ES8609485A1 - Un antibiotico antitumoral sandramicina - Google Patents
Un antibiotico antitumoral sandramicinaInfo
- Publication number
- ES8609485A1 ES8609485A1 ES544289A ES544289A ES8609485A1 ES 8609485 A1 ES8609485 A1 ES 8609485A1 ES 544289 A ES544289 A ES 544289A ES 544289 A ES544289 A ES 544289A ES 8609485 A1 ES8609485 A1 ES 8609485A1
- Authority
- ES
- Spain
- Prior art keywords
- antitumor antibiotic
- antibiotic compound
- sandramycin
- new
- nocardioides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003972 antineoplastic antibiotic Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- WXIVYIYCEBUEHL-RTQGILJWSA-N sandramycin Chemical compound C([C@H](C(=O)N1CCCC[C@H]1C(=O)NCC(=O)N(C)CC(=O)N(C)[C@H](C(OC1)=O)C(C)C)NC(=O)C=2C(=CC3=CC=CC=C3N=2)O)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)CNC(=O)[C@@H]2CCCCN2C(=O)[C@@H]1NC(=O)C1=NC2=CC=CC=C2C=C1O WXIVYIYCEBUEHL-RTQGILJWSA-N 0.000 abstract 2
- 108700026174 sandramycin Proteins 0.000 abstract 2
- 108010002156 Depsipeptides Proteins 0.000 abstract 1
- 241001495390 Nocardioides sp. Species 0.000 abstract 1
- 238000010171 animal model Methods 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/19—Antibiotic
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/27—Cyclic peptide or cyclic protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
PREPARACION DEL ANTIBIOTICO ANTITUMORAL SANDRAMICINA, DE FORMULA ESTRUCTURAL: (I). SE PRODUCE CULTIVANDO UN NUEVO MICROORGANISMO NOCARDIOOIDES SP.CEPA N.O C45.009 O UN MUTANTE, EN UN MEDIO DE CULTIVO CONVENCIONAL, ENTRE 25J Y 30JC Y EL PH ENTRE 6 Y 8,5. EL CALDO COMPLEMENTO DE LA FERMENTACION SE EXTRAE CON ACETATO DE ETILO MEZCLADO CON TIERRA DE DIATOMEAS Y SE FILTRA; SE SEPARA LA PARTE ORGANICA Y SE CONCENTRA POR EVAPORACION, EL EXTRACTO CRUDO DEL ANTIBIOTICO SE REPARTE EN UN DISOLVENTE HIDROCARBONADO ALIFATICO Y AGUA AL 10% EN METANOL, A LA FASE HIDROMETANOLICA SE AÑADE UN 25% MAS DE AGUA, EXTRAYENDO LA SOLCUION CON TETRACLORURO DE CARBONO; LA FASE DE AGUA EN METANOL 1:3 SE DILUYE EN AGUA A 7:13 EXTRAYENDO LA SOLUCION CON CLOROFORMO; LOS EXTRACTOS CONSEGUIDOS SE EVAPORAN AL VACIO, DANDO RESIDUOS QUE SE REUNEN Y SON CROMATOGRAFICADOS EN TIERRA DE DIATOMEAS; LAS FRACCIONES APROPIADAS SE EVAPORAN A SEQUEDAD.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/621,641 US4582639A (en) | 1984-06-18 | 1984-06-18 | Antitumor antibiotic compound |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8609485A1 true ES8609485A1 (es) | 1986-09-01 |
| ES544289A0 ES544289A0 (es) | 1986-09-01 |
Family
ID=24491001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES544289A Expired ES8609485A1 (es) | 1984-06-18 | 1985-06-17 | Un antibiotico antitumoral sandramicina |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US4582639A (es) |
| JP (1) | JPS6122099A (es) |
| KR (1) | KR930003107B1 (es) |
| AT (1) | AT395860B (es) |
| AU (1) | AU584075B2 (es) |
| BE (1) | BE902670A (es) |
| CA (1) | CA1230568A (es) |
| CH (1) | CH668974A5 (es) |
| DE (1) | DE3521436A1 (es) |
| DK (1) | DK272985A (es) |
| ES (1) | ES8609485A1 (es) |
| FI (1) | FI80475C (es) |
| FR (1) | FR2568892B1 (es) |
| GB (1) | GB2160529B (es) |
| GR (1) | GR851452B (es) |
| IE (1) | IE58629B1 (es) |
| IT (1) | IT1191622B (es) |
| LU (1) | LU85953A1 (es) |
| MY (1) | MY100478A (es) |
| NL (1) | NL8501708A (es) |
| PT (1) | PT80656B (es) |
| SE (1) | SE464524B (es) |
| ZA (1) | ZA852370B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4902781A (en) * | 1987-11-24 | 1990-02-20 | Taisho Pharmaceutical Co., Ltd. | Novel tripetide derivatives |
| DE3832362A1 (de) * | 1988-09-23 | 1990-03-29 | Sandoz Ag | Neue cyclopeptolide, verfahren zu ihrer herstellung und ihre verwendung |
| US5523219A (en) * | 1993-06-15 | 1996-06-04 | Bristol-Myers Squibb Company | Enzymatic hydrolysis method for the preparation of C-10 hydroxyl-bearing taxanes and enzymatic esterification method for the preparation of C-10 acyloxy-bearing |
| US5516676A (en) * | 1993-06-15 | 1996-05-14 | Bristol-Myers Squibb Company | Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom |
| US5643871A (en) * | 1993-11-23 | 1997-07-01 | Bristol-Meyers Squibb Company | Antitumor antibiotics |
| US5444043A (en) * | 1994-02-18 | 1995-08-22 | The Regents Of The University Of California | Cyclic heptapeptide anti-inflammatory agent |
| GB2294265A (en) * | 1994-10-20 | 1996-04-24 | Merck & Co Inc | Cyclic depsipeptides obtained from Actinomycete sp. |
| US6329497B1 (en) * | 1997-03-28 | 2001-12-11 | The Scripps Research Institute | Sandramycin analogs |
| US6001815A (en) * | 1997-12-25 | 1999-12-14 | Nisshin Flour Milling Co., Ltd. | Depsipeptides containing N-substituted glycine residue |
| KR100575681B1 (ko) | 2004-05-18 | 2006-05-03 | 엘지전자 주식회사 | 와인 냉장고의 진동절연 지지장치 |
| EP1924245A2 (en) * | 2005-08-19 | 2008-05-28 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Topical formulations of histone deacetylase inhibitors and methods of using the same |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4360458A (en) * | 1979-04-02 | 1982-11-23 | Bristol-Myers Company | Antitumor antibacterial agents |
| US4451456A (en) * | 1979-04-02 | 1984-05-29 | Bristol-Myers Company | Antitumor antibacterial agents |
-
1984
- 1984-06-18 US US06/621,641 patent/US4582639A/en not_active Expired - Fee Related
-
1985
- 1985-03-28 ZA ZA852370A patent/ZA852370B/xx unknown
- 1985-03-28 AU AU40480/85A patent/AU584075B2/en not_active Ceased
- 1985-04-26 CA CA000480249A patent/CA1230568A/en not_active Expired
- 1985-05-24 FI FI852082A patent/FI80475C/fi not_active IP Right Cessation
- 1985-05-29 JP JP60116338A patent/JPS6122099A/ja active Granted
- 1985-05-30 CH CH2290/85A patent/CH668974A5/de not_active IP Right Cessation
- 1985-06-13 NL NL8501708A patent/NL8501708A/nl not_active Application Discontinuation
- 1985-06-14 GR GR851452A patent/GR851452B/el unknown
- 1985-06-14 IT IT21156/85A patent/IT1191622B/it active
- 1985-06-14 DE DE19853521436 patent/DE3521436A1/de active Granted
- 1985-06-14 AT AT0178285A patent/AT395860B/de not_active IP Right Cessation
- 1985-06-17 DK DK272985A patent/DK272985A/da not_active Application Discontinuation
- 1985-06-17 GB GB08515256A patent/GB2160529B/en not_active Expired
- 1985-06-17 LU LU85953A patent/LU85953A1/fr unknown
- 1985-06-17 SE SE8502996A patent/SE464524B/sv not_active IP Right Cessation
- 1985-06-17 IE IE150485A patent/IE58629B1/en not_active IP Right Cessation
- 1985-06-17 FR FR858509170A patent/FR2568892B1/fr not_active Expired - Fee Related
- 1985-06-17 ES ES544289A patent/ES8609485A1/es not_active Expired
- 1985-06-17 BE BE0/215198A patent/BE902670A/fr not_active IP Right Cessation
- 1985-06-17 KR KR1019850004273A patent/KR930003107B1/ko not_active IP Right Cessation
- 1985-06-18 PT PT80656A patent/PT80656B/pt not_active IP Right Cessation
-
1987
- 1987-09-29 MY MYPI87002199A patent/MY100478A/en unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 20000503 |