ES8300777A1 - Metodo de obtener nuevos compuestos citostaticos del tipo de la vinblastina y similares. - Google Patents
Metodo de obtener nuevos compuestos citostaticos del tipo de la vinblastina y similares.Info
- Publication number
- ES8300777A1 ES8300777A1 ES505310A ES505310A ES8300777A1 ES 8300777 A1 ES8300777 A1 ES 8300777A1 ES 505310 A ES505310 A ES 505310A ES 505310 A ES505310 A ES 505310A ES 8300777 A1 ES8300777 A1 ES 8300777A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- image
- carbon atoms
- formula
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
PROCEDIMIENTO DE OBTENCION DE COMPUESTOS CITOSTATICOS DEL TIPO DE LA VINBLASTINA. SE HACE REACCIONAR EL COMPUESTO (II) O SUS SALES DE ADICION DE ACIDO, CON UN GRAN EXCESO DE ALCOHOLES DE FORMULA R''''<024>OH, EN PRESENCIA DE TRIOXIDO CROMO, UN DISOLVENTE ORGANICO, ANHIDRIDO ACETICO Y UN ACIDO; LA TEMPERATURA ESTA COMPRENDIDA PREFERENTEMENTE, ENTRE -50 Y -60<025>C. EL PH DE LA REACCION SE AJUSTA ENTRE 8 Y 10. EL PRODUCTO OBTENIDO (I), SE AISLA Y PURIFICA. SE EMPLEAN DE 50 A 150 EQUIVALENTES MOLARES DE ALCOHOL POR CADA EQUIVALENTE DEL COMPUESTO (II). R'' ES METOXI; R 2 ES ACETILO; R ES ALFA-ETILO O BETA-ETILO; R ES BETA-HIDROXILO O HIDROGENO; R'''' ES UN ALQUILO DE CADENA RECTA O RAMIFICADA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HU802562A HU181745B (en) | 1980-10-22 | 1980-10-22 | Process for producing new vinblastin and leurosidin derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES505310A0 ES505310A0 (es) | 1982-12-01 |
ES8300777A1 true ES8300777A1 (es) | 1982-12-01 |
Family
ID=10960005
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES505310A Expired ES8300777A1 (es) | 1980-10-22 | 1981-08-17 | Metodo de obtener nuevos compuestos citostaticos del tipo de la vinblastina y similares. |
Country Status (15)
Country | Link |
---|---|
JP (1) | JPS5772992A (es) |
AT (1) | AT376678B (es) |
BE (1) | BE889989A (es) |
CA (1) | CA1174672A (es) |
CH (1) | CH648320A5 (es) |
DE (1) | DE3132476A1 (es) |
ES (1) | ES8300777A1 (es) |
FR (1) | FR2492384B1 (es) |
GB (1) | GB2086378B (es) |
HU (1) | HU181745B (es) |
IL (1) | IL63593A0 (es) |
IT (1) | IT1138154B (es) |
NL (1) | NL8103844A (es) |
SE (1) | SE442116B (es) |
SU (1) | SU1053757A3 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU193318B (en) * | 1985-06-12 | 1987-09-28 | Richter Gedeon Vegyeszet | Process for producing new bis- indol derivatives |
HU198074B (en) * | 1985-06-12 | 1989-07-28 | Richter Gedeon Vegyeszet | Process for producing new bis-indole derivatives and pharmaceutical compositions comprising these compounds |
JPH0321210U (es) * | 1989-07-11 | 1991-03-01 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3899493A (en) * | 1972-12-29 | 1975-08-12 | Richter Gedeon Vegyeszet | Chromic acid oxidation of vinblastine sulfate to form vincristine |
HU178706B (en) * | 1979-04-23 | 1982-06-28 | Richter Gedeon Vegyeszet | Process for preparing bis-indole alkaloids and acid addition salts thereof |
JPS56128643A (en) * | 1980-03-13 | 1981-10-08 | Sintokogio Ltd | Vertical flaskless type molding machine |
-
1980
- 1980-10-22 HU HU802562A patent/HU181745B/hu not_active IP Right Cessation
-
1981
- 1981-08-17 IL IL63593A patent/IL63593A0/xx unknown
- 1981-08-17 JP JP56128642A patent/JPS5772992A/ja active Granted
- 1981-08-17 DE DE3132476A patent/DE3132476A1/de active Granted
- 1981-08-17 CA CA000383978A patent/CA1174672A/en not_active Expired
- 1981-08-17 NL NL8103844A patent/NL8103844A/nl not_active Application Discontinuation
- 1981-08-17 GB GB8125029A patent/GB2086378B/en not_active Expired
- 1981-08-17 AT AT0358681A patent/AT376678B/de not_active IP Right Cessation
- 1981-08-17 CH CH5313/81A patent/CH648320A5/de not_active IP Right Cessation
- 1981-08-17 SE SE8104877A patent/SE442116B/sv not_active IP Right Cessation
- 1981-08-17 ES ES505310A patent/ES8300777A1/es not_active Expired
- 1981-08-17 FR FR8115835A patent/FR2492384B1/fr not_active Expired
- 1981-08-17 BE BE0/205691A patent/BE889989A/fr not_active IP Right Cessation
- 1981-08-17 IT IT23540/81A patent/IT1138154B/it active
- 1981-08-17 SU SU813320101A patent/SU1053757A3/ru active
Also Published As
Publication number | Publication date |
---|---|
DE3132476C2 (es) | 1991-04-18 |
SE8104877L (sv) | 1982-04-23 |
IT8123540A0 (it) | 1981-08-17 |
IL63593A0 (en) | 1981-11-30 |
BE889989A (fr) | 1982-02-17 |
GB2086378A (en) | 1982-05-12 |
JPH0161118B2 (es) | 1989-12-27 |
SU1053757A3 (ru) | 1983-11-07 |
ES505310A0 (es) | 1982-12-01 |
AT376678B (de) | 1984-12-27 |
HU181745B (en) | 1983-11-28 |
IT1138154B (it) | 1986-09-17 |
JPS5772992A (en) | 1982-05-07 |
FR2492384B1 (fr) | 1986-04-04 |
GB2086378B (en) | 1984-07-25 |
CA1174672A (en) | 1984-09-18 |
FR2492384A1 (fr) | 1982-04-23 |
DE3132476A1 (de) | 1982-06-09 |
NL8103844A (nl) | 1982-05-17 |
SE442116B (sv) | 1985-12-02 |
CH648320A5 (de) | 1985-03-15 |
ATA358681A (de) | 1984-05-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970519 |