-04-30 Procedimiento para la obtencion de nuevos derivados fenolicos Expired ES8704868A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19853518655 DE3518655A1 (de) 1985-05-24 1985-05-24 Neue phenolderivate, diese enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel

Publications (2)

Publication Number Publication Date
ES554611A0 ES554611A0 (es) 1987-04-16
ES8704868A1 true ES8704868A1 (es) 1987-04-16

Family

ID=6271506

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554611A Expired ES8704868A1 (es) 1985-05-24 1986-04-30 Procedimiento para la obtencion de nuevos derivados fenolicos

Country Status (17)

Country Link
US (2) US4760087A (es)
EP (1) EP0202529B1 (es)
JP (1) JPH0796507B2 (es)
KR (1) KR930001324B1 (es)
AT (1) ATE48591T1 (es)
CA (1) CA1272723A (es)
DD (1) DD251339A5 (es)
DE (2) DE3518655A1 (es)
DK (1) DK240086A (es)
ES (1) ES8704868A1 (es)
FI (1) FI88708C (es)
GR (1) GR860777B (es)
HU (1) HU196048B (es)
IL (1) IL78317A0 (es)
PT (1) PT82521B (es)
SU (1) SU1591800A3 (es)
ZA (1) ZA862432B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1230859B (it) * 1989-06-05 1991-11-08 Corvi Camillo Spa 2 alchinilfenoli sostituiti ad azione anti infiammatoria, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.
DE4120698A1 (de) * 1991-06-22 1992-12-24 Gruenenthal Gmbh Substituierte phenoxyalkanole und deren ester, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
US5981591A (en) * 1992-12-04 1999-11-09 Mayor Pharmaceutical Laboratories, Inc. Sprayable analgesic composition and method of use
US6767925B1 (en) 1996-10-31 2004-07-27 Joseph A. Deihl Sprayable analgesic composition and method of use
DE19845372A1 (de) 1998-10-02 2000-04-20 Gruenenthal Gmbh Verwendung von Katecholderivaten als Proteinaseninhibitoren

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3033668A (en) * 1958-03-27 1962-05-08 Dow Chemical Co Method for inhibiting nitrification of ammonium nitrogen in soil
US4393075A (en) * 1980-04-14 1983-07-12 Takeda Chemical Industries, Ltd. Quinone compounds and their use in suppressing the production of SRS-A in mammals
JPS56150014A (en) * 1980-04-21 1981-11-20 Takeda Chem Ind Ltd Antiallergic agent
DE3169761D1 (en) * 1981-01-09 1985-05-09 Fisons Plc Phenoxy- and thiophenoxy compounds, methods for their preparation and pharmaceutical formulations containing them
US4432906A (en) * 1981-09-14 1984-02-21 Hoffmann-La Roche Inc. Inhibitors of SRS-synthesis
US4499299A (en) * 1981-12-30 1985-02-12 Ici Americas Inc. Pharmaceutically active phenylcarboxylic acid derivatives
US4497827A (en) * 1982-08-30 1985-02-05 Syntex (U.S.A.) Inc. Arachidonic acid analogues as anti-inflammatory and anti-allergic agents
EP0123543B1 (en) * 1983-04-21 1988-02-03 Merck Frosst Canada Inc. Leukotriene antagonists, their production and use and compositions containing them
JPS59204167A (ja) * 1983-05-02 1984-11-19 Takeda Chem Ind Ltd ヒドロキノン誘導体およびその製法
US4499295A (en) * 1983-05-09 1985-02-12 G. D. Searle & Co. Protease inhibitors
ES532455A0 (es) * 1983-05-13 1985-06-16 Yamanouchi Pharma Co Ltd Un procedimiento para la produccion de un derivado de catecol
US5105017A (en) * 1983-07-18 1992-04-14 Eli Lilly And Company Leukotriene antagonist intermediates
CA1242195A (en) * 1983-07-18 1988-09-20 David K. Herron Leukotriene antagonists
US4590304A (en) * 1984-03-21 1986-05-20 The United States Of America As Represented By The Secretary Of The Air Force Protected ethynylated phenols
US4733002A (en) * 1984-05-23 1988-03-22 Green Cross Corporation Lipoxygenase inhibitor
US4564476A (en) * 1984-10-29 1986-01-14 Mcneilab, Inc. Aryl fatty acid leukotriene synthesis inhibitors
GB8430072D0 (en) * 1984-11-28 1985-01-09 Lilly Industries Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
DE3518655A1 (de) 1986-11-27
HUT43805A (en) 1987-12-28
CA1272723A (en) 1990-08-14
ATE48591T1 (de) 1989-12-15
KR930001324B1 (ko) 1993-02-26
ZA862432B (en) 1986-11-26
EP0202529A3 (en) 1988-08-03
EP0202529B1 (de) 1989-12-13
FI862184A (fi) 1986-11-25
US4760087A (en) 1988-07-26
PT82521B (pt) 1988-03-03
EP0202529A2 (de) 1986-11-26
AU587456B2 (en) 1989-08-17
IL78317A0 (en) 1986-07-31
DK240086D0 (da) 1986-05-22
DE3667461D1 (de) 1990-01-18
JPS61271238A (ja) 1986-12-01
ES554611A0 (es) 1987-04-16
US4959391A (en) 1990-09-25
GR860777B (en) 1986-07-18
SU1591800A3 (ru) 1990-09-07
DD251339A5 (de) 1987-11-11
FI88708C (fi) 1993-06-28
DK240086A (da) 1986-11-25
KR860008963A (ko) 1986-12-19
PT82521A (de) 1986-06-01
FI88708B (fi) 1993-03-15
AU5758186A (en) 1986-11-27
HU196048B (en) 1988-09-28
FI862184A0 (fi) 1986-05-23
JPH0796507B2 (ja) 1995-10-18

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Legal Events

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FD2A Announcement of lapse in spain

Effective date: 20170627